Vitamin E: An overview of major research directions

Meta-Analysis: High-Dosage Vitamin E Supplementation May Increase All-Cause Mortality

2005 • 2,499 citations

Mortality in Randomized Trials of Antioxidant Supplements for Primary and Secondary Prevention

2007 • 2,208 citations

The chemistry and antioxidant properties of tocopherols and tocotrienols

1996 • 1,783 citations

Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids

2000 • 1,628 citations

Direct observation of a free radical interaction between vitamin E and vitamin C

1979 • 1,460 citations

Vitamin E, antioxidant and nothing more

2007 • 1,321 citations

Effects of Long-term Vitamin E Supplementation on Cardiovascular Events and Cancer

2005 • 1,160 citations

On the Existence of a Hitherto Unrecognized Dietary Factor Essential for Reproduction

1922 • 943 citations

VITAMIN SYNTHESIS IN PLANTS: Tocopherols and Carotenoids

2006 • 794 citations

Vitamin E and vitamin C treatment improves fibrosis in patients with nonalcoholic steatohepatitis

2003 • 704 citations

Tocotrienols: Vitamin E beyond tocopherols

2006 • 694 citations

Vitamin E Is Essential for Seed Longevity and for Preventing Lipid Peroxidation during Germination

2004 • 632 citations

Inverse correlation between plasma vitamin E and mortality from ischemic heart disease in cross-cultural epidemiology.

1989 • 630 citations

The European perspective on vitamin E: current knowledge and future research

2002 • 579 citations

Ataxia with isolated vitamin E deficiency is caused by mutations in the α–tocopherol transfer protein

1995 • 561 citations

The role of -tocopherol in plant stress tolerance

2005 • 558 citations

VITAMIN E, OXIDATIVE STRESS, AND INFLAMMATION

2005 • 555 citations

Elevating the Vitamin E Content of Plants Through Metabolic Engineering

1998 • 517 citations

Quantitative structure-activity relationship analysis of phenolic antioxidants

1999 • 511 citations

Molecular Aspects of α-Tocotrienol Antioxidant Action and Cell Signalling

2001 • 497 citations

Human plasma and tissue alpha-tocopherol concentrations in response to supplementation with deuterated natural and synthetic vitamin E

1998 • 382 citations

Effects of alpha-tocopherol and beta-carotene supplements on cancer incidence in the Alpha-Tocopherol Beta-Carotene Cancer Prevention Study

1995 • 380 citations

Non-Antioxidant Activities of Vitamin E

2004 • 374 citations

Vitamin E: beyond antioxidant function

1995 • 371 citations

Structural and dynamic membrane properties of .alpha.-tocopherol and .alpha.-tocotrienol: Implication to the molecular mechanism of their antioxidant potency

1993 • 368 citations

Molecular mechanism of α-tocopherol action

2007 • 348 citations

Tocotrienols in health and disease: The other half of the natural vitamin E family

2007 • 341 citations

Antioxidant Supplementation in Atherosclerosis Prevention (ASAP) study: a randomized trial of the effect of vitamins E and C on 3‐year progression of carotid atherosclerosis

2000 • 328 citations

Molecular Basis of Vitamin E Action

2000 • 322 citations

Isolation of an Arabidopsis mutant lacking vitamin E and identification of a cyclase essential for all tocopherol biosynthesis

2002 • 305 citations

New perspectives on vitamin E: γ-tocopherol and carboxyethylhydroxychroman metabolites in biology and medicine

2003 • 303 citations

Preferential incorporation of alpha-tocopherol vs gamma-tocopherol in human lipoproteins

1989 • 301 citations

Vitamins E and C are safe across a broad range of intakes1,2

2005 • 300 citations

Non‐antioxidant molecular functions of α‐tocopherol (vitamin E)

2002 • 299 citations

Relation of the tocopherol forms to incident Alzheimer disease and to cognitive change

2005 • 297 citations

Vitamin E Reduces the Uptake of Oxidized LDL by Inhibiting CD36 Scavenger Receptor Expression in Cultured Aortic Smooth Muscle Cells

2000 • 288 citations

Absorption, transport, and tissue delivery of vitamin E

2007 • 273 citations

Anti-inflammatory properties of α- and γ-tocopherol

2007 • 262 citations

Vitamin E: protective role of a Janus molecule

2001 • 261 citations

Delayed-onset ataxia in mice lacking α-tocopherol transfer protein: Model for neuronal degeneration caused by chronic oxidative stress

2001 • 254 citations

Novel urinary metabolite of alpha-tocopherol, 2,5,7,8-tetramethyl-2(2’-carboxyethyl)-6-hydroxychroman, as an indicator of an adequate vitamin E supply?

1995 • 245 citations

Impaired ability of patients with familial isolated vitamin E deficiency to incorporate alpha-tocopherol into lipoproteins secreted by the liver.

1990 • 242 citations

Increased atherosclerosis in hyperlipidemic mice deficient in α-tocopherol transfer protein and vitamin E

2000 • 235 citations

Scavenger Receptor Class B Type I (SR-BI) Is Involved in Vitamin E Transport across the Enterocyte

2005 • 229 citations

RRR- and SRR-alpha-tocopherols are secreted without discrimination in human chylomicrons, but RRR-alpha-tocopherol is preferentially secreted in very low density lipoproteins.

1990 • 227 citations

Vitamin E activates gene expression via the pregnane X receptor

2002 • 226 citations

Human α-tocopherol transfer protein: cDNA cloning, expression and chromosomal localization

1995 • 224 citations

A pilot study of the effects of d-alpha-tocopherol on hepatic stellate cell activation in chronic hepatitis C

1997 • 224 citations

Tocopherols Play a Crucial Role in Low-Temperature Adaptation and Phloem Loading in Arabidopsis

2006 • 220 citations

Neuroprotective Properties of the Natural Vitamin E α-Tocotrienol

2005 • 219 citations

Regulation of cell signalling by vitamin E

2002 • 215 citations

Localization of Friedreich ataxia phenotype with selective vitamin E deficiency to chromosome 8q by homozygosity mapping

1993 • 211 citations

Vitamin E is delivered to cells via the high affinity receptor for low-density lipoprotein

1984 • 204 citations

α-Tocopheryl Succinate, the Most Effective Form of Vitamin E for Adjuvant Cancer Treatment: A Review

2003 • 202 citations

Purification and characterization of the α‐tocopherol transfer protein from rat liver

1991 • 199 citations

A new endogenous natriuretic factor: LLU-alpha.

1996 • 194 citations

Ligand Specificity in the CRAL-TRIO Protein Family

2003 • 194 citations

Vitamin E in human skin: Organ-specific physiology and considerations for its use in dermatology

2007 • 180 citations

α-Tocopherol Metabolism Is Abnormal in Scavenger Receptor Class B Type I (SR-BI)-Deficient Mice

2002 • 179 citations

α-Tocopherol Transfer Protein Is Important for the Normal Development of Placental Labyrinthine Trophoblasts in Mice

2001 • 179 citations

γ‐Tocopherol inhibits human cancer cell cycle progression and cell proliferation by down‐regulation of cyclins

2002 • 177 citations

Spinocerebellar Degeneration Associated with a Selective Defect of Vitamin E Absorption

1985 • 177 citations

Age-dependent increase of collagenase expression can be reduced by α-tocopherol via protein kinase C inhibition

1999 • 177 citations

Vitamin E and Neurodegenerative Disorders Associated with Oxidative Stress

2002 • 176 citations

A Novel Human Tocopherol-associated Protein

2000 • 175 citations

Metabolically engineered oilseed crops with enhanced seed tocopherol

2005 • 174 citations

Physical and chemical scavenging of singlet molecular oxygen by tocopherols

1990 • 172 citations

Effects of supplemental alpha-tocopherol and beta-carotene on colorectal cancer: results from a controlled trial (Finland)

2000 • 170 citations

Vitamin E inhibits protein kinase c activity

1988 • 169 citations

ATP-binding Cassette Transporter A1 Mediates Cellular Secretion of α-Tocopherol

2001 • 168 citations

Modulation of signal transduction by vitamin E

2007 • 165 citations

Primary structure of alpha-tocopherol transfer protein from rat liver. Homology with cellular retinaldehyde-binding protein.

1993 • 160 citations

Separation of vitamin E (tocopherol, tocotrienol, and tocomonoenol) in palm oil

2004 • 156 citations

THE METABOLISM OF VITAMIN E

1956 • 153 citations

Ataxia with isolated vitamin E deficiency: neurological phenotype, clinical follow-up and novel mutations in TTPAgene in Italian families

2004 • 151 citations

Anti‐atherosclerotic effects of vitamin E – myth or reality?

2004 • 151 citations

Scavenger receptor class B, type I is expressed in porcine brain capillary endothelial cells and contributes to selective uptake of HDL‐associated vitamin E

2001 • 142 citations

Higher baseline serum concentrations of vitamin E are associated with lower total and cause-specific mortality in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study

2006 • 141 citations

The Discovery of the Antioxidant Function of Vitamin E: the contribution of Henry A. Mattill

2005 • 140 citations

Vitamin E Analogs, a Novel Group of “Mitocans,” as Anticancer Agents: The Importance of Being Redox-Silent

2007 • 138 citations

Antioxidants and the Autoxidation of Fats. IX. The Antioxidant Properties of the Tocopherols

1937 • 138 citations

The Molecular Basis of Vitamin E Retention: Structure of Human α-Tocopherol Transfer Protein

2003 • 137 citations

Friedreich's ataxia phenotype not linked to chromosome 9 and associated with selective autosomal recessive vitamin E deficiency in two inbred Tunisian families

1993 • 136 citations

Studies of LDL oxidation following α-, γ-, or δ-tocotrienyl acetate supplementation of hypercholesterolemic humans

2000 • 135 citations

Vitamin E succinate and cancer treatment: a vitamin E prototype for selective antitumour activity

2003 • 133 citations

THE METABOLISM OF VITAMIN E

1956 • 132 citations

Vitamin E and Breast Cancer

2004 • 127 citations

Antioxidants vitamin C and vitamin E for the prevention and treatment of cancer

2006 • 127 citations

Mitocans as anti-cancer agents targeting mitochondria: lessons from studies with vitamin E analogues, inhibitors of complex II

2007 • 126 citations

Localization of α-tocopherol transfer protein in the brains of patients with ataxia with vitamin E deficiency and other oxidative stress related neurodegenerative disorders

1999 • 126 citations

Novel urinary metabolite of d-delta-tocopherol in rats.

1984 • 124 citations

Characterization of the Vitamin E-Binding Properties of Human Plasma Afamin

2002 • 122 citations

Vitamin E and neurodegenerative diseases

2007 • 122 citations

Studies of the mechanism of vitamin E action. III. In vitro copolymerization of oxidized fats with protein

1955 • 121 citations

Vitamin E and its Role in the Prevention of Atherosclerosis and Carcinogenesis: A Review

2003 • 118 citations

Mitochondrial electron transport-linked tocopheroxyl radical reduction

1989 • 118 citations

Vitamin E and transfer proteins

2003 • 117 citations

Crystal structure of human α-tocopherol transfer protein bound to its ligand: Implications for ataxia with vitamin E deficiency

2003 • 116 citations

Gene expression profile of oxidant stress and neurodegeneration in transgenic mice deficient in α-tocopherol transfer protein

2003 • 116 citations

Inhibition of Lipid Peroxidation in Microsomes by Vitamin E

1960 • 112 citations

Unsaturated lipid peroxidation catalyzed by hematin compounds and its inhibition by vitamin E¹

1961 • 109 citations

α-Tocopherol may influence cellular signaling by modulating jasmonic acid levels in plants

2006 • 108 citations

The 80th Anniversary of Vitamin E: Beyond Its Antioxidant Properties

2002 • 107 citations

Identification of hepatic molecular mechanisms of action of alpha-tocopherol using global gene expression profile analysis in rats

2004 • 107 citations

Supernatant protein factor, which stimulates the conversion of squalene to lanosterol, is a cytosolic squalene transfer protein and enhances cholesterol biosynthesis

2001 • 106 citations

Human α‐tocopherol transfer protein: Gene structure and mutations in familial vitamin E deficiency

1996 • 103 citations

Delivery of orally supplemented α-tocotrienol to vital organs of rats and tocopherol-transport protein deficient mice

2005 • 102 citations

Tocopherol-Associated Protein Suppresses Prostate Cancer Cell Growth by Inhibition of the Phosphoinositide 3-Kinase Pathway

2005 • 101 citations

Vitamin E analogues as a novel group of mitocans: Anti-cancer agents that act by targeting mitochondria

2007 • 101 citations

Vitamin E sensitive genes in the developing rat fetal brain: a high‐density oligonucleotide microarray analysis

2002 • 101 citations

Tocopherol-Associated Protein Is a Ligand-Dependent Transcriptional Activator

2001 • 100 citations

The role of α-tocopherol in preventing disease: from epidemiology to molecular events

2003 • 100 citations

The effect of vitamin E on the structure of membrane lipid assemblies

2003 • 97 citations

Vitamin E in Humans: An Explanation of Clinical Trial Failure

2006 • 95 citations

α-Tocopheryl phosphate: A novel, natural form of vitamin E

2005 • 95 citations

Serum -Tocopherol and Subsequent Risk of Lung Cancer Among Male Smokers

1999 • 93 citations

α-Tocopherol down-regulates scavenger receptor activity in macrophages

1999 • 92 citations

Vitamine—vitamin. The early years of discovery

1997 • 91 citations

DIETARY REQUIREMENTS FOR REPRODUCTION

1924 • 90 citations

An α-tocopherol binding protein in rat liver cytoplasm

1975 • 90 citations

Vitamin E and drug metabolism

2003 • 89 citations

Postmortem study of ataxia with retinitis pigmentosa by mutation of the alpha -tocopherol transfer protein gene

2000 • 88 citations

Vitamin E therapy in Parkinson's disease

2003 • 88 citations

Cloning of novel human SEC14p-like proteins: ligand binding and functional properties

2003 • 88 citations

Dietary vitamin E modulates differential gene expression in the rat hippocampus: Potential implications for its neuroprotective properties

2005 • 86 citations

α-Tocopherol and Atherosclerosis

2001 • 84 citations

Deletion of vitamin E enhances phenotype of Alzheimer disease model mouse

2006 • 83 citations

Tocopherol (Vitamin E) in Alzheimer???s Disease and Other Neurodegenerative Disorders

2004 • 82 citations

An unusual vitamin E constituent (α-tocomonoenol) provides enhanced antioxidant protection in marine organisms adapted to cold-water environments

2001 • 82 citations

Modulation of cell proliferation and gene expression by α-tocopheryl phosphates: relevance to atherosclerosis and inflammation

2004 • 78 citations

α-Tocopherol Induces Expression of Connective Tissue Growth Factor and Antagonizes Tumor Necrosis Factor-α–Mediated Downregulation in Human Smooth Muscle Cells

2003 • 73 citations

Cellular, molecular and clinical aspects of vitamin E on atherosclerosis prevention

2007 • 72 citations

Molecular and Cellular Activities of Vitamin E Analogues

2007 • 70 citations

Studies of the mechanism of vitamin E action. II. Inhibition of unsaturated fatty acid oxidation catalyzed by hematin compounds

1954 • 66 citations

Regulatory role of vitamins E and C on extracellular matrix components of the vascular system

2007 • 65 citations

THE OXIDATIVE DESTRUCTION OF VITAMINS A AND E

1927 • 65 citations

Neuromuscular disease in patients with steatorrhoea.

1967 • 65 citations

The Auto-Oxidation of Fats with Reference to Their Destructive Effect on Vitamin E

1931 • 63 citations

Vitamin E and selenium participation in fatty acid desaturation A proposal for an enzymatic function of these nutrients

1986 • 58 citations

Induction of drug metabolizing enzymes by vitamin E

2005 • 57 citations

Vitamin E metabolism

2007 • 56 citations

The effect of tocopheryl phosphates on atherosclerosis progression in rabbits fed with a high cholesterol diet

2006 • 56 citations

Risk of Mortality with Vitamin E Supplements: The Cache County Study

2007 • 54 citations

α‐Tocopheryl succinate selectively induces apoptosis in neuroblastoma cells: potential therapy of malignancies of the nervous system?

2005 • 54 citations

Identification of a Low Molecular Mass (14.2 kDa) α-Tocopherol-Binding Protein in the Cytosol of Rat Liver and Heart

1993 • 53 citations

A function for the vitamin E metabolite α‐tocopherol quinone as an essential enzyme cofactor for the mitochondrial fatty acid desaturases

1999 • 51 citations

α-Tocopheryl succinate epitomizes a compound with a shift in biological activity due to pro-vitamin-to-vitamin conversion

2002 • 50 citations

On the Existence of Cellular Tocopheryl Phosphate, its Synthesis, Degradation and Cellular Roles: A Hypothesis

2005 • 50 citations

Vitamin E binding protein A famin Protects Neuronal Cells in vitro

2002 • 50 citations

Protective effect of vitamin E supplements on experimental atherosclerosis is modest and depends on preexisting vitamin E deficiency

2006 • 49 citations

Vitamin E: underestimated as an antioxidant

2004 • 49 citations

α‐tocopherol, an exogenous factor of adult hippocampal neurogenesis regulation

2003 • 44 citations

In Silico Search for Single Nucleotide Polymorphisms in Genes Important in Vitamin E Homeostasis

2004 • 43 citations

Linking tocopherols with cellular signaling in plants

2005 • 42 citations

THE NUTRITIVE PROPERTIES OF MILK, WITH SPECIAL REFERENCE TO REPRODUCTION IN THE ALBINO RAT

1920 • 41 citations

Molecular Mechanism of Cellular Uptake and Intracellular Translocation of α-Tocopherol: Role of Tocopherol-binding Proteins

1999 • 40 citations

The inhibition of hematin-catalyzed oxidations by α-tocopherol

1953 • 40 citations

Is there a future for antioxidants in atherogenesis?

2005 • 38 citations

Antioxidants Derived from Vitamin E: An Overview

2007 • 38 citations

THE NUTRITIVE PROPERTIES OF MILK WITH SPECIAL REFERENCE TO REPRODUCTION IN THE ALBINO RAT. II

1923 • 37 citations

Tocopherol-associated protein-1 accelerates apoptosis induced by α-tocopheryl succinate in mesothelioma cells

2006 • 37 citations

Effect of dietary vitamin E on lipofuscin accumulation with age in the rat brain

1994 • 36 citations

The first two decades of vitamin E.

1977 • 35 citations

Effect of Vitamin E in Coronary Heart Disease

1946 • 34 citations

Differential retention of α‐vitamin E is correlated with its transporter gene expression and growth inhibition efficacy in prostate cancer cells

2007 • 33 citations

Tocopherol-mediated modulation of age-related changes in microglial cells: Turnover of extracellular oxidized protein material

2006 • 32 citations

A novel 45 kDa secretory protein from rat olfactory epithelium: primary structure and localisation

1999 • 32 citations

Inverse correlation of vitamin E and ischemic heart disease.

1989 • 28 citations

Tocopherols Enhance Neurogenesis in Dentate Gyrus of Adult Rats

2002 • 28 citations

Regulation of hepatic cholesterol synthesis by a novel protein (SPF) that accelerates cholesterol biosynthesis

2006 • 27 citations

Recombinant SEC14-like proteins (TAP) possess GTPase activity

2004 • 27 citations

Supernatant protein factor stimulates HMG-CoA reductase in cell culture and in vitro

2004 • 26 citations

Tocopherol transfer protein deficiency modifies nuclear receptor transcriptional networks in lungs: Modulation by cigarette smoke in vivo

2007 • 25 citations

Cortical Gene Expression in the Vitamin E-Deficient Rat: Possible Mechanisms for the Electrophysiological Abnormalities of Visual and Neural Function

2006 • 23 citations

α-Tocopherol supports the survival and neurite extension of neurons cultured from various regions of fetal rat brain

1991 • 20 citations

Water‐soluble GTP‐binding protein from rat olfactory epithelium

1994 • 18 citations

Reduced expression of ?-tocopherol-associated protein is associated with tumor cell proliferation and the increased risk of prostate cancer recurrence

2007 • 18 citations

Vitamin E and Prostate Cancer: Is Vitamin E Succinate a Superior Chemopreventive Agent?

2005 • 18 citations

Molecular basis of α-tocopherol inhibition of smooth muscle cell proliferation in vitro

1992 • 18 citations

[25] α-Tocopherol-binding proteins: Purification and characterization

1997 • 18 citations

Isoelectric Point Mobility Shift Assay for Rapid Screening of Charged and Uncharged Ligands Bound to Proteins

2003 • 15 citations

45-KDa GTP-binding Protein from Rat Olfactory Epithelium: Purification, Characterization and Localization

1996 • 13 citations

Carotenoids and fat-soluble vitamins: contribution to food, feed and pharmaceuticals.

1970 • 13 citations

Rat supernatant protein factor-like protein (SPF2) stimulates squalene monooxygenase and is activated by protein kinase A

2004 • 12 citations

Vitamin E prevents the neuronal cell death by repressing cyclooxygenase-2 activity

2005 • 8 citations

Dietary factors in lipofuscinogenesis and ceroidogenesis

2002 • 7 citations

The role and importance of vitamin E for general health

2006 • 2 citations