Conversion of Bcl-2 to a Bax-like Death Effector by Caspases

DFF, a Heterodimeric Protein That Functions Downstream of Caspase-3 to Trigger DNA Fragmentation during Apoptosis

1997 • 1,848 citations

The proto-oncogene Bcl-2 and its role in regulating apoptosis

1997 • 1,768 citations

Bax-Deficient Mice with Lymphoid Hyperplasia and Male Germ Cell Death

1995 • 1,500 citations

X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death

1996 • 1,456 citations

Inhibition of Bax Channel-Forming Activity by Bcl-2

1997 • 1,023 citations

BID: a novel BH3 domain-only death agonist.

1996 • 921 citations

Substrate Specificities of Caspase Family Proteases

1997 • 871 citations

Bcl-2 and Fas/APO-1 regulate distinct pathways to lymphocyte apoptosis.

1995 • 791 citations

Bcl-2 Targets the Protein Kinase Raf-1 to Mitochondria

1996 • 785 citations

IL3-dependent mouse clones that express B-220 surface antigen, contain ig genes in germ-line configuration, and generate B lymphocytes in vivo

1985 • 718 citations

Proteolytic activation of protein kinase C delta by an ICE-like protease in apoptotic cells.

1995 • 684 citations

Taxol induces bcl-2 phosphorylation and death of prostate cancer cells.

1996 • 662 citations

Interaction of CED-4 with CED-3 and CED-9: A Molecular Framework for Cell Death

1997 • 635 citations

Apopain/CPP32 cleaves proteins that are essential for cellular repair: a fundamental principle of apoptotic death.

1996 • 621 citations

Molecular Ordering of the Cell Death Pathway

1996 • 589 citations

Lamin proteolysis facilitates nuclear events during apoptosis.

1996 • 587 citations

Bcl-2 Phosphorylation Required for Anti-apoptosis Function

1997 • 540 citations

Studies of the lamin proteinase reveal multiple parallel biochemical pathways during apoptotic execution.

1995 • 524 citations

Molecular ordering of the Fas-apoptotic pathway: The Fas/APO-1 protease Mch5 is a CrmA-inhibitable protease that activates multiple Ced-3/ICE-like cysteine proteases

1996 • 519 citations

Modulation of apoptosis by the widely distributed Bcl-2 homologue Bak

1995 • 514 citations

The Regulation of Anoikis: MEKK-1 Activation Requires Cleavage by Caspases

1997 • 507 citations

A conserved domain in Bak, distinct from BH1 and BH2, mediates cell death and protein binding functions.

1995 • 491 citations

Bax-independent inhibition of apoptosis by Bcl-XL

1996 • 484 citations

A Bcl-2 homolog encoded by Kaposi sarcoma-associated virus, human herpesvirus 8, inhibits apoptosis but does not heterodimerize with Bax or Bak

1997 • 437 citations

Structure-Function Analysis of Bcl-2 Protein

1995 • 419 citations

Bcl-2 and Bax function independently to regulate cell death

1997 • 397 citations

Growth factor modulation of p53-mediated growth arrest versus apoptosis.

1995 • 377 citations

FLICE Induced Apoptosis in a Cell-free System

1997 • 343 citations

Interaction between the C. elegans cell-death regulators CED-9 and CED-4

1997 • 304 citations

Identification of a novel regulatory domain in Bcl-xL and Bcl-2

1997 • 287 citations

A combinatorial approach for determining protease specificities: application to interleukin-1β converting enzyme (ICE)

1997 • 255 citations

Specific cleavage of the retinoblastoma protein by an ICE-like protease in apoptosis.

1996 • 247 citations

Specific Cleavage of α-Fodrin during Fas- and Tumor Necrosis Factor-induced Apoptosis Is Mediated by an Interleukin-1β-converting Enzyme/Ced-3 Protease Distinct from the Poly(ADP-ribose) Polymerase Protease

1996 • 211 citations

The protein bcl-2 alpha does not require membrane attachment, but two conserved domains to suppress apoptosis.

1994 • 186 citations

Degradation of Retinoblastoma Protein in Tumor Necrosis Factor- and CD95-induced Cell Death

1997 • 170 citations

Functional Dissection of the Human Bcl2 Protein: Sequence Requirements for Inhibition of Apoptosis

1996 • 126 citations

A Peptide Sequence from Bax That Converts Bcl-2 into an Activator of Apoptosis

1996 • 111 citations

Overexpression of the Bcl-2 Protein Increases the Half-life of p21Bax

1995 • 108 citations

Bax Can Antagonize Bcl-XL during Etoposide and Cisplatin-induced Cell Death Independently of Its Heterodimerization with Bcl-XL

1996 • 101 citations

Bax promotes neuronal survival and antagonises the survival effects of neurotrophic factors

1996 • 91 citations

Direct physical interaction between the Caenorhabditis elegans ‘death proteins’ CED‐3 and CED‐4

1997 • 83 citations

Virus-Induced Apoptosis

1997 • 73 citations