The Plasma Membrane Is the Site of Selective Phosphatidylserine Oxidation During Apoptosis: Role of Cytochromec

Induction of Apoptotic Program in Cell-Free Extracts: Requirement for dATP and Cytochrome c

1996 • 5,133 citations

Prevention of Apoptosis by Bcl-2: Release of Cytochrome c from Mitochondria Blocked

1997 • 4,921 citations

The Release of Cytochrome c from Mitochondria: A Primary Site for Bcl-2 Regulation of Apoptosis

1997 • 4,728 citations

Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis

1995 • 4,003 citations

Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages.

1992 • 3,279 citations

Early redistribution of plasma membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus: inhibition by overexpression of Bcl-2 and Abl.

1995 • 2,877 citations

A model for p53-induced apoptosis

1997 • 2,502 citations

Oxidative stress as a mediator of apoptosis

1994 • 2,210 citations

An APAF-1·Cytochrome c Multimeric Complex Is a Functional Apoptosome That Activates Procaspase-9

1999 • 2,088 citations

A Combinatorial Approach Defines Specificities of Members of the Caspase Family and Granzyme B

1997 • 2,054 citations

THE MITOCHONDRIAL DEATH/LIFE REGULATOR IN APOPTOSIS AND NECROSIS

1998 • 1,982 citations

Bcl-2 inhibition of neural death: decreased generation of reactive oxygen species

1993 • 1,692 citations

Sequential reduction of mitochondrial transmembrane potential and generation of reactive oxygen species in early programmed cell death.

1995 • 1,556 citations

Corpse clearance defines the meaning of cell death

2000 • 1,528 citations

Induction of apoptosis in fibroblasts by IL-1β-converting enzyme, a mammalian homolog of the C. elegans cell death gene ced-3

1993 • 1,387 citations

Triggering and modulation of apoptosis by oxidative stress

2000 • 1,315 citations

Mitochondrial cytochrome c release in apoptosis occurs upstream of DEVD-specific caspase activation and independently of mitochondrial transmembrane depolarization

1998 • 1,226 citations

Sequential activation of ICE-like and CPP32-like proteases during Fas-mediated apoptosis

1996 • 980 citations

A rapid and sensitive sub-micro phosphorus determination

1961 • 951 citations

Improved microfluorometric DNA determination in biological material using 33258 Hoechst

1979 • 860 citations

Cytochrome c: Can't Live with It—Can't Live without It

1997 • 768 citations

Mechanisms of phosphatidylserine exposure, a phagocyte recognition signal, on apoptotic T lymphocytes.

1995 • 675 citations

Alterations in mitochondrial structure and function are early events of dexamethasone-induced thymocyte apoptosis.

1995 • 598 citations

[16] Isolation of subcellular organelles

1990 • 563 citations

The role of proteases during apoptosis

1996 • 558 citations

Cytochrome c Promotes Caspase-9 Activation by Inducing Nucleotide Binding to Apaf-1

2000 • 493 citations

Appearance of Phosphatidylserine on Apoptotic Cells Requires Calcium-mediated Nonspecific Flip-Flop and Is Enhanced by Loss of the Aminophospholipid Translocase

1997 • 483 citations

Morphological and biochemical characterization and analysis of apoptosis

1997 • 478 citations

Apoptotic cell removal

2001 • 472 citations

Lipid translocation across the plasma membrane of mammalian cells

1999 • 437 citations

Role for the class A macrophage scavenger receptor in the phagocytosis of apoptotic thymocytes in vitro.

1996 • 427 citations

Cytochrome c activation of CPP32-like proteolysis plays a critical role in a Xenopus cell-free apoptosis system

1997 • 388 citations

Apaf-1 Oligomerizes into Biologically Active ∼700-kDa and Inactive ∼1.4-MDa Apoptosome Complexes

2000 • 321 citations

10N‐Nonyl acridine orange interacts with cardiolipin and allows the quantification of this phospholipid in isolated mitochondria

1992 • 320 citations

Oxidative stress in mitochondria: Its relationship to cellular Ca2+ homeostasis, cell death, proliferation, and differentiation

1991 • 307 citations

Mitochondria, oxygen free radicals, and apoptosis

2001 • 300 citations

A Role for Oxidative Stress in Apoptosis: Oxidation and Externalization of Phosphatidylserine Is Required for Macrophage Clearance of Cells Undergoing Fas-Mediated Apoptosis

2002 • 260 citations

Reversibility of the Binding of Cytochrome c to Liposomes

1995 • 258 citations

Transbilayer movement of fluorescent analogs of phosphatidylserine and phosphatidylethanolamine at the plasma membrane of cultured cells. Evidence for a protein-mediated and ATP-dependent process(es).

1987 • 238 citations

Inhibition of apoptosis by antioxidants in the human HL-60 leukemia cell line

1995 • 177 citations

Aminophospholipid translocase of human erythrocytes: phospholipid substrate specificity and effect of cholesterol

1989 • 172 citations

Oxidative signaling pathway for externalization of plasma membrane phosphatidylserine during apoptosis

2000 • 167 citations

Nitric Oxide–Induced Apoptosis in Human Leukemic Lines Requires Mitochondrial Lipid Degradation and Cytochrome C Release

1999 • 152 citations

Phosphatidylserine Exposure during Apoptosis Is a Cell-Type-Specific Event and Does Not Correlate with Plasma Membrane Phospholipid Scramblase Expression

1999 • 151 citations

Structural and Kinetic Description of Cytochrome c Unfolding Induced by the Interaction with Lipid Vesicles

1997 • 139 citations

Cytochrome c-catalyzed membrane lipid peroxidation by hydrogen peroxide

1991 • 129 citations

Reduction of Ferrylmyoglobin and Ferrylhemoglobin by Nitric Oxide: A Protective Mechanism against Ferryl Hemoprotein-Induced Oxidations

1995 • 125 citations

Collapse of the Inner Mitochondrial Transmembrane Potential Is Not Required for Apoptosis of HL60 Cells

1999 • 124 citations

Altered Cytochrome c Display Precedes Apoptotic Cell Death in Drosophila

1999 • 123 citations

Importance of the redox state of cytochrome c during caspase activation in cytosolic extracts

1998 • 120 citations

Transmembrane phospholipid distribution in blood cells: control mechanisms and pathophysiological significance.

1998 • 112 citations

Sphingolipids

1971 • 110 citations

Appetizing rancidity of apoptotic cells for macrophages: oxidation, externalization, and recognition of phosphatidylserine

2003 • 105 citations

Bcl-2 inhibits selective oxidation and externalization of phosphatidylserine during paraquat-induced apoptosis

1997 • 98 citations

Differential interactions of apo- and holocytochrome c with acidic membrane lipids in model systems and the implications for their import into mitochondria

1989 • 96 citations

The Apoptosome Pathway to Caspase Activation in Primary Human Neutrophils Exhibits Dramatically Reduced Requirements for Cytochrome c

2003 • 95 citations

Correlated flow cytometric analysis of terminal events in apoptosis reveals the absence of some changes in some model systems

1997 • 94 citations

Studies on the lipid dependency and mechanism of the translocation of the mitochondrial precursor protein apocytochrome c across model membranes.

1986 • 88 citations

Oxidative Damage Does Not Alter Membrane Phospholipid Asymmetry in Human Erythrocytes

1997 • 88 citations

Dissociation of Phagocyte Recognition of Cells Undergoing Apoptosis from Other Features of the Apoptotic Program

1998 • 82 citations

Alteration of the aminophospholipid translocase activity during in vivo and artificial aging of human erythrocytes

1990 • 80 citations

Lipid Specificity in the Interaction of Cytochrome c with Anionic Phospholipid Bilayers Revealed by Solid-State 31P NMR

1994 • 78 citations

Ferrylmyoglobin-catalyzed linoleic acid peroxidation

1990 • 77 citations

Aminophospholipid translocase and proteins involved in transmembrane phospholipid traffic

1997 • 75 citations

Macrophages lacking scavenger receptor A show a decrease in binding and uptake of acetylated low-density lipoprotein and of apoptotic thymocytes, but not of oxidatively damaged red blood cells

1997 • 75 citations

Non-random peroxidation of different classes of membrane phospholipids in live cells detected by metabolically integrated cis-parinaric acid

1996 • 74 citations

Random versus Selective Membrane Phospholipid Oxidation in Apoptosis: Role of Phosphatidylserine

1998 • 67 citations

The Role of Cytochrome c and Mitochondrial Catalase in Hydroperoxide-Induced Heart Mitochondrial Lipid Peroxidation

1993 • 62 citations

Surface exposure of phosphatidylserine during apoptosis of rat thymocytes precedes nuclear changes

1998 • 61 citations

Preferential lipid association and mode of penetration of apocytochrome c in mixed model membranes as monitored by tryptophanyl fluorescence quenching using brominated phospholipids

1987 • 51 citations

Preferential association of apocytochrome c with negatively charged phospholipids in mixed model membranes

1986 • 46 citations

Lipid hydroperoxide-induced peroxidation and turnover of endothelial cell phospholipids

1994 • 46 citations

Preparation and characterization of total, rough and smooth microsomes from the lung of control and methylcholanthrene-treated rats

1977 • 45 citations

Selective Peroxidation and Externalization of Phosphatidylserine in Normal Human Epidermal Keratinocytes During Oxidative Stress Induced by Cumene Hydroperoxide

2002 • 43 citations

Nitric Oxide Dissociates Lipid Oxidation from Apoptosis and Phosphatidylserine Externalization during Oxidative Stress

1999 • 40 citations

Phospholipid rearrangement of apoptotic membrane does not depend on nuclear activity

1998 • 37 citations

Sensitive and Specific Fluorescent Probing of Oxidative Stress in Different Classes of Membrane Phospholipids in Live Cells Using Metabolically Integrated cis-Parinaric Acid

2003 • 30 citations

Membrane phospholipid asymmetry: host response to the externalization of phosphatidylserine

1996 • 27 citations

Selective oxidation and externalization of membrane phosphatidylserine: Bcl-2-induced potentiation of the final common pathway for apoptosis

1999 • 25 citations

Inhibition of messenger RNA transcriptional activity in ML-1 human myeloblastic leukemia cell nuclei by antiserum to a c-myb-specific peptide.

1987 • 7 citations