Tocopherols and tocotrienols in membranes: A critical review

Free radicals in biology and medicine

1991 • 17,840 citations

Free radicals in biology and medicine

1985 • 2,999 citations

FUNCTIONS OF LIPID RAFTS IN BIOLOGICAL MEMBRANES

1998 • 2,942 citations

Meta-Analysis: High-Dosage Vitamin E Supplementation May Increase All-Cause Mortality

2005 • 2,499 citations

Mortality in Randomized Trials of Antioxidant Supplements for Primary and Secondary Prevention

2007 • 2,208 citations

Antioxidants in health and disease

2001 • 1,922 citations

Lipid polymorphism and the functional roles of lipids in biological membranes

1979 • 1,817 citations

The chemistry and antioxidant properties of tocopherols and tocotrienols

1996 • 1,783 citations

Model Systems, Lipid Rafts, and Cell Membranes

2004 • 1,625 citations

Rafts defined: a report on the Keystone symposium on lipid rafts and cell function

2006 • 1,424 citations

Physical principles of membrane organization

1980 • 1,381 citations

The State of Lipid Rafts: From Model Membranes to Cells

2003 • 1,334 citations

Vitamin E, antioxidant and nothing more

2007 • 1,321 citations

Biomembranes: molecular structure and function

1989 • 1,257 citations

Cytochrome c acts as a cardiolipin oxygenase required for release of proapoptotic factors

2005 • 1,169 citations

How lipids affect the activities of integral membrane proteins

2004 • 1,141 citations

Vitamin E: application of the principles of physical organic chemistry to the exploration of its structure and function

1986 • 1,103 citations

Phase equilibria of cholesterol/dipalmitoylphosphatidylcholine mixtures: deuterium nuclear magnetic resonance and differential scanning calorimetry

1990 • 1,100 citations

Shotgun lipidomics: Electrospray ionization mass spectrometric analysis and quantitation of cellular lipidomes directly from crude extracts of biological samples

2004 • 1,078 citations

Autoxidation of biological molecules. 1. Antioxidant activity of vitamin E and related chain-breaking phenolic antioxidants in vitro

1981 • 1,071 citations

Theory of self-assembly of lipid bilayers and vesicles

1977 • 903 citations

Autoxidation of biological molecules. 4. Maximizing the antioxidant activity of phenols

1985 • 769 citations

Measurement of Lipid Peroxidation

1998 • 733 citations

Vitamin E: A Comprehensive Treatise

1980 • 720 citations

Free radical recycling and intramembrane mobility in the antioxidant properties of alpha-tocopherol and alpha-tocotrienol

1991 • 641 citations

Vitamin E as the Biological Lipid Antioxidant

1962 • 581 citations

The European perspective on vitamin E: current knowledge and future research

2002 • 579 citations

Single-molecule microscopy on model membranes reveals anomalous diffusion

1997 • 554 citations

Vitamin E and its function in membranes

1999 • 537 citations

Chemistry and biology of vitamin E

2004 • 526 citations

Structure of Detergent-Resistant Membrane Domains: Does Phase Separation Occur in Biological Membranes?

1997 • 512 citations

Vitamin E and heart disease:

2000 • 456 citations

Lipid Composition and the Lateral Pressure Profile in Bilayers

1999 • 440 citations

Nonbilayer lipids affect peripheral and integral membrane proteins via changes in the lateral pressure profile

2004 • 435 citations

The influence of cholesterol on phospholipid membrane curvature and bending elasticity

1997 • 419 citations

Relative susceptibility of microsomes from lung, heart, liver, kidney, brain and testes to lipid peroxidation: Correlation with vitamin E content

1980 • 408 citations

Detergent-insoluble glycosphingolipid/cholesterol-rich membrane domains, lipid rafts and caveolae (Review)

1999 • 392 citations

FUNCTIONAL and STRUCTURAL ASPECTS OF BIOLOGICAL MEMBRANES: A SUGGESTED STRUCTURAL ROLE FOR VITAMIN E IN THE CONTROL OF MEMBRANE PERMEABILITY and STABILITY

1972 • 388 citations

Biophysical properties of lipids and dynamic membranes

2006 • 385 citations

Vitamin E in health and disease

1993 • 383 citations

Human plasma and tissue alpha-tocopherol concentrations in response to supplementation with deuterated natural and synthetic vitamin E

1998 • 382 citations

Rafts: Scale‐Dependent, Active Lipid Organization at the Cell Surface

2004 • 375 citations

Non-Antioxidant Activities of Vitamin E

2004 • 374 citations

Use of fluorescent probes to monitor molecular order and motions within liposome bilayers

1993 • 374 citations

Structural and dynamic membrane properties of .alpha.-tocopherol and .alpha.-tocotrienol: Implication to the molecular mechanism of their antioxidant potency

1993 • 368 citations

Free-radical chain oxidation of rat red blood cells by molecular oxygen and its inhibition by α-tocopherol

1987 • 366 citations

Sensitive fluorometric method for tissue tocopherol analysis

1976 • 352 citations

Lipid polymorphism and protein–lipid interactions

1998 • 351 citations

Molecular mechanism of α-tocopherol action

2007 • 348 citations

Biomembranes: Molecular structure and function

1989 • 345 citations

Comparative study on the action of tocopherols and tocotrienols as antioxidant: chemical and physical effects

2003 • 338 citations

The preference of cholesterol for phosphatidylcholine in mixed phosphatidylcholine-phosphatidylethanolamine bilayers

1976 • 338 citations

Oxidative lipidomics of apoptosis: redox catalytic interactions of cytochrome c with cardiolipin and phosphatidylserine

2004 • 333 citations

Membrane protein crystallization

2003 • 328 citations

The Influence of Lysolipids on the Spontaneous Curvature and Bending Elasticity of Phospholipid Membranes

2001 • 327 citations

The generation and actions of isoprostanes

1997 • 314 citations

Identification of inflammatory gene modules based on variations of human endothelial cell responses to oxidized lipids

2006 • 310 citations

The biochemical modes of action of vitamin e and selenium: A hypothesis

1973 • 310 citations

A rapid screening test to determine the antioxidant potencies of natural and synthetic antioxidants

1993 • 298 citations

Indices of lipid peroxidation in vivo: strengths and limitations

2000 • 294 citations

Antioxidant vitamins and coronary heart disease risk: a pooled analysis of 9 cohorts

2004 • 292 citations

Lipid Rafts and the Regulation of Exocytosis

2004 • 291 citations

Molecular Basis of Vitamin E Action

2003 • 286 citations

Establishing the Significance and Optimal Intake of Dietary Antioxidants: The Biomarker Concept

2009 • 286 citations

Lipid Polymorphism:The Molecular Basis of Nonbilayer Phases

1985 • 285 citations

The BAR‐domain family of proteins: a case of bending and binding?

2004 • 280 citations

Dynamics in the plasma membrane: how to combine fluidity and order

2006 • 274 citations

Shotgun lipidomics: multidimensional MS analysis of cellular lipidomes

2005 • 266 citations

Fusion peptides and the mechanism of viral fusion

2003 • 263 citations

α-Tocopherol specifically inactivates cellular protein kinase C α by changing its phosphorylation state

1998 • 259 citations

A model for the packing of lipids in bilayer membranes

1975 • 255 citations

Shrinking patches and slippery rafts: scales of domains in the plasma membrane

2001 • 251 citations

Measured effects of diacylglycerol on structural and elastic properties of phospholipid membranes

1996 • 247 citations

Interaction of vitamin C and vitamin E during free radical stress in plasma: An ESR study

1993 • 243 citations

Comparison of the efficiencies of several natural and synthetic antioxidants in aqueous SDS [sodium dodecyl sulfate] micelle solutions

1988 • 241 citations

α-Tocopherol Inhibits the Respiratory Burst in Human Monocytes

1998 • 233 citations

The location and function of vitamin E in membranes (Review)

2000 • 231 citations

Bar domain proteins: a role in tubulation, scission and actin assembly in clathrin-mediated endocytosis

2006 • 231 citations

Autoxidation of biological molecules. 2. Autoxidation of a model membrane. Comparison of the autoxidation of egg lecithin phosphatidylcholine in water and in chlorobenzene

1981 • 226 citations

Vitamin E activates gene expression via the pregnane X receptor

2002 • 226 citations

Diacylglycerols, lysolecithin, or hydrocarbons markedly alter the bilayer to hexagonal phase transition temperature of phosphatidylethanolamines

1985 • 224 citations

[34] Antioxidant properties of α-tocopherol and α-tocotrienol

1994 • 221 citations

Free radical biology – terminology and critical thinking

2004 • 215 citations

Routine Vitamin Supplementation To Prevent Cardiovascular Disease: A Summary of the Evidence for the U.S. Preventive Services Task Force

2003 • 214 citations

Estimation of peroxidative damage. A critical review.

1996 • 211 citations

Detection of Reactive Oxygen and Nitrogen Species by EPR Spin Trapping

2004 • 204 citations

Membranes of the world unite!

2006 • 204 citations

The BAR Domain Proteins: Molding Membranes in Fission, Fusion, and Phagy

2006 • 201 citations

Vitamin E: molecular and biological function

1994 • 197 citations

Vitamin E: An overview of major research directions

2007 • 197 citations

Ligand Specificity in the CRAL-TRIO Protein Family

2003 • 194 citations

Tocopherol, oxygen and biomembranes

1978 • 194 citations

THE ISOPROSTANES: THEIR QUANTIFICATION AS AN INDEX OF OXIDANT STRESS STATUS IN VIVO^†

2000 • 192 citations

Phospholipase A2s and lipid peroxidation

2000 • 188 citations

Nonbilayer phases of membrane lipids

1991 • 186 citations

Refinement of the fluid-mosaic model of membrane structure

1977 • 183 citations

Products of the isoprostane pathway: unique bioactive compounds and markers of lipid peroxidation

2002 • 183 citations

The rate of transmembrane movement of cholesterol in the human erythrocyte.

1981 • 179 citations

Influence of major structural features of tocopherols and tocotrienols on their ω-oxidation by tocopherol-ω-hydroxylase

2007 • 175 citations

Is the high propensity of ethanolamine plasmalogens to form non-lamellar lipid structures manifested in the properties of biomembranes?

1996 • 175 citations

Cholesterol facilitates the native mechanism of Ca2+-triggered membrane fusion

2005 • 175 citations

Faster plasma vitamin E disappearance in smokers is normalized by vitamin C supplementation

2005 • 174 citations

Use and abuse of exogenous H2O2 in studies of signal transduction

2007 • 174 citations

Mass spectrometry for detection of 4‐hydroxy‐trans‐2‐nonenal (HNE) adducts with peptides and proteins

2004 • 174 citations

Lipid polymorphism and biomembrane function

1997 • 171 citations

Lipid peroxidation during n−3 fatty acid and vitamin E supplementation in humans

1997 • 169 citations

Antiproliferative and apoptotic effects of tocopherols and tocotrienols on normal mouse mammary epithelial cells

2000 • 163 citations

1992 Syntex Award Lecture Model biomembranes: quantitative studies of peroxidation, antioxidant action, partitioning, and oxidative stress

1993 • 157 citations

[Evaluation of lipid peroxidation by measuring thiobarbituric acid reactive substances].

1998 • 154 citations

Relationship Between Vitamin E Requirement and Polyunsaturated Fatty Acid Intake in Man: a Review

2000 • 154 citations

BAR domains and membrane curvature: bringing your curves to the BAR.

2005 • 153 citations

Membrane lipids as signaling molecules

2007 • 153 citations

Comparative antioxidant activity of tocotrienols and other natural lipid-soluble antioxidants in a homogeneous system, and in rat and human lipoproteins

1993 • 153 citations

Anti‐atherosclerotic effects of vitamin E – myth or reality?

2004 • 151 citations

α-Tocopherol Decreases Interleukin-1β Release From Activated Human Monocytes by Inhibition of 5-Lipoxygenase

1999 • 150 citations

Effects of lysophosphatidylcholines on phosphatidylcholine and phosphatidylcholine/cholesterol liposome systems as revealed by 31P-NMR, electron microscopy and permeability studies

1981 • 148 citations

Tocopherol, Oxygen and Biomembranes

1978 • 144 citations

Tocopherol Stabilizes Membrane against Phospholipase A, Free Fatty Acids, and Lysophospholipids^a

1989 • 143 citations

The role of membrane biophysical properties in the regulation of protein kinase C activity

1990 • 142 citations

The Discovery of the Antioxidant Function of Vitamin E: the contribution of Henry A. Mattill

2005 • 140 citations

Recycling and Redox Cycling of Phenolic Antioxidants

1998 • 137 citations

The Molecular Basis of Vitamin E Retention: Structure of Human α-Tocopherol Transfer Protein

2003 • 137 citations

Bending membranes to the task: structural intermediates in bilayer fusion

1995 • 136 citations

Coantioxidants make alpha-tocopherol an efficient antioxidant for low-density lipoprotein

1995 • 136 citations

Antioxidant activity of vitamin E and related phenols. Importance of stereoelectronic factors

1980 • 134 citations

Inhibition of 5‐lipoxygenase by vitamin E

1985 • 133 citations

Formation of α-tocopherol complexes with fatty acids. A hypothetical mechanism of stabilization of biomembranes by vitamin E

1984 • 133 citations

Differential inhibitory effects of vitamin E and other antioxidants on prostaglandin synthetase, platelet aggregation and lipoxidase

1977 • 130 citations

Curvature and Bending Constants for Phosphatidylserine-Containing Membranes

2003 • 130 citations

Fluidity, permeability and antioxidant behaviour of model membranes incorporated with α-tocopherol and vitamin E acetate

1983 • 128 citations

Reaction of Ascorbate with the α-Tocopheroxyl Radical in Micellar and Bilayer Membrane Systems

1995 • 127 citations

Vitamin E Imaging and Localization in the Neuronal Membrane

2005 • 125 citations

Vitamin E: Biochemistry and health implications

1990 • 125 citations

Vitamin E and its Role in the Prevention of Atherosclerosis and Carcinogenesis: A Review

2003 • 118 citations

α-Tocopherol disappearance is faster in cigarette smokers and is inversely related to their ascorbic acid status

2005 • 118 citations

The use of antioxidant supplements in coronary heart disease

2002 • 117 citations

Crystal structure of human α-tocopherol transfer protein bound to its ligand: Implications for ataxia with vitamin E deficiency

2003 • 116 citations

Gene expression profile of oxidant stress and neurodegeneration in transgenic mice deficient in α-tocopherol transfer protein

2003 • 116 citations

The Isoprostanes: A Perspective

1997 • 115 citations

Is n-Pentane Really an Index of Lipid Peroxidation in Humans and Animals? A Methodological Reevaluation

1993 • 114 citations

Lipid Peroxidation and Biogenic Aldehydes: From the Identification of 4-Hydroxynonenal to Further Achievements in Biopathology

1998 • 112 citations

Estimation of the location of natural α-tocopherol in lipid bilayers by 13C-NMR spectroscopy

1985 • 111 citations

Role of lysophosphatidylcholine in the inhibition of endothelial cell motility by oxidized low density lipoprotein.

1996 • 109 citations

First Structural Evidence of a Specific Inhibition of Phospholipase A2 by α-Tocopherol (Vitamin E) and its Implications in Inflammation: Crystal Structure of the Complex Formed Between Phospholipase A2 and α-Tocopherol at 1.8Å Resolution

2002 • 108 citations

Unique in vivo applications of spin traps

2001 • 108 citations

Stopped-flow investigation of the reaction of vitamin C with tocopheroxyl radical in aqueous triton X-100 micellar solutions. The structure-activity relationship of the regeneration reaction of tocopherol by vitamin C.

1991 • 108 citations

γ‐Tocotrienol inhibits ErbB3‐dependent PI3K/Akt mitogenic signalling in neoplastic mammary epithelial cells

2006 • 108 citations

Interaction of vitamin E with saturated phospholipid bilayers

1982 • 107 citations

Appetizing rancidity of apoptotic cells for macrophages: oxidation, externalization, and recognition of phosphatidylserine

2003 • 105 citations

Membrane-stabilizing effect of vitamin E: Effect of α-tocopherol and its model compounds on fluidity of lecithin liposomes

1988 • 105 citations

Lipid polymorphism and membrane properties

1997 • 104 citations

Involvement of Calcium-independent Phospholipase A2in Hydrogen Peroxide-induced Accumulation of Free Fatty Acids in Human U937 Cells

2002 • 104 citations

Vitamin E protected cultured cortical neurons from oxidative stress‐induced cell death through the activation of mitogen‐activated protein kinase and phosphatidylinositol 3‐kinase

2006 • 102 citations

Electron paramagnetic spectroscopic evidence of exercise-induced free radical accumulation in human skeletal muscle

2007 • 102 citations

Bioavailability of vitamin E.

1997 • 101 citations

On the molecular-level mechanisms of peripheral protein-membrane interactions induced by lipids forming inverted non-lamellar phases

1996 • 99 citations

Anti-atherogenic effect of coenzyme Q10 in apolipoprotein E gene knockout mice11Dedicated to Lars Ernster for his pioneering contributions to research into coenzyme Q and his genuine passion and enthusiasm we were privileged to experience.

2000 • 98 citations

The effect of vitamin E on the structure of membrane lipid assemblies

2003 • 97 citations

Mammalian lysophospholipases

1999 • 96 citations

Biological Activity of Vitamin E Compounds and Natural Materials by the Resorption-Gestation Test, and Chemical Determination of the Vitamin E Activity in Foods and Feeds

1977 • 94 citations

Inhibition of IL-1β expression in THP-1 cells by probucol and tocopherol

1991 • 94 citations

Concentrations of vitamin E in various neuroanatomical regions and subcellular fractions, and the uptake of vitamin e by specific areas, of rat brain

1984 • 92 citations

Calorimetric and infrared spectroscopic studies of the interaction of α‐tocopherol and α‐tocopheryl acetate with phospholipid vesicles

1986 • 92 citations

Deuterium NMR study of the interaction of .alpha.-tocopherol with a phospholipid model membrane

1986 • 92 citations

Interaction of Vitamins A and E

1941 • 90 citations

Scavenging of radicals by vitamin E in the membranes as studied by spin labeling

1989 • 90 citations

Evidence for the formation of microdomains in liquid crystalline large unilamellar vesicles caused by hydrophobic mismatch of the constituent phospholipids

1996 • 88 citations

Antimicrobial activities of clofazimine and B669 are mediated by lysophospholipids

1992 • 87 citations

Antagonistic Effects of Oxidized Low Density Lipoprotein and α-Tocopherol on CD36 Scavenger Receptor Expression in Monocytes

2006 • 86 citations

Hemolysis of human erythrocytes induced by tamoxifen is related to disruption of membrane structure

2000 • 85 citations

Model of singlet oxygen scavenging by α-tocopherol in biomembranes

1980 • 85 citations

Free radicals in the 1900's: from in vitro to in vivo

2000 • 85 citations

The interaction of α‐tocopherol and homologues with shorter hydrocarbon chains with phospholipid bilayer dispersions

1988 • 85 citations

Miscibility of phosphatidylethanolamine-phosphatidylglycerol mixtures as a function of pH and acyl chain length

2000 • 84 citations

Structural properties of phospholipids in the rat liver inner mitochondrial membrane. A 31P-NMR study

1980 • 83 citations

Membrane stabilization of vitamin E; interactions of α-tocopherol with phospholipids in bilayer liposomes

1987 • 83 citations

Phospholipid Peroxidation Induces Cytosolic Phospholipase A2Activity: Membrane Effects versus Enzyme Phosphorylation

1997 • 82 citations

Mechanisms of stabilization of biomembranes by alpha-tocopherol

1990 • 80 citations

Active oxygen chemistry within the liposomal bilayer

2004 • 80 citations

Effect of lipid physical state on the rate of peroxidation of liposomes

1992 • 80 citations

Membrane microviscosity regulates endothelial cell motility

2002 • 79 citations

The relationship between α-tocopherol and phospholipid fatty acids in rat liver subcellular membrane fractions

1988 • 79 citations

Antioxidants and endothelium protection

2005 • 79 citations

Synthesis and kinetic study of antioxidant activity of new tocopherol (vitamin E) compounds

1989 • 78 citations

Differential Scanning Calorimetric Studies of the Interaction of Cholesterol with Distearoyl and Dielaidoyl Molecular Species of Phosphatidylcholine, Phosphatidylethanolamine, and Phosphatidylserine

1997 • 77 citations

Inhibition of HMC-1 Mast Cell Proliferation by Vitamin E

2004 • 77 citations

Protein kinase C involvement in lipid peroxidation and cell membrane damage induced by oxygen-based radicals in hepatocytes

1989 • 77 citations

Effect of Lipid Composition of Liposomes on Their Sensitivity to Peroxidation1

1984 • 76 citations

Binding of Cytochrome P450 Monooxygenase and Lipoxygenase Pathway Products by Heart Fatty Acid-Binding Protein

2001 • 76 citations

Regulation of Recombinant PKCα Activity by Protein Phosphatase 1 and Protein Phosphatase 2A

1998 • 75 citations

The ga-tocopherol and phospholipid fatty acid content of rat liver subcellular membranes in vitamin E and selenium deficiency

1988 • 75 citations

OKL38 is an oxidative stress response gene stimulated by oxidized phospholipids

2006 • 74 citations

Plasma membrane targeting of exocytic SNARE proteins

2004 • 73 citations

Fatty Acid Modulation of Epidermal Growth Factor-Induced Mouse Mammary Epithelial Cell Proliferation in Vitro

1994 • 72 citations

Transmembrane movement of cholesterol in small unilamellar vesicles detected by cholesterol oxidase.

1981 • 72 citations

Structure−Activity Relationship of the Free-Radical-Scavenging Reaction by Vitamin E (α-, β-, γ-, δ-Tocopherols) and Ubiquinol-10: pH Dependence of the Reaction Rates

2007 • 72 citations

The Enantiomer of Cholesterol

2004 • 72 citations

Cholesterol versus α-Tocopherol: Effects on Properties of Bilayers Made from Heteroacid Phosphatidylcholines

1996 • 71 citations

The Effect of α‐Tocopherol on the Synthesis, Phosphorylation and Activity of Protein Kinase C in Smooth Muscle Cells After Phorbol 12‐Myristate 13‐Acetate Down‐Regulation

1997 • 70 citations

Retinol transfer across and between phospholipid bilayer membranes

1988 • 69 citations

Cardiac applications of EPR imaging

2004 • 68 citations

Vitamin E Supplementation in the Prevention of Coronary Heart Disease

2001 • 68 citations

Antioxidant Properties of Natural and Synthetic Chromanol Derivatives: Study by Fast Kinetics and Electron Spin Resonance Spectroscopy

2005 • 68 citations

Random versus Selective Membrane Phospholipid Oxidation in Apoptosis: Role of Phosphatidylserine

1998 • 67 citations

Differences in the susceptibility of plant membrane lipids to peroxidation

1990 • 67 citations

Pitfalls in the use of breath pentane measurements to assess lipid peroxidation.

1994 • 67 citations

Localization of α‐Tocopherol in Membranes^a

1989 • 66 citations

Analysis of hepatic oxidative stress status by electron spin resonance spectroscopy and imaging

2000 • 66 citations

Enhanced Interfacial Catalysis and Hydrolytic Specificity of Phospholipase A2 toward Peroxidized Phosphatidylcholine Vesicles

1993 • 66 citations

Vitamin E: inhibition of retinol-induced hemolysis and membrane-stabilizing behavior.

1992 • 64 citations

?-Tocopherol decreases tumor necrosis factor-? mRNA and protein from activated human monocytes by inhibition of 5-lipoxygenase

2005 • 64 citations

A differential scanning calorimetry study of the interaction of α-tocopherol with mixtures of phospholipids

1987 • 63 citations

α‐tocopherol and the permeability to glucose and chromate of unsaturated liposomes

1977 • 62 citations

Vitamin E and the biological antioxidant theory.

1969 • 60 citations

Is there a vitamin E paradox?

2001 • 60 citations

Action of vitamin E as antioxidant in phospholipid liposomal membranes as studied by spin label technique.

1988 • 60 citations

Application of Gas Chromatography-Mass Spectrometry for Analysis of Isoprostanes: Their Role in Cardiovascular Disease

2003 • 60 citations

d-α-Tocopherol prevents the hyperglycemia induced activation of diacylglycerol (DAG)-protein kinase C (PKC) pathway in vascular smooth muscle cell by an increase of DAG kinase activity

1999 • 60 citations

Roles of Curvature and Hydrophobic Interstice Energy in Fusion: Studies of Lipid Perturbant Effects

2004 • 60 citations

The effect of α‐tocopherol on the thermotropic phase behaviour of dipalmitoylphosphatidylethanolamine

1999 • 59 citations

The membrane fluidity concept revisited by polarized fluorescence spectroscopy on different model membranes containing unsaturated lipids and sterols

1989 • 58 citations

Chapter 2 Membrane Lipid Molecular Structure and Polymorphism

1997 • 57 citations

Mobility and Molecular Orientation of Vitamin E in Liposomal Membranes as Determined by 19F NMR and Fluorescence Polarization Techniques

1993 • 57 citations

The effects of non-lamellar forming lipids on membrane protein-lipid interactions

1996 • 56 citations

Activation of cytosolic phospholipase A2 in Her14 fibroblasts by hydrogen peroxide: a p42/44MAPK-dependent and phosphorylation-independent mechanism

2004 • 55 citations

Kinetics of the reaction by which natural vitamin E is regenerated by vitamin C

2006 • 54 citations

Risk of Mortality with Vitamin E Supplements: The Cache County Study

2007 • 54 citations

Fluorescence study of the location and dynamics of α-tocopherol in phospholipid vesicles

1989 • 54 citations

Vitamin E Decreases the Order of the Phospholipid Model Membranes in the Gel Phase: An FTIR Study

1997 • 54 citations

Miscibility of phospholipids with identical headgroups and acyl chain lengths differing by two methylene units: Effects of headgroup structure and headgroup charge

1998 • 53 citations

Interaction between α-tocopherol and heteroacid phosphatidylcholines with different amounts of unsaturation

1996 • 52 citations

Importance of chroman ring and tyrosine phosphorylation in the subtype‐specific translocation and activation of diacylglycerol kinase α by <scp>d</scp>‐α‐tocopherol

2005 • 51 citations

Modulation of the activities of enzymes of membrane lipid metabolism by non-bilayer-forming lipids

1996 • 51 citations

Formation of α-tocopherol complexes with fatty acids. Nature of complexes

1985 • 51 citations

Vitamin E and Blood1

2015 • 51 citations

Oxidative stress, alpha-tocopherol therapy, and atherosclerosis

2002 • 50 citations

Decreases in rates of lipid exchange between Mycoplasma gallisepticum cells and unilamellar vesicles by incorporation of sphingomyelin.

1984 • 49 citations

Dissimilar protection of tocopherol isomers against membrane hydrolysis by phospholipase A2

1998 • 49 citations

Structure and dynamics of .alpha.-tocopherol in model membranes and in solution: a broad-line and high-resolution NMR study

1988 • 49 citations

Vitamin E : its usefulness in health and in curing diseases

1993 • 48 citations

Location and dynamics of α-tocopherol in model phospholipid membranes with different charges

1992 • 48 citations

Vitamin E and blood.

1985 • 48 citations

Is the Distribution of -Tocopherol in Membranes Consistent with Its Putative Functions?

2004 • 47 citations

Diffusion of α-Tocopherol in Membrane Models: Probing the Kinetics of Vitamin E Antioxidant Action by Fluorescence in Real Time

2004 • 45 citations

Tunneling Effect in Antioxidant, Prooxidant, and Regeneration Reactions of Vitamin E

2000 • 45 citations

Lysosomal membrane stabilization by α-tocopherol against the damaging action of Vipera russelli venom phospholipase A2

1997 • 45 citations

Influence of vitamin E on phosphatidylethanolamine lipid polymorphism

1990 • 45 citations

New aspects of the inhibition of soybean lipoxygenase by α-tocopherol evidence for the existence of a specific complex

1984 • 45 citations

Modulation of microglial superoxide production by α‐tocopherol in vitro: attenuation of p67^phox translocation by a protein phosphatase‐dependent pathway

2001 • 44 citations

Interaction of α-tocopherol with fatty acids in membranes and ethanol

1992 • 43 citations

Relative α-Tocopherol Deficiency in Cultured-Cells: Free Radical-Mediated Lipid Peroxidation, Lipid Oxidizability, and Cellular Polyunsaturated Fatty Acid Content

1995 • 43 citations

Red blood cell vitamin E concentrations in fetuses are related to but lower than those in mothers during gestation

1995 • 43 citations

Vitamin E inhibits hemolysis induced by hemin as a membrane stabilizer

2006 • 42 citations

The cubic phases of lipids

2004 • 41 citations

The Plasma Membrane Is the Site of Selective Phosphatidylserine Oxidation During Apoptosis: Role of Cytochromec

2004 • 41 citations

Inhibition of potassium transport and growth of mycobacteria exposed to clofazimine and B669 is associated with a calcium-independent increase in microbial phospholipase A2 activity

1999 • 41 citations

Magic angle spinning 13C-NMR spin-lattice relaxation study of the location and effects of ?-tocopherol, ubiquinone-10 and ubiquinol-10 in unsonicated model membranes

1993 • 40 citations

15‐Lipoxygenation of phospholipids may precede the sn‐2 cleavage by phospholipases A₂: reaction specificities of secretory and cytosolic phospholipases A₂ towards native and 15‐lipoxygenated arachidonoyl phospholipids

1998 • 40 citations

Peroxidation and phospholipase A2 hydrolytic susceptibility of liposomes consisting of mixed species of phosphatidylcholine and phosphatidylethanolamine

1992 • 40 citations

Pathological investigation of oxidative stress in the post‐genomic era

2007 • 40 citations

Curvature stress and polymorphism in membranes

1996 • 39 citations

Methodological Approaches for Assessing Lipid and Protein Oxidation and Modification in Plasma and Isolated Lipoproteins

2003 • 39 citations

The structure and chemistry of mammalian cell membranes.

1971 • 38 citations

Characterisation of Clusters of α‐Tocopherol in Gel and Fluid Phases of Dipalmitoylglycerophosphocholine

1995 • 37 citations

New developments in the isoprostane pathway: identification of novel highly reactive γ‐ketoaldehydes (isolevuglandins) and characterization of their protein adducts

1999 • 37 citations

Vitamin E suppresses 5-lipoxygenase-mediated oxidative stress in peripheral blood mononuclear cells of hemodialysis patients regardless of administration route

2001 • 36 citations

Rafts, Little Caves and Large Potholes: How Lipid Structure Interacts with Membrane Proteins to Create Functionally Diverse Membrane Environments

2004 • 35 citations

Effect of .ALPHA.-tocopherol on lipid peroxidation and acyl chain mobility of liver microsomes from vitamin E-difficient rat.

1984 • 35 citations

Effects of α-tocopherol on the lipid peroxidation and fluidity of porcine intestinal brush-border membranes

1986 • 35 citations

Electron spin resonance study of the interaction of alpha-tocopherol with phospholipid model membranes

1991 • 33 citations

Stabilization of synaptic membranes by α-tocopherol against the damaging action of phospholipases. Possible mechanism of biological action of vitamin E

1986 • 33 citations

Membrane stabilizing effect of vitamin E: Existence of a hydrogen bond between .ALPHA.-tocopherol and phospholipids in bilayer liposomes.

1990 • 33 citations

Interfacial properties of phosphatidylcholine bilayers containing vitamin E derivatives

2001 • 33 citations

Hydroxytamoxifen interaction with human erythrocyte membrane and induction of permeabilization and subsequent hemolysis

2001 • 32 citations

A comparison of the in vitro binding of α-tocopherol to microsomes of lung, liver, heart and brain of the rat

1981 • 32 citations

Reactions of biological antioxidants: III. Composition of biological membranes

1971 • 32 citations

Vitamin E mediated response of smooth muscle cell to oxidant stress

1999 • 32 citations

Thermotropic interaction of vitamin E with dimyristoyl and dipalmitoyl phosphatidylcholine liposomes.

1986 • 32 citations

Chapter 4 Hydration, Curvature, and Bending Elasticity of Phospholipid Monolayers

1997 • 31 citations

Effect of Temperature, Cholesterol Content, and Antioxidant Structure on the Mobility of Vitamin E Constituents in Biomembrane Models Studied by Laterally Diffusion-Controlled Fluorescence Quenching

2005 • 31 citations

Platelet phospholipids are differentially protected against oxidative degradation by plasmalogens

2002 • 31 citations

α-Tocopherol Interacts with Natural Micelle-Forming Single-Chain Phospholipids Stabilizing the Bilayer Phase

1993 • 30 citations

Production of Lipid‐Derived Free Radicals in L1210 Murine Leukemia Cells Is an Early Oxidative Event in the Photodynamic Action of Photofrin

1997 • 30 citations

α-tocopherol preserves endothelial cell migration in the presence of cell-oxidized low-density lipoprotein by inhibiting changes in cell membrane fluidity

2003 • 29 citations

CTP:phosphocholine cytidylyltransferase and protein kinase C recognize different physical features of membranes: differential responses to an oxidized phosphatidylcholine

2002 • 29 citations

Vitamin E-phospholipid interactions in model multilayer membranes: A spectroscopic study

1998 • 28 citations

Effects of tocopherols and 2,2′-carboxyethyl hydroxychromans on phorbol-ester-stimulated neutrophils

2007 • 28 citations

The interaction of α-tocopherol with phosphatidylserine vesicles and calcium

1996 • 28 citations

α-Tocopherol Prevents Cyclosporine A-Mediated Activation of Phospholipase A2 and Inhibition of Na+, K+-Adenosine Triphosphatase Activity in Cultured Hamster Renal Tubular Cells

1994 • 28 citations

Impact of oxidized lipids and antioxidants, such as vitamin E and lazaroids, on the structure and dynamics of unsaturated membranes

1992 • 28 citations

Susceptibility of Neonatal Lipoproteins to Oxidative Stress

1991 • 27 citations

Kinetics of lipid phase changes

1995 • 26 citations

Temporary membrane distortion of vascular smooth muscle cells is responsible for their apoptosis induced by platelet-activating factor-like oxidized phospholipids and their degradation product, lysophosphatidylcholine

2003 • 25 citations

Vitamin E: its usefulness in health and in curing diseases.

1993 • 25 citations

Future of ToxicologyLipid Peroxidation in the Future: From Biomarker to Etiology

2006 • 24 citations

Cortical Gene Expression in the Vitamin E-Deficient Rat: Possible Mechanisms for the Electrophysiological Abnormalities of Visual and Neural Function

2006 • 23 citations

Intermembrane transfer and antioxidant action of α-tocopherol in liposomes

1990 • 22 citations

PCR-verified microarray analysis and functionalin vitrostudies indicate a role of α-tocopherol in vesicular transport

2007 • 21 citations

Vitamin E attenuates the injurious effects of bioactive phospholipids on human ciliated epitheliumin vitro

2001 • 21 citations

Location of two antioxidants in oriented model membranes. Small-angle x-ray diffraction study

1991 • 21 citations

The influence of the lipid composition on the degree of lipid-peroxidation of liposomes.

1987 • 20 citations

Current status of electron spin resonance (ESR) forin vivodetection of free radicals

1998 • 19 citations

Future of ToxicologyLipidomics, an Important Emerging Area for Toxicologists: Focus on Lipid Oxidation Products

2007 • 19 citations

Molecular Associations of Vitamin E

2007 • 18 citations

5-Lipoxygenase-mediated mitochondrial damage and apoptosis of mononuclear cells in ESRD patients

2003 • 18 citations

The structure and phase behaviour of α-tocopherol-rich domains in 1-palmitoyl-2-oleoyl-phosphatidylethanolamine

2006 • 18 citations

Vitamin E and the Prevention of Atherosclerosis

2001 • 17 citations

Phospholipid oxidation catalyzed by cytochrome c in liposomes

1985 • 17 citations

Interactions Of Vitamin E With Free Radicals And Membranes

1990 • 16 citations

Selective inhibition of the non-enzymatic lipid peroxidation of phosphatidylserine in rod outer segments by alpha-tocopherol.

2000 • 16 citations

Phase separations of α-tocopherol in aqueous dispersions of distearoylphosphatidylethanolamine

2002 • 15 citations

Detection of bioradicals by in vivo L‐band electron spin resonance spectrometry

2004 • 13 citations

Vitamin E. Biochemistry and Health Implications (Annals of the New York Academy of Sciences, Vol. 570). Herausgegeben von A. T. Diplock, L. J. Machlin, L. Packer und W. A. Pryor. 555 Seiten, zahlr. Abb. und Tab. The New York Academy of Sciences, New York, N. Y., 1989. Preis: 135, ‐ $

1991 • 12 citations

Vitamin E Inhibits Anti-Fas-Induced Phosphatidylserine Oxidation but Does Not Affect Its Externalization During Apoptosis in Jurkat T Cells and Their Phagocytosis by J774A.1 Macrophages

2004 • 12 citations

Relationships between vitamin E status and erythrocyte stability in sheep

1989 • 11 citations

Vitamin E‐phospholipid interactions in model multilayer membranes: A spectroscopic study

1996 • 11 citations

Thin α-tocopherol films separating two aqueous phases

1970 • 11 citations

Location of a-Tocopherol in Phospholipid Vesicles and Its Dynamics in Inhibiting Lipid Peroxidation

2015 • 9 citations

Vitamin E and health

2004 • 8 citations

Interaction of ?-tocopherol with phospholipid liposomes: Absence of transbilayer mobility

1986 • 8 citations

Interaction of vitamin E and its model compounds with unsaturated fatty acids in homogeneous solution.

1988 • 8 citations

Localization of Vitamin E in Membranes

1998 • 7 citations

Studies on dl-α-tocopherol liquid membranes

1996 • 6 citations

Membrane stabilization by vitamin E: magnetic resonance studies of the interaction of alpha-tocopherol with fatty acid acyl chains in phospholipid model membranes.

1989 • 5 citations

Reply to W Cohn

1999 • 5 citations

Tocotrienols and Atherosclerosis

2004 • 5 citations

Membrane Stabilization by Vitamin E

2015 • 5 citations

Vitamin E and Health: Preface

2004 • 5 citations

Chapter 5 Phase Behavior of Membranes Containing Bioactive Lipids

1997 • 4 citations

[Effect of vitamin D and vitamin E on the erythrocyte membrane. I. Effect on in vitro osmolar resistance and lysis].

1978 • 2 citations

[Ubiquinone content and the oxidative-reductive enzymatic system activity in the liver of vitamin E-deficient rats administered alpha-tocopherol and its chlorine derivative].

1981 • 2 citations

Breath Pentane Output and Vitamin E

2015 • 1 citations