Targeting Transcription to the Neuromuscular Synapse

DEVELOPMENT OF THE VERTEBRATE NEUROMUSCULAR JUNCTION

1999 • 1,485 citations

ARIA, a protein that stimulates acetylcholine receptor synthesis, is a member of the neu ligand family

1993 • 612 citations

Expression of full-length utrophin prevents muscular dystrophy in mdx mice

1998 • 590 citations

Distinct roles of nerve and muscle in postsynaptic differentiation of the neuromuscular synapse

2001 • 519 citations

Patterning of Muscle Acetylcholine Receptor Gene Expression in the Absence of Motor Innervation

2001 • 463 citations

ETS Gene Er81 Controls the Formation of Functional Connections between Group Ia Sensory Afferents and Motor Neurons

2000 • 458 citations

A null mutation at the c-jun locus causes embryonic lethality and retarded cell growth in culture.

1993 • 393 citations

Rescue of the Cardiac Defect in ErbB2 Mutant Mice Reveals Essential Roles of ErbB2 in Peripheral Nervous System Development

1999 • 321 citations

Calcitonin gene-related peptide, a peptide present in spinal cord motoneurons, increases the number of acetylcholine receptors in primary cultures of chick embryo myotubes

1986 • 312 citations

The Structure of GABPα/β: An ETS Domain- Ankyrin Repeat Heterodimer Bound to DNA

1998 • 287 citations

Maintenance of Acetylcholine Receptor Number by Neuregulins at the Neuromuscular Junction in Vivo

1997 • 272 citations

Peripheral nervous system defects in erbB2 mutants following genetic rescue of heart development

1999 • 248 citations

Acetylcholine receptor gene expression at the developing neuromuscular junction.

1995 • 215 citations

The formation of neuromuscular synapses

1998 • 189 citations

Aberrant development of motor axons and neuromuscular synapses in erbB2-deficient mice

2000 • 181 citations

Physiological Regulation of the Immunological Synapse by Agrin

2001 • 177 citations

Cdk5 is involved in neuregulin-induced AChR expression at the neuromuscular junction

2001 • 171 citations

Synapse-Associated Expression of an Acetylcholine Receptor-Inducing Protein, ARIA/Heregulin, and Its Putative Receptors, ErbB2 and ErbB3, in Developing Mammalian Muscle

1995 • 170 citations

Implication of a multisubunit Ets-related transcription factor in synaptic expression of the nicotinic acetylcholine receptor

1998 • 153 citations

A Cysteine-Rich Isoform of Neuregulin Controls the Level of Expression of Neuronal Nicotinic Receptor Channels during Synaptogenesis

1998 • 143 citations

ARIA/HRG regulates AChR epsilon subunit gene expression at the neuromuscular synapse via activation of phosphatidylinositol 3-kinase and Ras/MAPK pathway.

1996 • 131 citations

ErbB3 and ErbB2/neu mediate the effect of heregulin on acetylcholine receptor gene expression in muscle: differential expression at the endplate.

1995 • 131 citations

Heregulin-stimulated acetylcholine receptor gene expression in muscle: requirement for MAP kinase and evidence for a parallel inhibitory pathway independent of electrical activity

1997 • 130 citations

Mice Lacking α-Calcitonin Gene-Related Peptide Exhibit Normal Cardiovascular Regulation and Neuromuscular Development

1999 • 125 citations

Induction of utrophin gene expression by heregulin in skeletal muscle cells: Role of the N-box motif and GA binding protein

1999 • 122 citations

Acetylcholine receptor-aggregating factor is similar to molecules concentrated at neuromuscular junctions

1985 • 117 citations

Agrin Can Mediate Acetylcholine Receptor Gene Expression in Muscle by Aggregation of Muscle-derived Neuregulins

1998 • 115 citations

Synapse Formation by Hippocampal Neurons from Agrin-Deficient Mice

1999 • 113 citations

Synapse-specific and neuregulin-induced transcription require an Ets site that binds GABPα/GABPβ

1998 • 112 citations

Activation of Utrophin Promoter by Heregulin via theets-related Transcription Factor Complex GA-binding Protein α/β

1999 • 108 citations

Induction of Acetylcholine Receptor Gene Expression by ARIA Requires Activation of Mitogen-activated Protein Kinase

1996 • 103 citations

Constitutively Active MuSK Is Clustered in the Absence of Agrin and Induces Ectopic Postsynaptic-Like Membranes in Skeletal Muscle Fibers

1999 • 102 citations

The Agrin/MuSK Signaling Pathway Is Spatially Segregated from the Neuregulin/ErbB Receptor Signaling Pathway at the Neuromuscular Junction

2000 • 102 citations

Identification of a DNA element determining synaptic expression of the mouse acetylcholine receptor delta-subunit gene.

1995 • 101 citations

Identification of an Element Crucial for the Sub-synaptic Expression of the Acetylcholine Receptor ε-Subunit Gene

1996 • 96 citations

Neu Differentiation Factor Stimulates Phosphorylation and Activation of the Sp1 Transcription Factor

1999 • 91 citations

An intronic enhancer containing an N-box motif is required for synapse- and tissue-specific expression of the acetylcholinesterase gene in skeletal muscle fibers

1999 • 87 citations

Mutation of the acetylcholine receptor ?-subunit promoter in congenital myasthenic syndrome

1999 • 86 citations

Congenital myasthenic syndrome caused by a mutation in the Ets-binding site of the promoter region of the acetylcholine receptor ϵ subunit gene

1999 • 85 citations

Substrate-bound agrin induces expression of acetylcholine receptor epsilon-subunit gene in cultured mammalian muscle cells.

1996 • 83 citations

The Ets Transcription Factor GABP Is Required for Postsynaptic Differentiation In Vivo

2000 • 76 citations

The PEA3 Ets transcription factor is a downstream target of the HER2/Neu receptor tyrosine kinase

1998 • 73 citations

Identification of a neuregulin and protein-tyrosine phosphatase response element in the nicotinic acetylcholine receptor ɛ subunit gene: Regulatory role of an Ets transcription factor

1998 • 60 citations

The GA-binding Protein Can Serve as Both an Activator and Repressor of ribosomal protein Gene Transcription

1996 • 55 citations

Modulation of morphine analgesia in αCGRP mutant mice

1999 • 55 citations

Essential Roles of c-JUN and c-JUN N-Terminal Kinase (JNK) in Neuregulin-Increased Expression of the Acetylcholine Receptor ε-Subunit

1999 • 48 citations

ERK MAP kinase activation is required for acetylcholine receptor inducing activity-induced increase in all five acetylcholine receptor subunit mRNAs as well as synapse-specific expression of acetylcholine receptor ε-transgene

1999 • 28 citations

Challenging the Neurocentric View of Neuromuscular Synapse Formation

2001 • 27 citations

The acetylcholine receptor

1979 • 15 citations

Strategy and prospects in neuroscience

1987 • 11 citations