Biosynthetic Processing of neu Differentiation Factor

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Human Breast Cancer: Correlation of Relapse and Survival with Amplification of the HER-2/ neu Oncogene

1987 • 11,429 citations

Studies of the HER-2/ neu Proto-Oncogene in Human Breast and Ovarian Cancer

1989 • 6,734 citations

Identification of Heregulin, a Specific Activator of p185 ^erbB2

1992 • 963 citations

Isolation of Chinese hamster cell mutants deficient in dihydrofolate reductase activity.

1980 • 903 citations

Glial growth factors are alternatively spliced erbB2 ligands expressed in the nervous system

1993 • 744 citations

Isolation and characterization of ERBB3, a third member of the ERBB/epidermal growth factor receptor family: evidence for overexpression in a subset of human mammary tumors.

1989 • 742 citations

Transmembrane form of the kit ligand growth factor is determined by alternative splicing and is missing in the SId mutant

1991 • 740 citations

MEMBRANE-ANCHORED GROWTH FACTORS

1993 • 676 citations

Coexpression of erbB2 and erbB3 proteins reconstitutes a high affinity receptor for heregulin.

1994 • 649 citations

ARIA, a protein that stimulates acetylcholine receptor synthesis, is a member of the neu ligand family

1993 • 612 citations

A neu acquaintance for ErbB3 and ErbB4: A role for receptor heterodimerization in growth signaling

1994 • 601 citations

Neu differentiation factor: A transmembrane glycoprotein containing an EGF domain and an immunoglobulin homology unit

1992 • 579 citations

Correlation of c-erbB-2 gene amplification and protein expression in human breast carcinoma with nodal status and nuclear grading.

1988 • 570 citations

Isolation of the NeuHER-2 stimulatory ligand: A 44 kd glycoprotein that induces differentiation of mammary tumor cells

1992 • 534 citations

Substrate specificity of protein kinase C

1986 • 521 citations

The TGF-α precursor expressed on the cell surface binds to the EGF receptor on adjacent cells, leading to signal transduction

1989 • 482 citations

Heregulin induces tyrosine phosphorylation of HER4/p180erbB4

1993 • 445 citations

Transmembrane TGF-α precursors activate EGF/TGF-α receptors

1989 • 432 citations

A nonsecretable cell surface mutant of tumor necrosis factor (TNF) kills by cell-to-cell contact

1990 • 409 citations

The erbB3 gene product is a receptor for heregulin.

1994 • 361 citations

Amplification and expression of sequences cotransfected with a modular dihydrofolate reductase complementary DNA gene

1982 • 356 citations

Differential expression and processing of two cell associated forms of the kit-ligand: KL-1 and KL-2.

1992 • 320 citations

Support of human hematopoiesis in long-term bone marrow cultures by murine stromal cells selectively expressing the membrane-bound and secreted forms of the human homolog of the steel gene product, stem cell factor.

1992 • 306 citations

Steel-Dickie mutation encodes a c-kit ligand lacking transmembrane and cytoplasmic domains.

1991 • 300 citations

Neu and its ligands: From an oncogene to neural factors

1993 • 286 citations

ErbB-3 and ErbB-4 function as the respective low and high affinity receptors of all Neu differentiation factor/heregulin isoforms.

1994 • 273 citations

Different transforming growth factor-α species are derived from a glycosylated and palmitoylated transmembrane precursor

1987 • 264 citations

Identification and purification of glial growth factor

1984 • 243 citations

Cell-type specific interaction of Neu differentiation factor (NDF/heregulin) with Neu/HER-2 suggests complex ligand-receptor relationships.

1993 • 237 citations

Structural and Functional Aspects of the Multiplicity of Neu Differentiation Factors

1994 • 220 citations

Cleavage of the membrane precursor for transforming growth factor alpha is a regulated process.

1991 • 209 citations

Acetylcholine receptor-inducing activity stimulates expression of the epsilon-subunit gene of the muscle acetylcholine receptor.

1991 • 158 citations

Inhibition of autoproteolytic activation of interstitial procollagenase by recombinant metalloproteinase inhibitor MI/TIMP-2

1991 • 156 citations

The cytoplasmic carboxy-terminal amino acid specifies cleavage of membrane TGFα into soluble growth factor

1992 • 126 citations

Purification of multiple forms of glial growth factor.

1993 • 99 citations

Juxtacrine cell signaling molecules

1993 • 89 citations

The number of Na+ channels in cultured chick muscle is increased by ARIA, an acetylcholine receptor-inducing activity

1993 • 85 citations

Apical junctions and cell signalling in epithelia

1993 • 84 citations

Association of the transmembrane TGF-alpha precursor with a protein kinase complex.

1994 • 83 citations

The exocrine protein trypsinogen is targeted into the secretory granules of an endocrine cell line: studies by gene transfer.

1985 • 82 citations

Activated release of membrane-anchored TGF-alpha in the absence of cytosol

1993 • 67 citations

NDF/heregulin stimulates the phosphorylation of Her3/erbB3

1994 • 65 citations

Neu Differentiation Factors: A Family of Alternatively Spliced Neuronal and Mesenchymal Factors

1994 • 63 citations

Neu differentiation factor upregulates epidermal migration and integrin expression in excisional wounds.

1995 • 61 citations

Genetic dissection of signal transduction mediated by the sevenless receptor tyrosine kinase in Drosophila

1994 • 26 citations

Signaling mechanisms in induction of the R7 photoreceptor in the developing Drosophila retina

1994 • 15 citations

An autocrine model for cell- and matrix-associated fibroblast growth factor.

1993 • 8 citations