Regulation of Bcl-2 proteins and of the permeability of the outer mitochondrial membrane

Serine Phosphorylation of Death Agonist BAD in Response to Survival Factor Results in Binding to 14-3-3 Not BCL-XL

1996 • 2,627 citations

A model for p53-induced apoptosis

1997 • 2,502 citations

Direct Activation of Bax by p53 Mediates Mitochondrial Membrane Permeabilization and Apoptosis

2004 • 1,977 citations

Mitochondria as the central control point of apoptosis

2000 • 1,875 citations

Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf

2004 • 1,769 citations

Differential Targeting of Prosurvival Bcl-2 Proteins by Their BH3-Only Ligands Allows Complementary Apoptotic Function

2005 • 1,751 citations

p53 Has a Direct Apoptogenic Role at the Mitochondria

2003 • 1,735 citations

BCL-2, BCL-XL Sequester BH3 Domain-Only Molecules Preventing BAX- and BAK-Mediated Mitochondrial Apoptosis

2001 • 1,672 citations

The Role of Dynamin-Related Protein 1, a Mediator of Mitochondrial Fission, in Apoptosis

2001 • 1,663 citations

Caspase structure, proteolytic substrates, and function during apoptotic cell death

1999 • 1,540 citations

Heat-shock protein 70 inhibits apoptosis by preventing recruitment of procaspase-9 to the Apaf-1 apoptosome

2000 • 1,484 citations

The Bcl-2 family: roles in cell survival and oncogenesis

2003 • 1,448 citations

Bid, Bax, and Lipids Cooperate to Form Supramolecular Openings in the Outer Mitochondrial Membrane

2002 • 1,443 citations

Bid-induced Conformational Change of Bax Is Responsible for Mitochondrial Cytochrome c Release during Apoptosis

1999 • 1,255 citations

tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c

2000 • 1,245 citations

p53AIP1, a Potential Mediator of p53-Dependent Apoptosis, and Its Regulation by Ser-46-Phosphorylated p53

2000 • 1,155 citations

Bid Induces the Oligomerization and Insertion of Bax into the Outer Mitochondrial Membrane

2000 • 1,150 citations

Conversion of Bcl-2 to a Bax-like Death Effector by Caspases

1997 • 1,116 citations

Loss of OPA1 Perturbates the Mitochondrial Inner Membrane Structure and Integrity, Leading to Cytochrome c Release and Apoptosis

2003 • 1,088 citations

Inhibition of Bax Channel-Forming Activity by Bcl-2

1997 • 1,023 citations

Many cuts to ruin: a comprehensive update of caspase substrates

2003 • 1,021 citations

A Distinct Pathway Remodels Mitochondrial Cristae and Mobilizes Cytochrome c during Apoptosis

2002 • 1,015 citations

Breaking the mitochondrial barrier

2001 • 947 citations

Inhibition of early apoptotic events by Akt/PKB is dependent on the first committed step of glycolysis and mitochondrial hexokinase

2001 • 921 citations

Cytochrome c release from mitochondria proceeds by a two-step process

2002 • 917 citations

Death Signal-induced Localization of p53 Protein to Mitochondria

2000 • 883 citations

Bcl-xL forms an ion channel in synthetic lipid membranes

1997 • 817 citations

Spatial and temporal association of Bax with mitochondrial fission sites, Drp1, and Mfn2 during apoptosis

2002 • 801 citations

VDAC2 Inhibits BAK Activation and Mitochondrial Apoptosis

2003 • 789 citations

Mitochondrial p53 activates Bak and causes disruption of a Bak–Mcl1 complex

2004 • 748 citations

Conformation of the Bax C-terminus regulates subcellular location and cell death

1999 • 723 citations

The permeability transition pore complex: another view

2002 • 702 citations

Keeping killers on a tight leash: transcriptional and post-translational control of the pro-apoptotic activity of BH3-only proteins

2002 • 699 citations

The Bcl-2 protein family: sensors and checkpoints for life-or-death decisions

2002 • 695 citations

Mitochondrial Binding of Hexokinase II Inhibits Bax-induced Cytochrome c Release and Apoptosis

2002 • 657 citations

Cytochrome c Release and Apoptosis Induced by Mitochondrial Targeting of Nuclear Orphan Receptor TR3

2000 • 651 citations

Conversion of Bcl-2 from Protector to Killer by Interaction with Nuclear Orphan Receptor Nur77/TR3

2004 • 644 citations

Molecular Cloning and Characterization of Bif-1

2001 • 637 citations

`The stress of dying': the role of heat shock proteins in the regulation of apoptosis

2004 • 618 citations

Hexokinase-Mitochondria Interaction Mediated by Akt Is Required to Inhibit Apoptosis in the Presence or Absence of Bax and Bak

2004 • 612 citations

Channel formation by antiapoptotic protein Bcl-2

1997 • 604 citations

Humanin peptide suppresses apoptosis by interfering with Bax activation

2003 • 578 citations

Acetylation of the C Terminus of Ku70 by CBP and PCAF Controls Bax-Mediated Apoptosis

2004 • 569 citations

A rescue factor abolishing neuronal cell death by a wide spectrum of familial Alzheimer's disease genes and Aβ

2001 • 561 citations

p53 Induces Apoptosis by Caspase Activation through Mitochondrial Cytochrome c Release

2000 • 553 citations

JNK promotes Bax translocation to mitochondria through phosphorylation of 14-3-3 proteins

2004 • 543 citations

Presence of a pre-apoptotic complex of pro-caspase-3, Hsp60 and Hsp10 in the mitochondrial fraction of Jurkat cells

1999 • 518 citations

Modulation of cell death by Bcl-x _L through caspase interaction

1998 • 505 citations

Comparison of the ion channel characteristics of proapoptotic BAX and antiapoptotic BCL-2

1997 • 489 citations

Heat Shock Protein 70 Inhibits Apoptosis Downstream of Cytochrome c Release and Upstream of Caspase-3 Activation

2000 • 469 citations

Cardiolipin provides specificity for targeting of tBid to mitochondria

2000 • 462 citations

Relationship of Membrane Curvature to the Formation of Pores by Magainin 2

1998 • 442 citations

Regulated and unregulated mitochondrial permeability transition pores: a new paradigm of pore structure and function?

2002 • 433 citations

Quantitation of mitochondrial dynamics by photolabeling of individual organelles shows that mitochondrial fusion is blocked during the Bax activation phase of apoptosis

2004 • 420 citations

×Phosphorylation of Bax Ser184 by Akt Regulates Its Activity and Apoptosis in Neutrophils

2004 • 382 citations

hsp70-DnaJ chaperone pair prevents nitric oxide- and CHOP-induced apoptosis by inhibiting translocation of Bax to mitochondria

2004 • 361 citations

Ku70 suppresses the apoptotic translocation of Bax to mitochondria

2003 • 358 citations

ARC, an inhibitor of apoptosis expressed in skeletal muscle and heart that interacts selectively with caspases

1998 • 350 citations

14-3-3 Interacts Directly with and Negatively Regulates Pro-apoptotic Bax

2003 • 344 citations

Direct Activation of Mitochondrial Apoptosis Machinery by c-Jun N-terminal Kinase in Adult Cardiac Myocytes

2002 • 342 citations

Mitochondrial phospholipid hydroperoxide glutathione peroxidase inhibits the release of cytochrome c from mitochondria by suppressing the peroxidation of cardiolipin in hypoglycaemia-induced apoptosis

2000 • 337 citations

Involvement of Histone H1.2 in Apoptosis Induced by DNA Double-Strand Breaks

2003 • 321 citations

Human αA- and αB-crystallins bind to Bax and Bcl-XS to sequester their translocation during staurosporine-induced apoptosis

2004 • 321 citations

The Peutz-Jegher Gene Product LKB1 Is a Mediator of p53-Dependent Cell Death

2001 • 316 citations

The Pro-Apoptotic Proteins, Bid and Bax, Cause a Limited Permeabilization of the Mitochondrial Outer Membrane That Is Enhanced by Cytosol

1999 • 316 citations

Mitochondrial translocation of cofilin is an early step in apoptosis induction

2003 • 315 citations

14-3-3 Proteins Mediate an Essential Anti-apoptotic Signal

2001 • 305 citations

Mitochondrial Translocation of Protein Kinase C δ in Phorbol Ester-induced Cytochrome c Release and Apoptosis

2000 • 301 citations

Identification of Novel Isoforms of the BH3 Domain Protein Bim Which Directly Activate Bax To Trigger Apoptosis

2002 • 287 citations

To die or not to die: how does p53 decide?

2004 • 284 citations

Akt Inhibits Apoptosis Downstream of BID Cleavage via a Glucose-Dependent Mechanism Involving Mitochondrial Hexokinases

2003 • 284 citations

Cytosolic Heat Shock Protein 60, Apoptosis, and Myocardial Injury

2002 • 276 citations

Combined and Individual Mitochondrial HSP60 and HSP10 Expression in Cardiac Myocytes Protects Mitochondrial Function and Prevents Apoptotic Cell Deaths Induced by Simulated Ischemia-Reoxygenation

2001 • 271 citations

Mitochondrial intermembrane junctional complexes and their involvement in cell death

2002 • 265 citations

Cardiolipin and apoptosis

2002 • 260 citations

The Small Heat Shock Protein αB-crystallin Negatively Regulates Apoptosis during Myogenic Differentiation by Inhibiting Caspase-3 Activation

2002 • 259 citations

Endophilin B1 is required for the maintenance of mitochondrial morphology

2004 • 253 citations

Loss of Molecular Interaction between Cytochrome c and Cardiolipin Due to Lipid Peroxidation

1999 • 248 citations

The First α Helix of Bax Plays a Necessary Role in Its Ligand-Induced Activation by the BH3-Only Proteins Bid and PUMA

2004 • 245 citations

Mitochondrial phospholipid hydroperoxide glutathione peroxidase inhibits the release of cytochrome c from mitochondria by suppressing the peroxidation of cardiolipin in hypoglycaemia-induced apoptosis

2000 • 244 citations

Distinct stages of cytochrome c release from mitochondria: evidence for a feedback amplification loop linking caspase activation to mitochondrial dysfunction in genotoxic stress induced apoptosis

2000 • 239 citations

ASC is a Bax adaptor and regulates the p53–Bax mitochondrial apoptosis pathway

2004 • 236 citations

Lipidic Pore Formation by the Concerted Action of Proapoptotic BAX and tBID

2004 • 234 citations

Nicotine Inactivation of the Proapoptotic Function of Bax through Phosphorylation

2005 • 232 citations

Bax-type Apoptotic Proteins Porate Pure Lipid Bilayers through a Mechanism Sensitive to Intrinsic Monolayer Curvature

2002 • 229 citations

Hsp10 and Hsp60 modulate Bcl-2 family and mitochondria apoptosis signaling induced by doxorubicin in cardiac muscle cells

2003 • 222 citations

The Small Heat Shock Protein αB-crystallin Is a Novel Inhibitor of TRAIL-induced Apoptosis That Suppresses the Activation of Caspase-3

2005 • 217 citations

Reactive oxygen species generated from the mitochondrial electron transport chain induce cytochrome c dissociation from beef‐heart submitochondrial particles via cardiolipin peroxidation. Possible role in the apoptosis

2001 • 217 citations

The late increase in intracellular free radical oxygen species during apoptosis is associated with cytochrome c release, caspase activation, and mitochondrial dysfunction

2003 • 200 citations

Bax oligomerization in mitochondrial membranes requires tBid (caspase-8-cleaved Bid) and a mitochondrial protein

2002 • 192 citations

Mitogenic Effect of Orphan Receptor TR3 and Its Regulation by MEKK1 in Lung Cancer Cells

2003 • 192 citations

mtCLIC/CLIC4, an Organellular Chloride Channel Protein, Is Increased by DNA Damage and Participates in the Apoptotic Response to p53

2002 • 180 citations

Ku70 acetylation mediates neuroblastoma cell death induced by histone deacetylase inhibitors

2005 • 175 citations

Retinoid X Receptor Regulates Nur77/Thyroid Hormone Receptor 3-Dependent Apoptosis by Modulating Its Nuclear Export and Mitochondrial Targeting

2004 • 171 citations

Apoptosis Repressor with Caspase Recruitment Domain Protects against Cell Death by Interfering with Bax Activation

2004 • 170 citations

Hsp72 and Stress Kinase c-jun N-Terminal Kinase Regulate the Bid-Dependent Pathway in Tumor Necrosis Factor-Induced Apoptosis

2002 • 170 citations

Differential Protective Activity of αA- and αB-crystallin in Lens Epithelial Cells

2000 • 164 citations

Inhibition of both the extrinsic and intrinsic death pathways through nonhomotypic death-fold interactions

2021 • 164 citations

Cytoprotective membrane-permeable peptides designed from the Bax-binding domain of Ku70

2003 • 157 citations

Bid-Cardiolipin Interaction at Mitochondrial Contact Site Contributes to Mitochondrial Cristae Reorganization and CytochromecRelease

2004 • 157 citations

Inhibition of Both the Extrinsic and Intrinsic Death Pathways through Nonhomotypic Death-Fold Interactions

2004 • 155 citations

The G2/M Regulator 14-3-3ς Prevents Apoptosis through Sequestration of Bax

2001 • 154 citations

MAP-1, a Novel Proapoptotic Protein Containing a BH3-like Motif That Associates with Bax through Its Bcl-2 Homology Domains

2001 • 147 citations

Rapid Apoptosis Induction by IGFBP-3 Involves an Insulin-like Growth Factor-independent Nucleomitochondrial Translocation of RXRα/Nur77

2005 • 144 citations

The Organellular Chloride Channel Protein CLIC4/mtCLIC Translocates to the Nucleus in Response to Cellular Stress and Accelerates Apoptosis

2004 • 144 citations

Cardiolipin and its metabolites move from mitochondria to other cellular membranes during death receptor-mediated apoptosis

2004 • 140 citations

And all of a sudden it's over: mitochondrial outer-membrane permeabilization in apoptosis

2002 • 139 citations

Bcl-2 family members: intracellular targeting, membrane-insertion, and changes in subcellular localization

2003 • 138 citations

Humanin Binds and Nullifies Bid Activity by Blocking Its Activation of Bax and Bak

2005 • 138 citations

p53 and Tumor Necrosis Factor α Regulate the Expression of a Mitochondrial Chloride Channel Protein

1999 • 133 citations

Membrane Fusion and the Lamellar-to-Inverted-Hexagonal Phase Transition in Cardiolipin Vesicle Systems Induced by Divalent Cations

1999 • 128 citations

p53AIP1 regulates the mitochondrial apoptotic pathway.

2002 • 125 citations

Bcl-x _L overexpression blocks bax-mediated mitochondrial contact site formation and apoptosis in rod photoreceptors of lead-exposed mice

2003 • 113 citations

Cytoprotective Peptide Humanin Binds and Inhibits Proapoptotic Bcl-2/Bax Family Protein BimEL

2005 • 109 citations

Phospholipid asymmetry of the outer membrane of rat liver mitochondria

1993 • 98 citations

Bax-dependent Regulation of Bak by Voltage-dependent Anion Channel 2

2005 • 98 citations

Phospho-ser 15-p53 translocates into mitochondria and interacts with Bcl-2 and Bcl-xL in eugenol-induced apoptosis

2005 • 81 citations

p53's believe it or not: lessons on transcription-independent death.

2003 • 79 citations

Bax-inhibiting peptide derived from mouse and rat Ku70

2004 • 77 citations

Characterization of Endophilin B1b, a Brain-specific Membrane-associated Lysophosphatidic Acid Acyl Transferase with Properties Distinct from Endophilin A1

2003 • 66 citations

RXRα acts as a carrier for TR3 nuclear export in a 9-cis retinoic acid-dependent manner in gastric cancer cells

2004 • 61 citations

Membrane perturbations induced by the apoptotic Bax protein

2002 • 43 citations

Phospholipid Membranes Form Specific Nonbilayer Molecular Arrangements That Are Antigenic

1999 • 38 citations

Capillary electrophoresis of cardiolipin with on‐line dye interaction and spectrophotometric detection

2003 • 31 citations

Membrane rearrangements in fusion mediated by viral proteins

1997 • 26 citations

Fatty acids enhance membrane permeabilization by pro-apoptotic Bax

2004 • 24 citations

Oligomeric C‐terminal truncated Bax preferentially releases cytochrome c but not adenylate kinase from mitochondria, outer membrane vesicles and proteoliposomes

2001 • 24 citations

Distinct role and functional mode of TR3 and RARα in mediating ATRA-induced signalling pathway in breast and gastric cancer cells

2003 • 22 citations