Lipidic Pore Formation by the Concerted Action of Proapoptotic BAX and tBID

Phosphorus Assay in Column Chromatography

1959 • 12,895 citations

Cleavage of BID by Caspase 8 Mediates the Mitochondrial Damage in the Fas Pathway of Apoptosis

1998 • 4,383 citations

Proapoptotic BAX and BAK: A Requisite Gateway to Mitochondrial Dysfunction and Death

2001 • 3,867 citations

Bid, a Bcl2 Interacting Protein, Mediates Cytochrome c Release from Mitochondria in Response to Activation of Cell Surface Death Receptors

1998 • 3,603 citations

Direct Activation of Bax by p53 Mediates Mitochondrial Membrane Permeabilization and Apoptosis

2004 • 1,977 citations

BCL-2, BCL-XL Sequester BH3 Domain-Only Molecules Preventing BAX- and BAK-Mediated Mitochondrial Apoptosis

2001 • 1,672 citations

Vesicles of variable sizes produced by a rapid extrusion procedure

1986 • 1,654 citations

Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics

2002 • 1,617 citations

Bid, Bax, and Lipids Cooperate to Form Supramolecular Openings in the Outer Mitochondrial Membrane

2002 • 1,443 citations

Bid-induced Conformational Change of Bax Is Responsible for Mitochondrial Cytochrome c Release during Apoptosis

1999 • 1,255 citations

Mitochondria

2003 • 1,233 citations

Bim: a novel member of the Bcl-2 family that promotes apoptosis

1998 • 1,154 citations

Bid Induces the Oligomerization and Insertion of Bax into the Outer Mitochondrial Membrane

2000 • 1,150 citations

Structure of Bax

2000 • 1,066 citations

Investigation of the subcellular distribution of the bcl-2 oncoprotein: residence in the nuclear envelope, endoplasmic reticulum, and outer mitochondrial membranes.

1993 • 1,044 citations

Caspase Cleaved BID Targets Mitochondria and Is Required for Cytochrome c Release, while BCL-XL Prevents This Release but Not Tumor Necrosis Factor-R1/Fas Death

1999 • 1,024 citations

Cytochrome c release from mitochondria proceeds by a two-step process

2002 • 917 citations

BH3-only proteins that bind pro-survival Bcl-2 family members fail to induce apoptosis in the absence of Bax and Bak

2001 • 815 citations

Spatial and temporal association of Bax with mitochondrial fission sites, Drp1, and Mfn2 during apoptosis

2002 • 801 citations

Mitochondrial p53 activates Bak and causes disruption of a Bak–Mcl1 complex

2004 • 748 citations

Keeping killers on a tight leash: transcriptional and post-translational control of the pro-apoptotic activity of BH3-only proteins

2002 • 699 citations

Conversion of Bcl-2 from Protector to Killer by Interaction with Nuclear Orphan Receptor Nur77/TR3

2004 • 644 citations

Bax oligomerization is required for channel-forming activity in liposomes and to trigger cytochrome c release from mitochondria

2000 • 619 citations

Bcl-2-family proteins and the role of mitochondria in apoptosis

2003 • 611 citations

Posttranslational N-Myristoylation of BID as a Molecular Switch for Targeting Mitochondria and Apoptosis

2000 • 555 citations

Cardiolipin provides specificity for targeting of tBid to mitochondria

2000 • 462 citations

Mitochondrial release of AIF and EndoG requires caspase activation downstream of Bax/Bak-mediated permeabilization

2003 • 434 citations

Mitochondrial contact sites. Lipid composition and dynamics.

1990 • 426 citations

Subcellular and submitochondrial mode of action of Bcl-2-like oncoproteins

1998 • 421 citations

Control of mitochondrial permeability by Bcl-2 family members

2003 • 365 citations

The Influence of Lysolipids on the Spontaneous Curvature and Bending Elasticity of Phospholipid Membranes

2001 • 327 citations

Involvement of Histone H1.2 in Apoptosis Induced by DNA Double-Strand Breaks

2003 • 321 citations

Biomembrane fusion: a new concept derived from model studies using two interacting planar lipid bilayers

1987 • 295 citations

Identification of Novel Isoforms of the BH3 Domain Protein Bim Which Directly Activate Bax To Trigger Apoptosis

2002 • 287 citations

Bax, but not Bcl-x _L , decreases the lifetime of planar phospholipid bilayer membranes at subnanomolar concentrations

1999 • 267 citations

Bax-type Apoptotic Proteins Porate Pure Lipid Bilayers through a Mechanism Sensitive to Intrinsic Monolayer Curvature

2002 • 229 citations

Interaction with a Membrane Surface Triggers a Reversible Conformational Change in Bax Normally Associated with Induction of Apoptosis

2003 • 199 citations

Ion Channel Activity of the BH3 Only Bcl-2 Family Member, BID

1999 • 195 citations

Bid, but Not Bax, Regulates VDAC Channels

2004 • 192 citations

Bax oligomerization in mitochondrial membranes requires tBid (caspase-8-cleaved Bid) and a mitochondrial protein

2002 • 192 citations

Subcellular localization of the bcl-2 protein in malignant and normal lymphoid cells.

1994 • 190 citations

Morphological changes of phosphatidylcholine bilayers induced by melittin: vesicularization, fusion, discoidal particles

1986 • 188 citations

The Effects of Acyl Chain Length and Saturation of Diacylglycerols and Phosphatidylcholines on Membrane Monolayer Curvature

2002 • 185 citations

Bid acts on the permeability transition pore complex to induce apoptosis

2000 • 174 citations

The Apoptotic Protein tBid Promotes Leakage by Altering Membrane Curvature

2002 • 166 citations

tBID Homooligomerizes in the Mitochondrial Membrane to Induce Apoptosis

2002 • 158 citations

The pro-apoptotic Bcl-2 family member tBid localizes to mitochondrial contact sites.

2001 • 141 citations

Cardiolipin and its metabolites move from mitochondria to other cellular membranes during death receptor-mediated apoptosis

2004 • 140 citations

Pro-apoptotic Cleavage Products of Bcl-xL Form Cytochrome c-conducting Pores in Pure Lipid Membranes

2001 • 139 citations

BH3 Death Domain Peptide Induces Cell Type-selective Mitochondrial Outer Membrane Permeability

2001 • 132 citations

Bid, a Widely Expressed Proapoptotic Protein of the Bcl-2 Family, Displays Lipid Transfer Activity

2001 • 130 citations

Constitutive association of the proapoptotic protein Bim with Bcl-2-related proteins on mitochondria in T cells

2004 • 128 citations

BOD (Bcl-2-Related Ovarian Death Gene) Is an Ovarian BH3 Domain-Containing Proapoptotic Bcl-2 Protein Capable of Dimerization with Diverse Antiapoptotic Bcl-2 Members

1998 • 128 citations

The Destabilization of Lipid Membranes Induced by the C-terminal Fragment of Caspase 8-cleaved Bid Is Inhibited by the N-terminal Fragment

2000 • 126 citations

Proapoptotic Bid binds to monolysocardiolipin, a new molecular connection between mitochondrial membranes and cell death

2003 • 125 citations

Mode of action of β-barrel pore-forming toxins of the staphylococcal α-hemolysin family

2001 • 119 citations

Activation of mitochondrial voltage-dependent anion channel by apro-apoptotic BH3-only protein Bim

2002 • 118 citations

Bcl-2 Family Members as Sentinels of Cellular Integrity and Role of Mitochondrial Intermembrane Space Proteins in Apoptotic Cell Death

2003 • 110 citations

Bcl-XL Protects BimEL-induced Bax Conformational Change and Cytochrome c Release Independent of Interacting with Bax or BimEL

2002 • 99 citations

Biphasic translocation of Bax to mitochondria

2002 • 79 citations

Membrane lipids and cell death: an overview

2004 • 78 citations

Inhibition of Bax-Induced CytochromecRelease from Neural Cell and Brain Mitochondria by Dibucaine and Propranolol

2003 • 78 citations

Cardiolipin Is Not Required for Bax-mediated Cytochrome c Release from Yeast Mitochondria

2004 • 74 citations

Mitochondrial Lipid Alterations during Fas- and Radiation-Induced Apoptosis

2001 • 69 citations

Transbilayer Lipid Diffusion Promoted by Bax: Implications for Apoptosis

2003 • 60 citations

Interaction of hagfish cathelicidin antimicrobial peptides with model lipid membranes

2002 • 53 citations

Continuous measurement of rapid transbilayer movement of a pyrene-labeled phospholipid analogue

2000 • 50 citations

Direct addition of BimL to mitochondria does not lead to cytochrome c release

2002 • 46 citations

Bax, along with Lipid Conspirators, Allows Cytochrome c to Escape Mitochondria

2002 • 42 citations

Membrane fusion: the process and its energy suppliers

2002 • 42 citations

Expression and Purification of Full-Length Human Bax α

1999 • 40 citations

B Cell Receptor-Mediated Apoptosis of Human Lymphocytes Is Associated with a New Regulatory Pathway of Bim Isoform Expression

2004 • 38 citations

Leakage and aggregation of phospholipid vesicles induced by the BH3‐only Bcl‐2 family member, BID

2001 • 29 citations

Fatty acids enhance membrane permeabilization by pro-apoptotic Bax

2004 • 24 citations

Mitochondrial Lipids as Apoptosis Regulators

2003 • 10 citations