Cyclin‐dependent protein kinases: Key regulators of the eukaryotic cell cycle

WAF1, a potential mediator of p53 tumor suppression

1993 • 8,360 citations

The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

1993 • 5,680 citations

A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4

1993 • 3,680 citations

p21 is a universal inhibitor of cyclin kinases

1993 • 3,408 citations

Principles of CDK regulation

1995 • 3,267 citations

Checkpoints: Controls That Ensure the Order of Cell Cycle Events

1989 • 3,036 citations

A Cell Cycle Regulator Potentially Involved in Genesis of Many Tumor Types

1994 • 2,821 citations

G1 phase progression: Cycling on cue

1994 • 2,706 citations

Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals

1994 • 2,154 citations

Cyclins and cancer II: Cyclin D and CDK inhibitors come of age

1994 • 2,122 citations

p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21

1994 • 2,071 citations

Mammalian G1 cyclins

1993 • 1,990 citations

pl5INK4B is a potentia| effector of TGF-β-induced cell cycle arrest

1994 • 1,932 citations

Cyclin A is required at two points in the human cell cycle.

1992 • 1,380 citations

ANIMAL CELL CYCLES AND THEIR CONTROL

1992 • 1,239 citations

Distinct Roles for Cyclin-Dependent Kinases in Cell Cycle Control

1993 • 1,096 citations

p35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5

1994 • 915 citations

The B-type cyclin kinase inhibitor p40SIC1 controls the G1 to S transition in S. cerevisiae

1994 • 902 citations

Cyclin a is required for the onset of DNA replication in mammalian fibroblasts

1991 • 884 citations

Cyclin-Dependent Regulation of G ₁ in Mammalian Fibroblasts

1993 • 767 citations

Mitosis in transition

1994 • 745 citations

Creative blocks: cell-cycle checkpoints and feedback controls

1992 • 686 citations

Differential effects by the p21 CDK inhibitor on PCNA-dependent DNA replication and repair

1994 • 657 citations

p21-containing cyclin kinases exist in both active and inactive states.

1994 • 646 citations

A novel cyclin associates with M015/CDK7 to form the CDK-activating kinase

1994 • 636 citations

Ordering S phase and M phase in the cell cycle

1994 • 596 citations

A brain-specific activator of cyclin-dependent kinase 5

1994 • 575 citations

Anaphase is initiated by proteolysis rather than by the inactivation of maturation-promoting factor

1993 • 569 citations

Cyclin E controls S phase progression and its down-regulation during Drosophila embryogenesis is required for the arrest of cell proliferation

1994 • 543 citations

Control of the yeast cell cycle by the Cdc28 protein kinase

1993 • 502 citations

Negative regulation of the growth-promoting transcription factor E2F-1 by a stably bound cyclin A-dependent protein kinase

1994 • 493 citations

Destruction of the CDC28/CLB mitotic kinase is not required for the metaphase to anaphase transition in budding yeast.

1993 • 483 citations

Closing the cell cycle circle in yeast: G2 cyclin proteolysis initiated at mitosis persists until the activation of G1 cyclins in the next cycle

1994 • 478 citations

The cell cycle: an introduction

1994 • 466 citations

Joining the complex: Cyclin-dependent kinase inhibitory proteins and the cell cycle

1994 • 460 citations

Cyclins and cyclin-dependent kinases: take your partners

1993 • 441 citations

The MO15 cell cycle kinase is associated with the TFIIH transcription-DNA repair factor

1994 • 432 citations

Relationship of CDK-activating kinase and RNA polymerase II CTD kinase TFIIH/TFIIK

1994 • 426 citations

Cdc2 regulatory factors

1994 • 414 citations

Temporal order of S phase and mitosis in fission yeast is determined by the state of the p34cdc2-mitotic B cyclin complex

1994 • 393 citations

The MO15 gene encodes the catalytic subunit of a protein kinase that activates cdc2 and other cyclin-dependent kinases (CDKs) through phosphorylation of Thr161 and its homologues.

1993 • 391 citations

The cdc2-related protein p40MO15 is the catalytic subunit of a protein kinase that can activate p33cdk2 and p34cdc2.

1993 • 377 citations

Mechanisms that help the yeast cell cycle clock tick: G2 cyclins transcriptionally activate G2 cyclins and repress G1 cyclins

1993 • 376 citations

Phosphorylation of the Transcription Factor PHO4 by a Cyclin-CDK Complex, PHO80-PHO85

1994 • 361 citations

Regulation of progression through the Gl phase of the cell cycle by the rum1+ gene

1994 • 356 citations

Cdk inhibitors: on the threshold of checkpoints and development

1994 • 326 citations

CAK, the p34cdc2 activating kinase, contains a protein identical or closely related to p40MO15.

1993 • 326 citations

Cell Cycle Regulation in the Yeasts Saccharomyces cerevisiae and Schizosaccharomyces pombe

1991 • 326 citations

The Role of p34 Kinases in the G1 to S-Phase Transition

1992 • 313 citations

Distinct molecular mechanism regulate cell cycle timing at successive stages of Drosophila embryogenesis.

1994 • 301 citations

Phosphorylation of RNA polymerase by the murine homologue of the cell-cycle control protein cdc2

1989 • 270 citations

A cyclin associated with the CDK-activating kinase MO15

1994 • 267 citations

The differential localization of human cyclins A and B is due to a cytoplasmic retention signal in cyclin B.

1994 • 267 citations

Direct Inhibition of the Yeast Cyclin-Dependent Kinase Cdc28-Cln by Far1

1994 • 258 citations

Cell cycle analysis of the activity, subcellular localization, and subunit composition of human CAK (CDK-activating kinase).

1994 • 254 citations

Activation of the various cyclin/cdc2 protein kinases

1993 • 253 citations

Rules to replicate by

1994 • 252 citations

Phosphate-Regulated Inactivation of the Kinase PHO80-PHO85 by the CDK Inhibitor PHO81

1994 • 239 citations

Cytokinesis

1992 • 239 citations

An Inhibitor of p34 ^CDC28 Protein Kinase Activity from Saccharomyces cerevisiae

1993 • 236 citations

Cellular substrates of p34cdc2 and its companion cyclin-dependent kinases

1993 • 235 citations

Synergistic action of Drosophila cyclins A and B during the G2-M transition.

1993 • 211 citations

Tumor suppressor genes

1994 • 206 citations

A- and B-type cyclins differentially modulate substrate specificity of cyclin-cdk complexes.

1993 • 190 citations

REGULATION OF EUKARYOTIC DNA REPLICATION

1994 • 170 citations

The PCL2 (ORFD)-PHO85 Cyclin-Dependent Kinase Complex: a Cell Cycle Regulator in Yeast

1994 • 164 citations

The cell cycle: an introduction

1994 • 164 citations

Multiple phosphorylation of stathmin. Identification of four sites phosphorylated in intact cells and in vitro by cyclic AMP-dependent protein kinase and p34cdc2.

1993 • 162 citations

Cyclins and their partners: from a simple idea to complicated reality.

1991 • 159 citations

Multi-site phosphorylation of the protein tyrosine phosphatase, PTP1B: identification of cell cycle regulated and phorbol ester stimulated sites of phosphorylation.

1993 • 156 citations

Cell Cycle Control by a Complex of the Cyclin HCS26 (PCL1) and the Kinase PHO85

1994 • 152 citations

Mitotic Regulation of Microtubule Cross-Linking Activity of CENP-E Kinetochore Protein

1994 • 148 citations

Phosphorylation of E2F-1 modulates its interaction with the retinoblastoma gene product and the adenoviral E4 19 kDa protein

1994 • 143 citations

P40SDB25, a putative CDK inhibitor, has a role in the M/G1 transition in Saccharomyces cerevisiae.

1994 • 142 citations

Identification of a novel vertebrate cyclin: cyclin B3 shares properties with both A- and B-type cyclins.

1994 • 120 citations

Signals and genes in the control of cell-cycle progression

1993 • 113 citations

Cell‐cycle‐regulated phosphorylation of oncoprotein 18 on Ser16, Ser25 and Ser38

1994 • 106 citations

Protein kinase regulation: insights from crystal structure analysis

1994 • 100 citations

p40MO15, a cdc2-related protein kinase involved in negative regulation of meiotic maturation of Xenopus oocytes.

1990 • 99 citations

Mitosis-specific phosphorylation of the nuclear oncoproteins Myc and Myb.

1992 • 93 citations

Nuclear localization of vertebrate cyclin a correlates with its ability to form complexes with cdk catalytic subunits

1993 • 90 citations

p40MO15 associates with a p36 subunit and requires both nuclear translocation and Thr176 phosphorylation to generate cdk-activating kinase activity in Xenopus oocytes.

1994 • 84 citations

Cell cycle regulation of the p34cdc2/p33cdk2-activating kinase p40MO15

1994 • 80 citations

The Kin28 Protein Kinase is Associated with a Cyclin in Saccharomyces cerevisiae

1993 • 77 citations

Characterization of the fission yeast mcs2 cyclin and its associated protein kinase activity.

1993 • 67 citations

Intermediate filaments: not so tough after all

1992 • 65 citations

Mitotic spindle morphogenesis in animal cells.

1991 • 57 citations

Expression and activity of p40MO15, the catalytic subunit of cdk-activating kinase, during Xenopus oogenesis and embryogenesis.

1994 • 57 citations

Elongation factor EF-1 delta, a new target for maturation-promoting factor in Xenopus oocytes.

1994 • 47 citations

Characterization of the in vitro reconstituted cyclin A or B1-dependent cdk2 and cdc2 kinase activities.

1993 • 38 citations

Regulation of cdc2 activity in Schizosaccharomyces pombe: the role of phosphorylation.

1991 • 31 citations

Cell cycle regulation in higher plants

1994 • 29 citations

Phosphorylation of ribonucleotide reductase R2 protein: In vivo and in vitro evidence of a role for p34cdc2 and CDK2 protein kinases

1993 • 27 citations

Biochemistry of cell cycle checkpoints at the G2/M and metaphase/anaphase transitions

1994 • 22 citations

Mitosis-specific phosphorylation of polyomavirus middle-sized tumor antigen and its role during cell transformation.

1993 • 13 citations

Phosphorylation of Rap1GAP during the Cell Cycle

1994 • 11 citations