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If not apoptosis, then what? Treatment-induced senescence and mitotic catastrophe in tumor cells

Data up to Jan 2025

Published2001
Citations713
References106

Total Citations Per Year

Abstract

References (106)

The serial cultivation of human diploid cell strains

1961 • 7,886 citations

A biomarker that identifies senescent human cells in culture and in aging skin in vivo.

1995 • 6,950 citations

CDK inhibitors: positive and negative regulators of G1-phase progression

1999 • 6,003 citations

Oncogenic ras Provokes Premature Cell Senescence Associated with Accumulation of p53 and p16INK4a

1997 • 4,870 citations

Requirement for p53 and p21 to Sustain G 2 Arrest After DNA Damage

1998 • 2,784 citations

Transforming growth factor-beta 1 induces alpha-smooth muscle actin expression in granulation tissue myofibroblasts and in quiescent and growing cultured fibroblasts

1993 • 2,169 citations

Role of the INK4a Locus in Tumor Suppression and Cell Mortality

1996 • 1,580 citations

Tumor Suppression at the Mouse INK4a Locus Mediated by the Alternative Reading Frame Product p19

1997 • 1,568 citations

Mutations of mitotic checkpoint genes in human cancers

1998 • 1,482 citations

Cloning of Senescent Cell-Derived Inhibitors of DNA Synthesis Using an Expression Screen

1994 • 1,368 citations

Apoptosis Signaling

2000 • 1,290 citations

DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts.

1994 • 1,165 citations

Kip/Cip and Ink4 Cdk inhibitors cooperate to induce cell cycle arrest in response to TGF-beta.

1995 • 959 citations

Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts

1996 • 944 citations

Transforming growth factor beta induces the cyclin-dependent kinase inhibitor p21 through a p53-independent mechanism.

1995 • 938 citations

Nucleolar Arf sequesters Mdm2 and activates p53

1999 • 937 citations

14-3-3σ is required to prevent mitotic catastrophe after DNA damage

1999 • 895 citations

Absence of cancer–associated changes in human fibroblasts immortalized with telomerase

1999 • 798 citations

Bypass of Senescence After Disruption of p21 CIP1/WAF1 Gene in Normal Diploid Human Fibroblasts

1997 • 797 citations

Differential Roles for Cyclin-Dependent Kinase Inhibitors p21 and p16 in the Mechanisms of Senescence and Differentiation in Human Fibroblasts

1999 • 784 citations

Mitotic block induced in HeLa cells by low concentrations of paclitaxel (Taxol) results in abnormal mitotic exit and apoptotic cell death.

1996 • 777 citations

Genetic Alterations of Cyclins, Cyclin-Dependent Kinases, and Cdk Inhibitors in Human Cancer

1996 • 751 citations

Uncoupling of S phase and mitosis induced by anticancer agents in cells lacking p21

1996 • 746 citations

Apoptosis, p53, and tumor cell sensitivity to anticancer agents.

1999 • 708 citations

Mammalian Cell Fusion : Induction of Premature Chromosome Condensation in Interphase Nuclei

1970 • 699 citations

Heterotypic Signaling between Epithelial Tumor Cells and Fibroblasts in Carcinoma Formation

2001 • 554 citations

Irradiated mammary gland stroma promotes the expression of tumorigenic potential by unirradiated epithelial cells.

2000 • 537 citations

A senescence-like phenotype distinguishes tumor cells that undergo terminal proliferation arrest after exposure to anticancer agents.

1999 • 536 citations

Accumulation of single-strand breaks is the major cause of telomere shortening in human fibroblasts

2000 • 532 citations

p21WAF1/Cip1: more than a break to the cell cycle?

2000 • 482 citations

Agents that cause DNA double strand breaks lead to p16INK4a enrichment and the premature senescence of normal fibroblasts

1998 • 481 citations

Transforming Growth Factor-β1 Promotes the Morphological and Functional Differentiation of the Myofibroblast

2000 • 466 citations

Human wee1 maintains mitotic timing by protecting the nucleus from cytoplasmically activated cdc2 kinase

1993 • 456 citations

Effects of p21Waf1/Cip1/Sdi1on cellular gene expression: Implications for carcinogenesis, senescence, and age-related diseases

2000 • 426 citations

Regulation of a Senescence Checkpoint Response by the E2F1 Transcription Factor and p14ARF Tumor Suppressor

2000 • 391 citations

Mechanisms of Taxol-induced cell death are concentration dependent.

1998 • 387 citations

Role of p53 and p21waf1/cip1 in senescence-like terminal proliferation arrest induced in human tumor cells by chemotherapeutic drugs

1999 • 380 citations

ATM-dependent telomere loss in aging human diploid fibroblasts and DNA damage lead to the post-translational activation of p53 protein involving poly(ADP-ribose) polymerase

1997 • 376 citations

Cancer, aging and cellular senescence.

2000 • 369 citations

Chfr defines a mitotic stress checkpoint that delays entry into metaphase

2000 • 366 citations

The drug efflux protein, P-glycoprotein, additionally protects drug-resistant tumor cells from multiple forms of caspase-dependent apoptosis

1998 • 357 citations

Cyclin-dependent kinase 2 (Cdk2) is required for centrosome duplication in mammalian cells

1999 • 329 citations

Stable cell membrane labelling

1989 • 320 citations

How does radiation kill cells?

1999 • 313 citations

Cellular senescence as a tumor-protection mechanism: the essential role of counting

2001 • 308 citations

Inhibitors of cyclin-dependent kinases induce features of replicative senescence in early passage human diploid fibroblasts

1998 • 305 citations

Subcytotoxic H2O2 Stress Triggers a Release of Transforming Growth Factor-β1, Which Induces Biomarkers of Cellular Senescence of Human Diploid Fibroblasts

2001 • 304 citations

Nuclear Localization of Cyclin B1 Controls Mitotic Entry After DNA Damage

1998 • 298 citations

Replicative senescence in normal liver, chronic hepatitis C, and hepatocellular carcinomas

2001 • 297 citations

Wild-type p53 triggers a rapid senescence program in human tumor cells lacking functional p53

1997 • 295 citations

p16INK4A and p19ARF act in overlapping pathways in cellular immortalization

2000 • 281 citations

Bleomycin, an apoptosis-mimetic drug that induces two types of cell death depending on the number of molecules internalized.

1993 • 277 citations

From cells to organisms: can we learn about aging from cells in culture?

2001 • 263 citations

Lack of Replicative Senescence in Cultured Rat Oligodendrocyte Precursor Cells

2001 • 229 citations

Specific Phosphorylation of Nucleophosmin on Thr199 by Cyclin- dependent Kinase 2-Cyclin E and Its Role in Centrosome Duplication

2001 • 226 citations

Dual modes of death induced by etoposide in human epithelial tumor cells allow Bcl-2 to inhibit apoptosis without affecting clonogenic survival.

1996 • 206 citations

p21Waf1/Cip1/Sdi1 induces permanent growth arrest with markers of replicative senescence in human tumor cells lacking functional p53

1999 • 200 citations

Rapid induction of senescence in human cervical carcinoma cells

2000 • 198 citations

Lack of Replicative Senescence in Normal Rodent Glia

2001 • 182 citations

Radiation-Induced Senescence-like Growth Arrest Requires TP53 Function but not Telomere Shortening

2001 • 170 citations

p21Waf1/Cip1/Sdi1-induced growth arrest is associated with depletion of mitosis-control proteins and leads to abnormal mitosis and endoreduplication in recovering cells

2000 • 163 citations

Reexpression of the retinoblastoma protein in tumor cells induces senescence and telomerase inhibition

1997 • 160 citations

p16INK4a can initiate an autonomous senescence program

2000 • 150 citations

Human MDR 1 Protein Overexpression Delays the Apoptotic Cascade in Chinese Hamster Ovary Fibroblasts

1997 • 149 citations

Evidence of cisplatin-induced senescent-like growth arrest in nasopharyngeal carcinoma cells.

1998 • 148 citations

The role of cell cycle progression in cisplatin-induced apoptosis in Chinese hamster ovary cells.

1994 • 145 citations

The Cat and Mouse Games That Genes, Viruses, and Cells Play

1997 • 138 citations

Induction of senescence in human malignant glioma cells by p16INK4A

1997 • 131 citations

Independent induction of senescence by p16INK4a and p21CIP1 in spontaneously immortalized human fibroblasts.

1998 • 123 citations

Uncoupling between Phenotypic Senescence and Cell Cycle Arrest in Aging p21-Deficient Fibroblasts

2000 • 116 citations

Transforming Growth Factor β Triggers Two Independent-Senescence Programs in Cancer Cells

1999 • 113 citations

Aging and Cellular Senescence.

1995 • 111 citations

Spontaneous premature chromosome condensation and mitotic catastrophe following irradiation of HeLa S3 cells

1997 • 110 citations

Dominant-negative polo-like kinase 1 induces mitotic catastrophe independent of cdc25C function.

2000 • 101 citations

Chapter 15 The Use and Action of Drugs in Analyzing Mitosis

1998 • 96 citations

Radiation-Induced Centrosome Overduplication and Multiple Mitotic Spindles in Human Tumor Cells

2000 • 95 citations

Retinoic Acid Inhibition of Cell Cycle Progression in MCF-7 Human Breast Cancer Cells

1997 • 93 citations

Effects of the multidrug transporter P-glycoprotein on cellular responses to ionizing radiation.

2000 • 92 citations

Desmoid tumors in adults: The role of radiotherapy in their management

1988 • 86 citations

Centrosome Duplication

2001 • 85 citations

Predictive assays for the therapy of rectum carcinoma

1986 • 80 citations

Apoptosis is critical for drug response in vivo

2001 • 78 citations

Evaluation of micronuclei frequency in the cultured peripheral blood lymphocytes of cancer patients before and after radiation treatment

2001 • 76 citations

Involvement of RB-1, p53, p16INK4 and telomerase in immortalisation of human cells.

1995 • 75 citations

Spontaneous premature chromosome condensation, micronucleus formation, and non-apoptotic cell death in heated HeLa S3 cells. Ultrastructural observations.

1995 • 70 citations

Increased gene expression of Alzheimer disease beta-amyloid precursor protein in senescent cultured fibroblasts.

1991 • 69 citations

Do prostatic biopsies 12 months or more after external irradiation for adenocarcinoma, stage III, predict long-term survival?

1983 • 54 citations

DNA Topoisomerase Inhibitors Induce Reversible Senescence in Normal Human Fibroblasts

1998 • 53 citations

A p53 and apoptotic independent role for p21waf1 in tumour response to radiation therapy

1999 • 51 citations

Apoptosis: mediator or mode of cell killing by anticancer agents?

2001 • 51 citations

Cellular mechanisms associated with the lack of chronic thermotolerance expression in HeLa S3 cells.

1992 • 49 citations

Hydroxyurea induces a senescence-like change of K562 human erythroleukemia cell

2000 • 40 citations

Does resistance to apoptosis affect clinical response to antitumor drugs?

2001 • 39 citations

Human mammary epithelial cells exhibit a differential p53-mediated response following exposure to ionizing radiation or UV light

1999 • 39 citations

Hydroxyurea induces a senescence-like change of K562 human erythroleukemia cell

2000 • 37 citations

The occurrence of apoptosis, abnormal mitoses, cells dying in mitosis and micronuclei in a human melanoma xenograft exposed to single dose irradiation.

1990 • 34 citations

The increment of micronucleus frequency in cervical carcinoma during irradiation in vivo and its prognostic value for tumour radiocurability

1999 • 33 citations

Cell senescence in human aging: a review of the theory.

2000 • 32 citations

Mitotic modifications and aberrations in cancer.

1989 • 29 citations

Changes in S-phase fraction and micronucleus frequency as prognostic factors in radiotherapy of cervical carcinoma

1995 • 26 citations

Prediction of radiosensitivity of oral cancers by serial cytological assay of nuclear changes

1998 • 25 citations

Uncoupling of M-phase kinase activation from the completion of S-phase by heat shock.

1996 • 20 citations

Cisplatin-induced p53-independent growth arrest and cell death in cancer cells.

1999 • 19 citations

Nuclear envelope formation around metaphase chromosomes: chromosome decondensation and nuclear envelope reconstitution during mitosis.

1982 • 15 citations

Micronuclei and Nuclear Abnormalities Observed in Erythroblasts in Myelodysplastic Syndromes and in de novo Acute Leukemia after Treatment

1999 • 14 citations

The occurrence of apoptosis, abnormal mitoses, cells dying in mitosis and micronuclei in a human melanoma xenograft exposed to single dose irradiation.

1990 • 10 citations

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If not apoptosis, then what? Treatment-induced senescence and mitotic catastrophe in… (2001) – Drug Resistance Updates | Metascience Observatory Explorer