Shrinking patches and slippery rafts: scales of domains in the plasma membrane

The Fluid Mosaic Model of the Structure of Cell Membranes

1972 • 8,835 citations

Sorting of GPI-anchored proteins to glycolipid-enriched membrane subdomains during transport to the apical cell surface

1992 • 2,905 citations

Structure and Function of Sphingolipid- and Cholesterol-rich Membrane Rafts

2000 • 2,321 citations

SINGLE-PARTICLE TRACKING:Applications to Membrane Dynamics

1997 • 1,768 citations

Lipid sorting in epithelial cells

1988 • 1,354 citations

Lipid Rafts Reconstituted in Model Membranes

2001 • 1,330 citations

Sphingolipid–Cholesterol Rafts Diffuse as Small Entities in the Plasma Membrane of Mammalian Cells

2000 • 987 citations

GPI-Anchored Cell-Surface Molecules Complexed to Protein Tyrosine Kinases

1991 • 848 citations

Characterization of lipid bilayer phases by confocal microscopy and fluorescence correlation spectroscopy

1999 • 841 citations

Tracking kinesin-driven movements with nanometre-scale precision

1988 • 816 citations

Evidence for Budding of Human Immunodeficiency Virus Type 1 Selectively from Glycolipid-Enriched Membrane Lipid Rafts

2000 • 768 citations

SNAREs are concentrated in cholesterol-dependent clusters that define docking and fusion sites for exocytosis

2001 • 669 citations

Interaction of influenza virus haemagglutinin with sphingolipid-cholesterol membrane domains via its transmembrane domain

1997 • 644 citations

Roles of lipid rafts in membrane transport

2001 • 623 citations

Gap43, Marcks, and Cap23 Modulate Pi(4,5)p2 at Plasmalemmal Rafts, and Regulate Cell Cortex Actin Dynamics through a Common Mechanism

2000 • 591 citations

Properties of lipid microdomains in a muscle cell membrane visualized by single molecule microscopy

2000 • 572 citations

Retention of prominin in microvilli reveals distinct cholesterol-based lipid micro-domains in the apical plasma membrane

2000 • 557 citations

Single-molecule microscopy on model membranes reveals anomalous diffusion

1997 • 554 citations

Rapid Cycling of Lipid Raft Markers between the Cell Surface and Golgi Complex

2001 • 525 citations

Constrained diffusion or immobile fraction on cell surfaces: a new interpretation

1996 • 469 citations

Evidence for Boundary Lipid in Membranes

1973 • 461 citations

The role of lipid rafts in T cell antigen receptor (TCR) signalling

2000 • 453 citations

Influenza Viruses Select Ordered Lipid Domains during Budding from the Plasma Membrane

1999 • 445 citations

High-Resolution FRET Microscopy of Cholera Toxin B-Subunit and GPI-anchored Proteins in Cell Plasma Membranes

2000 • 427 citations

Dynamical symmetries in a spherical geometry. I

1979 • 383 citations

Clathrin-dependent and -independent internalization of plasma membrane sphingolipids initiates two Golgi targeting pathways

2001 • 319 citations

Transient Confinement of a Glycosylphosphatidylinositol-Anchored Protein in the Plasma Membrane

1997 • 303 citations

Insolubility and redistribution of GPI-anchored proteins at the cell surface after detergent treatment.

1995 • 294 citations

Fc epsilon RI-mediated recruitment of p53/56lyn to detergent-resistant membrane domains accompanies cellular signaling.

1995 • 290 citations

Cholesterol modulates membrane traffic along the endocytic pathway in sphingolipid-storage diseases

1999 • 288 citations

Raft membrane domains: from a liquid-ordered membrane phase to a site of pathogen attack

2001 • 262 citations

Subcellular targeting by membrane lipids

2001 • 259 citations

Lateral Movements of Membrane Glycoproteins Restricted by Dynamic Cytoplasmic Barriers

1991 • 250 citations

Lipid microdomains in cell surface membranes

1997 • 245 citations

Micrometer-scale domains in fibroblast plasma membranes.

1987 • 236 citations

Implications of lipid microdomains for membrane curvature, budding and fission

2001 • 233 citations

Condensed complexes, rafts, and the chemical activity of cholesterol in membranes

2000 • 233 citations

Ectoenzymes of the kidney microvillar membrane. Differential solubilization by detergents can predict a glycosyl-phosphatidylinositol membrane anchor

1988 • 216 citations

Regulation Mechanism of the Lateral Diffusion of Band 3 in Erythrocyte Membranes by the Membrane Skeleton

1998 • 203 citations

Compartmentalized IgE Receptor–mediated Signal Transduction in Living Cells

1997 • 189 citations

Long-Range Order in Biomembranes

1977 • 175 citations

Anomalous Diffusion of Major Histocompatibility Complex Class I Molecules on HeLa Cells Determined by Single Particle Tracking

1999 • 174 citations

Selectivity of fluorescent lipid analogs for lipid domains

1980 • 166 citations

Microbial pathogenesis: Lipid rafts as pathogen portals

2000 • 154 citations

Caveolins and Cellular Cholesterol Balance

2000 • 145 citations

Differences between the lateral organization of conventional and inositol phospholipid-anchored membrane proteins. A further definition of micrometer scale membrane domains.

1991 • 126 citations

Membrane compartmentation and the response to antigen

1999 • 118 citations

Truncation mutants define and locate cytoplasmic barriers to lateral mobility of membrane glycoproteins.

1994 • 113 citations

Partitioning behavior of indocarbocyanine probes between coexisting gel and fluid phases in model membranes

1990 • 108 citations

Pulse EPR Detection of Lipid Exchange between Protein-Rich Raft and Bulk Domains in the Membrane: Methodology Development and Its Application to Studies of Influenza Viral Membrane

2001 • 102 citations

Fluctuations caught in the act

2000 • 99 citations

Nanometre-scale structure of fluid lipid membranes

2000 • 97 citations

A Model for Membrane Patchiness: Lateral Diffusion in the Presence of Barriers and Vesicle Traffic

1999 • 76 citations

The T Cell Receptor for Antigen: Signaling and Ligand Discrimination

2001 • 73 citations

Lateral mobility of proteins and lipids in the red cell membrane and the activation of adenylate cyclase by β‐adrenergic receptors

1988 • 72 citations

Patches, posts and fences: proteins and plasma membrane domains

1992 • 72 citations

Glycolipid-Enriched Membrane Domains Are Assembled into Membrane Patches by Associating with the Actin Cytoskeleton

2001 • 69 citations

THE LIPID‐PROTEIN INTERFACE IN BIOLOGICAL MEMBRANES *

1980 • 66 citations

Floating the Raft Hypothesis for Immune Receptors: Access to Rafts Controls Receptor Signaling and Trafficking

2001 • 59 citations

Cell Confluence-dependent Remodeling of Endothelial Membranes Mediated by Cholesterol

2000 • 58 citations

Compartmentalization of the Erythrocyte Membrane by the Membrane Skeleton: Intercompartmental Hop Diffusion of Band 3

1999 • 43 citations

Vesicle Trafficking and Cell Surface Membrane Patchiness

2001 • 42 citations

Outer Membrane Monolayer Domains from Two-Dimensional Surface Scanning Resistance Measurements

2000 • 33 citations

Single-Particle Tracking and Laser Optical Tweezers Studies of the Dynamics of Individual Protein Molecules in Membranes of Intact Human and Mouse Red Cells

2001 • 24 citations