Phospholipase A2s and lipid peroxidation

Free radicals in biology and medicine

1991 • 17,840 citations

Tissue-specific functions of individual glutathione peroxidases

1999 • 1,115 citations

Interleukin-4-dependent production of PPAR-γ ligands in macrophages by 12/15-lipoxygenase

1999 • 835 citations

Allergic and Nonallergic Asthmatics Have Distinct Patterns of T-Cell Activation and Cytokine Production in Peripheral Blood and Bronchoalveolar Lavage

1992 • 788 citations

Activation of Stress Signaling Pathways by the End Product of Lipid Peroxidation

1999 • 578 citations

Protective action of phospholipid hydroperoxide glutathione peroxidase against membrane-damaging lipid peroxidation. In situ reduction of phospholipid and cholesterol hydroperoxides.

1990 • 516 citations

Colocalization of 15-lipoxygenase mRNA and protein with epitopes of oxidized low density lipoprotein in macrophage-rich areas of atherosclerotic lesions.

1990 • 429 citations

The mechanism of NADPH-dependent lipid peroxidation. The propagation of lipid peroxidation.

1979 • 390 citations

Specific inflammatory cytokines regulate the expression of human monocyte 15-lipoxygenase.

1992 • 382 citations

Oxidatively modified LDL contains phospholipids with platelet-activating factor-like activity and stimulates the growth of smooth muscle cells.

1995 • 311 citations

A function for lipoxygenase in programmed organelle degradation

1998 • 294 citations

Selenoprotein P in Human Plasma as an Extracellular Phospholipid Hydroperoxide Glutathione Peroxidase

1999 • 255 citations

Oxygenation of biological membranes by the pure reticulocyte lipoxygenase.

1990 • 244 citations

Induction of 15-lipoxygenase by interleukin-13 in human blood monocytes.

1994 • 231 citations

Roles of Lipid Peroxidation in Modulation of Cellular Signaling Pathways, Cell Dysfunction, and Death in the Nervous System

1998 • 216 citations

A lipoxygenase in rabbit reticulocytes which attacks phospholipids and intact mitochondria

1975 • 202 citations

Positional specificity of a reticulocyte lipoxygenase. Conversion of arachidonic acid to 15-S-hydroperoxy-eicosatetraenoic acid.

1982 • 202 citations

Human alveolar macrophages have 15-lipoxygenase and generate 15(S)-hydroxy-5,8,11-cis-13-trans-eicosatetraenoic acid and lipoxins.

1993 • 196 citations

Increased hydrogen peroxide and thiobarbituric acid-reactive products in expired breath condensate of asthmatic patients

1997 • 187 citations

Non‐reactivity of the selenoenzyme glutathione peroxidase with enzymatically hydroperoxidized phospholipids

1983 • 171 citations

Selective incorporation of (15S)-hydroxyeicosatetraenoic acid in phosphatidylinositol of human neutrophils: agonist-induced deacylation and transformation of stored hydroxyeicosanoids.

1990 • 164 citations

Oxygenation of lipoproteins by mammalian lipoxygenases

1993 • 163 citations

Lipid peroxidation and phospholipase A2 activity in liposomes composed of unsaturated phospholipids: a structural basis for enzyme activation

1988 • 154 citations

Phospholipid hydroperoxide glutathione peroxidase activity of human glutathione transferases

1998 • 140 citations

Lipoxygenase-catalyzed oxygenation of storage lipids is implicated in lipid mobilization during germination.

1995 • 138 citations

The maturational breakdown of mitochondria in reticulocytes

1986 • 137 citations

Protection against Oxidative Stress-induced Cell Death by Intracellular Platelet-activating Factor-Acetylhydrolase II

1997 • 136 citations

Membrane Translocation of 15-Lipoxygenase in Hematopoietic Cells Is Calcium-Dependent and Activates the Oxygenase Activity of the Enzyme

1998 • 132 citations

Oxidative modification of human lipoproteins by lipoxygenases of different positional specificities

1994 • 132 citations

Deficiency of platelet-activating factor acetylhydrolase is a severity factor for asthma

1999 • 125 citations

Metabolism of epoxidized phosphatidylcholine by phospholipase A₂ and epoxide hydrolase

1981 • 111 citations

Identification of Amino Acid Determinants of the Positional Specificity of Mouse 8S-Lipoxygenase and Human 15S-Lipoxygenase-2

2000 • 107 citations

Microsomal lipid peroxidation: The role of NADPH — Cytochrome P450 reductase and cytochrome P450

1990 • 103 citations

Occurrence of lipoxygenase products in membranes of rabbit reticulocytes. Evidence for a role of the reticulocyte lipoxygenase in the maturation of red cells.

1990 • 100 citations

The role of 15-lipoxygenase in atherogenesis: pro- and antiatherogenic actions

1997 • 98 citations

Conformational changes in oxidized phospholipids and their preferential hydrolysis by phospholipase A2: A monolayer study

1993 • 98 citations

Regulation of 15-lipoxygenase expression in lung epithelial cells by interleukin-4

1996 • 95 citations

Biosynthesis, metabolization and biological importance of the primary 15-lipoxygenase metabolites 15-hydro(pero)xy-5Z,8Z,11Z,13E-eicosatetraenoic acid and 13-hydro(pero)xy-9Z,11E-octadecadienoic acid

1996 • 89 citations

Functional Characteristics of Bronchial Epithelium Obtained by Brushing from Asthmatic and Normal Subjects

1993 • 88 citations

Substitution of 15-hydroxyeicosatetraenoic acid in the phosphoinositide signaling pathway.

1991 • 88 citations

Investigation of the oxygenation of phospholipids by the porcine leukocyte and human platelet arachidonate 12‐lipoxygenases

1993 • 86 citations

Phospholipid Peroxidation Induces Cytosolic Phospholipase A2Activity: Membrane Effects versus Enzyme Phosphorylation

1997 • 82 citations

Histochemical Evidence for Induction of Arachidonate 15-Lipoxygenase in Airway Disease

1993 • 76 citations

The platelet-activating factor acetylhydrolase from human erythrocytes. Purification and properties.

1993 • 76 citations

Dietary Oxidized Linoleic Acid Modifies Lipid Composition of Rat Liver Microsomes and Increases Their Fluidity

1997 • 74 citations

Structural Elucidation of Oxygenated Storage Lipids in Cucumber Cotyledons

1997 • 73 citations

Evidence that lipid hydroperoxides inhibit plasma lecithin:cholesterol acyltransferase activity

1999 • 70 citations

Secretory Phospholipase A₂ and Lipoprotein Lipase Enhance 15-Lipoxygenase-Induced Enzymic and Nonenzymic Lipid Peroxidation in Low-Density Lipoproteins^†

1998 • 70 citations

[52] Lipoxygenase from rabbit reticulocytes

1981 • 66 citations

Enhanced Interfacial Catalysis and Hydrolytic Specificity of Phospholipase A2 toward Peroxidized Phosphatidylcholine Vesicles

1993 • 66 citations

Role of lipid structure in the activation of phospholipase A₂ by peroxidized phospholipids

1993 • 65 citations

Inverse regulation of lipid‐peroxidizing and hydroperoxyl lipid‐reducing enzymes by interleukins 4 and 13

1999 • 61 citations

Oxygenation of phosphatidylcholine by human polymorphonuclear leukocyte 15-lipoxygenase

1985 • 60 citations

Mammalian 15-Lipoxygenases

1999 • 57 citations

Arachidonate 15-lipoxygenase from human eosinophil-enriched leukocytes: Partial purification and properties

1988 • 56 citations

Lipid peroxidation, arachidonic acid and products of the lipoxygenase pathway in ischaemic preconditioning of rat heart

1998 • 47 citations

Preferential hydrolysis of peroxidized phospholipid by lysosomal phospholipase C

1988 • 47 citations

Subcellular distribution of lipoxygenase products in rabbit reticulocyte membranes*

1990 • 45 citations

Incorporation of 13-hydroxyoctadecadienoic acid (13-HODE) into epidermal ceramides and phospholipids: phospholipase C-catalyzed release of novel 13-HODE-containing diacylglycerol.

1994 • 42 citations

Do specific linoleate 13‐lipoxygenases initiate β‐oxidation?¹

1997 • 41 citations

Interleukin-4 Enhances 15-Lipoxygenase Activity and Incorporation of 15(S)-HETE into Cellular Phospholipids in Cultured Pulmonary Epithelial Cells

1999 • 41 citations

15‐Lipoxygenation of phospholipids may precede the sn‐2 cleavage by phospholipases A₂: reaction specificities of secretory and cytosolic phospholipases A₂ towards native and 15‐lipoxygenated arachidonoyl phospholipids

1998 • 40 citations

Maturational Breakdown of Mitochondria and Other Organelles in Reticulocytes

1990 • 40 citations

Peroxidation and phospholipase A2 hydrolytic susceptibility of liposomes consisting of mixed species of phosphatidylcholine and phosphatidylethanolamine

1992 • 40 citations

Oxygenation of biomembranes by mammalian lipoxygenases: The role of ubiquinone

1996 • 38 citations

Modulation of the beta-adrenergic response of cardiomyocytes by specific lipoxygenase products involves their incorporation into phosphatidylinositol and activation of protein kinase C.

1994 • 38 citations

Metabolism of Oxidized Phosphatidylcholines Formed in Oxidized Low Density Lipoprotein by Lecithin-Cholesterol Acyltransferase

1999 • 37 citations

Expression, purification and characterization of a human serine-dependent phospholipase A2 with high specificity for oxidized phospholipids and platelet activating factor

1998 • 32 citations

Purification of a Novel Phospholipase A2 from Bovine Seminal Plasma

1997 • 29 citations

Human Tracheal Epithelial Cells Selectively Incorporate 15-Hydroxyeicosatetraenoic Acid into Phosphatidylinositol

1993 • 27 citations

Structural identification of phosphatidylcholines having an oxidatively shortened linoleate residue generated through its oxygenation with soybean or rabbit reticulocyte lipoxygenase

2000 • 27 citations

Reticulocyte lipoxygenase changes the passive electrical properties of bovine heart submitochondrial particles

1983 • 27 citations

Specific binding of 15 HETE to lymphocytes. Effects on the fluidity of plasmatic membranes

1984 • 27 citations

Lipoxygenases and their Metabolites

1999 • 24 citations

Platelet-activating factor acetylhydrolase in red cell membranes. Does decreased activity impair erythrocyte deformability in ischemic stroke patients?

1993 • 23 citations

Platelet-activating Factor (PAF)-like Phospholipids Formed during Peroxidation of Phosphatidylcholines from Different Foodstuffs

1995 • 22 citations

Phospholipase A2 from bovine seminal plasma is a platelet-activating factor acetylhydrolase

1998 • 21 citations

15-HETE: Selective incorporation into inositol phospholipids of MDCK cells

1994 • 21 citations

Characterization of Phospholipase A2 Activity in Reticulocyte Endocytic Vesicles

1995 • 19 citations

Preferential Hydrolysis of Oxidized Phosphatidylcholine in Cholesterol-Containing Phosphatidylcholine Liposome by Phospholipase A2

1998 • 18 citations

Alteration in Membrane Fluidity of Rat Liver Microsomes and of Liposomes by Protoporphyrin and Its Anti-lipidperoxidative Effect.

2000 • 10 citations

Oxidation of esterified arachidonate by rat liver microsomes

1987 • 10 citations

1 Phospholipid Hydroperoxide Peroxidase Activities in Erythrocytes

1997 • 7 citations