Oxidative stress, alpha-tocopherol therapy, and atherosclerosis

Atherosclerosis — An Inflammatory Disease

1999 • 21,494 citations

The Effect of Vitamin E and Beta Carotene on the Incidence of Lung Cancer and Other Cancers in Male Smokers

1994 • 4,626 citations

Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial

1999 • 3,818 citations

Role of oxidized low density lipoprotein in atherogenesis.

1991 • 2,691 citations

Vitamin E Consumption and the Risk of Coronary Heart Disease in Men

1993 • 2,363 citations

LIPOPROTEIN METABOLISM IN THE MACROPHAGE: Implications for Cholesterol Deposition in Atherosclerosis

1983 • 2,306 citations

Randomised controlled trial of vitamin E in patients with coronary disease: Cambridge Heart Antioxidant Study (CHAOS)

1996 • 2,163 citations

Vitamin E Consumption and the Risk of Coronary Disease in Women

1993 • 2,158 citations

Molecular Bases of the Acute Coronary Syndromes

1995 • 2,049 citations

Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial. Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto miocardico.

1999 • 2,021 citations

Simvastatin and Niacin, Antioxidant Vitamins, or the Combination for the Prevention of Coronary Disease

2001 • 1,999 citations

Vitamin E Supplementation and Cardiovascular Events in High-Risk Patients

2000 • 1,945 citations

Atherosclerosis: Basic Mechanisms

1995 • 1,697 citations

The role of oxidized lipoproteins in atherogenesis

1996 • 1,382 citations

Circulating Adhesion Molecules VCAM-1, ICAM-1, and E-selectin in Carotid Atherosclerosis and Incident Coronary Heart Disease Cases

1997 • 1,334 citations

Autoantibody against oxidised LDL and progression of carotid atherosclerosis

1992 • 1,332 citations

Plasma concentration of soluble intercellular adhesion molecule 1 and risks of future myocardial infarction in apparently healthy men

1998 • 1,238 citations

Antiatherogenic effect of probucol unrelated to its hypocholesterolemic effect: evidence that antioxidants in vivo can selectively inhibit low density lipoprotein degradation in macrophage-rich fatty streaks and slow the progression of atherosclerosis in the Watanabe heritable hyperlipidemic rabbit.

1987 • 1,051 citations

Secondary prevention with antioxidants of cardiovascular disease in endstage renal disease (SPACE): randomised placebo-controlled trial

2000 • 1,022 citations

Dietary Antioxidant Vitamins and Death from Coronary Heart Disease in Postmenopausal Women

1996 • 976 citations

Lewis A. Conner Memorial Lecture

1997 • 754 citations

In Vivo Formation of 8-Iso-Prostaglandin F _2α and Platelet Activation in Diabetes Mellitus

1999 • 753 citations

Involvement of the immune system in human atherogenesis: current knowledge and unanswered questions.

1991 • 669 citations

Antioxidant Vitamin Intake and Coronary Mortality in a Longitudinal Population Study

1994 • 648 citations

Susceptibility to low-density lipoprotein oxidation and coronary atherosclerosis in man

1992 • 588 citations

Randomised trial of α-tocopherol and β-carotene supplements on incidence of major coronary events in men with previous myocardial infarction

1997 • 578 citations

Inhibition of cell proliferation by alpha-tocopherol. Role of protein kinase C.

1991 • 510 citations

Isoprostanes: Potential Markers of Oxidant Stress in Atherothrombotic Disease

1997 • 461 citations

Vitamin E and vitamin C supplement use and risk of all-cause and coronary heart disease mortality in older persons: the Established Populations for Epidemiologic Studies of the Elderly

1996 • 406 citations

The Effect of α-Tocopherol Supplementation on LDL Oxidation

1995 • 378 citations

The antioxidant butylated hydroxytoluene protects against atherosclerosis.

1991 • 362 citations

Localization of distinct F2-isoprostanes in human atherosclerotic lesions.

1997 • 345 citations

The effects of alpha tocopherol supplementation on monocyte function. Decreased lipid oxidation, interleukin 1 beta secretion, and monocyte adhesion to endothelium.

1996 • 344 citations

Oxidative Modification of LDL and Atherogenesis

1998 • 337 citations

Antioxidant Supplementation in Atherosclerosis Prevention (ASAP) study: a randomized trial of the effect of vitamins E and C on 3‐year progression of carotid atherosclerosis

2000 • 328 citations

The generation and actions of isoprostanes

1997 • 314 citations

α-Tocopherol Inhibits Aggregation of Human Platelets by a Protein Kinase C–Dependent Mechanism

1996 • 309 citations

Effect of dietary supplementation with alpha-tocopherol on the oxidative modification of low density lipoprotein.

1992 • 299 citations

d-alpha-tocopherol inhibition of vascular smooth muscle cell proliferation occurs at physiological concentrations, correlates with protein kinase C inhibition, and is independent of its antioxidant properties.

1995 • 290 citations

Effect of Vitamin E and Beta Carotene on the Incidence of Primary Nonfatal Myocardial Infarction and Fatal Coronary Heart Disease

1998 • 287 citations

Soluble Vascular Cell Adhesion Molecule-1 as a Biohumoral Correlate of Atherosclerosis

1997 • 272 citations

Antioxidant treatment of diabetic rats inhibits lipoprotein oxidation and cytotoxicity.

1989 • 265 citations

Circulating Cell Adhesion Molecules Are Correlated With Ultrasound-Based Assessment of Carotid Atherosclerosis

1998 • 263 citations

The effect of probucol on femoral atherosclerosis: The Probucol Quantitative Regression Swedish Trial (PQRST)

1994 • 251 citations

Antioxidants Inhibit the Expression of Intercellular Cell Adhesion Molecule-1 and Vascular Cell Adhesion Molecule-1 Induced by Oxidized LDL on Human Umbilical Vein Endothelial Cells

1997 • 228 citations

Effect of Vitamin E and Beta Carotene on the Incidence of Angina Pectoris

1996 • 218 citations

Tumor necrosis factor-alpha in human arterial wall with atherosclerosis

1991 • 215 citations

Alpha-tocopherol inhibits agonist-induced monocytic cell adhesion to cultured human endothelial cells.

1994 • 213 citations

Dietary Supplementation With n-3 Polyunsaturated Fatty Acids and Vitamin E After Myocardial Infarction: Results of the Gissi-Prevenzione Trial

2000 • 209 citations

Low density lipoprotein is protected from oxidation and the progression of atherosclerosis is slowed in cholesterol-fed rabbits by the antioxidant N,N'-diphenyl-phenylenediamine.

1992 • 207 citations

Vascular incorporation of alpha-tocopherol prevents endothelial dysfunction due to oxidized LDL by inhibiting protein kinase C stimulation.

1996 • 203 citations

Prostaglandin F₂-Like Compounds, F₂-Isoprostanes, Are Present in Increased Amounts in Human Atherosclerotic Lesions

1997 • 196 citations

Cytokines and growth factors in atherogenesis.

1992 • 183 citations

Inhibition of smooth muscle cell proliferation and protein kinase C activity by tocopherols and tocotrienols

1993 • 178 citations

Low-Density Lipoprotein Postsecretory Modification, Monocyte Function, and Circulating Adhesion Molecules in Type 2 Diabetic Patients With and Without Macrovascular Complications

2000 • 171 citations

Increased Levels of Soluble P-Selectin in Hypercholesterolemic Patients

1998 • 169 citations

Simvastatin and niacin, antioxidant vitamins, or the combination for the prevention of coronary disease

2002 • 161 citations

Vitamin E: a sensor and an information transducer of the cell oxidation state

1995 • 142 citations

Vitamin E Inhibits Low-Density Lipoprotein–Induced Adhesion of Monocytes to Human Aortic Endothelial Cells In Vitro

1997 • 135 citations

Multiple lipid oxidation products in low density lipoproteins induce interleukin-1 beta release from human blood mononuclear cells.

1994 • 129 citations

Effect of vitamin E on endothelial vasodilator function in patients with hypercholesterolemia, chronic smoking or both

1999 • 123 citations

Alpha-tocopherol supplementation decreases the oxidative susceptibility of LDL in renal failure patients on dialysis therapy

2000 • 120 citations

Divergence between LDL Oxidative Susceptibility and Urinary F2-Isoprostanes as Measures of Oxidative Stress in Type 2 Diabetes

2001 • 120 citations

The effects of alpha‐tocopherol on critical cells in atherogenesis

1998 • 112 citations

The influence of antioxidant nutrients on platelet function in healthy volunteers

1997 • 111 citations

Vitamin E Supplementation, Plasma Lipids and Incidence of Restenosis after Percutaneous Transluminal Coronary Angioplasty (PTCA)

1993 • 111 citations

Linoleic acid activates nuclear transcription factor-κB (NF-κB) and induces NF-κB-dependent transcription in cultured endothelial cells

1996 • 108 citations

The Effect of α-Tocopherol on Monocyte Proatherogenic Activity

2001 • 98 citations

Dose-Response Comparison of RRR -α-Tocopherol and All-Racemic α-Tocopherol on LDL Oxidation

1997 • 98 citations

Influence of vitamin E on platelet function in humans.

1991 • 98 citations

Effect of alpha-tocopherol on restenosis after angioplasty in a model of experimental atherosclerosis.

1995 • 90 citations

Effect of Alpha-Tocopherol Administration on Platelet Function in Man

1983 • 85 citations

α-Tocopherol and Atherosclerosis

2001 • 84 citations

Moderate supplementation with natural α-tocopherol decreases platelet aggregation and low-density lipoprotein oxidation

1999 • 64 citations

Multiple growth factors are associated with lesions of atherosclerosis: Specificity or redundancy?

1996 • 62 citations

New roles of low density lipoproteins and vitamin E in the pathogenesis of atherosclerosis.

1995 • 61 citations

Effect of vitamin E and beta carotene on the incidence of angina pectoris. A randomized, double-blind, controlled trial

1996 • 53 citations

Endothelial Activation by Cytokines^a

1997 • 52 citations

Effects on Health of Dietary Supplementation with 100 mgd-α-Tocopheryl Acetate, Daily for 6 Years

1995 • 33 citations

Antioxidants and vitamins to reduce cardiovascular disease

2000 • 33 citations

Failure to demonstrate a major anti-inflammatory effect with alpha tocopherol supplementation (400 IU/day) in normal subjects

2001 • 28 citations