Effects of in Vivo Heregulin β1 Treatment in Wild-Type and ErbB Gene-Targeted Mice Depend on Receptor Levels and Pregnancy

Human Breast Cancer: Correlation of Relapse and Survival with Amplification of the HER-2/ neu Oncogene

1987 • 11,429 citations

Studies of the HER-2/ neu Proto-Oncogene in Human Breast and Ovarian Cancer

1989 • 6,734 citations

Requirement for neuregulin receptor erbB2 in neural and cardiac development

1995 • 1,272 citations

Multiple essential functions of neuregulin in development

1995 • 1,236 citations

Aberrant neural and cardiac development in mice lacking the ErbB4 neuregulin receptor

1995 • 1,108 citations

Identification of Heregulin, a Specific Activator of p185 ^erbB2

1992 • 963 citations

Diversification of Neu differentiation factor and epidermal growth factor signaling by combinatorial receptor interactions.

1996 • 772 citations

Molecular basis of symbiosis between Rhizobium and legumes

1997 • 767 citations

Isolation and characterization of ERBB3, a third member of the ERBB/epidermal growth factor receptor family: evidence for overexpression in a subset of human mammary tumors.

1989 • 742 citations

Ligand-specific activation of HER4/p180erbB4, a fourth member of the epidermal growth factor receptor family.

1993 • 724 citations

Insect cell-expressed p180erbB3 possesses an impaired tyrosine kinase activity.

1994 • 692 citations

Coexpression of erbB2 and erbB3 proteins reconstitutes a high affinity receptor for heregulin.

1994 • 649 citations

A neu acquaintance for ErbB3 and ErbB4: A role for receptor heterodimerization in growth signaling

1994 • 601 citations

ErbB3 is involved in activation of phosphatidylinositol 3-kinase by epidermal growth factor.

1994 • 520 citations

Glial growth factor restricts mammalian neural crest stem cells to a glial fate

1994 • 496 citations

Neuregulins Promote Survival and Growth of Cardiac Myocytes

1998 • 493 citations

Actions of Placental and Fetal Adrenal Steroid Hormones in Primate Pregnancy*

1995 • 469 citations

ErbB3 is required for normal cerebellar and cardiac development: a comparison with ErbB2- and heregulin-deficient mice

1997 • 462 citations

Neu differentiation factor is a neuron-glia signal and regulates survival, proliferation, and maturation of rat schwann cell precursors

1995 • 449 citations

Heregulin induces tyrosine phosphorylation of HER4/p180erbB4

1993 • 445 citations

A point mutation in the neu oncogene mimics ligand induction of receptor aggregation

1989 • 432 citations

Molecular cloning and expression of an additional epidermal growth factor receptor-related gene.

1990 • 375 citations

The erbB3 gene product is a receptor for heregulin.

1994 • 361 citations

Elevated serum c-erbB-2 antigen levels and decreased response to hormone therapy of breast cancer.

1995 • 312 citations

ErbB-3 and ErbB-4 function as the respective low and high affinity receptors of all Neu differentiation factor/heregulin isoforms.

1994 • 273 citations

A Dual Role oferbB2in Myelination and in Expansion of the Schwann Cell Precursor Pool

2000 • 260 citations

Cell death in the Schwann cell lineage and its regulation by neuregulin.

1996 • 237 citations

Efficient coupling with phosphatidylinositol 3-kinase, but not phospholipase C gamma or GTPase-activating protein, distinguishes ErbB-3 signaling from that of other ErbB/EGFR family members.

1994 • 231 citations

Differential expression of ARIA isoforms in the rat brain

1995 • 229 citations

Neuregulins in Development

1996 • 229 citations

Axonal Regulation of Schwann Cell Proliferation and Survival and the Initial Events of Myelination Requires PI 3-Kinase Activity

2000 • 224 citations

Epidermal growth factor-dependent association of phosphatidylinositol 3-kinase with the erbB3 gene product.

1994 • 198 citations

ErbB3 Is Involved in Activation of Phosphatidylinositol 3-Kinase by Epidermal Growth Factor

1994 • 194 citations

Expression of the c-erbB-3 protein in normal human adult and fetal tissues.

1992 • 183 citations

Distinct isoforms of neuregulin are expressed in mesenchymal and neuronal cells during mouse development.

1994 • 180 citations

Dynamic expression and activation of ERBB receptors in the developing mouse mammary gland.

1998 • 166 citations

Stage- and tissue-specific expression of the neu oncogene in rat development.

1987 • 163 citations

Heregulin, but not ErbB2 or ErbB3, heterozygous mutant mice exhibit hyperactivity in multiple behavioral tasks

2000 • 144 citations

NDF/heregulin induces persistence of terminal end buds and adenocarcinomas in the mammary glands of transgenic mice.

1996 • 123 citations

Neural expression and chromosomal mapping of Neu differentiation factor to 8p12-p21.

1993 • 119 citations

ErbB receptors and EGF-like ligands: cell lineage determination and oncogenesis through combinatorial signaling.

1997 • 117 citations

Actions of placental and fetal adrenal steroid hormones in primate pregnancy

1995 • 117 citations

Transforming growth factor α disrupts the normal program of cellular differentiation in the gastric mucosa of transgenic mice

1995 • 115 citations

Heregulin induces in vivo proliferation and differentiation of mammary epithelium into secretory lobuloalveoli.

1996 • 112 citations

Pharmacokinetics in pregnancy and placental drug transfer.

1989 • 92 citations

Characterization of a breast cancer cell differentiation factor that specifically activates the HER4/p180erbB4 receptor.

1993 • 68 citations

Decrease of c-erbB-2 and c-myc RNA levels in tamoxifen-treated breast cancer.

1991 • 66 citations

Overexpression of transforming growth factor-α alters differentiation of gastric cell lineages

1996 • 63 citations

An intron 1 enhancer element mediates oestrogen-induced suppression of ERBB2 expression

1997 • 63 citations

AP-2 transcription factors in the regulation of ERBB2 gene transcription by oestrogen

2000 • 61 citations

Expression of heregulin α, erbB2, and erbB3 and their influences on proliferation of gastric epithelial cells

1999 • 44 citations

Analysis of Heregulin-Induced ErbB2 Phosphorylation with a High-Throughput Kinase Receptor Activation Enzyme-Linked Immunosorbant Assay

1996 • 27 citations

Heregulin-? is especially potent in activating phosphatidylinositol 3-kinase in nontransformed human mammary epithelial cells

2000 • 23 citations