A rescue factor abolishing neuronal cell death by a wide spectrum of familial Alzheimer's disease genes and Aβ

Apoptosis is induced by beta-amyloid in cultured central nervous system neurons.

1993 • 1,035 citations

Machine learning approaches for the prediction of signal peptides and other protein sorting signals

1999 • 610 citations

Signal sequences: more than just greasy peptides

1998 • 544 citations

Destabilization of β-catenin by mutations in presenilin-1 potentiates neuronal apoptosis

1998 • 512 citations

Interfering with Apoptosis: Ca ²⁺ -Binding Protein ALG-2 and Alzheimer's Disease Gene ALG-3

1996 • 481 citations

Participation of Presenilin 2 in Apoptosis: Enhanced Basal Activity Conferred by an Alzheimer Mutation

1996 • 424 citations

A second cytotoxic proteolytic peptide derived from amyloid β-protein precursor

2000 • 386 citations

Insulin-like growth factor I protects and rescues hippocampal neurons against β-amyloid- and human amylin-induced toxicity

1997 • 325 citations

Alzheimerʼs PS-1 mutation perturbs calcium homeostasis and sensitizes PC12 cells to death induced by amyloid β-peptide

1996 • 321 citations

Amyloid β interacts with the amyloid precursor protein: a potential toxic mechanism in Alzheimer's disease

2000 • 256 citations

G Protein-Mediated Neuronal DNA Fragmentation Induced by Familial Alzheimer's Disease-Associated Mutants of APP

1996 • 213 citations

Mechanisms of Neuroprotection by a Novel Rescue Factor Humanin from Swedish Mutant Amyloid Precursor Protein

2001 • 206 citations

Generation of an Apoptotic Intracellular Peptide by γ-Secretase Cleavage of Alzheimer's Amyloid ß Protein Precursor

2000 • 200 citations

Basic FGF attenuates amyloid β-peptide-induced oxidative stress, mitochondrial dysfunction, and impairment of Na+/K+-ATPase activity in hippocampal neurons

1997 • 162 citations

Mutant Presenilin-1 Induces Apoptosis and Downregulates Akt/PKB

1999 • 139 citations

Activity-dependent neurotrophic factor: structure-activity relationships of femtomolar-acting peptides.

1998 • 125 citations

Neurotrophic factors [activity-dependent neurotrophic factor (ADNF) and basic fibroblast growth factor (bFGF)] interrupt excitotoxic neurodegenerative cascades promoted by a PS1 mutation

1999 • 124 citations

Neuronal Apoptosis by Apolipoprotein E4 through Low-Density Lipoprotein Receptor-Related Protein and Heterotrimeric GTPases

2000 • 83 citations

Insulin-Like Growth Factor I (IGF-I) Protects Cells from Apoptosis by Alzheimer's V642I Mutant Amyloid Precursor Protein through IGF-I Receptor in an IGF-Binding Protein-Sensitive Manner

2001 • 77 citations

Book Reviews Science and Dissent in Post-Mao China, reviewed by M. Goldman * Comparative Vertebrate Neuroanatomy, E. G. Jones * Particle Physics, P. Forman * Vignette * Browsings

1996 • 70 citations

Multiple Mechanisms Underlie Neurotoxicity by Different Types of Alzheimer's Disease Mutations of Amyloid Precursor Protein

2000 • 66 citations

Expression of mutant amyloid precursor proteins induces apoptosis in PC12 cells

1997 • 65 citations

A rapid fluorometric assay to measure neuronal survival in vitro

1993 • 63 citations

Antibody-Regulated Neurotoxic Function of Cell-Surface β-Amyloid Precursor Protein

2000 • 59 citations

Characterization of human presenilin 1 transgenic rats: increased sensitivity to apoptosis in primary neuronal cultures

1998 • 50 citations

Genes and susceptible loci of Alzheimer’s disease

1999 • 48 citations

Death of PC12 cells and hippocampal neurons induced by adenoviral-mediated FAD human amyloid precursor protein gene expression

1999 • 39 citations

Secreted Aβ Does Not Mediate Neurotoxicity by Antibody-Stimulated Amyloid Precursor Protein

2001 • 32 citations

V642I APP-Inducible Neuronal Cells: A Model System for Investigating Alzheimer's Disorders

2000 • 26 citations