Changing views of the role of matrix metalloproteinases in metastasis

A genetic model for colorectal tumorigenesis

1990 • 11,800 citations

Cancer: Principles and Practice of Oncology.

1991 • 8,402 citations

Lessons from Hereditary Colorectal Cancer

1996 • 4,900 citations

Matrix Metalloproteinases: A Review

1993 • 2,998 citations

Metastatic potential correlates with enzymatic degradation of basement membrane collagen

1980 • 1,778 citations

Molecular themes in oncogenesis

1991 • 1,663 citations

COLLAGENOLYTIC ACTIVITY IN AMPHIBIAN TISSUES: A TISSUE CULTURE ASSAY

1962 • 1,275 citations

A novel metalloproteinase gene specifically expressed in stromal cells of breast carcinomas

1990 • 1,140 citations

KiSS-1, a Novel Human Malignant Melanoma Metastasis-Suppressor Gene

1996 • 1,013 citations

Metastasis: Quantitative Analysis of Distribution and Fate of Tumor Emboli Labeled With <sup>125</sup>I-5-Iodo-2′ -deoxyuridine<xref ref-type="fn" rid="FN2">2</xref><xref ref-type="fn" rid="FN3">3</xref>

1970 • 990 citations

Membrane Type 1 Matrix Metalloproteinase Digests Interstitial Collagens and Other Extracellular Matrix Macromolecules

1997 • 926 citations

Matrix Metalloproteinase-2 Is an Interstitial Collagenase

1995 • 917 citations

Quantitative relationships of intravascular tumor cells, tumor vessels, and pulmonary metastases following tumor implantation.

1974 • 775 citations

Tumor invasion through the human amniotic membrane: Requirement for a proteinase cascade

1986 • 764 citations

KAI1 , a Metastasis Suppressor Gene for Prostate Cancer on Human Chromosome 11p11.2

1995 • 757 citations

Tumor invasion and metastasis: an imbalance of positive and negative regulation.

1991 • 711 citations

Sequence of human tissue inhibitor of metalloproteinases and its identity to erythroid-potentiating activity

1985 • 702 citations

Human fibroblast collagenase. Complete primary structure and homology to an oncogene transformation-induced rat protein.

1986 • 645 citations

Intestinal tumorigenesis is suppressed in mice lacking the metalloproteinase matrilysin

1997 • 612 citations

Molecular Cloning and Characterization of Human Tissue Inhibitor of Metalloproteinase 4

1996 • 547 citations

Expression of most matrix metalloproteinase family members in breast cancer represents a tumor-induced host response.

1996 • 515 citations

Loss of basement membrane components by invasive tumors but not by their benign counterparts.

1983 • 497 citations

Tissue inhibitor of metalloproteinases-3 (TIMP-3) is an extracellular matrix-associated protein with a distinctive pattern of expression in mouse cells and tissues.

1994 • 485 citations

Antisense RNA-Induced Reduction in Murine TIMP Levels Confers Oncogenicity on Swiss 3T3 Cells

1989 • 459 citations

Cell growth-promoting activity of tissue inhibitor of metalloproteinases-2 (TIMP-2)

1994 • 456 citations

Quantitation of cell shedding into efferent blood of mammary adenocarcinoma.

1975 • 444 citations

Comparison of human stromelysin and collagenase by cloning and sequence analysis

1986 • 443 citations

Inhibition of invasion and metastasis in cells transfected with an inhibitor of metalloproteinases.

1992 • 429 citations

Contributions of tumor and stromal matrix metalloproteinases to tumor progression, invasion and metastasis

1995 • 429 citations

Direct evidence linking expression of matrix metalloproteinase 9 (92-kDa gelatinase/collagenase) to the metastatic phenotype in transformed rat embryo cells.

1994 • 395 citations

The Molecular Basis of Cancer

1985 • 389 citations

A synthetic matrix metalloproteinase inhibitor decreases tumor burden and prolongs survival of mice bearing human ovarian carcinoma xenografts.

1993 • 383 citations

Effects of inhibitors of plasminogen activator, serine proteinases, and collagenase IV on the invasion of basement membranes by metastatic cells

1988 • 352 citations

Epidermal growth factor and oncogenes induce transcription of the same cellular mRNA in rat fibroblasts.

1985 • 344 citations

Role of collagenases in tumor cell invasion

1982 • 340 citations

Molecular cloning of a novel membrane-type matrix metalloproteinase from a human breast carcinoma.

1996 • 330 citations

Tumor Cell Invasion Inhibited by TIMP-2

1991 • 324 citations

Inhibition by human recombinant tissue inhibitor of metalloproteinases of human amnion invasion and lung colonization by murine B16-F10 melanoma cells.

1988 • 312 citations

Inhibition of angiogenesis by tissue inhibitor of metalloproteinase

1994 • 299 citations

Molecular characterization and expression of the gene encoding human erythroid-potentiating activity

1985 • 279 citations

A new inhibitor of metalloproteinases from chicken: ChIMP-3. A third member of the TIMP family.

1992 • 274 citations

Steps in tumor metastasis: new concepts from intravital videomicroscopy

1995 • 268 citations

Evidence for the Clonal Origin of Spontaneous Metastases

1982 • 265 citations

The mRNA coding for the secreted protease transin is expressed more abundantly in malignant than in benign tumors.

1986 • 260 citations

Expression and localization of matrix‐degrading metalloproteinases during colorectal tumorigenesis

1994 • 256 citations

Type IV collagenases in invasive tumors

1993 • 256 citations

Matrix metalloproteinase inhibitor BB-94 (batimastat)inhibits human colon tumor growth and spread in a patient-like orthotopic model in nude mice.

1994 • 254 citations

Identification and Characterization of a Novel Human Matrix Metalloproteinase with Unique Structural Characteristics, Chromosomal Location, and Tissue Distribution

1997 • 254 citations

Growth Stimulation of Human Keratinocytes by Tissue Inhibitor of Metalloproteinases

1991 • 241 citations

Inhibition of Angiogenesis and Murine Hemangioma Growth by Batimastat, a Synthetic Inhibitor of Matrix Metalloproteinases

1995 • 234 citations

Inhibition of Collagenolytic Activity and Metastasis of Tumor Cells by a Recombinant Human Tissue Inhibitor of Metalloproteinases

1990 • 233 citations

Suppression of the Tumorigenic and Metastatic Abilities of Murine B16-F10 Melanoma Cells In Vivo by the Overexpression of the Tissue Inhibitor of the Metalloproteinases-1

1994 • 221 citations

Inhibition of the metastatic spread and growth of B16‐BL6 murine melanoma by a synthetic matrix metalloproteinase inhibitor

1994 • 218 citations

Inhibition of matrix metalloproteinase 9 expression by a ribozyme blocks metastasis in a rat sarcoma model system.

1996 • 217 citations

Mr 92,000 gelatinase release correlates with the metastatic phenotype in transformed rat embryo cells.

1990 • 202 citations

Expression of the metalloproteinase matrilysin in DU-145 cells increases their invasive potential in severe combined immunodeficient mice.

1993 • 201 citations

Tissue inhibitor of metalloproteinase‐2 (TIMP‐2) has erythroid‐potentiating activity

1992 • 200 citations

Control of lymphatic and hematogenous metastasis of a rat mammary carcinoma by the matrix metalloproteinase inhibitor batimastat (BB-94).

1996 • 195 citations

Secretion of basement membrane collagen degrading enzyme and plasminogen activator by transformed cells – role in metastasis

1982 • 195 citations

Effect of Matrix Metalloproteinase Inhibitor Batimastat on Breast Cancer Regrowth and Metastasis in Athymic Mice

1995 • 190 citations

Modulation of matrilysin levels in colon carcinoma cell lines affects tumorigenicity in vivo.

1994 • 189 citations

High levels of tissue inhibitor of metalloproteinase-2 (TIMP-2) expression are associated with poor outcome in invasive bladder cancer.

1996 • 188 citations

Inhibition of organ invasion by the matrix metalloproteinase inhibitor batimastat (BB-94) in two human colon carcinoma metastasis models.

1995 • 184 citations

Fate of melanoma cells entering the microcirculation: over 80% survive and extravasate.

1995 • 177 citations

Tumor invasion and host extracellular matrix

1983 • 176 citations

Metalloproteinase inhibition and erythroid potentiation are independent activities of tissue inhibitor of metalloproteinases-1

1995 • 172 citations

Effect of tissue inhibitor of the matrix metalloproteinases-2 expression on the growth and spontaneous metastasis of a human melanoma cell line.

1994 • 168 citations

Structure and expression in breast tumors of human TIMP-3, a new member of the metalloproteinase inhibitor family.

1994 • 162 citations

Molecular and cellular basis of cancer invasion and metastasis: Implications for treatment

1994 • 162 citations

Overexpression of metalloproteinase inhibitor in B16F10 cells does not affect extravasation but reduces tumor growth.

1994 • 160 citations

Degradation of Basement Membrane by Murine Tumor Cells2

1977 • 156 citations

Collagenolytic mechanisms in tumor cell invasion

1984 • 146 citations

Collagenase Expression in Transgenic Mouse Skin Causes Hyperkeratosis and Acanthosis and Increases Susceptibility to Tumorigenesis

1995 • 141 citations

Inhibition of angiogenesis by the matrix metalloprotease inhibitor N-[2R-2-(hydroxamidocarbonymethyl)-4-methylpentanoyl)]-L-tryptophan methylamide.

1994 • 141 citations

Suppression of Invasion by Inducible Expression of Tissue Inhibitor of Metalloproteinase-1 (TIMP-1) in B 16-F10 Melanoma Cells

1992 • 137 citations

Mammary carcinoma cell lines of high and low metastatic potential differ not in extravasation but in subsequent migration and growth

1994 • 135 citations

Inhibition of tumor invasion of smooth muscle cell layers by recombinant human metalloproteinase inhibitor.

1991 • 135 citations

Protease inhibitors: Role and potential therapeutic use in human cancer

1994 • 134 citations

Overexpression of tissue inhibitor of metalloproteinases-2 retroviral-mediated gene transfer in vivo inhibits tumor growth and invasion.

1996 • 134 citations

Early interactions of cancer cells with the microvasculature in mouse liver and muscle during hematogenous metastasis: videomicroscopic analysis

1993 • 129 citations

Ras-responsive genes and tumor metastasis.

1993 • 127 citations

Identification of MMP-18, a Putative Novel Human Matrix Metalloproteinase

1996 • 123 citations

Expression of membrane-type matrix metalloproteinase 1 (MT1-MMP) in tumor cells enhances pulmonary metastasis in an experimental metastasis assay.

1996 • 121 citations

Complex Roles of Matrix Metalloproteinases in Tumor Progression

1996 • 121 citations

Targeted mutagenesis of Timp-1 reveals that lung tumor invasion is influenced by Timp-1 genotype of the tumor but not by that of the host.

1996 • 121 citations

Decreased tumor formation in 7,12-dimethylbenzanthracene-treated stromelysin-1 transgenic mice is associated with alterations in mammary epithelial cell apoptosis.

1995 • 114 citations

Independence of metastatic ability and extravasation: metastatic ras-transformed and control fibroblasts extravasate equally well.

1996 • 111 citations

Targeted disruption of the tissue inhibitor of metalloproteinases gene increases the invasive behavior of primitive mesenchymal cells derived from embryonic stem cells in vitro.

1992 • 109 citations

Tissue inhibitor of metalloproteinase 1 is a negative regulator of the metastatic ability of a human gastric cancer cell line, KKLS, in the chick embryo.

1993 • 108 citations

A metalloproteinase inhibitor as an inhibitor of neovascularization

1991 • 106 citations

Combination therapy including a gelatinase inhibitor and cytotoxic agent reduces local invasion and metastasis of murine Lewis lung carcinoma.

1996 • 104 citations

Molecular mechanisms of cancer metastasis

1991 • 103 citations

Mammary gland tumor formation in transgenic mice overexpressing stromelysin-1

1995 • 100 citations

Inhibition of SV40 T antigen-induced hepatocellular carcinoma in TIMP-1 transgenic mice.

1996 • 99 citations

Stromelysin-3 expression promotes tumor take in nude mice.

1996 • 92 citations

Early Steps in Hematogenous Metastasis of B16F1 Melanoma Cells in Chick Embryos Studied by High-Resolution Intravital Videomicroscopy

1992 • 92 citations

TIMP-2 Growth-Stimulatory Activity: A Concentration- and Cell Type-Specific Response in the Presence of Insulin

1996 • 86 citations

The potential roles of nm23 in cancer metastasis and cellular differentiation

1995 • 85 citations

7th Jan Waldenström Lecture. The Biology of Human Cancer Metastasis

1991 • 78 citations

Up-regulation of TIMP-1 expression in B16-F10 melanoma cells suppresses their metastatic ability in chick embryo

1992 • 76 citations

TIMP-2, a Growth-Stimulatory Protein from SV40-Transformed Human Fibroblasts

1993 • 75 citations

Inhibition of metastasis in human gastric cancer cells transfected with tissue inhibitor of metalloproteinase 1 gene in nude mice

1996 • 74 citations

Biochemical and Molecular Aspects of Selected Cancers

1991 • 74 citations

The biology of human cancer metastasis

1991 • 73 citations

The Role of the Matrix Metalloproteinase Stromelysin in the Progression of Squamous Cell Carcinomas

1991 • 72 citations

Cloning of cDNAs encoding human TIMP-3, a novel member of the tissue inhibitor of metalloproteinase family

1994 • 69 citations

Marked acceleration of the metastatic phenotype of a rat bladder carcinoma cell line by the expression of human gelatinase a

1995 • 68 citations

Inhibition of growth of human tumor cells in nude mice by a metalloproteinase inhibitor

1994 • 65 citations

Do proteases play a role in cancer invasion and metastasis?

1987 • 65 citations

Regulation of Lysosomal Endopeptidases in Malignant Neoplasia

1994 • 64 citations

Quantitation of tumorigenic disseminating and arrested cancer cells

1984 • 57 citations

Clonality of Pulmonary Metastases From the Bladder 6 Subline of the B16 Melanoma Studied by Southern Hybridization

1987 • 49 citations

Different Patterns of Gene Expression in ras-Resistant and ras-Sensitive Cells

1991 • 40 citations

Lack of suppression of tumor cell phenotype by overexpression of TIMP-3 in mouse JB6 tumor cells identification of a transfectant with increased tumorigenicity and invasiveness.

1996 • 36 citations

Ultrastructure of the blood vessels in the chick allantois and chorioallantois.

1971 • 35 citations

Cloning and Characterization of Human Tissue Inhibitor of Metalloproteinases-3

1994 • 35 citations

Absence of metastatic sequelae during long-term treatment of malignant ascites by peritoneo-venous shunting. A clinico-pathological report.

1984 • 33 citations

Effect of matrix metalloproteinase inhibitors on tumor growth and spontaneous metastasis

1996 • 32 citations

Urokinase plasminogen activator (uPA) and its type 1 inhibitor (PAI-1): Regulators of proteolysis during cancer invasion and prognostic parameters in Breast cancer

1994 • 30 citations

Use of NeoR B16F1 murine melanoma cells to assess clonality of experimental metastases in the immune-deficient chick embryo

1988 • 28 citations

Utilization of transgenic mice in the study of matrix degrading proteinases and their inhibitors

1995 • 19 citations

Prospects for cancer genetics.

1995 • 14 citations

Attempts to understand metastasis formation. I. Metastasis-related molecules. Introduction.

1996 • 13 citations

DNA Transfection, Genetic Instability, and Metastasis

1989 • 1 citations