ARIA: A Neuromuscular Junction Neuregulin

Signal transduction by receptors with tyrosine kinase activity

1990 • 5,528 citations

Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells

1984 • 2,762 citations

Close similarity of epidermal growth factor receptor and v-erb-B oncogene protein sequences

1984 • 2,564 citations

The Immunoglobulin Superfamily—Domains for Cell Surface Recognition

1988 • 2,237 citations

GROWTH FACTOR RECEPTOR TYROSINE KINASES

1988 • 1,841 citations

Growth factor signaling by receptor tyrosine kinases

1992 • 1,450 citations

Requirement for neuregulin receptor erbB2 in neural and cardiac development

1995 • 1,272 citations

Multiple essential functions of neuregulin in development

1995 • 1,236 citations

The neu oncogene: an erb-B-related gene encoding a 185,000-Mr tumour antigen

1984 • 1,153 citations

The neu oncogene encodes an epidermal growth factor receptor-related protein

1986 • 1,131 citations

Aberrant neural and cardiac development in mice lacking the ErbB4 neuregulin receptor

1995 • 1,108 citations

The MyoD family and myogenesis: Redundancy, networks, and thresholds

1993 • 1,062 citations

Molecular distinction between fetal and adult forms of muscle acetylcholine receptor

1986 • 979 citations

Identification of Heregulin, a Specific Activator of p185 ^erbB2

1992 • 963 citations

Synaptic structure and development: The neuromuscular junction

1993 • 846 citations

Glial growth factors are alternatively spliced erbB2 ligands expressed in the nervous system

1993 • 744 citations

Isolation and characterization of ERBB3, a third member of the ERBB/epidermal growth factor receptor family: evidence for overexpression in a subset of human mammary tumors.

1989 • 742 citations

Ligand-specific activation of HER4/p180erbB4, a fourth member of the epidermal growth factor receptor family.

1993 • 724 citations

MEMBRANE-ANCHORED GROWTH FACTORS

1993 • 676 citations

Coexpression of erbB2 and erbB3 proteins reconstitutes a high affinity receptor for heregulin.

1994 • 649 citations

The Agrin Hypothesis

1990 • 637 citations

ARIA, a protein that stimulates acetylcholine receptor synthesis, is a member of the neu ligand family

1993 • 612 citations

A neu acquaintance for ErbB3 and ErbB4: A role for receptor heterodimerization in growth signaling

1994 • 601 citations

Neu differentiation factor: A transmembrane glycoprotein containing an EGF domain and an immunoglobulin homology unit

1992 • 579 citations

Cooperative signaling of ErbB3 and ErbB2 in neoplastic transformation and human mammary carcinomas.

1995 • 546 citations

Isolation of the NeuHER-2 stimulatory ligand: A 44 kd glycoprotein that induces differentiation of mammary tumor cells

1992 • 534 citations

Failure of postsynaptic specialization to develop at neuromuscular junctions of rapsyn-deficient mice

1995 • 530 citations

Glial growth factor restricts mammalian neural crest stem cells to a glial fate

1994 • 496 citations

Calcitonin gene-related peptide regulates muscle acetylcholine receptor synthesis

1986 • 472 citations

Nerve‐induced and spontaneous redistribution of acetylcholine receptors on cultured muscle cells.

1977 • 459 citations

Neu differentiation factor is a neuron-glia signal and regulates survival, proliferation, and maturation of rat schwann cell precursors

1995 • 449 citations

Heregulin induces tyrosine phosphorylation of HER4/p180erbB4

1993 • 445 citations

An extended family of protein-tyrosine kinase genes differentially expressed in the vertebrate nervous system

1991 • 427 citations

Receptor tyrosine kinase specific for the skeletal muscle lineage: Expression in embryonic muscle, at the neuromuscular junction, and after injury

1995 • 409 citations

Heregulin-dependent regulation of HER2/neu oncogenic signaling by heterodimerization with HER3.

1995 • 407 citations

Quantitation of junctional and extrajunctional acetylcholine receptors by electron microscope autoradiography after (125)I-α-bungarotoxin binding at mouse neuromuscular junctions

1976 • 398 citations

Molecular cloning and expression of an additional epidermal growth factor receptor-related gene.

1990 • 375 citations

Heterodimerization and functional interaction between EGF receptor family members: a new signaling paradigm with implications for breast cancer research

1995 • 374 citations

Acetylcholine receptor turnover in membranes of developing muscle fibers.

1975 • 364 citations

The erbB3 gene product is a receptor for heregulin.

1994 • 361 citations

Acetylcholine receptors in regenerating muscle accumulate at original synaptic sites in the absence of the nerve.

1979 • 355 citations

Developmental Regulation of Nicotinic Acetylcholine Receptors

1987 • 354 citations

Early events in neuromuscular junction formation in vitro: induction of acetylcholine receptor clusters in the postsynaptic membrane and morphology of newly formed synapses.

1979 • 348 citations

Concentration of acetylcholine receptor mRNA in synaptic regions of adult muscle fibres

1985 • 344 citations

Platelet-derived growth factors and fibroblast growth factors are mitogens for rat Schwann cells.

1990 • 316 citations

Primary structure and expression of a sodium channel characteristic of denervated and immature rat skeletal muscle

1990 • 297 citations

The schwann cell precursor and its fate: A study of cell death and differentiation during gliogenesis in rat embryonic nerves

1994 • 295 citations

Neu and its ligands: From an oncogene to neural factors

1993 • 286 citations

Schwann cell apoptosis at developing neuromuscular junctions is regulated by glial growth factor

1996 • 283 citations

The distribution of acetylcholine sensitivity over uninnervated and innervated muscle fibers grown in cell culture

1973 • 280 citations

Neuregulins are concentrated at nerve-muscle synapses and activate ACh–receptor gene expression

1995 • 276 citations

Distribution of Na+ channels and ankyrin in neuromuscular junctions is complementary to that of acetylcholine receptors and the 43 kd protein

1989 • 274 citations

Axon-induced mitogenesis of human Schwann cells involves heregulin and p185erbB2.

1995 • 273 citations

The distribution of α‐bungarotoxin binding sites on mammalian skeletal muscle developing in vivo

1977 • 266 citations

Neural factors regulate AChR subunit mRNAs at rat neuromuscular synapses.

1991 • 256 citations

Schwann cell growth factors

1978 • 254 citations

The influence of heregulins on human Schwann cell proliferation

1995 • 252 citations

Identification of a phosphoprotein specifically induced by the transforming DNA of rat neuroblastomas

1982 • 251 citations

Calcitonin gene-related peptide and muscle activity regulate acetylcholine receptor alpha-subunit mRNA levels by distinct intracellular pathways.

1987 • 247 citations

Induction of acetylcholine receptors on cultured skeletal muscle by a factor extracted from brain and spinal cord.

1979 • 245 citations

Identification and purification of glial growth factor

1984 • 243 citations

Cell-type specific interaction of Neu differentiation factor (NDF/heregulin) with Neu/HER-2 suggests complex ligand-receptor relationships.

1993 • 237 citations

Efficient coupling with phosphatidylinositol 3-kinase, but not phospholipase C gamma or GTPase-activating protein, distinguishes ErbB-3 signaling from that of other ErbB/EGFR family members.

1994 • 231 citations

Differential expression of ARIA isoforms in the rat brain

1995 • 229 citations

Nicotinic acetylcholine receptors in vertebrate muscle: Properties, distribution and neural control

1985 • 229 citations

Neuregulins with an Ig-like domain are essential for mouse myocardial and neuronal development.

1996 • 228 citations

Purification and preliminary characterization of a glial growth factor from the bovine pituitary.

1980 • 225 citations

Structural and Functional Aspects of the Multiplicity of Neu Differentiation Factors

1994 • 220 citations

Immunological evidence for a change in subunits of the acetylcholine receptor in developing and denervated rat muscle

1988 • 218 citations

Detection of the nicotinic acetylcholine receptor alpha-subunit mRNA by in situ hybridization at neuromuscular junctions of 15-day-old chick striated muscles.

1988 • 217 citations

Acetylcholine receptor gene expression at the developing neuromuscular junction.

1995 • 215 citations

Structure-Function relationships for the EGF/TGF-α family of mitogens

1994 • 215 citations

Calcitonin gene-related peptide elevates cyclic AMP levels in chick skeletal muscle: possible neurotrophic role for a coexisting neuronal messenger.

1987 • 207 citations

Imprinting of acetylcholine receptor messenger RNA accumulation in mammalian neuromuscular synapses

1990 • 200 citations

The distribution of acetylcholine sensitivity at the post‐synaptic membrane of vertebrate skeletal twitch muscles: iontophoretic mapping in the micron range.

1975 • 184 citations

Purification and characterization of a polypeptide from chick brain that promotes the accumulation of acetylcholine receptors in chick myotubes.

1986 • 184 citations

Distinct isoforms of neuregulin are expressed in mesenchymal and neuronal cells during mouse development.

1994 • 180 citations

Selective expression of an acetylcholine receptor–lacZ transgene in synaptic nuclei of adult muscle fibers

1991 • 178 citations

Neuregulin receptors, erbB3 and erbB4, are localized at neuromuscular synapses.

1995 • 172 citations

A neuronal cell surface heparan sulfate proteoglycan is required for dorsal root ganglion neuron stimulation of Schwann cell proliferation.

1985 • 171 citations

Sensory and Motor Neuron-derived Factor. A NOVEL HEREGULIN VARIANT HIGHLY EXPRESSED IN SENSORY AND MOTOR NEURONS

1995 • 170 citations

Synapse-Associated Expression of an Acetylcholine Receptor-Inducing Protein, ARIA/Heregulin, and Its Putative Receptors, ErbB2 and ErbB3, in Developing Mammalian Muscle

1995 • 170 citations

Acetylcholine receptor-inducing activity stimulates expression of the epsilon-subunit gene of the muscle acetylcholine receptor.

1991 • 158 citations

The regulation of synaptogenesis during normal development and following activity blockade

1991 • 149 citations

Structural and functional aspects of the multiplicity of Neu differentiation factors.

1994 • 148 citations

Localization of nicotinic acetylcholine receptor alpha-subunit transcripts during myogenesis and motor endplate development in the chick.

1989 • 146 citations

Internal and external differentiations of the postsynaptic membrane at the neuromuscular junction

1982 • 144 citations

Heregulin Stimulates Mitogenesis and Phosphatidylinositol 3-Kinase in Mouse Fibroblasts Transfected with erbB2/neu and erbB3

1995 • 141 citations

On the contraction of muscle, chiefly in relation to the presence of ‘receptive’ substances

1907 • 139 citations

Dynamics of nerve-muscle interaction in developing and mature neuromuscular junctions

1995 • 137 citations

The neuronal cell-surface molecule mitogenic for Schwann cells is a heparin-binding protein.

1988 • 134 citations

Cell-specific cyclic AMP-mediated induction of the PDGF receptor.

1990 • 134 citations

Glial growth factor and nerve-dependent proliferation in the regeneration blastema of urodele amphibians

1986 • 133 citations

ErbB3 and ErbB2/neu mediate the effect of heregulin on acetylcholine receptor gene expression in muscle: differential expression at the endplate.

1995 • 131 citations

Spatial and temporal expression of acetylcholine receptor RNAs in innervated and denervated rat soleus muscle

1989 • 129 citations

ARIA can be released from extracellular matrix through cleavage of a heparin-binding domain.

1995 • 128 citations

Regulation of the acetylcholine receptor ϵ subunit gene by recombinant ARIA: An in vitro model for transynaptic gene regulation

1995 • 127 citations

The cytoplasmic carboxy-terminal amino acid specifies cleavage of membrane TGFα into soluble growth factor

1992 • 126 citations

Spatial restriction of AChR gene expression to subsynaptic nuclei

1992 • 122 citations

Neural expression and chromosomal mapping of Neu differentiation factor to 8p12-p21.

1993 • 119 citations

Schwann cells: early lineage, regulation of proliferation and control of myelin formation

1992 • 119 citations

A prion-like protein from chicken brain copurifies with an acetylcholine receptor-inducing activity.

1991 • 118 citations

Mediators of angiogenesis: the biological significance of basic fibroblast growth factor (bFGF)-heparin and heparan sulfate interactions.

1992 • 117 citations

Expression of theneuproto‐oncogene by schwann cells during peripheral nerve development and wallerian degeneration

1992 • 114 citations

On the mechanism of acetylcholine receptor accumulation at newly formed synapses on chick myotubes

1985 • 111 citations

Expression of multiple neuregulin transcripts in postnatal rat brains

1994 • 109 citations

The (Greek) Key to Structures of Neural Adhesion Molecules

1996 • 103 citations

Identification of a DNA element determining synaptic expression of the mouse acetylcholine receptor delta-subunit gene.

1995 • 101 citations

Purification of multiple forms of glial growth factor.

1993 • 99 citations

Fine structural distribution of acetylcholine receptors at developing mouse neuromuscular junctions

1983 • 96 citations

Acetylcholine receptor-inducing factor from chicken brain increases the level of mRNA encoding the receptor alpha subunit.

1988 • 93 citations

Sensitivity to Acetylcholine in Rat Slow Muscle

1966 • 93 citations

ARIA is concentrated in nerve terminals at neuromuscular junctions and at other synapses

1995 • 92 citations

The Structural Basis for the Specificity of Epidermal Growth Factor and Heregulin Binding

1995 • 91 citations

Biosynthetic Processing of neu Differentiation Factor

1995 • 89 citations

Na channel distribution in vertebrate skeletal muscle.

1986 • 87 citations

ARIA is concentrated in the synaptic basal lamina of the developing chick neuromuscular junction.

1995 • 86 citations

The development of functional neuromuscular junctionsin vitro: An ultrastructural and physiological study

1980 • 85 citations

The number of Na+ channels in cultured chick muscle is increased by ARIA, an acetylcholine receptor-inducing activity

1993 • 85 citations

Neural regulation of muscle acetylcholine receptor epsilon- and alpha-subunit gene promoters in transgenic mice.

1993 • 80 citations

Fluorescently labelled Na+ channels are localized and immobilized to synapses of innervated muscle fibres

1986 • 80 citations

Fibroblast Growth Factors and Insulin Growth Factors Combine to Promote Survival of Rat Schwann Cell Precursors Without Induction of DNA Synthesis

1995 • 79 citations

ARIA, a protein that stimulates acetylcholine receptor synthesis, also induces tyrosine phosphorylation of a 185-kDa muscle transmembrane protein.

1993 • 77 citations

Differential Expression Patterns of Five Acetylcholine Receptor Subunit Genes in Rat Muscle During Development

1995 • 68 citations

Induction of adult-type nicotinic acetylcholine receptor gene expression in noninnervated regenerating muscle

1991 • 64 citations

Neu Differentiation Factors: A Family of Alternatively Spliced Neuronal and Mesenchymal Factors

1994 • 63 citations

Mr 42,000 ARIA: A Protein That May Regulate the Accumulation of Acetylcholine Receptors at Developing Chick Neuromuscular Junctions

1990 • 60 citations

Synaptic basal lamina contains a signal for synapse-specific transcription

1992 • 60 citations

Synapse-specific expression of acetylcholine receptor genes and their products at original synaptic sites in rat soleus muscle fibres regenerating in the absence of innervation

1992 • 59 citations

Induction of acetylcholine receptor synthesis and aggregation: Partial purification of low-molecular-weight activity

1983 • 58 citations

The acetylcholine channel open time in chick muscle is not decreased following innervation.

1980 • 57 citations

An 83-nucleotide promoter of the acetylcholine receptor epsilon-subunit gene confers preferential synaptic expression in mouse muscle.

1993 • 56 citations

Aggregation of sodium channels during development and maturation of the neuromuscular junction

1993 • 54 citations

Local neurotrophic repression of gene transcripts encoding fetal AChRs at rat neuromuscular synapses.

1995 • 52 citations

Human schwann cells in vitro. II. Myelination of sensory axons following extensive purification and heregulin‐induced expansion

1995 • 49 citations

Solution structure of the epidermal growth factor-like domain of heregulin-alpha, a ligand for p180erbB-4.

1994 • 47 citations

Spatial distribution of acetylcholine receptors at developing chick neuromuscular junctions

1983 • 45 citations

Post-translational Processing of Membrane-associated neu Differentiation Factor Proisoforms Expressed in Mammalian Cells

1995 • 43 citations

Schwann cell heparan sulfate proteoglycans play a critical role in glial growth factor/neuregulin signaling

1996 • 41 citations

Autoradiographic localization of voltage-dependent sodium channels on the mouse neuromuscular junction using 125I-alpha scorpion toxin. II. Sodium distribution on postsynaptic membranes

1992 • 40 citations

Studies on the Structure and Function of Glycosylated and Nonglycosylated neu Differentiation Factors

1995 • 40 citations

Selective effects of ascorbic acid on acetylcholine receptor number and distribution.

1986 • 38 citations

Acetylcholine receptor expression in primary cultures of embryonic chick myotubes—I. Discoordinate regulation of α-, γ- and δ-subunit gene expression by calcitonin gene-related peptide and by muscle electrical activity

1989 • 38 citations

Nerve-Dependent Induction of AChR ϵ-Subunit Gene Expression in Muscle Is Independent of State of Differentiation

1994 • 28 citations

Normal development of nerve—muscle synapses in mice lacking the prion protein gene

1992 • 27 citations

Acetylcholine receptor expression in primary cultures of embryonic chick myotubes—II. Comparison between the effects of spinal cord cells and calcitonin gene-related peptide

1989 • 27 citations

Agrin: A Synaptic Basal Lamina Protein That Regulates Development of the Neuromuscular Junction

1992 • 18 citations

Sodium channels aggregate at former synaptic sites in innervated and denervated regenerating muscles

1994 • 18 citations

On safari with PrP: prion diseases of animals

1995 • 11 citations

The Pi Mu Epsilon Mathematical Fraternity

1923 • 1 citations