Generation and degradation of human endostatin proteins by various proteinases

Endostatin: An Endogenous Inhibitor of Angiogenesis and Tumor Growth

1997 • 4,504 citations

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1994 • 3,367 citations

Cancer metastasis and angiogenesis: An imbalance of positive and negative regulation

1991 • 2,774 citations

Handbook of Proteolytic Enzymes

2004 • 2,698 citations

L-trans-Epoxysuccinyl-leucylamido(4-guanidino)butane (E-64) and its analogues as inhibitors of cysteine proteinases including cathepsins B, H and L

1982 • 1,024 citations

Matrix metalloproteinases in angiogenesis: a moving target for therapeutic intervention

1999 • 840 citations

Matrix Metalloproteinases Regulate Neovascularization by Acting as Pericellular Fibrinolysins

1998 • 716 citations

A novel coumarin‐labelled peptide for sensitive continuous assays of the matrix metalloproteinases

1992 • 692 citations

Endostatin Induces Endothelial Cell Apoptosis

1999 • 594 citations

Secreted cathepsin L generates endostatin from collagen XVIII

2000 • 459 citations

Endostatin inhibits VEGF-induced endothelial cell migration and tumor growth independently of zinc binding

1999 • 451 citations

Angiostatin-converting Enzyme Activities of Human Matrilysin (MMP-7) and Gelatinase B/Type IV Collagenase (MMP-9)

1997 • 430 citations

Plasminogen Activators and Matrix Metalloproteinases in Angiogenesis

1996 • 341 citations

Structure, function and tissue forms of the C-terminal globular domain of collagen XVIII containing the angiogenesis inhibitor endostatin

1998 • 337 citations

Collagen XVIII Is a Basement Membrane Heparan Sulfate Proteoglycan

1998 • 335 citations

The generation of endostatin is mediated by elastase.

1999 • 295 citations

Endostatin: yeast production, mutants, and antitumor effect in renal cell carcinoma.

1999 • 246 citations

Angiogenesis: A Paradigm for Balanced Extracellular Proteolysis during Cell Migration and Morphogenesis

1996 • 220 citations

Endostatins derived from collagens XV and XVIII differ in structural and binding properties, tissue distribution and anti-angiogenic activity

2000 • 215 citations

Mouse Col18a1 is expressed in a tissue-specific manner as three alternative variants and is localized in basement membrane zones.

1995 • 194 citations

Purification and characterization of matrix metalloproteinase 9 from U937 monocytic leukaemia and HT1080 fibrosarcoma cells

1992 • 191 citations

Isolation and sequencing of cDNAs for proteins with multiple domains of Gly-Xaa-Yaa repeats identify a distinct family of collagenous proteins.

1994 • 190 citations

Alpha 1(XVIII), a collagen chain with frequent interruptions in the collagenous sequence, a distinct tissue distribution, and homology with type XV collagen.

1994 • 179 citations

Interaction of human cathepsin D with the inhibitor pepstatin

1976 • 150 citations

Angiogenesis inhibitor endostatin is a distinct component of elastic fibers in vessel walls

1999 • 136 citations

Cloning of cDNA and Genomic DNA Encoding Human Type XVIII Collagen and Localization of the α1(XVIII) Collagen Gene to Mouse Chromosome 10 and Human Chromosome 21

1994 • 131 citations

Identification of Three N-terminal Ends of Type XVIII Collagen Chains and Tissue-specific Differences in the Expression of the Corresponding Transcripts

1995 • 128 citations

Isolation and characterization of the circulating form of human endostatin

1997 • 115 citations

Expression of human cathepsin K in Pichia pastoris and preliminary crystallographic studies of an inhibitor complex

1997 • 106 citations

Primary structure of the alpha 1 chain of mouse type XVIII collagen, partial structure of the corresponding gene, and comparison of the alpha 1(XVIII) chain with its homologue, the alpha 1(XV) collagen chain.

1994 • 93 citations

[6] Active-site titration of peptidases

1995 • 81 citations

Alpha 1 (XVIII), a collagen chain with frequent interruptions in the collagenous sequence, a distinct tissue distribution, and homology with type XV collagen

1994 • 66 citations