Indices of lipid peroxidation in vivo: strengths and limitations

Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes

1991 • 6,550 citations

Beyond Cholesterol

1989 • 6,533 citations

Thromboxanes: a new group of biologically active compounds derived from prostaglandin endoperoxides.

1975 • 3,075 citations

Lipid peroxidation: its mechanism, measurement, and significance

1993 • 2,324 citations

LIPOPROTEIN METABOLISM IN THE MACROPHAGE: Implications for Cholesterol Deposition in Atherosclerosis

1983 • 2,306 citations

A series of prostaglandin F2-like compounds are produced in vivo in humans by a non-cyclooxygenase, free radical-catalyzed mechanism.

1990 • 1,896 citations

Low density lipoprotein undergoes oxidative modification in vivo.

1989 • 1,537 citations

The oxidation hypothesis of atherosclerosis

1994 • 1,418 citations

Oxidants and human disease: some new concepts ¹

1987 • 1,171 citations

Oxidatively modified low density lipoproteins: a potential role in recruitment and retention of monocyte/macrophages during atherogenesis.

1987 • 1,152 citations

Free Radicals and Antioxidants: A Personal View

2009 • 1,095 citations

Identification of 4-hydroxynonenal as a cytotoxic product originating from the peroxidation of liver microsomal lipids

1980 • 1,094 citations

LIPID PEROXIDATION, OXYGEN RADICALS, CELL DAMAGE, AND ANTIOXIDANT THERAPY

1984 • 820 citations

Non-cyclooxygenase-derived prostanoids (F2-isoprostanes) are formed in situ on phospholipids.

1992 • 742 citations

The Yin and Yang of Oxidation in the Development of the Fatty Streak

1996 • 705 citations

Receptor-mediated endocytosis: insights from the lipoprotein receptor system.

1979 • 701 citations

Antisera and monoclonal antibodies specific for epitopes generated during oxidative modification of low density lipoprotein.

1990 • 627 citations

Modulation of Oxidant Stress In Vivo in Chronic Cigarette Smokers

1996 • 621 citations

Receptor-mediated endocytosis

1985 • 577 citations

Review. Recent advances in lipid oxidation

1991 • 538 citations

Free Radicals, Lipid Peroxidation and Cancer

1982 • 530 citations

Glomerular actions of a free radical-generated novel prostaglandin, 8-epi-prostaglandin F2 alpha, in the rat. Evidence for interaction with thromboxane A2 receptors.

1992 • 510 citations

Vitamin E suppresses isoprostane generation in vivo and reduces atherosclerosis in ApoE-deficient mice

1998 • 509 citations

Ethane Evolution: A New Index of Lipid Peroxidation

1974 • 449 citations

Isoprostanes: Formation, Analysis and Use As Indices of Lipid Peroxidation in Vivo

1999 • 384 citations

Localization of distinct F2-isoprostanes in human atherosclerotic lesions.

1997 • 345 citations

Immunological characterization of urinary 8-epi-prostaglandin F2 alpha excretion in man.

1995 • 340 citations

Free Radicals, Lipid Peroxidation and Cancer

1982 • 320 citations

Cylooxygenase-dependent Formation of the Isoprostane, 8-Epi Prostaglandin F2α

1995 • 262 citations

Evidence for the existence of F2-isoprostane receptors on rat vascular smooth muscle cells

1993 • 260 citations

Aldehydes in biological systems

1977 • 259 citations

Alcohol-induced generation of lipid peroxidation products in humans

1999 • 249 citations

IPF _2α -I: An index of lipid peroxidation in humans

1998 • 218 citations

Increased Formation of the Isoprostanes IPF _2α -I and 8-Epi-Prostaglandin F _2α in Acute Coronary Angioplasty

1997 • 211 citations

Local Amplification of Platelet Function by 8-Epi Prostaglandin F2α Is Not Mediated by Thromboxane Receptor Isoforms

1996 • 205 citations

Cardiovascular Responses to the Isoprostanes iPF _2α -III and iPE ₂ -III Are Mediated via the Thromboxane A ₂ Receptor In Vivo

2000 • 191 citations

Generation of 8-Epiprostaglandin F by Human Monocytes

1996 • 189 citations

Modification of low density lipoprotein with 4-hydroxynonenal induces uptake by macrophages.

1989 • 186 citations

The relationship of hydroxyeicosatetraenoic acids and F2-isoprostanes to plaque instability in human carotid atherosclerosis

1999 • 174 citations

Aspects to Consider When Detecting and Measuring Lipid Peroxidation

1986 • 172 citations

Quantitative high performance liquid chromatography/tandem mass spectrometric analysis of the four classes of F ₂ -isoprostanes in human urine

1999 • 169 citations

Effect of oxidative stress on receptors and signal transmission

1992 • 162 citations

Evidence for carbon tetrachloride- and ethanol-induced lipid peroxidation in Vivo demonstrated by ethane production in mice and rats

1977 • 160 citations

Quantification of the Major Urinary Metabolite of 15-F2t-Isoprostane (8-iso-PGF2α) by a Stable Isotope Dilution Mass Spectrometric Assay

1999 • 155 citations

Assay of Malondialdehyde in Biological Fluids by Gas Chromatography-Mass Spectrometry

1994 • 149 citations

Monitoring lipid peroxidation by breath analysis: Endogenous hydrocarbons and their metabolic elimination

1980 • 141 citations

Evidence for increased lipid peroxidation in multiple sclerosis

1992 • 136 citations

Effects of diffusible products of peroxidation of rat liver microsomal lipids

1979 • 131 citations

High breath pentane concentrations during acute myocardial infarction

1991 • 129 citations

Formation of yellow, orange, and red pigments in the reaction of alk-2-enals with 2-thiobarbituric acid

1987 • 128 citations

Effects of a novel prostaglandin, 8-epi-PGF2 alpha, in rabbit lung in situ

1992 • 127 citations

Prostaglandin F2α (PGF2α) and the Isoprostane, 8,12-iso-Isoprostane F2α-III, Induce Cardiomyocyte Hypertrophy

1998 • 126 citations

Effects of 4-hydroxynonenal on isolated hepatocytes. Studies on chemiluminescence response, alkane production and glutathione status

1983 • 109 citations

Breath Pentane Excretion as a Marker of Disease Activity in Rheumatoid Arthritis

1988 • 103 citations

Functional Characterization of the Ocular Prostaglandin F2α (PGF2α) Receptor

1997 • 103 citations

Isoleukotrienes Are Biologically Active Free Radical Products of Lipid Peroxidation

1995 • 100 citations

The experimental and clinical pathology of diene conjugation

1987 • 100 citations

Pentane and isoprene in expired air from humans: gas-chromatographic analysis of single breath

1994 • 99 citations

Identification and Measurement of Endogenous β-Oxidation Metabolites of 8-epi-Prostaglandin F2α

1999 • 99 citations

Increased circulating products of lipid peroxidation in patients with alcoholic liver disease.

1998 • 98 citations

The role of altered lipoproteins in the pathogenesis of atherosclerosis

1987 • 94 citations

Increased Circulating Products of Lipid Peroxidation in Patients with Alcoholic Liver Disease

1998 • 89 citations

4-Hydroxynonenal, a novel indicator of lipid peroxidation for reperfusion injury of the myocardium

1995 • 84 citations

Identification of Two Major F2 Isoprostanes, 8,12-Iso- and 5-epi-8,12-Iso-isoprostane F2α-VI, in Human Urine

1998 • 83 citations

Raised concentrations of aldehyde lipid peroxidation products in premature infants with chronic lung disease

1999 • 82 citations

Lipid peroxidation and molecular damage to polyunsaturated fatty acids in rat liver. Recognition of two classes of hydroperoxides formed under conditions in vivo

1986 • 75 citations

Increased N-pentane Excretion in Humans: A Consequence of Pulmonary Oxygen Exposure

1986 • 73 citations

Antiaggregatory activity of 8-epi-prostaglandin F2 alpha and other F-series prostanoids and their binding to thromboxane A2/prostaglandin H2 receptors in human platelets.

1994 • 69 citations

Pitfalls in the use of breath pentane measurements to assess lipid peroxidation.

1994 • 67 citations

Reversible inhibition of DNA and protein synthesis by cumene hydroperoxide and 4-hydroxy-nonenal

1988 • 62 citations

The composition of alkanes in exhaled air of rats as a result of lipid peroxidation in vivo Effects of dietary fatty acids, vitamin E and selenium

1981 • 60 citations

Dietary β-Carotene and α-Tocopherol Combination Does Not Inhibit Atherogenesis in an ApoE–Deficient Mouse Model

1999 • 59 citations

4-Hydroxy-2,3-trans-nonenal stimulates microsomal lipid peroxidation by reducing the glutathione-dependent protection

1987 • 59 citations

4-Hydroxynonenal induces a DNA-binding protein similar to the heat-shock factor

1989 • 57 citations

Measurement of the diene conjugated form of linoleic acid in plasma by high performance liquid chromatography: A questionable non-invasive assay of free radical activity?

1985 • 55 citations

Measurement of n-Alkanals and hydroxyalkenals in biological samples

1993 • 54 citations

The inhibitory effect of 4‐hydroxy‐nonenal on DNA‐polymerases alpha and beta from rat liver and rapidly dividing Yoshida ascites hepatoma

1986 • 52 citations

Interaction Between Neutrophils and 4-Hydroxyalkenals and Consequences on Neutrophil Motility

1988 • 48 citations

Specific Analysis in Plasma and Urine of 2,3-Dinor-5,6-dihydro-isoprostane F2α-III, a Metabolite of Isoprostane F2α-III and an Oxidation Product of γ-Linolenic Acid

2000 • 41 citations

Effect of oxygen tension on the generation of alkanes and malondialdehyde by peroxidizing rat liver microsomes

1987 • 38 citations

The pharmacokinetics of pentane, a by-product of lipid peroxidation.

1987 • 31 citations

Pentane Measurement in Ventilated Infants Using a Commercially Available System

1997 • 31 citations

Ethane exhalation and vitamin E/ubiquinol status as markers of lipid peroxidation in ferrocene iron—loaded rats

1995 • 25 citations