The G2/M Regulator 14-3-3ς Prevents Apoptosis through Sequestration of Bax

p53, the Cellular Gatekeeper for Growth and Division

1997 • 7,621 citations

Surfing the p53 network

2000 • 6,487 citations

Inhibitors of mammalian G1 cyclin-dependent kinases.

1995 • 3,258 citations

Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-β

2000 • 3,241 citations

Requirement for p53 and p21 to Sustain G ₂ Arrest After DNA Damage

1998 • 2,784 citations

A model for p53-induced apoptosis

1997 • 2,502 citations

Caspases: killer proteases

1997 • 2,440 citations

p53: puzzle and paradigm.

1996 • 2,363 citations

Linkage of ATM to Cell Cycle Regulation by the Chk2 Protein Kinase

1998 • 1,314 citations

Is a p53-Regulated Inhibitor of G2/M Progression

1997 • 1,238 citations

bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes

1991 • 1,223 citations

bcl-2 transgene inhibits T cell death and perturbs thymic self-censorship

1991 • 1,090 citations

14-3-3σ is required to prevent mitotic catastrophe after DNA damage

1999 • 895 citations

p53

2000 • 785 citations

Uncoupling of S phase and mitosis induced by anticancer agents in cells lacking p21

1996 • 746 citations

Mitochondrial Release of Caspase-2 and -9 during the Apoptotic Process

1999 • 730 citations

Apaf-1 and Caspase-9 in p53-Dependent Apoptosis and Tumor Inhibition

1999 • 663 citations

14-3-3 Proteins and Survival Kinases Cooperate to Inactivate BAD by BH3 Domain Phosphorylation

2000 • 634 citations

Caspases and caspase inhibitors

1997 • 573 citations

Presence of a pre-apoptotic complex of pro-caspase-3, Hsp60 and Hsp10 in the mitochondrial fraction of Jurkat cells

1999 • 518 citations

Inhibition of CDK activity and PCNA-dependent DNA replication by p21 is blocked by interaction with the HPV-16 E7 oncoprotein

1997 • 506 citations

High frequency of hypermethylation at the 14-3-3 σ locus leads to gene silencing in breast cancer

2000 • 442 citations

Cleavage of p21Cip1/Waf1 and p27Kip1 Mediates Apoptosis in Endothelial Cells through Activation of Cdk2: Role of a Caspase Cascade

1998 • 441 citations

p53 regulates a G ₂ checkpoint through cyclin B1

1999 • 428 citations

14-3-3 proteins block apoptosis and differentially regulate MAPK cascades

2000 • 285 citations

Cooperative effects of genes controlling the G₂/M checkpoint

2000 • 269 citations

Caspase-mediated cleavage of p21Waf1/Cip1 converts cancer cells from growth arrest to undergoing apoptosis

1999 • 238 citations

Frequent hypermethylation of CpG islands and loss of expression of the 14-3-3 σ gene in human hepatocellular carcinoma

2000 • 232 citations

Downregulation of 14-3-3σ Prevents Clonal Evolution and Leads to Immortalization of Primary Human Keratinocytes

2000 • 228 citations

Cdc25 Inhibited In Vivo and In Vitro by Checkpoint Kinases Cds1 and Chk1

1999 • 223 citations

Cleavage of CDK Inhibitor p21Cip1/Waf1 by Caspases Is an Early Event during DNA Damage-induced Apoptosis

1998 • 215 citations

Immunohistochemical analysis of in vivo patterns of Bak expression, a proapoptotic member of the Bcl-2 protein family.

1996 • 207 citations

Molecular Cloning and Expression of the Transformation Sensitive Epithelial Marker Stratifin

1993 • 177 citations

Complementary DNA cloning of a novel epithelial cell marker protein, HME1, that may be down-regulated in neoplastic mammary cells.

1992 • 149 citations

The G₂ Checkpoint Is Maintained by Redundant Pathways

1999 • 116 citations

Mutated p21WAF1/CIP1/SDI1 lacking CDK-inhibitory activity fails to prevent apoptosis in human colorectal carcinoma cells

1998 • 87 citations

Inhibiting CDK inhibitors: new lessons from DNA tumor viruses

1998 • 38 citations

Identification of CIP-1-associated Regulator of Cyclin B (CARB), a Novel p21-binding Protein Acting in the G2 Phase of the Cell Cycle

2000 • 32 citations