Extracellular matrix remodelling: the role of matrix metalloproteinases

New functions for the matrix metalloproteinases in cancer progression

2002 • 5,937 citations

Involvement of chemokine receptors in breast cancer metastasis

2001 • 5,203 citations

How Matrix Metalloproteinases Regulate Cell Behavior

2001 • 3,860 citations

Matrix Metalloproteinases

1999 • 3,774 citations

Matrix Metalloproteinase Inhibitors and Cancer—Trials and Tribulations

2002 • 2,711 citations

Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis

2000 • 2,700 citations

A matrix metalloproteinase expressed on the surface of invasive tumour cells

1994 • 2,561 citations

TGF-β signaling in tumor suppression and cancer progression

2001 • 2,235 citations

VEGF couples hypertrophic cartilage remodeling, ossification and angiogenesis during endochondral bone formation

1999 • 2,034 citations

Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-beta and promotes tumor invasion and angiogenesis.

2000 • 1,945 citations

Hyaluronan ¹

1992 • 1,787 citations

Recruitment of Stem and Progenitor Cells from the Bone Marrow Niche Requires MMP-9 Mediated Release of Kit-Ligand

2002 • 1,755 citations

MMP-9/Gelatinase B Is a Key Regulator of Growth Plate Angiogenesis and Apoptosis of Hypertrophic Chondrocytes

1998 • 1,753 citations

MATRIX PROTEOGLYCANS: From Molecular Design to Cellular Function

1998 • 1,623 citations

Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-β and promotes tumor invasion and angiogenesis

2000 • 1,604 citations

Changing views of the role of matrix metalloproteinases in metastasis

1997 • 1,585 citations

Mechanism Of Cell Surface Activation Of 72-kDa Type IV Collagenase

1995 • 1,576 citations

Localization of Matrix Metalloproteinase MMP-2 to the Surface of Invasive Cells by Interaction with Integrin αvβ3

1996 • 1,555 citations

Tissue inhibitors of metalloproteinases: structure, regulation and biological functions.

1997 • 1,510 citations

Compensation mechanism in tumor cell migration

2003 • 1,360 citations

ECM and Cell Surface Proteolysis: Regulating Cellular Ecology

1997 • 1,311 citations

MMP-9 Supplied by Bone Marrow–Derived Cells Contributes to Skin Carcinogenesis

2000 • 1,306 citations

MT1-MMP-Deficient Mice Develop Dwarfism, Osteopenia, Arthritis, and Connective Tissue Disease due to Inadequate Collagen Turnover

1999 • 1,280 citations

COLLAGENOLYTIC ACTIVITY IN AMPHIBIAN TISSUES: A TISSUE CULTURE ASSAY

1962 • 1,275 citations

Matrix metalloproteinases: they're not just for matrix anymore!

2001 • 1,257 citations

Induction of Cell Migration by Matrix Metalloprotease-2 Cleavage of Laminin-5

1997 • 1,227 citations

Activation mechanisms of matrix metalloproteinases.

1997 • 1,134 citations

The Stromal Proteinase MMP3/Stromelysin-1 Promotes Mammary Carcinogenesis

1999 • 916 citations

Reduced angiogenesis and tumor progression in gelatinase A-deficient mice.

1998 • 887 citations

Matrix metalloproteinases in tumor invasion and metastasis

2000 • 820 citations

[13] Evolutionary families of metallopeptidases

1995 • 794 citations

Impaired endochondral ossification and angiogenesis in mice deficient in membrane-type matrix metalloproteinase I

2000 • 792 citations

Development of Matrix Metalloproteinase Inhibitors in Cancer Therapy

2001 • 788 citations

Inflammation Dampened by Gelatinase A Cleavage of Monocyte Chemoattractant Protein-3

2000 • 771 citations

Immune-mediated eradication of tumors through the blockade of transforming growth factor-β signaling in T cells

2001 • 759 citations

Matrilysin Shedding of Syndecan-1 Regulates Chemokine Mobilization and Transepithelial Efflux of Neutrophils in Acute Lung Injury

2002 • 734 citations

Membrane-Type 1 Matrix Metalloproteinase Cleaves Cd44 and Promotes Cell Migration

2001 • 732 citations

Matrix Metalloproteinases Regulate Neovascularization by Acting as Pericellular Fibrinolysins

1998 • 716 citations

The integrin αvβ8 mediates epithelial homeostasis through MT1-MMP–dependent activation of TGF-β1

2002 • 701 citations

Localization of matrix metalloproteinase 9 to the cell surface provides a mechanism for CD44-mediated tumor invasion

1999 • 699 citations

The Membrane-Anchored MMP Inhibitor RECK Is a Key Regulator of Extracellular Matrix Integrity and Angiogenesis

2001 • 699 citations

The metzincins — Topological and sequential relations between the astacins, adamalysins, serralysins, and matrixins (collagenases) define a super family of zinc‐peptidases

1995 • 691 citations

Release of an invasion promoter E-cadherin fragment by matrilysin and stromelysin-1

2001 • 685 citations

Role of Cell Surface Metalloprotease Mt1-Mmp in Epithelial Cell Migration over Laminin-5

2000 • 650 citations

Matrix Metalloproteinase Activity Inactivates the CXC Chemokine Stromal Cell-derived Factor-1

2001 • 649 citations

Intestinal tumorigenesis is suppressed in mice lacking the metalloproteinase matrilysin

1997 • 612 citations

TNF‐α converting enzyme (TACE) is inhibited by TIMP‐3

1998 • 604 citations

The Degradation of Human Endothelial Cell-derived Perlecan and Release of Bound Basic Fibroblast Growth Factor by Stromelysin, Collagenase, Plasmin, and Heparanases

1996 • 601 citations

The Activity of Collagenase-1 Is Required for Keratinocyte Migration on a Type I Collagen Matrix

1997 • 600 citations

Regulation of Cell Invasion and Morphogenesis in a Three-Dimensional Type I Collagen Matrix by Membrane-Type Matrix Metalloproteinases 1, 2, and 3

2000 • 588 citations

Matrix metal loproteinases and the development of cancer

1996 • 569 citations

Impaired wound healing in mice with a disrupted plasminogen gene

1996 • 568 citations

Tumor targeting with a selective gelatinase inhibitor

1999 • 554 citations

Macrophage-Derived Metalloelastase Is Responsible for the Generation of Angiostatin in Lewis Lung Carcinoma

1997 • 537 citations

Interaction of 92-kDa type IV collagenase with the tissue inhibitor of metalloproteinases prevents dimerization, complex formation with interstitial collagenase, and activation of the proenzyme with stromelysin.

1992 • 519 citations

Proteolytic exposure of a cryptic site within collagen type IV is required for angiogenesis and tumor growth in vivo

2001 • 475 citations

CD44 anchors the assembly of matrilysin/MMP-7 with heparin-binding epidermal growth factor precursor and ErbB4 and regulates female reproductive organ remodeling

2002 • 472 citations

Thrombospondin-1 suppresses spontaneous tumor growth and inhibits activation of matrix metalloproteinase-9 and mobilization of vascular endothelial growth factor

2001 • 463 citations

Requirement for Specific Proteases in Cancer Cell Intravasation as Revealed by a Novel Semiquantitative PCR-Based Assay

1998 • 459 citations

Cell growth-promoting activity of tissue inhibitor of metalloproteinases-2 (TIMP-2)

1994 • 456 citations

Matrix Metalloproteinases Generate Angiostatin: Effects on Neovascularization

1998 • 446 citations

Marimastat as First-Line Therapy for Patients With Unresectable Pancreatic Cancer: A Randomized Trial

2001 • 432 citations

The metalloproteinase matrilysin proteolytically generates active soluble Fas ligand and potentiates epithelial cell apoptosis

1999 • 421 citations

Transmembrane/cytoplasmic domain-mediated membrane type 1-matrix metalloprotease docking to invadopodia is required for cell invasion

1997 • 419 citations

Targeted expression of stromelysin-1 in mammary gland provides evidence for a role of proteinases in branching morphogenesis and the requirement for an intact basement membrane for tissue-specific gene expression [published erratum appears in J Cell Biol 1996 Feb;132(4):following 752]

1994 • 405 citations

Gelatinase B: a tuner and amplifier of immune functions

2001 • 401 citations

Matrix metalloproteinase-2 is required for the switch to the angiogenic phenotype in a tumor model

2000 • 389 citations

TIMP-2 Is Required for Efficient Activation of proMMP-2 in Vivo

2000 • 383 citations

Generation and degradation of human endostatin proteins by various proteinases

2000 • 379 citations

MT1-MMP Initiates Activation of pro-MMP-2 and Integrin αvβ3 Promotes Maturation of MMP-2 in Breast Carcinoma Cells

2001 • 373 citations

Matrix metalloproteinase-7-mediated cleavage of Fas ligand protects tumor cells from chemotherapeutic drug cytotoxicity.

2001 • 365 citations

Matrix metalloproteinase-7–dependent release of tumor necrosis factor-α in a model of herniated disc resorption

2000 • 357 citations

Matrix metalloproteinase 2 releases active soluble ectodomain of fibroblast growth factor receptor 1.

1996 • 353 citations

Expression and function of matrix metalloproteinases and their inhibitors at the maternal-embryonic boundary during mouse embryo implantation

1996 • 345 citations

Stimulation of Matrix Metalloproteinase Production by Recombinant Extracellular Matrix Metalloproteinase Inducer from Transfected Chinese Hamster Ovary Cells

1997 • 341 citations

Matrix Metalloproteinase-3 Releases Active Heparin-binding EGF-like Growth Factor by Cleavage at a Specific Juxtamembrane Site

1997 • 329 citations

Endostatin inhibits endothelial and tumor cellular invasion by blocking the activation and catalytic activity of matrix metalloproteinase.

2000 • 316 citations

Collective cell movement in primary melanoma explants: plasticity of cell-cell interaction, beta1-integrin function, and migration strategies.

2002 • 314 citations

The genetic transformation of bone biology

1999 • 313 citations

In Vivo Evidence That the Stromelysin-3 Metalloproteinase Contributes in a Paracrine Manner to Epithelial Cell Malignancy

1998 • 290 citations

Extracellular Matrix Metalloproteinase 2 Levels Are Regulated by the Low Density Lipoprotein-related Scavenger Receptor and Thrombospondin 2

2001 • 286 citations

A targeted mutation at the known collagenase cleavage site in mouse type I collagen impairs tissue remodeling.

1995 • 280 citations

Functional overlap between two classes of matrix-degrading proteases in wound healing

1999 • 273 citations

Epithelial-Mesenchymal Transitions in Cancer Progression

1996 • 271 citations

Matrix Metalloproteinase-9/Gelatinase B Is Required for Process Outgrowth by Oligodendrocytes

1999 • 268 citations

A novel role of metalloproteinase in cancer-mediated immunosuppression.

2001 • 267 citations

CD44v3,8-10 is involved in cytoskeleton-mediated tumor cell migration and matrix metalloproteinase (MMP-9) association in metastatic breast cancer cells

1998 • 265 citations

Disruption of matrix metalloproteinase 2 binding to integrin alpha vbeta 3 by an organic molecule inhibits angiogenesis and tumor growth in vivo

2000 • 264 citations

Membrane Type 1-Matrix Metalloproteinase Is Activated during Migration of Human Endothelial Cells and Modulates Endothelial Motility and Matrix Remodeling

2001 • 250 citations

Thrombospondin Type 1 Repeats Interact with Matrix Metalloproteinase 2

2000 • 249 citations

Rescue of mammary epithelial cell apoptosis and entactin degradation by a tissue inhibitor of metalloproteinases-1 transgene.

1996 • 238 citations

Cleavage of the HER2 ectodomain is a pervanadate-activable process that is inhibited by the tissue inhibitor of metalloproteases-1 in breast cancer cells.

1999 • 235 citations

Impaired Wound Contraction in Stromelysin-1–Deficient Mice

1999 • 232 citations

A Novel Protease-docking Function of Integrin at Invadopodia

1999 • 225 citations

Inhibition of matrix metalloproteinase 9 expression by a ribozyme blocks metastasis in a rat sarcoma model system.

1996 • 217 citations

Matrix metalloproteinase 9 (MMP-9/gelatinase B) proteolytically cleaves ICAM-1 and participates in tumor cell resistance to natural killer cell-mediated cytotoxicity

2002 • 213 citations

Processing of Integrin αv Subunit by Membrane Type 1 Matrix Metalloproteinase Stimulates Migration of Breast Carcinoma Cells on Vitronectin and Enhances Tyrosine Phosphorylation of Focal Adhesion Kinase

2002 • 212 citations

Pro-collagenase-1 (Matrix Metalloproteinase-1) Binds the α2β1 Integrin upon Release from Keratinocytes Migrating on Type I Collagen

2001 • 209 citations

Identification of Insulin-like Growth Factor-binding Protein-1 as a Potential Physiological Substrate for Human Stromelysin-3

1997 • 208 citations

Activation of β1 Integrin Signaling Stimulates Tyrosine Phosphorylation of p190 and Membrane-protrusive Activities at Invadopodia

1998 • 204 citations

Matrix metalloproteinases are expressed during ductal and alveolar mammary morphogenesis, and misregulation of stromelysin-1 in transgenic mice induces unscheduled alveolar development.

1995 • 194 citations

The Matrix Metalloproteinase-9 Regulates the Insulin-like Growth Factor-triggered Autocrine Response in DU-145 Carcinoma Cells

1999 • 186 citations

Angiogenesis: vascular remodeling of the extracellular matrix involves metalloproteinases

2003 • 184 citations

Matrix Metalloproteinases MMP2 and MMP9 Are Produced in Early Stages of Kidney Morphogenesis but Only MMP9 Is Required for Renal Organogenesis In Vitro

1997 • 183 citations

TGF-β Plays a Key Role in Morphogenesis of the Pancreatic Islets of Langerhans by Controlling the Activity of the Matrix Metalloproteinase MMP-2

1998 • 174 citations

EMMPRIN (CD147), an inducer of matrix metalloproteinase synthesis, also binds interstitial collagenase to the tumor cell surface.

2000 • 172 citations

Human Fibroblast Collagenase-α-Macroglobulin Interactions

1989 • 164 citations

Selective suppression of matrix metalloproteinase-9 in human glioblastoma cells by antisense gene transfer impairs glioblastoma cell invasion.

2000 • 162 citations

The matrix metalloproteinase matrilysin influences early-stage mammary tumorigenesis.

1998 • 162 citations

The heparin binding 25 kDa fragment of thrombospondin‐1 promotes angiogenesis and modulates gelatinase and TIMP‐2 production in endothelial cells

2000 • 147 citations

Growth factor–induced angiogenesis in vivo requires specific cleavage of fibrillar type I collagen

2001 • 144 citations

Collagenase Expression in Transgenic Mouse Skin Causes Hyperkeratosis and Acanthosis and Increases Susceptibility to Tumorigenesis

1995 • 141 citations

High Affinity Binding of Latent Matrix Metalloproteinase-9 to the α2(IV) Chain of Collagen IV

1998 • 138 citations

Preparation and Characterization of Recombinant Tissue Inhibitor of Metalloproteinase 4 (TIMP-4)

1997 • 138 citations

Role of the matrixin MMP-2 in multicellular organization of adipocytes cultured in basement membrane components

1997 • 138 citations

Overexpression of membrane-type matrix metalloproteinase-1 gene induces mammary gland abnormalities and adenocarcinoma in transgenic mice.

2001 • 137 citations

High cancer cell death in syngeneic tumors developed in host mice deficient for the stromelysin-3 matrix metalloproteinase.

2001 • 125 citations

Proteases Associated with Invadopodia, and Their Role in Degradation of Extracellular Matrix

1996 • 123 citations

Stimulation of mammary tumorigenesis by systemic tissue inhibitor of matrix metalloproteinase 4 gene delivery.

2001 • 120 citations

Mammary carcinoma cells over-expressing tissue inhibitor of metalloproteinases-1show vascular endothelial growth factor expression

1998 • 119 citations

Cleavage of β4 Integrin by Matrilysin

1997 • 115 citations

Shedding of c-Met is regulated by crosstalk between a G-protein coupled receptor and the EGF receptor and is mediated by a TIMP-3 sensitive metalloproteinase

2014 • 112 citations

Shedding of c-Met is regulated by crosstalk between a G-protein coupled receptor and the EGF receptor and is mediated by a TIMP-3 sensitive metalloproteinase

2001 • 105 citations

The role of interstitial collagens in cleft formation of mouse embryonic submandibular gland during initial branching

1988 • 101 citations

Aspirin Inhibits Matrix Metalloproteinase-2 Activity, Increases E-Cadherin Production, and Inhibits in Vitro Invasion of Tumor Cells

2001 • 100 citations

Human macrophage metalloelastase gene expression in colorectal carcinoma and its clinicopathologic significance

2001 • 100 citations

The Migration of Purified Osteoclasts Through Collagen Is Inhibited by Matrix Metalloproteinase Inhibitors

1998 • 98 citations

Tyrosine Phosphorylation and Proteolysis

1998 • 87 citations

Enhanced Tumor Growth and Invasiveness in Vivo by a Carboxyl-Terminal Fragment of α1-Proteinase Inhibitor Generated by Matrix Metalloproteinases

1999 • 78 citations

Stromal Expression of MMP‐9 and Urokinase Receptor Is Inversely Associated with Liver Metastasis and with Infiltrating Growth in Human Colorectal Cancer: A Novel Approach from Immune/Inflammatory Aspect

1997 • 75 citations

Cancer biology: Extracellular proteinases in malignancy

1999 • 74 citations

Induction of Matrix Metalloproteinase MMP‐9 (92‐kDa Gelatinase) by Retinoic Acid in Human Neuroblastoma SKNBE Cells

2000 • 67 citations

Stromelysin-1-Deficient Fibroblasts Display Impaired Contractionin Vitro

1999 • 66 citations

Matrix Metalloproteinase-19 Is Expressed in Myeloid Cells in an Adhesion-Dependent Manner and Associates with the Cell Surface

2002 • 60 citations

Stromelysin‐3 suppresses tumor cell apoptosis in a murine model*

2001 • 59 citations

Role of membrane-type matrix metalloproteinase 1 (MT-1-MMP), MMP-2, and its inhibitor in nephrogenesis

1999 • 59 citations

Inhibition of peritoneal dissemination in human gastric cancer by MMP-7-specific antisense oligonucleotide.

2001 • 43 citations

Metalloproteinases regulate parietal endoderm differentiating and migrating in cultured mouse embryos

1997 • 41 citations

Regulation of matrilysin in the rat uterus

1996 • 33 citations

Generation and Activity of the Ternary Gelatinase B / TIMP-1 / LMW-Stromelysin-1 Complex

1995 • 27 citations

CELL BIOLOGY: A Series of Monographs

1993 • 5 citations