Anti‐atherosclerotic effects of vitamin E – myth or reality?

The pathogenesis of atherosclerosis: a perspective for the 1990s

1993 • 10,730 citations

Beyond Cholesterol

1989 • 6,533 citations

Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial

1999 • 3,818 citations

Randomised controlled trial of vitamin E in patients with coronary disease: Cambridge Heart Antioxidant Study (CHAOS)

1996 • 2,163 citations

Book ReviewAmbulatory Pediatric Care

1989 • 2,075 citations

Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial. Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto miocardico.

1999 • 2,021 citations

Vitamin E Supplementation and Cardiovascular Events in High-Risk Patients

2000 • 1,945 citations

Enhanced cellular oxidant stress by the interaction of advanced glycation end products with their receptors/binding proteins

1994 • 1,311 citations

Use of antioxidant vitamins for the prevention of cardiovascular disease: meta-analysis of randomised trials

2003 • 1,094 citations

Vascular cell adhesion molecule-1 (VCAM-1) gene transcription and expression are regulated through an antioxidant-sensitive mechanism in human vascular endothelial cells.

1993 • 1,079 citations

Secondary prevention with antioxidants of cardiovascular disease in endstage renal disease (SPACE): randomised placebo-controlled trial

2000 • 1,022 citations

Targeted disruption of the class B scavenger receptor CD36 protects against atherosclerotic lesion development in mice

2000 • 1,020 citations

γ-Tocopherol, the major form of vitamin E in the US diet, deserves more attention

2001 • 757 citations

Vitamin E: Antioxidant Activity, Biokinetics, and Bioavailability

1990 • 739 citations

NF-κB: pivotal mediator or innocent bystander in atherogenesis?

2001 • 729 citations

Free radical recycling and intramembrane mobility in the antioxidant properties of alpha-tocopherol and alpha-tocotrienol

1991 • 641 citations

Affinity for α‐tocopherol transfer protein as a determinant of the biological activities of vitamin E analogs

1997 • 624 citations

The European perspective on vitamin E: current knowledge and future research

2002 • 579 citations

Peroxisome Proliferator-activated Receptor α Activation Modulates Cellular Redox Status, Represses Nuclear Factor-κB Signaling, and Reduces Inflammatory Cytokine Production in Aging

1998 • 542 citations

Coordinate Regulation of the Expression of the Fatty Acid Transport Protein and Acyl-CoA Synthetase Genes by PPARα and PPARγ Activators

1997 • 533 citations

γ-Tocopherol and its major metabolite, in contrast to α-tocopherol, inhibit cyclooxygenase activity in macrophages and epithelial cells

2000 • 512 citations

Inhibition of cell proliferation by alpha-tocopherol. Role of protein kinase C.

1991 • 510 citations

Human plasma and tissue alpha-tocopherol concentrations in response to supplementation with deuterated natural and synthetic vitamin E

1998 • 382 citations

The effects of alpha tocopherol supplementation on monocyte function. Decreased lipid oxidation, interleukin 1 beta secretion, and monocyte adhesion to endothelium.

1996 • 344 citations

Antioxidant Supplementation in Atherosclerosis Prevention (ASAP) study: a randomized trial of the effect of vitamins E and C on 3‐year progression of carotid atherosclerosis

2000 • 328 citations

γ‐Tocopherol, but not α‐tocopherol, decreases proinflammatory eicosanoids and inflammation damage in rats

2003 • 318 citations

α-Tocopherol Inhibits Aggregation of Human Platelets by a Protein Kinase C–Dependent Mechanism

1996 • 309 citations

Tocopherol‐mediated peroxidation of lipoproteins: implications for vitamin E as a potential antiatherogenic supplement

1999 • 301 citations

Effect of vitamins C and E on progression of transplant-associated arteriosclerosis: a randomised trial

2002 • 292 citations

Genetic control of inflammatory gene induction and NF-kappa B-like transcription factor activation in response to an atherogenic diet in mice.

1993 • 291 citations

d-alpha-tocopherol inhibition of vascular smooth muscle cell proliferation occurs at physiological concentrations, correlates with protein kinase C inhibition, and is independent of its antioxidant properties.

1995 • 290 citations

Vitamin E Reduces the Uptake of Oxidized LDL by Inhibiting CD36 Scavenger Receptor Expression in Cultured Aortic Smooth Muscle Cells

2000 • 288 citations

Effects of Vitamin E on Lipid Peroxidation in Healthy Persons

2001 • 274 citations

Vitamin E: protective role of a Janus molecule

2001 • 261 citations

α-Tocopherol specifically inactivates cellular protein kinase C α by changing its phosphorylation state

1998 • 259 citations

Novel urinary metabolite of alpha-tocopherol, 2,5,7,8-tetramethyl-2(2’-carboxyethyl)-6-hydroxychroman, as an indicator of an adequate vitamin E supply?

1995 • 245 citations

Inhibition of NF-κB Activation by Vitamin E Derivatives

1993 • 243 citations

Effects of d-alpha-tocopherol supplementation on experimentally induced primate atherosclerosis.

1992 • 240 citations

Increased atherosclerosis in hyperlipidemic mice deficient in α-tocopherol transfer protein and vitamin E

2000 • 235 citations

α-Tocopherol Inhibits the Respiratory Burst in Human Monocytes

1998 • 233 citations

Differential effects of α- and γ-tocopherol on low-density lipoprotein oxidation, superoxide activity, platelet aggregation and arterial thrombogenesis

1999 • 229 citations

Vitamin E activates gene expression via the pregnane X receptor

2002 • 226 citations

Effect of Vitamin E and Beta Carotene on the Incidence of Angina Pectoris

1996 • 218 citations

Regulation of cell signalling by vitamin E

2002 • 215 citations

Alpha-tocopherol inhibits agonist-induced monocytic cell adhesion to cultured human endothelial cells.

1994 • 213 citations

A new endogenous natriuretic factor: LLU-alpha.

1996 • 194 citations

Effects of d-α-Tocopherol Supplementation on Experimentally Induced Primate Atherosclerosis

1992 • 188 citations

Human plasma phospholipid transfer protein accelerates exchange/transfer of α-tocopherol between lipoproteins and cells

1995 • 182 citations

γ‐Tocopherol inhibits human cancer cell cycle progression and cell proliferation by down‐regulation of cyclins

2002 • 177 citations

Absorption, Transport and Metabolism of Vitamin E

1991 • 160 citations

Rat liver α-tocopherol binding protein

1977 • 156 citations

THE METABOLISM OF VITAMIN E

1956 • 153 citations

α-Tocopherol Decreases Interleukin-1β Release From Activated Human Monocytes by Inhibition of 5-Lipoxygenase

1999 • 150 citations

Treatment of Disseminated Granuloma Annulare with Oral Vitamin E: ‘Primum Nil Nocere'

2013 • 147 citations

Vitamin E dietary supplementation inhibits transforming growth factor β1 gene expression in the rat liver

1992 • 143 citations

Friedreich‐like ataxia with retinitis pigmentosa caused by the His¹⁰¹Gln mutation of the α‐Tocopherol transfer protein gene

1997 • 141 citations

α-Tocopherol decreases CD36 expression in human monocyte-derived macrophages

2001 • 140 citations

Oxidative stress increases the expression of the CD36 scavenger receptor and the cellular uptake of oxidized low-density lipoprotein in macrophages from atherosclerotic mice: protective role of antioxidants and of paraoxonase

2002 • 139 citations

Vitamin E analogues as inducers of apoptosis: structure–function relation

2003 • 135 citations

Effect of vitamin E on human aortic endothelial cell production of chemokines and adhesion to monocytes

1999 • 134 citations

Synthetic as compared with natural vitamin E is preferentially excreted as α‐CEHC in human urine: studies using deuterated α‐tocopheryl acetates

1998 • 133 citations

The ambivalence of vitamin E in atherogenesis

1999 • 133 citations

THE METABOLISM OF VITAMIN E

1956 • 132 citations

α-Tocopherol Enrichment of Monocytes Decreases Agonist-Induced Adhesion to Human Endothelial Cells

1998 • 127 citations

Gamma (γ) tocopherol upregulates peroxisome proliferator activated receptor (PPAR) gamma (γ) expression in SW 480 human colon cancer cell lines

2003 • 127 citations

Localization of α-tocopherol transfer protein in the brains of patients with ataxia with vitamin E deficiency and other oxidative stress related neurodegenerative disorders

1999 • 126 citations

Novel urinary metabolite of d-delta-tocopherol in rats.

1984 • 124 citations

Atherosclerosis: from lesion formation to plaque activation and endothelial dysfunction

2000 • 120 citations

Modulation of Activator Protein‐1 (AP‐1) Transcription Factor and Protein Kinase C by Hydrogen Peroxide and <scp>d</scp>‐α‐Tocopherol in Vascular Smooth Muscle Cells

1994 • 116 citations

Gene expression profile of oxidant stress and neurodegeneration in transgenic mice deficient in α-tocopherol transfer protein

2003 • 116 citations

Vitamin E inhibits IL-4 gene expression in peripheral blood T cells

2002 • 113 citations

Vitamin E and Macrophage Cyclooxygenase Regulation in the Aged

2001 • 109 citations

Alpha and gamma tocopherol metabolism in healthy subjects and patients with end-stage renal disease

2003 • 107 citations

Effect of Selenium and Vitamin E Deficiency on Differential Gene Expression in Rat Liver

2001 • 105 citations

HDL is the major source of vitamin E for type II pneumocytes

1999 • 104 citations

Dose-Response Comparison of RRR -α-Tocopherol and All-Racemic α-Tocopherol on LDL Oxidation

1997 • 98 citations

α-Tocopherol down-regulates scavenger receptor activity in macrophages

1999 • 92 citations

σ-Tocopherol: An Efficient Protector of Lipids Against Nitric Oxide-initiated Peroxidative Damage

2009 • 91 citations

Modulation of Cell Proliferation and Cell Cycle Regulators by Vitamin E in Human Prostate Carcinoma Cell Lines

2002 • 90 citations

Cloning of novel human SEC14p-like proteins: ligand binding and functional properties

2003 • 88 citations

α‐tocopherol protects against expression of adhesion molecules on neutrophils and endothelial cells

1998 • 86 citations

Expression of NF-kappa B and I kappa B-alpha by aortic endothelium in an arterial injury model.

1996 • 84 citations

Regulation of Recombinant PKCα Activity by Protein Phosphatase 1 and Protein Phosphatase 2A

1998 • 75 citations

Relative Effects of α- and γ-Tocopherol on Low-Density Lipoprotein Oxidation and Superoxide Dismutase and Nitric Oxide Synthase Activity and Protein Expression in Rats

1999 • 74 citations

α-Tocopherol Induces Expression of Connective Tissue Growth Factor and Antagonizes Tumor Necrosis Factor-α–Mediated Downregulation in Human Smooth Muscle Cells

2003 • 73 citations

Macrophages Stimulated with IFN-γ Activate NF-κB and Induce MCP-1 Gene Expression in Primary Human Endothelial Cells

2000 • 72 citations

Vitamin E protects against polymorphonuclear leukocyte-dependent adhesion to endothelial cells

1999 • 72 citations

The Effect of α‐Tocopherol on the Synthesis, Phosphorylation and Activity of Protein Kinase C in Smooth Muscle Cells After Phorbol 12‐Myristate 13‐Acetate Down‐Regulation

1997 • 70 citations

α- and δ-tocopherol induce expression of hepatic α-tocopherol-transfer-protein mRNA

1998 • 70 citations

The Effect of α-Tocopherol on the Nitration of γ-Tocopherol by Peroxynitrite

1999 • 69 citations

Modulation by α- and γ-tocopherol and oxidized low-density lipoprotein of apoptotic signaling in human coronary smooth muscle cells∗

2000 • 67 citations

Endogenous natriuretic factors 7: biospecificity of a natriuretic gamma-tocopherol metabolite LLU-alpha.

1997 • 67 citations

Inter- and intra-individual variation in plasma and red blood cell vitamin E after supplementation

2000 • 66 citations

Moderate supplementation with natural α-tocopherol decreases platelet aggregation and low-density lipoprotein oxidation

1999 • 64 citations

Vitamin E inhibits CD95 ligand expression and protects T cells from activation-induced cell death

2002 • 63 citations

Vitamin E inhibits CD95 ligand expression and protects T cells from activation-induced cell death

2002 • 58 citations

Selective Inhibition by α-Tocopherol of Vascular Cell Adhesion Molecule-1 Expression in Human Vascular Endothelial Cells

2000 • 56 citations

Identification of a Low Molecular Mass (14.2 kDa) α-Tocopherol-Binding Protein in the Cytosol of Rat Liver and Heart

1993 • 53 citations

Macrophages, oxidised lipids and atherosclerosis

1983 • 50 citations

High-density lipoprotein (HDL3)-associated α-tocopherol is taken up by HepG2 cells via the selective uptake pathway and resecreted with endogenously synthesized apo-lipoprotein B-rich lipoprotein particles

1998 • 47 citations

Age-Associated Alterations in Splenic iNOS Regulation: Influence of Constitutively Expressed IFN-γ and Correction Following Supplementation with PPARα Activators or Vitamin E

1999 • 45 citations

α-Tocopherol transfer protein gene: Exon skipping of all transcripts causes ataxia

1997 • 43 citations

Protective effect of d-α-tocopherol on the function of human mesangial cells exposed to high glucose concentrations

1997 • 40 citations

Identification of a human CD36 isoform produced by exon skipping. Conservation of exon organization and pre-mRNA splicing patterns with a CD36 gene family member, CLA-1.

1994 • 39 citations

Effect of α-Tocopherol Status on α-Tocopherol Transfer Protein Expression and Its Messenger RNA Level in Rat Liver

1998 • 39 citations

Genetic polymorphism of apolipoprotein A-IV in five different regions of Europe. Relations to plasma lipoproteins and to history of myocardial infarction: the EARS study

1994 • 39 citations

Suppressive Effect of Antioxidants on Intercellular Adhesion Molecule-1 (ICAM-1) Expression in Human Epidermal Keratinocytes

1994 • 38 citations

Inhibitory effects of vitamin E on endothelial‐dependent adhesive interactions with leukocytes induced by oxidized low density lipoprotein

2000 • 38 citations

Alpha-Tocopherol But Not Beta-Tocopherol Inhibits Thrombin-Induced PKC Activation and Endothelin Secretion in Endothelial Cells

1998 • 36 citations

Dietary vitamin E supplementation inhibits thrombin‐induced platelet aggregation, but not monocyte adhesiveness, in patients with hypercholesterolaemia

1997 • 35 citations

Differential inhibition by α- and β-tocopherol of human erythroleukemia cell adhesion: role of integrins

2001 • 35 citations

Effect of Vitamin E in Coronary Heart Disease

1946 • 34 citations

α-Tocopherol protects against diet induced atherosclerosis in New Zealand white rabbits

2002 • 33 citations

α-Tocopherol, but notγ-tocopherol inhibits 7β-hydroxycholesterol-induced apoptosis in human U937 cells

2001 • 30 citations

Monocyte superoxide production is inversely related to normal content of α-tocopherol in low-density lipoprotein

1998 • 30 citations

Dl-alpha-tocopherol, a potent inhibitor of phorbol ester induced shape change of erythro- and megakaryoblastic leukemia cells

1997 • 29 citations

Influence of an inducible nitric oxide synthase promoter variant on clinical variables in patients with coronary artery disease

2001 • 29 citations

Suppression of interleukin-1 beta and LDL scavenger receptor expression in macrophages by a selective protein kinase C inhibitor.

1991 • 29 citations

Alpha-tocopherol but not beta-tocopherol inhibits thrombin-induced PKC activation and endothelin secretion in endothelial cells

1998 • 28 citations

α-Tocopherol modulates the low density lipoprotein receptor of human HepG2 cells

2003 • 26 citations

Immunological dysregulation of lung cells in response to vitamin E deficiency

2001 • 26 citations

Influences of alpha-tocopherol on cholesterol metabolism and fatty streak development in apolipoprotein E-deficient mice fed an atherogenic diet

2001 • 23 citations

RRR-alpha-tocopherol regulation of gene transcription in response to the cell oxidant status.

1998 • 22 citations

Alpha‐tocopherol protects against monocyte Mac‐1 (CD11b/CD18) expression and Mac‐1‐dependent adhesion to endothelial cells induced by oxidized low‐density lipoprotein

2000 • 19 citations

GISSI-Prevenzione trial

1999 • 18 citations

Monocyte chemoattractant protein-1 involvement in the α-tocopherol-induced reduction of atherosclerotic lesions in apolipoprotein E knockout mice

2003 • 17 citations

Alpha-tocopherol downregulates the expression of GPIIb promoter in HEL cells

2000 • 15 citations

Alternatively spliced mRNA molecules of the thrombospondin receptor (CD36) in human PBMC

1999 • 14 citations

Prolonged, low dose α-tocopherol therapy counteracts intercellular cell adhesion molecule-1 activation

2002 • 14 citations

Influence of an inducible nitric oxide synthase promoter variant on clinical variables in patients with coronary artery disease

2001 • 11 citations