Pathological investigation of oxidative stress in the post‐genomic era
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Abstract
References (185)
Free radicals in biology and medicine
1991 • 17,840 citations
Superoxide Dismutase
1969 • 12,578 citations
Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor
1987 • 10,774 citations
Free Radicals in Biology and Medicine
2015 • 8,284 citations
Genetics and Analysis of Quantitative Traits
2002 • 6,393 citations
Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly
1996 • 5,498 citations
Oxygen-Derived Free Radicals in Postischemic Tissue Injury
1985 • 5,488 citations
The Pathobiology of Diabetic Complications
2005 • 4,849 citations
Genetics and analysis of quantitative traits
1999 • 4,350 citations
Helicobacter pyloriInfection and the Development of Gastric Cancer
2001 • 4,276 citations
An Nrf2/Small Maf Heterodimer Mediates the Induction of Phase II Detoxifying Enzyme Genes through Antioxidant Response Elements
1997 • 3,743 citations
Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain
1999 • 3,344 citations
NOX enzymes and the biology of reactive oxygen
2004 • 2,940 citations
LXXIII.—Oxidation of tartaric acid in presence of iron
1894 • 2,887 citations
The risk of colorectal cancer in ulcerative colitis: a meta-analysis
2001 • 2,788 citations
Protein Oxidation and Aging
1992 • 2,687 citations
[37] Carbonyl assays for determination of oxidatively modified proteins
1994 • 2,605 citations
Tumor Hypoxia: Definitions and Current Clinical, Biologic, and Molecular Aspects
2001 • 2,558 citations
Chromosome territories, nuclear architecture and gene regulation in mammalian cells
2001 • 2,239 citations
Carbon monoxide has anti-inflammatory effects involving the mitogen-activated protein kinase pathway
2000 • 2,074 citations
Oxidative Stress Sensor Keap1 Functions as an Adaptor for Cul3-Based E3 Ligase To Regulate Proteasomal Degradation of Nrf2
2004 • 2,037 citations
Antioxidant and redox regulation of gene transcription
1996 • 1,999 citations
Oxidation of tartaric acid in presence of iron
1894 • 1,515 citations
Transcription Factor Nrf2 Coordinately Regulates a Group of Oxidative Stress-inducible Genes in Macrophages
2000 • 1,411 citations
Non–coding RNA genes and the modern RNA world
2001 • 1,407 citations
Oxidants as Stimulators of Signal Transduction
1997 • 1,380 citations
Oxygen, oxidative stress, hypoxia, and heart failure
2005 • 1,289 citations
Nitrosylation
2001 • 1,229 citations
Persistent oxidative stress in cancer
1995 • 1,218 citations
Purine bases, nucleosides, and nucleotides: aqueous solution redox chemistry and transformation reactions of their radical cations and e- and OH adducts
1989 • 1,215 citations
The Possible Role of Hydrogen Sulfide as an Endogenous Smooth Muscle Relaxant in Synergy with Nitric Oxide
1997 • 1,196 citations
Oxygen, oxidative stress, hypoxia, and heart failure
2005 • 1,192 citations
ASK1 is required for sustained activations of JNK/p38 MAP kinases and apoptosis
2001 • 1,181 citations
REDOX REGULATION OF CELLULAR ACTIVATION
1997 • 1,121 citations
The Genetic Basis of Human Cancer
1997 • 1,113 citations
Analysis of a form of oxidative DNA damage, 8-hydroxy-2′-deoxyguanosine, as a marker of cellular oxidative stress during carcinogenesis
1997 • 1,108 citations
S-nitrosylated GAPDH initiates apoptotic cell death by nuclear translocation following Siah1 binding
2005 • 1,029 citations
Membrane transport of hydrogen peroxide
2006 • 1,013 citations
Protection against electrophile and oxidant stress by induction of the phase 2 response: Fate of cysteines of the Keap1 sensor modified by inducers
2004 • 948 citations
A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity
2002 • 944 citations
Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2
1998 • 906 citations
The Genetic Basis of Human Cancer
1999 • 827 citations
Cancer Incidence in Atomic Bomb Survivors. Part III: Leukemia, Lymphoma and Multiple Myeloma, 1950-1987
1994 • 783 citations
Identification of Thioredoxin-binding Protein-2/Vitamin D3 Up-regulated Protein 1 as a Negative Regulator of Thioredoxin Function and Expression
1999 • 696 citations
Mitochondrial DNA Damage and Dysfunction Associated With Oxidative Stress in Failing Hearts After Myocardial Infarction
2001 • 686 citations
Crystal structures of bovine milk xanthine dehydrogenase and xanthine oxidase: Structure-based mechanism of conversion
2000 • 680 citations
ROS-dependent activation of the TRAF6-ASK1-p38 pathway is selectively required for TLR4-mediated innate immunity
2005 • 648 citations
Chemical basis of inflammation-induced carcinogenesis
2003 • 613 citations
Quantitative immunohistochemical determination of 8-hydroxy-2'-deoxyguanosine by a monoclonal antibody N45.1: its application to ferric nitrilotriacetate-induced renal carcinogenesis model.
1997 • 579 citations
Identification by redox proteomics of glutathionylated proteins in oxidatively stressed human T lymphocytes
2002 • 565 citations
Iron-induced carcinogenesis: The role of redox regulation
1996 • 556 citations
Reactive oxygen species‐induced molecular damage and its application in pathology
1999 • 549 citations
Accumulation of single-strand breaks is the major cause of telomere shortening in human fibroblasts
2000 • 532 citations
Chemical determination of free radical-induced damage to DNA
1991 • 523 citations
The quantitative risks of mesothelioma and lung cancer in relation to asbestos exposure
2000 • 513 citations
Hyperglycemia causes oxidative stress in pancreatic beta-cells of GK rats, a model of type 2 diabetes.
1999 • 509 citations
The NAD(P)H Oxidase Homolog Nox4 Modulates Insulin-Stimulated Generation of H2O2 and Plays an Integral Role in Insulin Signal Transduction
2004 • 506 citations
Nox1 Is Involved in Angiotensin II–Mediated Hypertension
2005 • 460 citations
Inactivating Mutations in the Gene for Thyroid Oxidase 2 (THOX2) and Congenital Hypothyroidism
2002 • 460 citations
The glial glutamate transporter, GLT‐1, is oxidatively modified by 4‐hydroxy‐2‐nonenal in the Alzheimer's disease brain: the role of Aβ1–42
2001 • 458 citations
Epidermal Growth Factor Receptor-dependent Akt Activation by Oxidative Stress Enhances Cell Survival
2000 • 455 citations
Nitric Oxide Regulates Exocytosis by S-Nitrosylation of N-ethylmaleimide-Sensitive Factor
2003 • 441 citations
Site‐specific DNA damage at GGG sequence by oxidative stress may accelerate telomere shortening
1999 • 418 citations
Redox regulation in the lens
2003 • 405 citations
Drusen, choroidal neovascularization, and retinal pigment epithelium dysfunction in SOD1-deficient mice: A model of age-related macular degeneration
2006 • 401 citations
Evolutionary conservation of chromosome territory arrangements in cell nuclei from higher primates
2002 • 389 citations
Carbon monoxide: an endogenous modulator of sinusoidal tone in the perfused rat liver.
1995 • 388 citations
Free radicals, aging, and degenerative diseases
1987 • 375 citations
Mechanism of Ca2+ Activation of the NADPH Oxidase 5 (NOX5)
2004 • 371 citations
Distinctive activation mechanisms and functions for protein kinase Cδ
2004 • 368 citations
Thyroid hormone-induced oxidative stress
2006 • 365 citations
The quantitative risks of mesothelioma and lung cancer in relation to asbestos exposure
2000 • 361 citations
Tissue-specific spatial organization of genomes
2004 • 360 citations
Selective Inactivation of α-Ketoglutarate Dehydrogenase and Pyruvate Dehydrogenase: Reaction of Lipoic Acid with 4-Hydroxy-2-nonenal
1998 • 350 citations
Mammalian microRNAs: a small world for fine-tuning gene expression
2006 • 349 citations
Chromosome territories
2007 • 349 citations
Colon Cancer, Dysplasia, and Surveillance in Patients with Ulcerative Colitis
1987 • 341 citations
Formation of 4-hydroxy-2-nonenal-modified proteins in the renal proximal tubules of rats treated with a renal carcinogen, ferric nitrilotriacetate.
1994 • 337 citations
Identification of Human and Mouse p19, a Novel CDK4 and CDK6 Inhibitor with Homology to p16ink4
1995 • 336 citations
4-Hydroxy-2-nonenal-mediated Impairment of Intracellular Proteolysis during Oxidative Stress
1999 • 320 citations
Free radicals, aging, and degenerative diseases
1986 • 311 citations
Non‐antioxidant molecular functions of α‐tocopherol (vitamin E)
2002 • 299 citations
Effects of NADPH oxidase inhibitor in diabetic nephropathy
2005 • 297 citations
The Superoxide-Generating Oxidase Nox1 Is Functionally Required for Ras Oncogene Transformation
2004 • 295 citations
VDUP1 upregulated by TGF-β1 and 1,25-dihydorxyvitamin D3 inhibits tumor cell growth by blocking cell-cycle progression
2003 • 269 citations
Cancer risk in patients with hereditary hemochromatosis and in their first-degree relatives
2003 • 265 citations
The superoxide‐producing NAD(P)H oxidase Nox4 in the nucleus of human vascular endothelial cells
2005 • 265 citations
Vestibular defects in head-tilt mice result from mutations inNox3, encoding an NADPH oxidase
2004 • 260 citations
Role of Reactive Oxygen Species in Skin Carcinogenesis
2004 • 255 citations
Formation of hydrogen peroxide and hydroxyl radicals from Aβ and α-synuclein as a possible mechanism of cell death in Alzheimer’s disease and Parkinson’s disease 1,2 1This article is part of a series of reviews on “Causes and Consequences of Oxidative Stress in Alzheimer’s Disease.” The full list of papers may be found on the homepage of the journal. 2Guest Editors: Mark A. Smith and George Perry
2002 • 254 citations
A Mutation in the SDHC Gene of Complex II Increases Oxidative Stress, Resulting in Apoptosis and Tumorigenesis
2005 • 246 citations
CANCER STATISTICS FOR JAPAN
1923 • 244 citations
Oxidative stress and delayed-onset muscle damage after exercise
2004 • 230 citations
Rapid and selective cerebral hypothermia achieved using a cooling helmet
2004 • 221 citations
Roles of MAPKKK ASK1 in Stress-Induced Cell Death.
2003 • 221 citations
Immunohistochemical detection of 4-hydroxy-2-nonenal adducts in Alzheimer's disease is associated with inheritance of APOE4.
1997 • 219 citations
Recruitment of Tumor Necrosis Factor Receptor-associated Factor Family Proteins to Apoptosis Signal-regulating Kinase 1 Signalosome Is Essential for Oxidative Stress-induced Cell Death
2005 • 214 citations
Positional cloning of the combined hyperlipidemia gene Hyplip1
2001 • 208 citations
The monoclonal antibody specific for the 4‐hydroxy‐2‐nonenal histidine adduct
1995 • 206 citations
Interaction between Protein Kinase C δ and the c-Abl Tyrosine Kinase in the Cellular Response to Oxidative Stress
2000 • 199 citations
Non-Hodgkin's lymphoma of the pleural cavity developing from long-standing pyothorax
1987 • 198 citations
Effect of Antibiotics on the Generation of Reactive Oxygen Species
1986 • 191 citations
IκB Kinase, a Molecular Target for Inhibition by 4-Hydroxy-2-nonenal
2001 • 190 citations
Melanoma metastasis suppression by chromosome 6: evidence for a pathway regulated by CRSP3 and TXNIP.
2003 • 182 citations
Modification of Heat Shock Protein 90 by 4-Hydroxynonenal in a Rat Model of Chronic Alcoholic Liver Disease
2005 • 173 citations
DNA base modifications in renal chromatin of wistar rats treated with a renal carcinogen, ferric nitrilotriacetate
1994 • 173 citations
Hepatic Iron Overload Induces Hepatocellular Carcinoma in Transgenic Mice Expressing the Hepatitis C Virus Polyprotein
2006 • 166 citations
Diesel Exhaust Particles Enhance Lung Injury Related to Bacterial Endotoxin through Expression of Proinflammatory Cytokines, Chemokines, and Intercellular Adhesion Molecule-1
2002 • 165 citations
Using anti-5,5-dimethyl-1-pyrroline N-oxide (anti-DMPO) to detect protein radicals in time and space with immuno-spin trapping
2004 • 164 citations
Axis determination by inhibition of Wnt signaling in Xenopus
1999 • 163 citations
Reduced Histone Deacetylase in COPD
2006 • 158 citations
Mechanism of the Conversion of Xanthine Dehydrogenase to Xanthine Oxidase
2005 • 156 citations
A Prospective Study of Incident Squamous Cell Carcinoma of the Skin in the Nurses' Health Study
1995 • 154 citations
Regulation of intracellular localization of human MTH1, OGG1, and MYH proteins for repair of oxidative DNA damage
2001 • 153 citations
Redox-active Protein Thioredoxin Prevents Proinflammatory Cytokine- or Bleomycin-induced Lung Injury
2003 • 151 citations
Proteomic analysis of 4-hydroxy-2-nonenal-modified proteins in G93A-SOD1 transgenic mice-A model of familial amyotrophic lateral sclerosis
2005 • 150 citations
S‐nitrosation of Cys‐800 of HIF‐1α protein activates its interaction with p300 and stimulates its transcriptional activity
2003 • 147 citations
Complexities of the DNA base excision repair pathway for repair of oxidative DNA damage
2001 • 137 citations
Role of Nicotinamide Adenine Dinucleotide Phosphate Oxidase 1 in Oxidative Burst Response to Toll-Like Receptor 5 Signaling in Large Intestinal Epithelial Cells
2004 • 135 citations
On the mechanism of protein palmitoylation
2004 • 132 citations
E-4-hydroxy-2-nonenal is cytotoxic and cross-links cytoskeletal proteins in P19 neuroglial cultures.
1996 • 132 citations
Oxidative stress: Excited oxygen species and enzyme activity
1985 • 131 citations
Loss of Thioredoxin-Binding Protein-2/Vitamin D3 Up-Regulated Protein 1 in Human T-Cell Leukemia Virus Type I-Dependent T-Cell Transformation
2004 • 126 citations
Antioxidant Strategies in Respiratory Medicine
2006 • 126 citations
Increased Carbon Monoxide in Exhaled Air of Subjects with Upper Respiratory Tract Infections
1998 • 125 citations
Mice Lacking Thioredoxin-interacting Protein Provide Evidence Linking Cellular Redox State to Appropriate Response to Nutritional Signals
2004 • 124 citations
Decreased Total and Corrected Antioxidant Capacity in Patients with Inflammatory Bowel Disease
2004 • 121 citations
Excess iron induces hepatic oxidative stress and transforming growth factor ?1 in genetic hemochromatosis
1997 • 120 citations
High incidence of allelic loss on chromosome 5 and inactivation of p15INK4B and p16INK4A tumor suppressor genes in oxystress-induced renal cell carcinoma of rats
1999 • 118 citations
Impaired fatty acid utilization in thioredoxin binding protein‐2 (TBP‐2)‐deficient mice: a unique animal model of Reye syndrome
2005 • 116 citations
Comparative Genome Analysis Identifies the Vitamin D Receptor Gene as a Direct Target of p53-Mediated Transcriptional Activation
2006 • 108 citations
Peroxynitrite activates kinases of the src family and upregulates tyrosine phosphorylation signaling 1,2 1This article is part of a series of reviews on “Reactive Nitrogen Species, Tyrosine Nitration and Cell Signaling.” The full list of papers may be found on the homepage of the journal. 2Guest Editor: Harry Ischiropoulos
2002 • 106 citations
Evidence for Free Radical Generation Due to NADH Oxidation by Aldehyde Oxidase During Ethanol Metabolism
1995 • 105 citations
ReviewThe Defense Mechanisms in Mammalian Cells against Oxidative Damage in Nucleic Acids and their Involvement in the Suppression of Mutagenesis and Cell Death
2004 • 101 citations
Serum 4-Hydroxy-2-Nonenal-Modified Albumin Is Elevated in Patients with Type 2 Diabetes Mellitus
2000 • 100 citations
Superoxide dismutase in ocular structures.
1985 • 100 citations
ON GLUTATHIONE
1922 • 97 citations
In vivo protection of a water-soluble derivative of vitamin E, Trolox, against methylmercury-intoxication in the rat
2001 • 94 citations
Long-term use of vitamin E-coated polysulfone membrane reduces oxidative stress markers in haemodialysis patients
2005 • 90 citations
Free radical activity of industrial fibers: role of iron in oxidative stress and activation of transcription factors.
1997 • 90 citations
IL-2 receptor(p55)/Tac-inducing factor. Purification and characterization of adult T cell leukemia-derived factor.
1988 • 90 citations
Molecular Evolution of the Myeloperoxidase Family
2000 • 89 citations
Two distinct mechanisms for loss of thioredoxin-binding protein-2 in oxidative stress-induced renal carcinogenesis
2005 • 89 citations
Advanced glycation end-products induce apoptosis involving the signaling pathways of oxidative stress in bovine retinal pericytes
2006 • 87 citations
The role of leptin in progression of non-alcoholic fatty liver disease
2005 • 83 citations
Vitamin D3 up-regulated protein 1 (VDUP1) expression in gastrointestinal cancer and its relation to stage of disease.
2003 • 83 citations
Induction of a Wide Range of C2–12 Aldehydes and C7–12 Acyloins in the Kidney of Wistar Rats After Treatment With a Renal Carcinogen, Ferric Nitrilotriacetate
1997 • 81 citations
Modulation of cell proliferation and gene expression by α-tocopheryl phosphates: relevance to atherosclerosis and inflammation
2004 • 78 citations
A Severe Diabetic Nephropathy Model With Early Development of Nodule-Like Lesions Induced by Megsin Overexpression in RAGE/iNOS Transgenic Mice
2006 • 78 citations
The Roles of Superoxide Anion and Methylene Blue in the Reductive Activation of Indoleamine 2,3-Dioxygenase by Ascorbic Acid or by Xanthine Oxidase-Hypoxanthine
1989 • 74 citations
Proteomic method detects oxidatively induced protein carbonyls in muscles of a diabetes model Otsuka Long-evans Tokushima Fatty (OLETF) rat
2002 • 74 citations
Spectrum and Range of Oxidative Stress Responses of Human Lens Epithelial Cells to H2O2 Insult
2003 • 72 citations
Low Incidence of Point Mutations in H‐, K‐ and N‐ras Oncogenes and p53 Tumor Suppressor Gene in Renal Cell Carcinoma and Peritoneal Mesothelioma of Wistar Rats Induced by Ferric Nitrilotriacetate
1995 • 68 citations
Aging: A shift from redox regulation to oxidative damage
2006 • 66 citations
Formation of Acrolein-derived 2′-Deoxyadenosine Adduct in an Iron-induced Carcinogenesis Model
2003 • 66 citations
Enhanced resistancy of thioredoxin-transgenic mice against influenza virus-induced pneumonia
2002 • 64 citations
Loss of interleukin-2-dependency in HTLV-I-infected T cells on gene silencing of thioredoxin-binding protein-2
2005 • 62 citations
Specific Allelic Loss of p16 Tumor Suppressor Gene after Weeks of Iron-Mediated Oxidative Damage during Rat Renal Carcinogenesis
2002 • 61 citations
Identification of 4-hydroxynonenal-modified retinal proteins induced by photooxidative stress prior to retinal degeneration
2006 • 59 citations
Immuno–spin trapping of DNA radicals
2006 • 55 citations
Crotonaldehyde accumulates in glial cells of Alzheimer’s disease brain
2006 • 50 citations
The Role of Superoxide and Hydroperoxide in the Reductive Activation of Tryptophan-2,3-dioxygenase
1971 • 48 citations
Contrasting Genome-Wide Distribution of 8-Hydroxyguanine and Acrolein-Modified Adenine during Oxidative Stress-Induced Renal Carcinogenesis
2006 • 48 citations
Induction of Reversible Cysteine-Targeted Protein Oxidation by an Endogenous Electrophile 15-Deoxy-Δ12,14-prostaglandin J2
2004 • 48 citations
Addition of the Antioxidant Probucol to Angiotensin II Type I Receptor Antagonist Arrests Progressive Mesangioproliferative Glomerulonephritis in the Rat
2006 • 48 citations
Lysophosphatidylcholine Enhances Cytokine Production of Endothelial Cells via Induction of L-Type Amino Acid Transporter 1 and Cell Surface Antigen 4F2
2004 • 47 citations
Susceptibility of actin to modification by 4-hydroxy-2-nonenal
2005 • 45 citations
Cytoprotective Effects of Nitroglycerin in Ischemia–Reperfusion-Induced Lung Injury
2000 • 44 citations
Iron-induced oxidant stress in nonparenchymal liver cells: mitochondrial derangement and fibrosis in acutely iron-dosed gerbils and its prevention by silybin.
2002 • 44 citations
Evaluation by High-Resolution Ultrasonography of Endothelial Function in Brachial Artery After Kawasaki Disease and the Effects of Intravenous Administration of Vitamin C.
2002 • 37 citations
Addition of electrophilic lipids to actin alters filament structure
2006 • 30 citations
Oxidative DNA damage induced by hair dye components ortho-phenylenediamines and the enhancement by superoxide dismutase
2006 • 29 citations
Anti-Psoriatic Drug Anthralin Activates JNK via Lipid Peroxidation: Mononuclear Cells are More Sensitive than Keratinocytes
2000 • 29 citations
MCI-186 (edaravone), a novel free radical scavenger, protects against acute autoimmune myocarditis in rats
2005 • 28 citations
Decreased Oxidative State in Non-Lesional Skin of Atopic Dermatitis
2002 • 24 citations
Reactive oxygen species generation in gingival fibroblasts of Down syndrome patients detected by electron spin resonance spectroscopy
2006 • 23 citations
Protein-Bound 4-Hydroxy-2-Nonenal as a Marker of Oxidative Stress
2005 • 22 citations
Augmentation of Heme Oxygenase-1 Expression in the Graft Immediately After Implantation in Adult Living-Donor Liver Transplantation
2005 • 22 citations
The Impact of Antireflux Surgery on Oxidative Stress of Esophageal Mucosa Caused by Gastroesophageal Reflux Disease: 4-yr Follow-Up Study
2006 • 20 citations
Clinical Significance of Serum Thioredoxin 1 Levels in Patients with Acute Pancreatitis
2006 • 20 citations
Carcinogenesis and Chemoprevention in Gastric Cancer Associated with Helicobacter pylori Infection: Role of Oxidants and Antioxidants
2005 • 20 citations
Comparison of stable nitroxide, 3-substituted 2,2,5,5-tetramethylpyrrolidine-N-oxyls, with respect to protection from radiation, prevention of DNA damage, and distribution in mice
2005 • 16 citations
Retinopatía del prematuro y estrés oxidativo
2006 • 16 citations
The Discovery of tRNA by Paul C. Zamecnik
2005 • 14 citations
α-Tocopherol induces calnexin in renal tubular cells: Another protective mechanism against free radical-induced cellular damage
2006 • 5 citations