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Pathological investigation of oxidative stress in the post‐genomic era

Data up to Jan 2025

Published2007
Citations40
References185

Total Citations Per Year

Abstract

References (185)

Free radicals in biology and medicine

1991 • 17,840 citations

Superoxide Dismutase

1969 • 12,578 citations

Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor

1987 • 10,774 citations

Free Radicals in Biology and Medicine

2015 • 8,284 citations

Genetics and Analysis of Quantitative Traits

2002 • 6,393 citations

Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly

1996 • 5,498 citations

Oxygen-Derived Free Radicals in Postischemic Tissue Injury

1985 • 5,488 citations

The Pathobiology of Diabetic Complications

2005 • 4,849 citations

Genetics and analysis of quantitative traits

1999 • 4,350 citations

Helicobacter pyloriInfection and the Development of Gastric Cancer

2001 • 4,276 citations

An Nrf2/Small Maf Heterodimer Mediates the Induction of Phase II Detoxifying Enzyme Genes through Antioxidant Response Elements

1997 • 3,743 citations

Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain

1999 • 3,344 citations

NOX enzymes and the biology of reactive oxygen

2004 • 2,940 citations

LXXIII.—Oxidation of tartaric acid in presence of iron

1894 • 2,887 citations

The risk of colorectal cancer in ulcerative colitis: a meta-analysis

2001 • 2,788 citations

Protein Oxidation and Aging

1992 • 2,687 citations

[37] Carbonyl assays for determination of oxidatively modified proteins

1994 • 2,605 citations

Tumor Hypoxia: Definitions and Current Clinical, Biologic, and Molecular Aspects

2001 • 2,558 citations

Chromosome territories, nuclear architecture and gene regulation in mammalian cells

2001 • 2,239 citations

Carbon monoxide has anti-inflammatory effects involving the mitogen-activated protein kinase pathway

2000 • 2,074 citations

Oxidative Stress Sensor Keap1 Functions as an Adaptor for Cul3-Based E3 Ligase To Regulate Proteasomal Degradation of Nrf2

2004 • 2,037 citations

Antioxidant and redox regulation of gene transcription

1996 • 1,999 citations

Oxidation of tartaric acid in presence of iron

1894 • 1,515 citations

Transcription Factor Nrf2 Coordinately Regulates a Group of Oxidative Stress-inducible Genes in Macrophages

2000 • 1,411 citations

Non–coding RNA genes and the modern RNA world

2001 • 1,407 citations

Oxidants as Stimulators of Signal Transduction

1997 • 1,380 citations

Oxygen, oxidative stress, hypoxia, and heart failure

2005 • 1,289 citations

Nitrosylation

2001 • 1,229 citations

Persistent oxidative stress in cancer

1995 • 1,218 citations

Purine bases, nucleosides, and nucleotides: aqueous solution redox chemistry and transformation reactions of their radical cations and e- and OH adducts

1989 • 1,215 citations

The Possible Role of Hydrogen Sulfide as an Endogenous Smooth Muscle Relaxant in Synergy with Nitric Oxide

1997 • 1,196 citations

Oxygen, oxidative stress, hypoxia, and heart failure

2005 • 1,192 citations

ASK1 is required for sustained activations of JNK/p38 MAP kinases and apoptosis

2001 • 1,181 citations

REDOX REGULATION OF CELLULAR ACTIVATION

1997 • 1,121 citations

The Genetic Basis of Human Cancer

1997 • 1,113 citations

Analysis of a form of oxidative DNA damage, 8-hydroxy-2′-deoxyguanosine, as a marker of cellular oxidative stress during carcinogenesis

1997 • 1,108 citations

S-nitrosylated GAPDH initiates apoptotic cell death by nuclear translocation following Siah1 binding

2005 • 1,029 citations

Membrane transport of hydrogen peroxide

2006 • 1,013 citations

Protection against electrophile and oxidant stress by induction of the phase 2 response: Fate of cysteines of the Keap1 sensor modified by inducers

2004 • 948 citations

A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity

2002 • 944 citations

Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2

1998 • 906 citations

The Genetic Basis of Human Cancer

1999 • 827 citations

Cancer Incidence in Atomic Bomb Survivors. Part III: Leukemia, Lymphoma and Multiple Myeloma, 1950-1987

1994 • 783 citations

Identification of Thioredoxin-binding Protein-2/Vitamin D3 Up-regulated Protein 1 as a Negative Regulator of Thioredoxin Function and Expression

1999 • 696 citations

Mitochondrial DNA Damage and Dysfunction Associated With Oxidative Stress in Failing Hearts After Myocardial Infarction

2001 • 686 citations

Crystal structures of bovine milk xanthine dehydrogenase and xanthine oxidase: Structure-based mechanism of conversion

2000 • 680 citations

ROS-dependent activation of the TRAF6-ASK1-p38 pathway is selectively required for TLR4-mediated innate immunity

2005 • 648 citations

Chemical basis of inflammation-induced carcinogenesis

2003 • 613 citations

Quantitative immunohistochemical determination of 8-hydroxy-2'-deoxyguanosine by a monoclonal antibody N45.1: its application to ferric nitrilotriacetate-induced renal carcinogenesis model.

1997 • 579 citations

Identification by redox proteomics of glutathionylated proteins in oxidatively stressed human T lymphocytes

2002 • 565 citations

Iron-induced carcinogenesis: The role of redox regulation

1996 • 556 citations

Reactive oxygen species‐induced molecular damage and its application in pathology

1999 • 549 citations

Accumulation of single-strand breaks is the major cause of telomere shortening in human fibroblasts

2000 • 532 citations

Chemical determination of free radical-induced damage to DNA

1991 • 523 citations

The quantitative risks of mesothelioma and lung cancer in relation to asbestos exposure

2000 • 513 citations

Hyperglycemia causes oxidative stress in pancreatic beta-cells of GK rats, a model of type 2 diabetes.

1999 • 509 citations

The NAD(P)H Oxidase Homolog Nox4 Modulates Insulin-Stimulated Generation of H2O2 and Plays an Integral Role in Insulin Signal Transduction

2004 • 506 citations

Nox1 Is Involved in Angiotensin II–Mediated Hypertension

2005 • 460 citations

Inactivating Mutations in the Gene for Thyroid Oxidase 2 (THOX2) and Congenital Hypothyroidism

2002 • 460 citations

The glial glutamate transporter, GLT‐1, is oxidatively modified by 4‐hydroxy‐2‐nonenal in the Alzheimer's disease brain: the role of Aβ1–42

2001 • 458 citations

Epidermal Growth Factor Receptor-dependent Akt Activation by Oxidative Stress Enhances Cell Survival

2000 • 455 citations

Nitric Oxide Regulates Exocytosis by S-Nitrosylation of N-ethylmaleimide-Sensitive Factor

2003 • 441 citations

Site‐specific DNA damage at GGG sequence by oxidative stress may accelerate telomere shortening

1999 • 418 citations

Redox regulation in the lens

2003 • 405 citations

Drusen, choroidal neovascularization, and retinal pigment epithelium dysfunction in SOD1-deficient mice: A model of age-related macular degeneration

2006 • 401 citations

Evolutionary conservation of chromosome territory arrangements in cell nuclei from higher primates

2002 • 389 citations

Carbon monoxide: an endogenous modulator of sinusoidal tone in the perfused rat liver.

1995 • 388 citations

Free radicals, aging, and degenerative diseases

1987 • 375 citations

Mechanism of Ca2+ Activation of the NADPH Oxidase 5 (NOX5)

2004 • 371 citations

Distinctive activation mechanisms and functions for protein kinase Cδ

2004 • 368 citations

Thyroid hormone-induced oxidative stress

2006 • 365 citations

The quantitative risks of mesothelioma and lung cancer in relation to asbestos exposure

2000 • 361 citations

Tissue-specific spatial organization of genomes

2004 • 360 citations

Selective Inactivation of α-Ketoglutarate Dehydrogenase and Pyruvate Dehydrogenase: Reaction of Lipoic Acid with 4-Hydroxy-2-nonenal

1998 • 350 citations

Mammalian microRNAs: a small world for fine-tuning gene expression

2006 • 349 citations

Chromosome territories

2007 • 349 citations

Colon Cancer, Dysplasia, and Surveillance in Patients with Ulcerative Colitis

1987 • 341 citations

Formation of 4-hydroxy-2-nonenal-modified proteins in the renal proximal tubules of rats treated with a renal carcinogen, ferric nitrilotriacetate.

1994 • 337 citations

Identification of Human and Mouse p19, a Novel CDK4 and CDK6 Inhibitor with Homology to p16ink4

1995 • 336 citations

4-Hydroxy-2-nonenal-mediated Impairment of Intracellular Proteolysis during Oxidative Stress

1999 • 320 citations

Free radicals, aging, and degenerative diseases

1986 • 311 citations

Non‐antioxidant molecular functions of α‐tocopherol (vitamin E)

2002 • 299 citations

Effects of NADPH oxidase inhibitor in diabetic nephropathy

2005 • 297 citations

The Superoxide-Generating Oxidase Nox1 Is Functionally Required for Ras Oncogene Transformation

2004 • 295 citations

VDUP1 upregulated by TGF-β1 and 1,25-dihydorxyvitamin D3 inhibits tumor cell growth by blocking cell-cycle progression

2003 • 269 citations

Cancer risk in patients with hereditary hemochromatosis and in their first-degree relatives

2003 • 265 citations

The superoxide‐producing NAD(P)H oxidase Nox4 in the nucleus of human vascular endothelial cells

2005 • 265 citations

Vestibular defects in head-tilt mice result from mutations inNox3, encoding an NADPH oxidase

2004 • 260 citations

Role of Reactive Oxygen Species in Skin Carcinogenesis

2004 • 255 citations

Formation of hydrogen peroxide and hydroxyl radicals from Aβ and α-synuclein as a possible mechanism of cell death in Alzheimer’s disease and Parkinson’s disease 1,2 1This article is part of a series of reviews on “Causes and Consequences of Oxidative Stress in Alzheimer’s Disease.” The full list of papers may be found on the homepage of the journal. 2Guest Editors: Mark A. Smith and George Perry

2002 • 254 citations

A Mutation in the SDHC Gene of Complex II Increases Oxidative Stress, Resulting in Apoptosis and Tumorigenesis

2005 • 246 citations

CANCER STATISTICS FOR JAPAN

1923 • 244 citations

Oxidative stress and delayed-onset muscle damage after exercise

2004 • 230 citations

Rapid and selective cerebral hypothermia achieved using a cooling helmet

2004 • 221 citations

Roles of MAPKKK ASK1 in Stress-Induced Cell Death.

2003 • 221 citations

Immunohistochemical detection of 4-hydroxy-2-nonenal adducts in Alzheimer's disease is associated with inheritance of APOE4.

1997 • 219 citations

Recruitment of Tumor Necrosis Factor Receptor-associated Factor Family Proteins to Apoptosis Signal-regulating Kinase 1 Signalosome Is Essential for Oxidative Stress-induced Cell Death

2005 • 214 citations

Positional cloning of the combined hyperlipidemia gene Hyplip1

2001 • 208 citations

The monoclonal antibody specific for the 4‐hydroxy‐2‐nonenal histidine adduct

1995 • 206 citations

Interaction between Protein Kinase C δ and the c-Abl Tyrosine Kinase in the Cellular Response to Oxidative Stress

2000 • 199 citations

Non-Hodgkin's lymphoma of the pleural cavity developing from long-standing pyothorax

1987 • 198 citations

Effect of Antibiotics on the Generation of Reactive Oxygen Species

1986 • 191 citations

IκB Kinase, a Molecular Target for Inhibition by 4-Hydroxy-2-nonenal

2001 • 190 citations

Melanoma metastasis suppression by chromosome 6: evidence for a pathway regulated by CRSP3 and TXNIP.

2003 • 182 citations

Modification of Heat Shock Protein 90 by 4-Hydroxynonenal in a Rat Model of Chronic Alcoholic Liver Disease

2005 • 173 citations

DNA base modifications in renal chromatin of wistar rats treated with a renal carcinogen, ferric nitrilotriacetate

1994 • 173 citations

Hepatic Iron Overload Induces Hepatocellular Carcinoma in Transgenic Mice Expressing the Hepatitis C Virus Polyprotein

2006 • 166 citations

Diesel Exhaust Particles Enhance Lung Injury Related to Bacterial Endotoxin through Expression of Proinflammatory Cytokines, Chemokines, and Intercellular Adhesion Molecule-1

2002 • 165 citations

Using anti-5,5-dimethyl-1-pyrroline N-oxide (anti-DMPO) to detect protein radicals in time and space with immuno-spin trapping

2004 • 164 citations

Axis determination by inhibition of Wnt signaling in Xenopus

1999 • 163 citations

Reduced Histone Deacetylase in COPD

2006 • 158 citations

Mechanism of the Conversion of Xanthine Dehydrogenase to Xanthine Oxidase

2005 • 156 citations

A Prospective Study of Incident Squamous Cell Carcinoma of the Skin in the Nurses' Health Study

1995 • 154 citations

Regulation of intracellular localization of human MTH1, OGG1, and MYH proteins for repair of oxidative DNA damage

2001 • 153 citations

Redox-active Protein Thioredoxin Prevents Proinflammatory Cytokine- or Bleomycin-induced Lung Injury

2003 • 151 citations

Proteomic analysis of 4-hydroxy-2-nonenal-modified proteins in G93A-SOD1 transgenic mice-A model of familial amyotrophic lateral sclerosis

2005 • 150 citations

S‐nitrosation of Cys‐800 of HIF‐1α protein activates its interaction with p300 and stimulates its transcriptional activity

2003 • 147 citations

Complexities of the DNA base excision repair pathway for repair of oxidative DNA damage

2001 • 137 citations

Role of Nicotinamide Adenine Dinucleotide Phosphate Oxidase 1 in Oxidative Burst Response to Toll-Like Receptor 5 Signaling in Large Intestinal Epithelial Cells

2004 • 135 citations

On the mechanism of protein palmitoylation

2004 • 132 citations

E-4-hydroxy-2-nonenal is cytotoxic and cross-links cytoskeletal proteins in P19 neuroglial cultures.

1996 • 132 citations

Oxidative stress: Excited oxygen species and enzyme activity

1985 • 131 citations

Loss of Thioredoxin-Binding Protein-2/Vitamin D3 Up-Regulated Protein 1 in Human T-Cell Leukemia Virus Type I-Dependent T-Cell Transformation

2004 • 126 citations

Antioxidant Strategies in Respiratory Medicine

2006 • 126 citations

Increased Carbon Monoxide in Exhaled Air of Subjects with Upper Respiratory Tract Infections

1998 • 125 citations

Mice Lacking Thioredoxin-interacting Protein Provide Evidence Linking Cellular Redox State to Appropriate Response to Nutritional Signals

2004 • 124 citations

Decreased Total and Corrected Antioxidant Capacity in Patients with Inflammatory Bowel Disease

2004 • 121 citations

Excess iron induces hepatic oxidative stress and transforming growth factor ?1 in genetic hemochromatosis

1997 • 120 citations

High incidence of allelic loss on chromosome 5 and inactivation of p15INK4B and p16INK4A tumor suppressor genes in oxystress-induced renal cell carcinoma of rats

1999 • 118 citations

Impaired fatty acid utilization in thioredoxin binding protein‐2 (TBP‐2)‐deficient mice: a unique animal model of Reye syndrome

2005 • 116 citations

Comparative Genome Analysis Identifies the Vitamin D Receptor Gene as a Direct Target of p53-Mediated Transcriptional Activation

2006 • 108 citations

Peroxynitrite activates kinases of the src family and upregulates tyrosine phosphorylation signaling 1,2 1This article is part of a series of reviews on “Reactive Nitrogen Species, Tyrosine Nitration and Cell Signaling.” The full list of papers may be found on the homepage of the journal. 2Guest Editor: Harry Ischiropoulos

2002 • 106 citations

Evidence for Free Radical Generation Due to NADH Oxidation by Aldehyde Oxidase During Ethanol Metabolism

1995 • 105 citations

ReviewThe Defense Mechanisms in Mammalian Cells against Oxidative Damage in Nucleic Acids and their Involvement in the Suppression of Mutagenesis and Cell Death

2004 • 101 citations

Serum 4-Hydroxy-2-Nonenal-Modified Albumin Is Elevated in Patients with Type 2 Diabetes Mellitus

2000 • 100 citations

Superoxide dismutase in ocular structures.

1985 • 100 citations

ON GLUTATHIONE

1922 • 97 citations

In vivo protection of a water-soluble derivative of vitamin E, Trolox, against methylmercury-intoxication in the rat

2001 • 94 citations

Long-term use of vitamin E-coated polysulfone membrane reduces oxidative stress markers in haemodialysis patients

2005 • 90 citations

Free radical activity of industrial fibers: role of iron in oxidative stress and activation of transcription factors.

1997 • 90 citations

IL-2 receptor(p55)/Tac-inducing factor. Purification and characterization of adult T cell leukemia-derived factor.

1988 • 90 citations

Molecular Evolution of the Myeloperoxidase Family

2000 • 89 citations

Two distinct mechanisms for loss of thioredoxin-binding protein-2 in oxidative stress-induced renal carcinogenesis

2005 • 89 citations

Advanced glycation end-products induce apoptosis involving the signaling pathways of oxidative stress in bovine retinal pericytes

2006 • 87 citations

The role of leptin in progression of non-alcoholic fatty liver disease

2005 • 83 citations

Vitamin D3 up-regulated protein 1 (VDUP1) expression in gastrointestinal cancer and its relation to stage of disease.

2003 • 83 citations

Induction of a Wide Range of C2–12 Aldehydes and C7–12 Acyloins in the Kidney of Wistar Rats After Treatment With a Renal Carcinogen, Ferric Nitrilotriacetate

1997 • 81 citations

Modulation of cell proliferation and gene expression by α-tocopheryl phosphates: relevance to atherosclerosis and inflammation

2004 • 78 citations

A Severe Diabetic Nephropathy Model With Early Development of Nodule-Like Lesions Induced by Megsin Overexpression in RAGE/iNOS Transgenic Mice

2006 • 78 citations

The Roles of Superoxide Anion and Methylene Blue in the Reductive Activation of Indoleamine 2,3-Dioxygenase by Ascorbic Acid or by Xanthine Oxidase-Hypoxanthine

1989 • 74 citations

Proteomic method detects oxidatively induced protein carbonyls in muscles of a diabetes model Otsuka Long-evans Tokushima Fatty (OLETF) rat

2002 • 74 citations

Spectrum and Range of Oxidative Stress Responses of Human Lens Epithelial Cells to H2O2 Insult

2003 • 72 citations

Low Incidence of Point Mutations in H‐, K‐ and N‐ras Oncogenes and p53 Tumor Suppressor Gene in Renal Cell Carcinoma and Peritoneal Mesothelioma of Wistar Rats Induced by Ferric Nitrilotriacetate

1995 • 68 citations

Aging: A shift from redox regulation to oxidative damage

2006 • 66 citations

Formation of Acrolein-derived 2′-Deoxyadenosine Adduct in an Iron-induced Carcinogenesis Model

2003 • 66 citations

Enhanced resistancy of thioredoxin-transgenic mice against influenza virus-induced pneumonia

2002 • 64 citations

Loss of interleukin-2-dependency in HTLV-I-infected T cells on gene silencing of thioredoxin-binding protein-2

2005 • 62 citations

Specific Allelic Loss of p16 Tumor Suppressor Gene after Weeks of Iron-Mediated Oxidative Damage during Rat Renal Carcinogenesis

2002 • 61 citations

Identification of 4-hydroxynonenal-modified retinal proteins induced by photooxidative stress prior to retinal degeneration

2006 • 59 citations

Immuno–spin trapping of DNA radicals

2006 • 55 citations

Crotonaldehyde accumulates in glial cells of Alzheimer’s disease brain

2006 • 50 citations

The Role of Superoxide and Hydroperoxide in the Reductive Activation of Tryptophan-2,3-dioxygenase

1971 • 48 citations

Contrasting Genome-Wide Distribution of 8-Hydroxyguanine and Acrolein-Modified Adenine during Oxidative Stress-Induced Renal Carcinogenesis

2006 • 48 citations

Induction of Reversible Cysteine-Targeted Protein Oxidation by an Endogenous Electrophile 15-Deoxy-Δ12,14-prostaglandin J2

2004 • 48 citations

Addition of the Antioxidant Probucol to Angiotensin II Type I Receptor Antagonist Arrests Progressive Mesangioproliferative Glomerulonephritis in the Rat

2006 • 48 citations

Lysophosphatidylcholine Enhances Cytokine Production of Endothelial Cells via Induction of L-Type Amino Acid Transporter 1 and Cell Surface Antigen 4F2

2004 • 47 citations

Susceptibility of actin to modification by 4-hydroxy-2-nonenal

2005 • 45 citations

Cytoprotective Effects of Nitroglycerin in Ischemia–Reperfusion-Induced Lung Injury

2000 • 44 citations

Iron-induced oxidant stress in nonparenchymal liver cells: mitochondrial derangement and fibrosis in acutely iron-dosed gerbils and its prevention by silybin.

2002 • 44 citations

Evaluation by High-Resolution Ultrasonography of Endothelial Function in Brachial Artery After Kawasaki Disease and the Effects of Intravenous Administration of Vitamin C.

2002 • 37 citations

Addition of electrophilic lipids to actin alters filament structure

2006 • 30 citations

Oxidative DNA damage induced by hair dye components ortho-phenylenediamines and the enhancement by superoxide dismutase

2006 • 29 citations

Anti-Psoriatic Drug Anthralin Activates JNK via Lipid Peroxidation: Mononuclear Cells are More Sensitive than Keratinocytes

2000 • 29 citations

MCI-186 (edaravone), a novel free radical scavenger, protects against acute autoimmune myocarditis in rats

2005 • 28 citations

Decreased Oxidative State in Non-Lesional Skin of Atopic Dermatitis

2002 • 24 citations

Reactive oxygen species generation in gingival fibroblasts of Down syndrome patients detected by electron spin resonance spectroscopy

2006 • 23 citations

Protein-Bound 4-Hydroxy-2-Nonenal as a Marker of Oxidative Stress

2005 • 22 citations

Augmentation of Heme Oxygenase-1 Expression in the Graft Immediately After Implantation in Adult Living-Donor Liver Transplantation

2005 • 22 citations

The Impact of Antireflux Surgery on Oxidative Stress of Esophageal Mucosa Caused by Gastroesophageal Reflux Disease: 4-yr Follow-Up Study

2006 • 20 citations

Clinical Significance of Serum Thioredoxin 1 Levels in Patients with Acute Pancreatitis

2006 • 20 citations

Carcinogenesis and Chemoprevention in Gastric Cancer Associated with Helicobacter pylori Infection: Role of Oxidants and Antioxidants

2005 • 20 citations

Comparison of stable nitroxide, 3-substituted 2,2,5,5-tetramethylpyrrolidine-N-oxyls, with respect to protection from radiation, prevention of DNA damage, and distribution in mice

2005 • 16 citations

Retinopatía del prematuro y estrés oxidativo

2006 • 16 citations

The Discovery of tRNA by Paul C. Zamecnik

2005 • 14 citations

α-Tocopherol induces calnexin in renal tubular cells: Another protective mechanism against free radical-induced cellular damage

2006 • 5 citations

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