GGF/Neuregulin Is a Neuronal Signal That Promotes the Proliferation and Survival and Inhibits the Differentiation of Oligodendrocyte Progenitors

Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissue.

1980 • 3,822 citations

Cell death and control of cell survival in the oligodendrocyte lineage

1992 • 1,331 citations

Monoclonal antibodies (O1 to O4) to oligodendrocyte cell surfaces: An immunocytological study in the central nervous system

1981 • 1,131 citations

Identification of Heregulin, a Specific Activator of p185 ^erbB2

1992 • 963 citations

The oligodendrocyte and its many cellular processes

1993 • 837 citations

Platelet-derived growth factor promotes division and motility and inhibits premature differentiation of the oligodendrocyte/type-2 astrocyte progenitor ceil

1988 • 833 citations

Platelet-derived growth factor from astrocytes drives the clock that times oligodendrocyte development in culture

1988 • 760 citations

A role for platelet-derived growth factor in normal gliogenesis in the central nervous system

1988 • 756 citations

Glial growth factors are alternatively spliced erbB2 ligands expressed in the nervous system

1993 • 744 citations

Glial Cell Diversification in the Rat Optic Nerve

1989 • 725 citations

Both oligodendrocytes and astrocytes develop from progenitors in the subventricular zone of postnatal rat forebrain

1993 • 714 citations

Multiple extracellular signals are required for long-term oligodendrocyte survival

1993 • 707 citations

Proliferation of oligodendrocyte precursor cells depends on electrical activity in axons

1993 • 622 citations

FGF modulates the PDGF-driven pathway of oligodendrocyte development

1990 • 586 citations

Cooperation between two growth factors promotes extended self-renewal and inhibits differentiation of oligodendrocyte-type-2 astrocyte (O-2A) progenitor cells.

1990 • 573 citations

Glial growth factor restricts mammalian neural crest stem cells to a glial fate

1994 • 496 citations

Neu differentiation factor is a neuron-glia signal and regulates survival, proliferation, and maturation of rat schwann cell precursors

1995 • 449 citations

An extended family of protein-tyrosine kinase genes differentially expressed in the vertebrate nervous system

1991 • 427 citations

CG‐4, A new bipotential glial cell line from rat brain, is capable of differentiating in vitro into either mature oligodendrocytes or type‐2 astrocytes

1992 • 409 citations

Control of oligodendrocyte number in the developing rat optic nerve

1994 • 385 citations

The Cellular Response to Neuregulins Is Governed by Complex Interactions of the erbB Receptor Family

1995 • 364 citations

Insulin‐like growth factor I promotes cell proliferation and oligodendroglial commitment in rat glial progenitor cells developing in vitro

1988 • 361 citations

PDGF A-chain gene is expressed by mammalian neurons during development and in maturity

1991 • 360 citations

The schwann cell precursor and its fate: A study of cell death and differentiation during gliogenesis in rat embryonic nerves

1994 • 295 citations

Neu and its ligands: From an oncogene to neural factors

1993 • 286 citations

Schwann cell apoptosis at developing neuromuscular junctions is regulated by glial growth factor

1996 • 283 citations

The brain fibroblast growth factor (FGF) is localized in neurons

1986 • 276 citations

Neuregulins are concentrated at nerve-muscle synapses and activate ACh–receptor gene expression

1995 • 276 citations

Axon-induced mitogenesis of human Schwann cells involves heregulin and p185erbB2.

1995 • 273 citations

Two proliferative stages of the oligodendrocyte lineage (A2B5+O4- and O4+GaIC-) under different mitogenic control

1990 • 270 citations

The influence of heregulins on human Schwann cell proliferation

1995 • 252 citations

Proliferation and migration of undifferentiated precursor cells in the rat during postnatal gliogenesis

1966 • 241 citations

Differential expression of ARIA isoforms in the rat brain

1995 • 229 citations

Fibroblast growth factor is a mitogen for oligodendrocytes in vitro

1985 • 227 citations

Purification and preliminary characterization of a glial growth factor from the bovine pituitary.

1980 • 225 citations

Characterization of cultured rat oligodendrocytes proliferating in a serum-free, chemically defined medium.

1985 • 205 citations

Distinct isoforms of neuregulin are expressed in mesenchymal and neuronal cells during mouse development.

1994 • 180 citations

Neuregulins and their receptors

1995 • 178 citations

Spatial and temporal patterns of oligodendrocyte differentiation in rat cerebrum and cerebellum

1988 • 174 citations

Sensory and Motor Neuron-derived Factor. A NOVEL HEREGULIN VARIANT HIGHLY EXPRESSED IN SENSORY AND MOTOR NEURONS

1995 • 170 citations

Glial Cell Mitogens bFGF and PDGF Differentially Regulate Development of O4+GalC- Oligodendrocyte Progenitors

1993 • 170 citations

Neuroglial reactions secondary to wallerian degeneration in the optic nerve of the postnatal rat: Ultrastructural and quantitative study

1977 • 166 citations

Stage- and tissue-specific expression of the neu oncogene in rat development.

1987 • 163 citations

Transforming growth factor-beta 1 regulates axon/Schwann cell interactions.

1995 • 153 citations

Brain neurons and glial cells express Neu differentiation factor/heregulin: a survival factor for astrocytes.

1994 • 147 citations

O2A progenitor cells transplanted into the neonatal rat brain develop into oligodendrocytes but not astrocytes.

1993 • 142 citations

The origin of remyelinating cells in the adult central nervous system: The role of the mature oligodendrocyte

1991 • 132 citations

Effects of neonatal transection on glial cell development in the rat optic nerve: evidence that the oligodendrocyte-type 2 astrocyte cell lineage depends on axons for its survival

1984 • 131 citations

Neural expression and chromosomal mapping of Neu differentiation factor to 8p12-p21.

1993 • 119 citations

Negative regulation of the P o gene in Schwann cells: suppression of Po mRNA and protein induction in cultured Schwann cells by FGF2 and TGFβ1, TGFβ2 and TGFβ3

1994 • 117 citations

Evidence that axons are mitogenic for oligodendrocytes isolated from adult animals

1986 • 113 citations

Down-regulation of the POU transcription factor SCIP is an early event in oligodendrocyte differentiation in vitro

1992 • 112 citations

Expression of multiple neuregulin transcripts in postnatal rat brains

1994 • 109 citations

Apoptosis occurs in the oligodendroglial lineage, and is prevented by basic fibroblast growth factor

1995 • 99 citations

A role for the acetylcholine receptor-inducing protein ARIA in oligodendrocyte development.

1994 • 99 citations

Neuron‐oligodendroglial interactions during central nervous system development

1993 • 91 citations

Cultured Schwann Cells Constitutively Express the Myelin Protein P0

1996 • 91 citations

Neuronal influences on glial progenitor cell development

1989 • 85 citations

Developmental expression of the basic fibroblast growth factor gene in rat brain

1991 • 81 citations

Axons modulate myelin protein messenger RNA levels during central nervous system myelination in vivo

1990 • 80 citations

Regulation of oligodendrocyte differentiation

1992 • 74 citations

The inhibition of oligodendrocytic differentiation of O‐2A progenitors caused by basic fibroblast growth factor is overridden by astrocytes

1993 • 72 citations

Transforming growth factor-beta blocks myelination but not ensheathment of axons by Schwann cells in vitro

1995 • 71 citations

Growth factor stimulation triggers apoptotic cell death in mature oligodendrocytes

1996 • 68 citations

Basic fibroblast growth factor down‐regulates myelin basic protein gene expression and alters myelin compaction of mature oligodendrocytes in vitro

1995 • 64 citations

O‐2A glial progenitors from mature brain respond to CNS neuronal cell line‐derived growth factors

1991 • 55 citations

Neurons and astrocytes influence the development of purified o‐2a progenitor cells

1991 • 52 citations

Effect of optic nerve transection upon myelin protein gene expression by oligodendrocytes: evidence for axonal influences on gene expression

1990 • 52 citations

Mitogenic Effect of Axolemma‐Enriched Fraction on Cultured Oligodendrocytes

1989 • 52 citations

Analysis of integrin expression on oligodendrocytes during axo-glial interaction by using rat-mouse xenocultures

1996 • 36 citations

Schwann cell lineage-specific neu (erbB-2) gene expression in the developing rat nervous system.

1993 • 32 citations

Distribution of fibroblast growth factor in the central and peripheral nervous systems of various mammals

1986 • 31 citations

Rat cerebral cortical neurons in primary culture release a mitogen specific for early (GD3+/04−) oligodendroglial progenitors

1993 • 30 citations

Schwann cells and cells in the oligodendrocyte lineage proliferate in response to a 50,000 dalton membrane‐associated mitogen present in developing brain

1992 • 25 citations

Extracts from Neuron-Enriched Cultures of Chick Telencephalon Stimulate the Proliferation of Rat Oligodendrocytes

1985 • 23 citations

Myelination in vitro of rodent dorsal root ganglia by glial progenitor cells

1994 • 14 citations

Culture Methods for Oligodendrocyte Cell Lines and Oligodendrocyte-Type 2 Astrocyte Lineage Cells

1990 • 7 citations