Unique in vivo applications of spin traps

Glutathione and its role in cellular functions

1999 • 1,693 citations

A methodology for analysis of tissue sulfhydryl components

1972 • 413 citations

[11] Diamide: An oxidant probe for thiols

1995 • 333 citations

Trapping of free radicals with direct in vivo EPR detection: a comparison of 5,5-dimethyl-1-pyrroline-N-oxide and 5-diethoxyphosphoryl-5-methyl-1-pyrroline-N-oxide as spin traps for HO and SO4•−

1999 • 278 citations

Nitroxide spin labels : reactions in biology and chemistry

1995 • 255 citations

In vivo EPR detection and imaging of endogenous nitric oxide in lipopolysaccharide-treated mice

1996 • 235 citations

Three-dimensional spectral-spatial EPR imaging of free radicals in the heart: a technique for imaging tissue metabolism and oxygenation.

1994 • 209 citations

Direct evidence of NO production in rat hippocampus and cortex using a new fluorescent indicator

1998 • 200 citations

EPR detection of heme and nonheme iron-containing protein nitrosylation by nitric oxide during rejection of rat heart allograft.

1992 • 195 citations

Magnetic Resonance Imaging of Biological Specimens by Electron Paramagnetic Resonance of Nitroxide Spin Labels

1985 • 195 citations

NO: an inhibitor of cell death

1999 • 191 citations

Influence of alpha-lipoic acid on intracellular glutathione in vitro and in vivo.

1992 • 185 citations

Direct evidence for in vivo hydroxyl-radical generation in experimental iron overload: an ESR spin-trapping investigation.

1991 • 185 citations

Quantitative Measurement of Superoxide Generation Using the Spin Trap 5-(Diethoxyphosphoryl)-5-methyl- 1-pyrroline-N-oxide

1997 • 176 citations

Spin trapping of nitric oxide produced in vivo in septic‐shock mice

1994 • 174 citations

Physiology and pathophysiology of nitric oxide.

1996 • 141 citations

Formation of Free Radicals and Nitric Oxide Derivative of Hemoglobin in Rats During Shock Syndrome

1990 • 135 citations

[13] Determination of biothiols by bromobimane labeling and high-performance liquid chromatography

1995 • 117 citations

On the spin trapping and ESR detection of oxygen-derived radicals generated inside cells.

1986 • 117 citations

Detection of nitric oxide production in lipopolysaccharide-treated rats by ESR using carbon monoxide hemoglobin

1992 • 115 citations

Detection of nitric oxide production in mice by spin-trapping electron paramagnetic resonance spectroscopy

1995 • 113 citations

Contribution of nitric oxide synthase to luminol-dependent chemiluminescence generated by phorbol-ester-activated Kupffer cells

1991 • 102 citations

Detection of glutathione in the human brain in vivo by means of double quantum coherence filtering

1999 • 97 citations

Complexes of Fe2+ with diethyldithiocarbamate or N-methyl-d-glucamine dithiocarbamate as traps of nitric oxide in animal tissues: comparative investigations

1997 • 94 citations

Evaluation of DEPMPO as a spin trapping agent in biological systems

1999 • 91 citations

Quantitative determination of SH groups in low- and high-molecular-weight compounds by an electron spin resonance method

1989 • 89 citations

Redox properties of iron–dithiocarbamates and their nitrosyl derivatives: implications for their use as traps of nitric oxide in biological systems

2000 • 75 citations

Postischemic free radical production in the venous blood of the regionally ischemic swine heart. Effect of deferoxamine.

1991 • 69 citations

The cellular-induced decay of DMPO spin adducts of ·OH and ·O2−

1989 • 68 citations

Developing in Vivo EPR Oximetry for Clinical use

1998 • 64 citations

Quantitative determination and reversible modification of thiols using imidazolidine biradical disulfide label

1997 • 62 citations

Studies of Human and Rat Blood under Oxidative Stress: Changes in Plasma Thiol Level, Antioxidant Enzyme Activity, Protein Carbonyl Content, and Fluidity of Erythrocyte Membrane

1996 • 61 citations

Determination and characterization of nitric oxide generation in mice by in vivo l‐band EPR spectroscopy

1997 • 61 citations

Nitrone Spin-Traps Block Calcium Channels and Induce Pulmonary Artery Relaxation Independent of Free Radicals

1993 • 60 citations

Frequency Dependence of EPR Signal-to-Noise

1999 • 59 citations

One‐ and two‐dimensional EPR imaging studies on Phantoms and Plant specimens

1985 • 57 citations

NMR spin trapping: Detection of free radical reactions using a phosphorus-containing nitrone spin trap

1999 • 55 citations

Biological spin trapping II. Toxicity of nitrone spin traps: dose-ranging in the rat

1995 • 54 citations

In vivo imaging of spin-trapped nitric oxide in rats with septic shock: MRI spin trapping

1999 • 53 citations

Subcellular Distribution of Two Spin Trapping Agents in Rat Heart: Possible Explanation for Their Different Protective Effects Against Doxorubicin-Induced Cardiotoxicity

1992 • 51 citations

Studies on the Origin of the Hydroxyl Spin Adduct of DMPO Produced from the Stimulation of Neutrophils by Phorbol-12-Myristate-13-Acetate

1987 • 48 citations

Use of Imidazoline Nitroxides in Studies of Chemical Reactions ESR Measurements of the Concentration and Reactivity of Protons, Thiols, and Nitric Oxide

2006 • 45 citations

Peep Decreases Oxygenation of the Intestinal Mucosa Despite Normalization of Cardiac Output

1998 • 45 citations

Nitrone spin traps and their pyrrolidine analogs in myocardial reperfusion injury : hemodynamic and ESR implications

1998 • 38 citations

Detection of Free Radical Metabolite Formation Usingin VivoEPR Spectroscopy: Evidence of Rat Hemoglobin Thiyl Radical Formation Following Administration of Phenylhydrazine

1996 • 38 citations

An introduction to 19F NMR spectroscopy

1971 • 38 citations

Interactions of nitroxides with plasma and blood: Effect on 1/T₁ of water protons

1990 • 35 citations

EPR method for the measurement of cellular sulfhydryl groups

1991 • 35 citations

Ex vivo EPR detection of nitric oxide in brain tissue

1999 • 34 citations

NMR spin trapping: detection of free radical reactions with a new fluorinated DMPO analog

2001 • 32 citations

Modification of Relaxation of Lipid Protons by Molecular Oxygen and Nitroxides

1987 • 30 citations

[16] Noninvasive measurement of thiol levels in cellsand isolated organs

1995 • 27 citations

Effects of the spin trap α-phenyl n-tert-butyl nitrone on myocardial function and flow: A dose-response study in the open-chest dog and in the isolated rat heart

1993 • 26 citations

In vivo EPR evidence for free radical adducts of nifedipine

1999 • 25 citations

N-tert-butyl-alpha-phenylnitrone: a free radical trap with unanticipated effects on diaphragm function

1996 • 23 citations

Protective effects of a cyclic nitrone antioxidant in animal models of endotoxic shock and chronic bacteremia.

1994 • 20 citations

Development of fluorinated, NMR-active spin traps for studies of free radical chemistry

1989 • 18 citations

Detection of free radicals in blood by electron spin resonance in a model of respiratory failure in the rat

1994 • 15 citations

Spin trapping of superoxide radicals following stimulation of neutrophils with fMLP is temperature dependent

1993 • 13 citations

[Plasma-membrane fluidity studies of murine neuroblastoma and malignant melanoma cells under irradiation].

1992 • 7 citations

Use of spin-traps during warm ischemia-reperfusion in rat liver: comparative effect on energetic metabolism studied using31P nuclear magnetic resonance

1997 • 7 citations

19F-NMR spin trapping: detection of free radical reactions with new fluorinated spin traps

1999 • 2 citations