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Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

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Novel primitive lymphoid tumours induced in transgenic mice by cooperation between myc and bcl-2

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14-3-3σ is required to prevent mitotic catastrophe after DNA damage

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Survivin, versatile modulation of cell division and apoptosis in cancer

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MDC1 is a mediator of the mammalian DNA damage checkpoint

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Cellular senescence as a tumor-suppressor mechanism

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Autophagosome Formation in Mammalian Cells.

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Molecular basis of the VHL hereditary cancer syndrome

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Loss of p16Ink4a with retention of p19Arf predisposes mice to tumorigenesis

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Abnormal Centrosome Amplification in the Absence of p53

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Differential Roles for Cyclin-Dependent Kinase Inhibitors p21 and p16 in the Mechanisms of Senescence and Differentiation in Human Fibroblasts

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Fas Ligand-Induced Apoptosis

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Mitotic block induced in HeLa cells by low concentrations of paclitaxel (Taxol) results in abnormal mitotic exit and apoptotic cell death.

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Cloning and Genomic Organization of Beclin 1, a Candidate Tumor Suppressor Gene on Chromosome 17q21

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Identification of Omi/HtrA2 as a Mitochondrial Apoptotic Serine Protease That Disrupts Inhibitor of Apoptosis Protein-Caspase Interaction

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Role for c-myc in Activation-Induced Apoptotic Cell Death in T Cell Hybridomas

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Molecular Cloning of the Chromosomal Breakpoint of B-Cell Lymphomas and Leukemias with the t(11;14) Chromosome Translocation

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Proteolysis That Is Inhibited by Hedgehog Targets Cubitus interruptus Protein to the Nucleus and Converts It to a Repressor

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Loss of normal p53 function confers sensitization to Taxol by increasing G2/M arrest and apoptosis

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Aurora-A overexpression reveals tetraploidization as a major route to centrosome amplification in p53-/- cells

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Phosphorylation by aurora kinase A induces Mdm2-mediated destabilization and inhibition of p53

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The Tumor Suppressor PTEN Positively Regulates Macroautophagy by Inhibiting the Phosphatidylinositol 3-Kinase/Protein Kinase B Pathway

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53BP1, a Mediator of the DNA Damage Checkpoint

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Loss of p16Ink4a confers susceptibility to metastatic melanoma in mice

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HtrA2 Promotes Cell Death through Its Serine Protease Activity and Its Ability to Antagonize Inhibitor of Apoptosis Proteins

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Do all programmed cell deaths occur via apoptosis?

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Chromosomal passengers and the (aurora) ABCs of mitosis

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Survivin and the inner centromere protein INCENP show similar cell-cycle localization and gene knockout phenotype

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Autophagy in the Eukaryotic Cell

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The Serine Protease Omi/HtrA2 Regulates Apoptosis by Binding XIAP through a Reaper-like Motif

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MDC1 is required for the intra-S-phase DNA damage checkpoint

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Characterization of the p53-Dependent Postmitotic Checkpoint following Spindle Disruption

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A putative serine/threonine kinase encoding gene BTAK on chromosome 20q13 is amplified and overexpressed in human breast cancer cell lines

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BRCA1 regulates the G2/M checkpoint by activating Chk1 kinase upon DNA damage

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The Mitotic Spindle: A Self-Made Machine

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HBXIP functions as a cofactor of survivin in apoptosis suppression

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Targeted disruption of the cell-cycle checkpoint gene ATR leads to early embryonic lethality in mice

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Autophagy Is Activated by Apoptotic Signalling in Sympathetic Neurons: An Alternative Mechanism of Death Execution

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53BP1 functions in an ATM-dependent checkpoint pathway that is constitutively activated in human cancer

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p53 Binding Protein 53BP1 Is Required for DNA Damage Responses and Tumor Suppression in Mice

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Requirement for the CD95 Receptor-Ligand Pathway in c-Myc-Induced Apoptosis

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Autophagy: a barrier or an adaptive response to cancer

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MDC1 is coupled to activated CHK2 in mammalian DNA damage response pathways

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Regulation of GLUT1 Gene Transcription by the Serine/Threonine Kinase Akt1

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The Pro-Apoptotic Proteins, Bid and Bax, Cause a Limited Permeabilization of the Mitochondrial Outer Membrane That Is Enhanced by Cytosol

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Survivin is required for a sustained spindle checkpoint arrest in response to lack of tension

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Inactivation of p53 enhances sensitivity to multiple chemotherapeutic agents.

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The Survivin-like C. elegans BIR-1 Protein Acts with the Aurora-like Kinase AIR-2 to Affect Chromosomes and the Spindle Midzone

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Caenorhabditis elegans inhibitor of apoptosis protein (IAP) homologue BIR-1 plays a conserved role in cytokinesis

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Mammalian Target of Rapamycin (mTOR): Pro- and Anti-Apoptotic

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Silencing of the Novel p53 Target Gene Snk/Plk2 Leads to Mitotic Catastrophe in Paclitaxel (Taxol)-Exposed Cells

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Reducing mammary cancer risk through premature stem cell senescence

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Inactivation of p53 in a Human Ovarian Cancer Cell Line Increases the Sensitivity to Paclitaxel by Inducing G2/M Arrest and Apoptosis

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c-myc Induces Autophagy in Rat 3Y1 Fibroblast Cells

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Differential effects of BCL-2 on survival and proliferation of human B-lymphoma cells following γ-irradiation

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