Regulation of GLUT1 Gene Transcription by the Serine/Threonine Kinase Akt1

A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002).

1994 • 3,249 citations

Mitogen-activated protein kinase pathways

1997 • 2,513 citations

Signalling through the lipid products of phosphoinositide-3-OH kinase

1997 • 1,314 citations

Expression of a Constitutively Active Akt Ser/Thr Kinase in 3T3-L1 Adipocytes Stimulates Glucose Uptake and Glucose Transporter 4 Translocation

1996 • 1,277 citations

Protein kinase B (c-Akt): a multifunctional mediator of phosphatidylinositol 3-kinase activation

1998 • 1,101 citations

Phosphoinositide 3-kinase: the key switch mechanism in insulin signalling

1998 • 969 citations

CREB Is a Regulatory Target for the Protein Kinase Akt/PKB

1998 • 939 citations

Elevated Levels of Glucose Transport and Transporter Messenger RNA Are Induced by ras or src Oncogenes

1987 • 789 citations

Caenorhabditis elegans Akt/PKB transduces insulin receptor-like signals from AGE-1 PI3 kinase to the DAF-16 transcription factor

1998 • 680 citations

Insulin induces transcription of target genes through the hypoxia-inducible factor HIF-1alpha /ARNT

1998 • 561 citations

Regulation of gene expression by insulin

1996 • 543 citations

Induction of Vascular Endothelial Growth Factor by Hypoxia Is Modulated by a Phosphatidylinositol 3-Kinase/Akt Signaling Pathway in Ha-ras-Transformed Cells Through a Hypoxia Inducible Factor-1 Transcriptional Element

1997 • 501 citations

NF-κB Activation: The IκB Kinase Revealed?

1997 • 492 citations

Evidence of insulin-stimulated phosphorylation and activation of the mammalian target of rapamycin mediated by a protein kinase B signaling pathway

1998 • 487 citations

Structure, Function, and Regulation of the Mammalian Facilitative Glucose Transporter Gene Family

1996 • 369 citations

Constitutive activation of protein kinase B alpha by membrane targeting promotes glucose and system A amino acid transport, protein synthesis, and inactivation of glycogen synthase kinase 3 in L6 muscle cells.

1998 • 338 citations

Construction and Characterization of a Conditionally Active Version of the Serine/Threonine Kinase Akt

1998 • 318 citations

Transformation of Rat Fibroblasts by FSV Rapidly Increases Glucose Transporter Gene Transcription

1987 • 286 citations

Activation of protein kinase B β and γ isoforms by insulin in vivo and by 3-phosphoinositide-dependent protein kinase-1 in vitro: comparison with protein kinase B α

1998 • 275 citations

Insulin Increases the Association of Akt-2 with Glut4-containing Vesicles

1998 • 242 citations

Protein Kinase B/Akt Mediates Effects of Insulin on Hepatic Insulin-like Growth Factor-binding Protein-1 Gene Expression through a Conserved Insulin Response Sequence

1998 • 164 citations

Dual Control of glut1 Glucose Transporter Gene Expression by Hypoxia and by Inhibition of Oxidative Phosphorylation

1997 • 163 citations

Insulin Stimulation of the Fatty Acid Synthase Promoter Is Mediated by the Phosphatidylinositol 3-Kinase Pathway

1998 • 144 citations

Improved Glucose Tolerance Restores Insulin-Stimulated Akt Kinase Activity and Glucose Transport in Skeletal Muscle From Diabetic Goto-Kakizaki Rats

1997 • 138 citations

The Acquisition of Increased Insulin-responsive Hexose Transport in 3T3-L1 Adipocytes Correlates with Expression of a Novel Transporter Gene

1989 • 137 citations

Subcellular localization and trafficking of the GLUT4 glucose transporter isoform in insulin‐responsive cells

1994 • 133 citations

AKT2, a member of the protein kinase B family, is activated by growth factors, v-Ha-ras, and v-src through phosphatidylinositol 3-kinase in human ovarian epithelial cancer cells.

1998 • 130 citations

Activation of Protein Kinase B/Akt Is Sufficient to Repress the Glucocorticoid and cAMP Induction of Phosphoenolpyruvate Carboxykinase Gene

1998 • 127 citations

Regulation of glucose transport and GLUT1 glucose transporter expression by O2 in muscle cells in culture

1992 • 120 citations

Insulin and Glucose-dependent Regulation of the Glucose Transport System in the Rat L6 Skeletal Muscle Cell Line

1989 • 110 citations

Central Role for Phosphatidylinositide 3-Kinase in the Repression of Glucose-6-phosphatase Gene Transcription by Insulin

1998 • 94 citations

Ischemic injury induces brain glucose transporter gene expression.

1993 • 87 citations

Assessment of the Roles of Mitogen-activated Protein Kinase, Phosphatidylinositol 3-Kinase, Protein Kinase B, and Protein Kinase C in Insulin Inhibition of cAMP-induced Phosphoenolpyruvate Carboxykinase Gene Transcription

1998 • 83 citations

Role of p21ras in insulin-stimulated glucose transport in 3T3-L1 adipocytes.

1994 • 73 citations

Transcriptional Activation of the Glut1 Gene in Response to Oxidative Stress in L6 Myotubes

1997 • 62 citations

The Insulin-dependent Biosynthesis of GLUT1 and GLUT3 Glucose Transporters in L6 Muscle Cells Is Mediated by Distinct Pathways

1995 • 59 citations

Structure, function and biosynthesis of GLUTI

1997 • 44 citations

Transformation stimulates glucose transporter gene expression in the absence of protein kinase C.

1989 • 42 citations

The role of insulin in activation of two enhancers in the mouse GLUT1 gene.

1994 • 22 citations