Lipid polymorphism and protein–lipid interactions

Lipid polymorphism and the functional roles of lipids in biological membranes

1979 • 1,817 citations

Structure of the inverted hexagonal (HII) phase, and non-lamellar phase transitions of lipids

1990 • 1,056 citations

Lipidic cubic phases: A novel concept for the crystallization of membrane proteins

1996 • 968 citations

THE STRUCTURE OF THE LIQUID-CRYSTALLINE PHASES OF LIPID-WATER SYSTEMS

1962 • 853 citations

Physical properties of surfactant bilayer membranes: thermal transitions, elasticity, rigidity, cohesion and colloidal interactions

1987 • 773 citations

An Antimicrobial Peptide, Magainin 2, Induced Rapid Flip-Flop of Phospholipids Coupled with Pore Formation and Peptide Translocation

1996 • 688 citations

Magainins as paradigm for the mode of action of pore forming polypeptides

1998 • 574 citations

The Lateral Pressure Profile in Membranes: A Physical Mechanism of General Anesthesia

1997 • 453 citations

Relationship of Membrane Curvature to the Formation of Pores by Magainin 2

1998 • 442 citations

Molecular Basis for Membrane Selectivity of an Antimicrobial Peptide, Magainin 2

1995 • 398 citations

Energetics of intermediates in membrane fusion: comparison of stalk and inverted micellar intermediate mechanisms

1993 • 388 citations

The mechanism of lamellar-to-inverted hexagonal phase transitions in phosphatidylethanolamine: implications for membrane fusion mechanisms

1997 • 347 citations

Pore formation and translocation of melittin

1997 • 322 citations

The Language of Shape

1997 • 278 citations

Induction of Nonbilayer Structures in Diacylphosphatidylcholine Model Membranes by Transmembrane α-Helical Peptides: Importance of Hydrophobic Mismatch and Proposed Role of Tryptophans

1996 • 266 citations

Orientational and Aggregational States of Magainin 2 in Phospholipid Bilayers

1994 • 264 citations

Probability of alamethicin conductance states varies with nonlamellar tendency of bilayer phospholipids

1993 • 259 citations

Measured effects of diacylglycerol on structural and elastic properties of phospholipid membranes

1996 • 247 citations

The hemifusion intermediate and its conversion to complete fusion: regulation by membrane composition

1995 • 241 citations

Physiological levels of diacylglycerols in phospholipid membranes induce membrane fusion and stabilize inverted phases

1989 • 224 citations

Biological significance of lipid polymorphism: the cubic phases

1997 • 222 citations

Non-bilayer lipids and biological fusion intermediates

1996 • 211 citations

Geometrical aspects of the frustration in the cubic phases of lyotropic liquid crystals.

1988 • 203 citations

Effect of lipid composition on the calcium/adenosine 5'-triphosphate coupling ratio of the calcium(2+)-ATPase of sarcoplasmic reticulum

1984 • 193 citations

Lysolipids reversibly inhibit Ca²⁺‐, GTP‐ and pH‐dependent fusion of biological membranes

1993 • 189 citations

Interaction of the HIV-1 Fusion Peptide with Phospholipid Vesicles: Different Structural Requirements for Fusion and Leakage

1994 • 183 citations

Fusion of influenza hemagglutinin-expressing fibroblasts with glycophorin-bearing liposomes: role of hemagglutinin surface density

1990 • 175 citations

Pore-Forming Peptides Induce Rapid Phospholipid Flip-Flop in Membranes

1994 • 170 citations

Transbilayer Transport of Ions and Lipids Coupled with Mastoparan X Translocation

1996 • 161 citations

Diastereomers of Cytolysins, a Novel Class of Potent Antibacterial Peptides

1996 • 158 citations

Nontopological Saddle-Splay and Curvature Instabilities from Anisotropic Membrane Inclusions

1996 • 151 citations

Lipid Bilayer Electrostatic Energy, Curvature Stress, and Assembly of Gramicidin Channels

1997 • 146 citations

Influence of the Angle Subtended by the Positively Charged Helix Face on the Membrane Activity of Amphipathic, Antibacterial Peptides

1997 • 146 citations

Permeabilization and fusion of uncharged lipid vesicles induced by the HIV-1 fusion peptide adopting an extended conformation: dose and sequence effects

1997 • 141 citations

Structural and Kinetic Description of Cytochrome c Unfolding Induced by the Interaction with Lipid Vesicles

1997 • 139 citations

Bilayer to non-bilayer transition in mixtures of phosphatidylethanolamine and phosphatidylcholine: Implications for membrane properties

1981 • 134 citations

Nonlamellar Phases Induced by the Interaction of Gramicidin S with Lipid Bilayers. A Possible Relationship to Membrane-Disrupting Activity

1997 • 130 citations

Theoretical and functional analysis of the SIV fusion peptide.

1991 • 126 citations

Amphipathic Helix

2012 • 119 citations

Evidence That Bilayer Bending Rigidity Affects Membrane Protein Folding

1997 • 115 citations

Reciprocal effects of apolipoprotein and lytic peptide analogs on membranes. Cross-sectional molecular shapes of amphipathic alpha helixes control membrane stability.

1993 • 106 citations

Lipid polymorphism and membrane properties

1997 • 104 citations

Orientation and structure of the NH2-terminal HIV-1 gp41 peptide in fused and aggregated liposomes

1993 • 102 citations

Influenza Virus−Liposome Lipid Mixing Is Leaky and Largely Insensitive to the Material Properties of the Target Membrane

1996 • 101 citations

The Concentration-Dependent Membrane Activity of Cecropin A

1997 • 98 citations

Morphological changes induced by phospholipase C and by sphingomyelinase on large unilamellar vesicles: a cryo-transmission electron microscopy study of liposome fusion

1997 • 97 citations

Lysolipid exchange with lipid vesicle membranes

1995 • 94 citations

Topological properties of two cubic phases of a phospholipid : cholesterol: diacylglycerol aqueous system and their possible implications in the phospholipase C‐induced liposome fusion

1995 • 91 citations

The amino-terminal peptide of HIV-1 glycoprotein 41 interacts with human erythrocyte membranes: peptide conformation, orientation and aggregation

1992 • 90 citations

Structural Aspects of the Interaction of peptidyl‐glycylleucine‐carboxyamide, a Highly Potent Antimicrobial Peptide from Frog Skin, with Lipids

1997 • 89 citations

Small concentrations of alamethicin induce a cubic phase in bulk phosphatidylethanolamine mixtures

1996 • 85 citations

Interaction of the influenza hemagglutinin fusion peptide with lipid bilayers: area expansion and permeation

1997 • 84 citations

Structural Study of the Relationship between the Rate of Membrane Fusion and the Ability of the Fusion Peptide of Influenza Virus To Perturb Bilayers

1997 • 80 citations

Role of Lipid Polymorphism in Pulmonary Surfactant

1996 • 79 citations

Relationship Between the Infectivity of Influenza Virus and the Ability of Its Fusion Peptide to Perturb Bilayers

1994 • 78 citations

Structural Study of the Interaction between the SIV Fusion Peptide and Model Membranes

1996 • 75 citations

Effect of glycophorin on lipid polymorphism

1982 • 73 citations

Role of the position of unsaturation on the phase behavior and intrinsic curvature of phosphatidylethanolamines

1996 • 68 citations

Membrane Orientation of the SIV Fusion Peptide Determines Its Effect on Bilayer Stability and Ability to Promote Membrane Fusion

1994 • 67 citations

Calorimetric detection of curvature strain in phospholipid bilayers

1994 • 67 citations

Phase separation and hexagonal HII phase formation by gramicidins A, B and C in dioleoylphosphatidylcholine model membranes. A study on the role of the tryptophan residues

1987 • 66 citations

Lipid extracts from membranes of Acholeplasma laidlawii A grown with different fatty acids have a nearly constant spontaneous curvature

1995 • 64 citations

Chapter 8 Influence of Nonlamellar-Forming Lipids on Rhodopsin

1997 • 64 citations

Modulation of dolichyl-phosphomannose synthase activity by changes in the lipid environment of the enzyme

1988 • 63 citations

Simulation Studies of Alamethicin-Bilayer Interactions

1997 • 62 citations

The relationship between the effects of drugs on bilayer stability and on protein kinase C activity

1987 • 60 citations

Conformation of alamethicin in phospholipid vesicles: Implications for insertion models

1988 • 59 citations

Interaction of the δ-Endotoxin CytA from Bacillus thuringiensis var. israelensis with Lipid Membranes

1997 • 55 citations

Crystal structure of the Gramicidin/Potassium thiocyanate complex

1997 • 53 citations

Relationship of phospholipid hexagonal phases to biological phenomena

1990 • 52 citations

Modulation of the activities of enzymes of membrane lipid metabolism by non-bilayer-forming lipids

1996 • 51 citations

Chapter 1 The Cubic Phases of Lipids

1997 • 44 citations

Chemical specificity and physical properties of the lipid bilayer in the regulation of protein kinase C by anionic phospholipids: evidence for the lack of a specific binding site for phosphatidylserine.

1996 • 43 citations

High-speed magic angle spinning solid-state 1H nuclear magnetic resonance study of the conformation of gramicidin A in lipid bilayers

1995 • 42 citations

Increased Activation of Protein Kinase C with Cubic Phase Lipid Compared with Liposomes

1998 • 41 citations

Role of Lipids in the Permeabilization of Membranes by Class L Amphipathic Helical Peptides

1997 • 37 citations

Efficient Modulation of Glucolipid Enzyme Activities in Membranes of Acholeplasma laidlawii by the Type of Lipids in the Bilayer Matrix

1995 • 37 citations

Cytoplasmic and Extracellular IsK Peptides Activate Endogenous K and Cl Channels in Xenopus Oocytes

1996 • 36 citations

The effects of membrane physical properties on the fusion of Sendai virus with human erythrocyte ghosts and liposomes. Analysis of kinetics and extent of fusion.

1994 • 36 citations

Fluorescent probes of membrane surface properties

1996 • 33 citations

Influenza hemagglutinin-mediated membrane fusion does not involve inverted phase lipid intermediates.

1993 • 33 citations

Lysophosphatidylcholine inhibits vesicles fusion induced by the NH2-terminal extremity of SIV/HIV fusogenic proteins

1995 • 31 citations

A mismatch between the length of gramicidin and the lipid acyl chains is a prerequisite for HII phase formation in phosphatidylcholine model membranes

1989 • 27 citations

Conformation of gramicidin in relation to its ability to form bilayers with lysophosphatidylcholine

1988 • 27 citations

Interfacial Membrane Properties Modulate Protein Kinase C Activation: Role of the Position of Acyl Chain Unsaturation

1998 • 26 citations

The Effect of an Integral Membrane Protein on Lipid Polymorphism in the Cardiolipin‐Ca²⁺ System

1983 • 25 citations

Studies of kinetics and equilibrium membrane binding of class A and class L model amphipathic peptides1This work was supported by the Medical Research Council of Canada, grant MT-7654 and in part by NIH 90734343.1

1998 • 24 citations

Chapter 7 Membrane Properties and the Activation of Protein Kinase C and Phospholipase A2

1997 • 24 citations

Bilayer-stabilizing properties of myelin basic protein in dioleoylphosphatidylethanolamine systems

1989 • 24 citations

Accumulation of Sendai virus glycoproteins in cell-cell contact regions and its role in cell fusion

1991 • 22 citations

Amphipathic peptide affects the lateral domain organization of lipid bilayers

1997 • 22 citations

Chapter 6 Modulation of Lipid Polymorphism by Peptides

1997 • 20 citations

Effect of non-bilayer lipids on the activity of membrane enzymes

1996 • 18 citations

Chapter 10 Membrane Fusion Intermediates

1997 • 17 citations

Effect of phosphorylation on receptor conformation: the metarhodopsin I .tautm. metarhodopsin II equilibrium in multiply phosphorylated rhodopsin

1992 • 16 citations

Chapter 13 Phospholipid Structure and Escherichia Coli Membranes

1997 • 16 citations

Zwitterionic amphiphiles that raise the bilayer to hexagonal phase transition temperature inhibit protein kinase C The exception that proves the rule

1992 • 15 citations

Capacities of Pardaxin Analogs to Induce Fusion and Leakage of Negatively Charged Phospholipid Vesicles Are Not Necessarily Correlated

1994 • 13 citations

Chapter 9 Liposome Fusion

1997 • 12 citations

Chapter 3 NMR Studies of Membrane Lipid Properties

1997 • 11 citations

Intermediates in Membrane Fusion

1995 • 11 citations

Possible involvement of nonbilayer lipids in the stimulation of the activity of cytochrome P450SCC (CYP11A1) and its propensity to induce vesicle aggregation

1997 • 10 citations

Chapter 14 Regulation of Lipid Syntheses in Acholeplasrna Laidlawii

1997 • 8 citations

Chapter 11 Morphology of Membrane Fusion

1997 • 8 citations

Synergistic effects of Ca²⁺ and wheat germ agglutinin on the lamellar‐hexagonal (H_II) phase transition of glycophorin‐containing egg‐phosphatidylethanolamine membranes

1991 • 7 citations