Conditional mutation of the ErbB2 (HER2) receptor in cardiomyocytes leads to dilated cardiomyopathy

Use of Chemotherapy plus a Monoclonal Antibody against HER2 for Metastatic Breast Cancer That Overexpresses HER2

2001 • 11,070 citations

Untangling the ErbB signalling network

2001 • 6,623 citations

EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF

1999 • 1,484 citations

Multiple essential functions of neuregulin in development

1995 • 1,236 citations

The Genetic Basis for Cardiomyopathy

2001 • 1,049 citations

Molecular and Cellular Mechanisms of Cardiac Arrhythmias

2001 • 998 citations

Signaling Pathways for Cardiac Hypertrophy and Failure

1999 • 867 citations

Loss of a gp130 Cardiac Muscle Cell Survival Pathway Is a Critical Event in the Onset of Heart Failure during Biomechanical Stress

1999 • 666 citations

Nonclinical studies addressing the mechanism of action of trastuzumab (Herceptin).

1999 • 650 citations

Z/AP, a Double Reporter for Cre-Mediated Recombination

1999 • 539 citations

Impairment of the myocardial ultrastructure and changes of the cytoskeleton in dilated cardiomyopathy.

1991 • 517 citations

Neuregulins Promote Survival and Growth of Cardiac Myocytes

1998 • 493 citations

Cell communication networks: epidermal growth factor receptor transactivation as the paradigm for interreceptor signal transmission

2001 • 463 citations

Stress Pathways and Heart Failure

1999 • 463 citations

Receptor-mediated Regulation of the Nonselective Cation Channels TRPC4 and TRPC5

2000 • 422 citations

Absence of pressure overload induced myocardial hypertrophy after conditional inactivation of Gαq/Gα11 in cardiomyocytes

2001 • 372 citations

Binding specificities and affinities of egf domains for ErbB receptors

1999 • 370 citations

The ErbB2 and ErbB3 receptors and their ligand, neuregulin-1, are essential for development of the sympathetic nervous system

1998 • 334 citations

Examination of the Transverse Tubular System in Living Cardiac Rat Myocytes by 2-Photon Microscopy and Digital Image–Processing Techniques

1999 • 328 citations

Analysis of ATF3, a Transcription Factor Induced by Physiological Stresses and Modulated by gadd153/Chop10

1996 • 305 citations

Molecular targets for breast cancer therapy and prevention

2001 • 292 citations

ERBIN: a basolateral PDZ protein that interacts with the mammalian ERBB2/HER2 receptor

2000 • 289 citations

Neuregulin, a factor with many functions in the life of a Schwann cell

2000 • 282 citations

The role of cytoskeletal proteins in cardiomyopathies

1998 • 275 citations

A Dual Role oferbB2in Myelination and in Expansion of the Schwann Cell Precursor Pool

2000 • 260 citations

Neuregulins in Development

1996 • 229 citations

Expression profiling reveals distinct sets of genes altered during induction and regression of cardiac hypertrophy

2000 • 209 citations

Dilated and Failing Cardiomyopathy in Bradykinin B ₂ Receptor Knockout Mice

1999 • 172 citations

Selective Requirement of Myosin Light Chain 2v in Embryonic Heart Function

1998 • 172 citations

The internal and external protein scaffold of the T-tubular system in cardiomyocytes

1998 • 141 citations

Ablation of Serotonin 5-HT _2B Receptors in Mice Leads to Abnormal Cardiac Structure and Function

2001 • 136 citations

Cardiotoxicity in patients receiving transtuzumab (Herceptin): primary toxicity, synergistic or sequential stress, or surveillance artifact?

1999 • 133 citations

Neuregulin in Cardiac Hypertrophy in Rats With Aortic Stenosis

1999 • 130 citations

Growth Factor-specific Signaling Pathway Stimulation and Gene Expression Mediated by ErbB Receptors

2001 • 122 citations

Should Dukes' B patients receive adjuvant therapy? A statistical perspective

2001 • 105 citations

Clinical, histochemical, and ultrastructural correlation in septal endomyocardial biopsies from chronic chagasic patients: Detection of early myocardial damage

1987 • 101 citations

Transgenic Mice with Cardiac-Specific Expression of Activating Transcription Factor 3, a Stress-Inducible Gene, Have Conduction Abnormalities and Contractile Dysfunction

2001 • 100 citations

Cardiac toxicity of trastuzumab (Herceptin): Implications for the design of adjuvant trials

2001 • 94 citations

Acute Suppression of Inwardly Rectifying Kir2.1 Channels by Direct Tyrosine Kinase Phosphorylation

1998 • 93 citations

Synergistic Roles of Neuregulin-1 and Insulin-like Growth Factor-I in Activation of the Phosphatidylinositol 3-Kinase Pathway and Cardiac Chamber Morphogenesis

1999 • 89 citations

The ERBB2/HER2 Receptor Differentially Interacts with ERBIN and PICK1 PSD-95/DLG/ZO-1 Domain Proteins

2001 • 87 citations

Identification of Genes Regulated During Mechanical Load-induced Cardiac Hypertrophy

2000 • 77 citations

Genetically Engineered Models with Alterations in Cardiac Membrane Calcium-Handling Proteins

2000 • 76 citations

Localization and modulation of ErbB receptor tyrosine kinases

2001 • 54 citations

Human myocardial morphologic and functional changes in the first 24 hours after doxorubicin administration.

1981 • 53 citations

A Post-transcriptional Compensatory Pathway in Heterozygous Ventricular Myosin Light Chain 2-Deficient Mice Results in Lack of Gene Dosage Effect during Normal Cardiac Growth or Hypertrophy

1999 • 45 citations

Epidermal Growth Factor Produces Inotropic and Chronotropic Effects in Rat Hearts by Increasing Cyclic AMP Accumulation

1993 • 39 citations

Epidermal growth factor increases if in rabbit SA node cells by activating a tyrosine kinase

2000 • 35 citations

Cardiomyopathies and their role in sudden death

1985 • 24 citations

The current role and future prospects of paclitaxel in the treatment of small cell lung cancer.

1999 • 17 citations