Macrophage-Derived Metalloelastase Is Responsible for the Generation of Angiostatin in Lewis Lung Carcinoma

Angiostatin: A novel angiogenesis inhibitor that mediates the suppression of metastases by a lewis lung carcinoma

1994 • 3,367 citations

Secretory products of macrophages.

1987 • 2,670 citations

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1995 • 1,863 citations

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1980 • 1,750 citations

F4/80, a monoclonal antibody directed specifically against the mouse macrophage

1981 • 1,582 citations

The matrix‐degrading metalloproteinases

1992 • 1,383 citations

Angiostatin induces and sustains dormancy of human primary tumors in mice

1996 • 1,193 citations

Critical factors in the biology of human cancer metastasis: twenty-eighth G.H.A. Clowes memorial award lecture.

1990 • 1,147 citations

The implications of angiogenesis for the biology and therapy of cancer metastasis

1994 • 1,120 citations

The origin and function of tumor-associated macrophages

1992 • 1,081 citations

Human 92- and 72-kilodalton type IV collagenases are elastases.

1991 • 550 citations

Elastase secretion by stimulated macrophages. Characterization and regulation.

1975 • 522 citations

Metalloelastase is required for macrophage-mediated proteolysis and matrix invasion in mice.

1996 • 496 citations

Cloning and characterization of a unique elastolytic metalloproteinase produced by human alveolar macrophages.

1993 • 479 citations

Presence of a growth-stimulating factor in serum following primary tumor removal in mice.

1989 • 365 citations

Macrophages and metastasis--a biological approach to cancer therapy.

1985 • 354 citations

The Neutral Proteases of Human Granulocytes

1974 • 316 citations

Progress in cancer research and therapy

1978 • 311 citations

Increased expression of the Mr 72,000 type IV collagenase in human colonic adenocarcinoma.

1991 • 282 citations

Critical factors in the biology of human cancer metastasis.

1995 • 266 citations

Mouse macrophage elastase. Purification and characterization as a metalloproteinase

1981 • 260 citations

Modulation of the Organ Microenvironment for Treatment of Cancer Metastasis

1995 • 244 citations

Amino-acid Sequence of Porcine Pancreatic Elastase and its Homologies with other Serine Proteinases

1970 • 219 citations

The Structural Basis for the Elastolytic Activity of the 92-kDa and 72-kDa Gelatinases

1996 • 216 citations

Human prostate carcinoma cells express enzymatic activity that converts human plasminogen to the angiogenesis inhibitor, angiostatin.

1996 • 199 citations

Human alveolar macrophages produce a fibroblast-like collagenase and collagenase inhibitor.

1985 • 199 citations

Molecular cloning, chromosomal localization, and bacterial expression of a murine macrophage metalloelastase.

1992 • 197 citations

Progress in Cancer Research and Therapy.

1978 • 195 citations

Recognition and destruction of neoplastic cells by activated macrophages: discrimination of altered self

1988 • 186 citations

Suppression of metalloproteinase biosynthesis in human alveolar macrophages by interleukin-4.

1992 • 172 citations

Human Macrophage Metalloelastase. GENOMIC ORGANIZATION, CHROMOSOMAL LOCATION, GENE LINKAGE, AND TISSUE-SPECIFIC EXPRESSION

1995 • 156 citations

Neutral Proteases of Human Granulocytes III. Interaction between Human Granulocyte Elastase and Plasma Protease Inhibitors

1974 • 153 citations

Concomitant Tumor Immunity and the Resistance to a Second Tumor Challenge

1983 • 139 citations

The inhibition of tumor growth by tumor mass.

1991 • 137 citations

Tyrosine phosphorylation of mitogen-activated protein kinases is necessary for activation of murine macrophages by natural and synthetic bacterial products.

1993 • 133 citations

Enhanced Metastatic Potential of Tumor Cells Harvested From Spontaneous Metastases of Heterogeneous Murine Tumors<xref ref-type="fn" rid="FN2">2</xref><xref ref-type="fn" rid="FN3">3</xref><xref ref-type="fn" rid="FN4">4</xref>

1982 • 133 citations

Factors in the Production and Growth of tumor Metastases.

1913 • 128 citations

Induction of macrophage metalloproteinases by extracellular matrix. Evidence for enzyme- and substrate-specific responses involving prostaglandin-dependent mechanisms.

1993 • 128 citations

Regulatory mechanisms for the expression of type IV collagenases/gelatinases in murine macrophages.

1994 • 124 citations

The matrix metalloprotease matrilysin (PUMP) is expressed in developing human mononuclear phagocytes.

1992 • 121 citations

Macrophages and cancer

1990 • 109 citations

Limited proteolysis by macrophage elastase inactivates human alpha 1-proteinase inhibitor.

1980 • 107 citations

Organ-Specific Modulation of Steady-State mdr Gene Expression and Drug Resistance in Murine Colon Cancer Cells

1994 • 103 citations

GROWTH OF A LOCAL TUMOR EXERTS A SPECIFIC INHIBITORY EFFECT ON PROGRESSION OF LUNG METASTASES

1978 • 96 citations

Macrophage content of metastatic and nonmetastatic rodent neoplasms.

1981 • 94 citations

Two competing influences that may explain concomitant tumor resistance.

1993 • 88 citations

Matrix metalloproteinase-9 (92-kd gelatinase/type IV collagenase equals gelatinase B) can degrade arterial elastin.

1994 • 81 citations

Macrophage infiltration and tumor progression

1985 • 76 citations

Differential regulation of metalloelastase activity in murine peritoneal macrophages by granulocyte-macrophage colony-stimulating factor and macrophage colony-stimulating factor.

1996 • 62 citations

Immunological mechanisms in metastatic spread and the antimetastatic effects of C. parvum

1977 • 62 citations

Control of Lung Metastasis Progression in Mice: Role of Growth Kinetics of 3LL Lewis Lung Carcinoma and Host Immune Reactivity<xref ref-type="fn" rid="fn2">2</xref>, <xref ref-type="fn" rid="fn3">3</xref>

1980 • 62 citations

A correlation between GM‐CSF gene expression and metastases in murine tumors

1991 • 61 citations

Divergent effects of macrophage toxins on growth of primary tumors and lung metastases in mice

1980 • 60 citations

Murine Tumor Cells Metastasizing Selectively in the Liver: Ability to Produce Hepatocyte‐activating Cytokines Interleukin‐1 and/or ‐6

1991 • 57 citations

Different Deficiencies in the Prevention of Tumorigenic-Low-Metastatic Murine K-1735b Melanoma Cells From Producing Metastases<xref ref-type="fn" rid="FN2">2</xref>

1986 • 54 citations

Therapy of Cancer Metastasis by Systemic Activation of Macrophages

1994 • 52 citations

Activation of inducible nitric oxide synthase gene in murine macrophages requires protein phosphatases 1 and 2A activities

1995 • 40 citations

Resistance of tumor-bearing mice to a second tumor challenge.

1983 • 34 citations

Macrophage-Derived Cell Regulatory Factors

1990 • 30 citations

Selective proteolysis of immunoglobulins by mouse macrophage elastase.

1983 • 27 citations

Different patterns of macrophage infiltration into allogeneic-murine and xenogeneic-human neoplasms growing in nude mice.

1992 • 27 citations

Macrophage-derived cell regulatory factors

1989 • 26 citations

Stimulation of the metastatic properties of lewis‐lung‐carcinoma cells by autologous granulocyte‐macrophage colony‐stimulating factor

1992 • 24 citations

Mononuclear Phagocytes in the Control of Primary and Secondary Tumor Growth

1982 • 5 citations