Human αA- and αB-crystallins bind to Bax and Bcl-XS to sequester their translocation during staurosporine-induced apoptosis

Mitochondria and Apoptosis

1998 • 8,909 citations

Apoptosis by Death Factor

1997 • 5,038 citations

Prevention of Apoptosis by Bcl-2: Release of Cytochrome c from Mitochondria Blocked

1997 • 4,921 citations

The Release of Cytochrome c from Mitochondria: A Primary Site for Bcl-2 Regulation of Apoptosis

1997 • 4,728 citations

Proapoptotic BAX and BAK: A Requisite Gateway to Mitochondrial Dysfunction and Death

2001 • 3,867 citations

The Bcl2 family: regulators of the cellular life-or-death switch

2002 • 3,782 citations

BCL-2 family members and the mitochondria in apoptosis

1999 • 3,657 citations

bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death

1993 • 3,111 citations

Regulation of cell death: the calcium–apoptosis link

2003 • 2,826 citations

Alpha-crystallin can function as a molecular chaperone.

1992 • 1,822 citations

Movement of Bax from the Cytosol to Mitochondria during Apoptosis

1997 • 1,805 citations

BCL-2, BCL-XL Sequester BH3 Domain-Only Molecules Preventing BAX- and BAK-Mediated Mitochondrial Apoptosis

2001 • 1,672 citations

Bax directly induces release of cytochrome c from isolated mitochondria

1998 • 1,514 citations

Heat-shock protein 70 inhibits apoptosis by preventing recruitment of procaspase-9 to the Apaf-1 apoptosome

2000 • 1,484 citations

Bcl-xL Regulates the Membrane Potential and Volume Homeostasis of Mitochondria

1997 • 1,389 citations

ARPE-19, A Human Retinal Pigment Epithelial Cell Line with Differentiated Properties

1996 • 1,254 citations

Mitochondrial cytochrome c release in apoptosis occurs upstream of DEVD-specific caspase activation and independently of mitochondrial transmembrane depolarization

1998 • 1,226 citations

Bid Induces the Oligomerization and Insertion of Bax into the Outer Mitochondrial Membrane

2000 • 1,150 citations

Apaf1 Is Required for Mitochondrial Pathways of Apoptosis and Brain Development

1998 • 1,143 citations

Enforced dimerization of BAX results in its translocation, mitochondrial dysfunction and apoptosis

1998 • 1,100 citations

Structure of Bax

2000 • 1,066 citations

A missense mutation in the αB-crystallin chaperone gene causes a desmin-related myopathy

1998 • 1,061 citations

Hsp27 negatively regulates cell death by interacting with cytochrome c

2000 • 972 citations

Role of the Human Heat Shock Protein hsp70 in Protection against Stress-Induced Apoptosis

1997 • 961 citations

Four small Drosophila heat shock proteins are related to each other and to mammalian alpha-crystallin.

1982 • 792 citations

Conformation of the Bax C-terminus regulates subcellular location and cell death

1999 • 723 citations

Hsp70 exerts its anti-apoptotic function downstream of caspase-3-like proteases

1998 • 692 citations

Bax-induced Cytochrome C Release from Mitochondria Is Independent of the Permeability Transition Pore but Highly Dependent on Mg2+ Ions

1998 • 645 citations

Regulated Targeting of BAX to Mitochondria

1998 • 617 citations

Small Stress Proteins as Novel Regulators of Apoptosis

1996 • 614 citations

Properties of a clonal muscle cell line from rat heart

1976 • 572 citations

Human hsp27, Drosophila hsp27 and human alphaB-crystallin expression-mediated increase in glutathione is essential for the protective activity of these proteins against TNFalpha-induced cell death.

1996 • 568 citations

Negative regulation of cytochrome c-mediated oligomerization of Apaf-1 and activation of procaspase-9 by heat shock protein 90

2000 • 558 citations

FLICE-Inhibitory Proteins: Regulators of Death Receptor-Mediated Apoptosis

2001 • 550 citations

Presence of a pre-apoptotic complex of pro-caspase-3, Hsp60 and Hsp10 in the mitochondrial fraction of Jurkat cells

1999 • 518 citations

BAG-1 modulates the chaperone activity of Hsp70/Hsc70

1997 • 511 citations

HSP27 inhibits cytochrome c‐dependent activation of procaspase‐9

1999 • 496 citations

Heat Shock Protein 70 Inhibits Apoptosis Downstream of Cytochrome c Release and Upstream of Caspase-3 Activation

2000 • 469 citations

Autosomal dominant congenital cataract associated with a missense mutation in the human alpha crystallin gene CRYAA

1998 • 441 citations

Hsp27 as a Negative Regulator of Cytochrome c Release

2002 • 429 citations

Role for Bcl-x_Las an inhibitor of cytosolic cytochrome C accumulation in DNA damage-induced apoptosis

1997 • 397 citations

p38 Map Kinase Mediates Bax Translocation in Nitric Oxide–Induced Apoptosis in Neurons

2000 • 391 citations

Lens epithelial cell apoptosis appears to be a common cellular basis for non-congenital cataract development in humans and animals.

1995 • 384 citations

Mutation R120G in αB-crystallin, which is linked to a desmin-related myopathy, results in an irregular structure and defective chaperone-like function

1999 • 369 citations

The Small Heat Shock Protein αB-Crystallin Negatively Regulates Cytochrome c- and Caspase-8-dependent Activation of Caspase-3 by Inhibiting Its Autoproteolytic Maturation

2001 • 358 citations

Bcl-2 inhibits Bax translocation from cytosol to mitochondria during drug-induced apoptosis of human tumor cells

2000 • 345 citations

Constitutive expression of human hsp27, Drosophila hsp27, or human alpha B-crystallin confers resistance to TNF- and oxidative stress-induced cytotoxicity in stably transfected murine L929 fibroblasts.

1995 • 344 citations

Hsp27 functions as a negative regulator of cytochrome c-dependent activation of procaspase-3

2000 • 313 citations

Hsp60 accelerates the maturation of pro-caspase-3 by upstream activator proteases during apoptosis

1999 • 305 citations

Functional Consequences of the Sustained or Transient Activation by Bax of the Mitochondrial Permeability Transition Pore

1999 • 295 citations

Small stress proteins: chaperones that act as regulators of intracellular redox state and programmed cell death.

1998 • 283 citations

The Small Heat Shock Protein αB-crystallin Negatively Regulates Apoptosis during Myogenic Differentiation by Inhibiting Caspase-3 Activation

2002 • 259 citations

A forkhead gene, FoxE3, is essential for lens epithelial proliferation and closure of the lens vesicle

2000 • 255 citations

Protection of Neuronal Cells from Apoptosis by Hsp27 Delivered with a Herpes Simplex Virus-based Vector

1999 • 216 citations

Mutagenesis of the BH3 Domain of BAX Identifies Residues Critical for Dimerization and Killing

1998 • 206 citations

The Mechanisms of hsp27 Antibody-Mediated Apoptosis in Retinal Neuronal Cells

2000 • 194 citations

Hypertonic stress induces αB-crystallin expression

1992 • 187 citations

The chaperone activity of bovine alpha crystallin. Interaction with other lens crystallins in native and denatured states.

1994 • 177 citations

Lens Protein

1982 • 169 citations

Differential Protective Activity of αA- and αB-crystallin in Lens Epithelial Cells

2000 • 164 citations

Lens epithelial cell apoptosis is an early event in the development of UVB-induced cataract

1996 • 163 citations

Heat-shock proteins as death determinants

2000 • 162 citations

Conformational and Functional Differences between Recombinant Human Lens αA- and αB-Crystallin

1997 • 159 citations

αB-crystallin Gene Induction and Phosphorylation by MKK6-activated p38

2000 • 152 citations

Human Lens Epithelial Cell Line

1998 • 142 citations

Microphthalmia due to p53-mediated apoptosis of anterior lens epithelial cells in mice lacking the CREB-2 transcription factor

2000 • 139 citations

Alpha-crystallin/small heat shock protein has autokinase activity.

1994 • 138 citations

A recombinant bcl-x s adenovirus selectively induces apoptosis in cancer cells but not in normal bone marrow cells.

1995 • 134 citations

Requirement for TGFβ receptor signaling during terminal lens fiber differentiation

2001 • 130 citations

αB-Crystallin Expression in Mouse NIH 3T3 Fibroblasts: Glucocorticoid Responsiveness and Involvement in Thermal Protection

1993 • 126 citations

A Role for Mitochondrial Bak in Apoptotic Response to Anticancer Drugs

2001 • 124 citations

α-Crystallin, a Molecular Chaperone, Forms a Stable Complex with Carbonic Anhydrase upon Heat Denaturation

1993 • 116 citations

Apoptosis in Gastric Epithelial Cells Is Induced byHelicobacter pyloriand Accompanied by Increased Expression of BAK

1997 • 110 citations

Mutation of R116C Results in Highly Oligomerized αA-Crystallin with Modified Structure and Defective Chaperone-like Function

2000 • 105 citations

bcl-2 and bak may play a pivotal role in sodium butyrate-induced apoptosis in colonic epithelial cells; however overexpression of bcl-2 does not protect against bak-mediated apoptosis

1997 • 100 citations

Apoptosis in the rat lens after in vivo threshold dose ultraviolet irradiation.

1998 • 95 citations

Dietary curcumin prevents ocular toxicity of naphthalene in rats

2000 • 91 citations

Human bcl-2 Gene Attenuates the Ability of Rabbit Lens Epithelial Cells against H2O2-induced Apoptosis through Down-regulation of the αB-crystallin Gene

2001 • 91 citations

Binding of the Stress ProteinαB-crystallin to Cardiac Myofibrils Correlates with the Degree of Myocardial Damage During Ischemia/Reperfusionin vivo

1999 • 87 citations

Bcl-xS and Bax induce different apoptotic pathways in PC12 cells

2000 • 82 citations

Characterization of the α-γ and α-β Complex: Evidence for an In Vivo Functional Role of α-Crystallin as a Molecular Chaperone

1994 • 80 citations

Alpha B-crystallin expression in mouse NIH 3T3 fibroblasts: glucocorticoid responsiveness and involvement in thermal protection.

1993 • 79 citations

Death at an early age. Apoptosis in inherited retinal degenerations.

1995 • 79 citations

The R116C Mutation in αA-crystallin Diminishes Its Protective Ability against Stress-induced Lens Epithelial Cell Apoptosis

2002 • 75 citations

Critical requirement of BAX for manifestation of apoptosis induced by multiple stimuli in human epithelial cancer cells.

2002 • 74 citations

Conversion from Oligomers to Tetramers Enhances Autophosphorylation by Lens αA-Crystallin

1995 • 74 citations

Calcimycin-induced lens epithelial cell apoptosis contributes to cataract formation

1995 • 74 citations

Cyclin D- and E-Dependent Kinases and the p57^KIP2 Inhibitor: Cooperative Interactions In Vivo

1999 • 69 citations

Staurosporine-induced neuronal death: multiple mechanisms and methodological implications

2000 • 67 citations

Evidence for Apoptosis in the Selenite Rat Model of Cataract

2000 • 67 citations

Apoptotic cell death in the lens epithelium of rat sugar cataract

2003 • 66 citations

Bcl-x expression influences keratinocyte cell survival but not terminal differentiation.

1997 • 66 citations

Caspase-3 Is Actively Involved in Okadaic Acid-Induced Lens Epithelial Cell Apoptosis

2001 • 59 citations

Contrasting roles for c-Myc and L-Myc in the regulation of cellular growth and differentiation in vivo.

1995 • 57 citations

Okadaic acid‐induced lens epithelial cell apoptosis requires inhibition of phosphatase‐1 and is associated with induction of gene expression including p53 and bax

1998 • 50 citations

The rd gene defect triggers programmed rod cell death. The Proctor Lecture.

1994 • 44 citations

Defective Bax activation in Hodgkin B-cell lines confers resistance to staurosporine-induced apoptosis

2002 • 43 citations

Bcl-xS enhances adenoviral vector-induced apoptosis in neuroblastoma cells.

1996 • 32 citations

Cataractogenesis in Neonatal Sprague-Dawley Rats by N-Methyl-N-Nitrosourea

2000 • 26 citations

Low power density microwave radiation induced early changes in rabbit lens epithelial cells.

2001 • 20 citations