From JNK to Pay Dirt: Jun Kinases, their Biochemistry, Physiology and Clinical Importance

Phosphorylation Meets Ubiquitination: The Control of NF-κB Activity

2000 • 4,644 citations

Signal Transduction by the JNK Group of MAP Kinases

2000 • 4,096 citations

The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation

1991 • 3,396 citations

A central role for JNK in obesity and insulin resistance

2002 • 3,225 citations

JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain

1994 • 3,219 citations

Atherosclerosis

2001 • 2,982 citations

The stress-activated protein kinase subfamily of c-Jun kinases

1994 • 2,616 citations

Induction of Apoptosis by ASK1, a Mammalian MAPKKK That Activates SAPK/JNK and p38 Signaling Pathways

1997 • 2,284 citations

Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain.

1993 • 1,902 citations

Reactive Oxygen Species Promote TNFα-Induced Death and Sustained JNK Activation by Inhibiting MAP Kinase Phosphatases

2005 • 1,727 citations

AP-1 in cell proliferation and survival

2001 • 1,686 citations

Phosphorylation of c-jun mediated by MAP kinases

1991 • 1,495 citations

Transcription Factor ATF2 Regulation by the JNK Signal Transduction Pathway

1995 • 1,453 citations

The c-Jun NH2-terminal Kinase Promotes Insulin Resistance during Association with Insulin Receptor Substrate-1 and Phosphorylation of Ser307

2000 • 1,423 citations

Selective interaction of JNK protein kinase isoforms with transcription factors.

1996 • 1,333 citations

Identification of a Member of the MAPKKK Family as a Potential Mediator of TGF-β Signal Transduction

1995 • 1,318 citations

The jun proto-oncogene is positively autoregulated by its product, Jun/AP-1

1988 • 1,256 citations

Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene

1997 • 1,229 citations

ASK1 is required for sustained activations of JNK/p38 MAP kinases and apoptosis

2001 • 1,181 citations

Self-perpetuating states in signal transduction: positive feedback, double-negative feedback and bistability

2002 • 1,107 citations

Differential Activation of ERK and JNK Mitogen-Activated Protein Kinases by Raf-1 and MEKK

1994 • 1,092 citations

Molecular Mechanisms RegulatinG Th1 Immune Responses

2003 • 1,005 citations

Phosphorylation of Ser307 in Insulin Receptor Substrate-1 Blocks Interactions with the Insulin Receptor and Inhibits Insulin Action

2002 • 973 citations

JNK is involved in signal integration during costimulation of T lymphocytes

1994 • 929 citations

IRS proteins and the common path to diabetes

2002 • 907 citations

The Jnk1 and Jnk2 Protein Kinases Are Required for Regional Specific Apoptosis during Early Brain Development

1999 • 888 citations

The mammalian ultraviolet response is triggered by activation of src tyrosine kinases

1992 • 874 citations

β-Arrestin 2: A Receptor-Regulated MAPK Scaffold for the Activation of JNK3

2000 • 804 citations

A conserved docking motif in MAP kinases common to substrates, activators and regulators

2000 • 801 citations

Oncogenic and transcriptional cooperation with Ha-Ras requires phosphorylation of c-Jun on serines 63 and 73

1991 • 800 citations

c-Jun N-terminal kinase is required for metalloproteinase expression and joint destruction in inflammatory arthritis

2001 • 772 citations

Regulation of MAP Kinase Signaling Modules by Scaffold Proteins in Mammals

2003 • 766 citations

Inflammatory pathways and insulin action

2003 • 716 citations

A Cytoplasmic Inhibitor of the JNK Signal Transduction Pathway

1997 • 678 citations

A Mammalian Scaffold Complex That Selectively Mediates MAP Kinase Activation

1998 • 653 citations

JNK2 contains a specificity-determining region responsible for efficient c-Jun binding and phosphorylation.

1994 • 639 citations

Ha-Ras augments c-Jun activity and stimulates phosphorylation of its activation domain

1991 • 626 citations

Cargo of Kinesin Identified as Jip Scaffolding Proteins and Associated Signaling Molecules

2001 • 593 citations

Defective T Cell Differentiation in the Absence of Jnk1

1998 • 590 citations

Transcriptional regulation of the IL-2 gene

1995 • 579 citations

c-Jun Can Recruit JNK to Phosphorylate Dimerization Partners via Specific Docking Interactions

1996 • 495 citations

Withdrawal of Survival Factors Results in Activation of the JNK Pathway in Neuronal Cells Leading to Fas Ligand Induction and Cell Death

1999 • 472 citations

JNK phosphorylates paxillin and regulates cell migration

2003 • 461 citations

Differentiation of CD4+ T Cells to Th1 Cells Requires MAP Kinase JNK2

1998 • 454 citations

Transcriptional regulation by MAP kinases

1995 • 431 citations

The tumor promoter arsenite stimulates AP-1 activity by inhibiting a JNK phosphatase.

1996 • 419 citations

A JNK signal transduction pathway that mediates morphogenesis and an immune response in Drosophila.

1996 • 407 citations

JNK-mediated induction of cyclooxygenase 2 is required for neurodegeneration in a mouse model of Parkinson's disease

2004 • 406 citations

Structural organization of MAP-kinase signaling modules by scaffold proteins in yeast and mammals

1998 • 395 citations

A critical role of neural-specific JNK3 for ischemic apoptosis

2003 • 395 citations

Jun Turnover Is Controlled Through JNK-Dependent Phosphorylation of the E3 Ligase Itch

2004 • 386 citations

Distinct Roles for JNK1 and JNK2 in Regulating JNK Activity and c-Jun-Dependent Cell Proliferation

2004 • 374 citations

A global response to a global problem : the epidemic of overnutrition.

2002 • 373 citations

JNK1 Is Required for Maintenance of Neuronal Microtubules and Controls Phosphorylation of Microtubule-Associated Proteins

2003 • 368 citations

Regulation of IL-4 expression by the transcription factor JunB during T helper cell differentiation

1999 • 364 citations

Oncoprotein-mediated signalling cascade stimulates c-Jun activity by phosphorylation of serines 63 and 73.

1992 • 343 citations

Dysregulation of T lymphocyte function in itchy mice: a role for Itch in TH2 differentiation

2002 • 326 citations

JNK is required for effector T-cell function but not for T-cell activation

2000 • 322 citations

The PHD Domain of MEKK1 Acts as an E3 Ubiquitin Ligase and Mediates Ubiquitination and Degradation of ERK1/2

2002 • 314 citations

MLK-3 activates the SAPK/JNK and p38/RK pathways via SEK1 and MKK3/6.

1996 • 314 citations

The regulation of AP-1 activity by mitogen-activated protein kinases

1996 • 312 citations

MAP kinase phosphatases.

2002 • 311 citations

Crystal Structures of MAP Kinase p38 Complexed to the Docking Sites on Its Nuclear Substrate MEF2A and Activator MKK3b

2002 • 309 citations

Activation of MEK-1 and SEK-1 by Tpl-2 proto-oncoprotein, a novel MAP kinase kinase kinase.

1996 • 308 citations

MEK kinases are regulated by EGF and selectively interact with Rac/Cdc42

1997 • 300 citations

Interaction of a Mitogen-Activated Protein Kinase Signaling Module with the Neuronal Protein JIP3

2000 • 278 citations

UV-induced signal transduction

1997 • 277 citations

Requirement of JNK2 for Scavenger Receptor A-Mediated Foam Cell Formation in Atherogenesis

2004 • 277 citations

JSAP1, a Novel Jun N-Terminal Protein Kinase (JNK)-Binding Protein That Functions as a Scaffold Factor in the JNK Signaling Pathway

1999 • 272 citations

1. Signal transduction by the c-Jun N-terminal kinase

1999 • 264 citations

Structural basis for the selective inhibition of JNK1 by the scaffolding protein JIP1 and SP600125

2004 • 262 citations

Targeting the JNK MAPK cascade for inhibition: basic science and therapeutic potential

2003 • 261 citations

Ubiquitous and lymphocyte-specific factors are involved in the induction of the mouse interleukin 2 gene in T lymphocytes.

1989 • 256 citations

Regulation of innate and adaptive immune responses by MAP kinase phosphatase 5

2004 • 247 citations

The control of cell motility and epithelial morphogenesis by Jun kinases

2004 • 243 citations

Physiological Roles of ASK1-Mediated Signal Transduction in Oxidative Stress- and Endoplasmic Reticulum Stress-Induced Apoptosis: Advanced Findings from ASK1 Knockout Mice

2002 • 243 citations

Cloning of a Novel Mitogen-activated Protein Kinase Kinase Kinase, MEKK4, That Selectively Regulates the c-Jun Amino Terminal Kinase Pathway

1997 • 242 citations

Bistability in the JNK cascade

2001 • 237 citations

Requirement of the JIP1 scaffold protein for stress-induced JNK activation

2001 • 230 citations

The Role of Cell Death in Regulating the Size and Shape of the Mammalian Forebrain

1999 • 229 citations

Molecular Cloning of Mitogen-activated Protein/ERK Kinase Kinases (MEKK) 2 and 3

1996 • 227 citations

The JNK Pathway Regulates the In Vivo Deletion of Immature CD4+CD8+ Thymocytes

1998 • 221 citations

C-Jun Nh2-Terminal Kinase (Jnk)1 and Jnk2 Have Similar and Stage-Dependent Roles in Regulating T Cell Apoptosis and Proliferation

2001 • 219 citations

Molecular Cloning and Characterization of a Novel Dual Specificity Phosphatase, MKP-5

1999 • 216 citations

Akt1 Regulates a JNK Scaffold during Excitotoxic Apoptosis

2002 • 206 citations

Identification of Promoters Bound by c-Jun/ATF2 during Rapid Large-Scale Gene Activation following Genotoxic Stress

2004 • 203 citations

JNKK1 organizes a MAP kinase module through specific and sequential interactions with upstream and downstream components mediated by its amino-terminal extension

1998 • 201 citations

Synergistic activation of SAPK1/JNK1 by two MAP kinase kinases in vitro

1998 • 196 citations

The gene MAPK8IP1, encoding islet-brain-1, is a candidate for type 2 diabetes

2000 • 180 citations

A role for MEK kinase 1 in TGF- /activin-induced epithelium movement and embryonic eyelid closure

2003 • 176 citations

Actin-biding Protein-280 Binds the Stress-activated Protein Kinase (SAPK) Activator SEK-1 and Is Required for Tumor Necrosis Factor-α Activation of SAPK in Melanoma Cells

1997 • 169 citations

How does the immune system distinguish self from nonself?

2000 • 162 citations

Jun N-terminal kinase in rheumatoid arthritis.

1999 • 155 citations

Tobacco and obesity epidemics: not so different after all?

2004 • 149 citations

MKP5, a new member of the MAP kinase phosphatase family, which selectively dephosphorylates stress-activated kinases

1999 • 145 citations

Isolation of TAO1, a Protein Kinase That Activates MEKs in Stress-activated Protein Kinase Cascades

1998 • 142 citations

The JNK Cascade as a Biochemical Switch in Mammalian Cells

2003 • 141 citations

Dual Leucine Zipper-bearing Kinase (DLK) Activates p46SAPK and p38 but Not ERK2

1996 • 140 citations

c-Jun NH2-Terminal Kinase (JNK)1 and JNK2 Have Distinct Roles in CD8+ T Cell Activation

2002 • 137 citations

Th2 cell-specific cytokine expression and allergen-induced airway inflammation depend on JunB

2002 • 137 citations

JLP: A scaffolding protein that tethers JNK/p38MAPK signaling modules and transcription factors

2002 • 133 citations

Mitogen-activated Protein Kinase Phosphatases Inactivate Stress-activated Protein Kinase Pathways in Vivo

1997 • 132 citations

Activation of the JNK pathway by distantly related protein kinases, MEKK and MUK.

1996 • 130 citations

In vivo protein-DNA interactions at the c-jun promoter: preformed complexes mediate the UV response.

1993 • 128 citations

C-Jun NH(2)-terminal kinase mediates proliferation and tumor growth of human prostate carcinoma.

2003 • 118 citations

An essential role of the JIP1 scaffold protein for JNK activation in adipose tissue

2004 • 118 citations

Joint damage and inflammation in c‐Jun N‐terminal kinase 2 knockout mice with passive murine collagen‐induced arthritis

2002 • 115 citations

Protective Role for c-Jun in the Cellular Response to DNA Damage

2001 • 114 citations

MEKK1 Binds Directly to the c-Jun N-terminal Kinases/Stress-activated Protein Kinases

1997 • 111 citations

A Novel Specific Role for IκB Kinase Complex-associated Protein in Cytosolic Stress Signaling

2002 • 105 citations

The JNK-interacting Protein-1 Scaffold Protein Targets MAPK Phosphatase-7 to Dephosphorylate JNK

2003 • 102 citations

Recognition of ERK MAP kinase by PEA-15 reveals a common docking site within the death domain and death effector domain

2002 • 101 citations

Activation of the Drosophila MLK by Ceramide Reveals TNF-α and Ceramide as Agonists of Mammalian MLK3

2002 • 98 citations

Isolation of the Protein Kinase TAO2 and Identification of Its Mitogen-activated Protein Kinase/Extracellular Signal-regulated Kinase Kinase Binding Domain

1999 • 96 citations

MEKK1 interacts with ?-actinin and localizes to stress fibers and focal adhesions

1999 • 93 citations

Ubiquitylation of MEKK1 Inhibits Its Phosphorylation of MKK1 and MKK4 and Activation of the ERK1/2 and JNK Pathways

2003 • 93 citations

c-Jun NH2-Terminal Kinase (JNK)1 and JNK2 Signaling Pathways Have Divergent Roles in CD8+ T Cell–mediated Antiviral Immunity

2002 • 85 citations

RhoA Binds to the Amino Terminus of MEKK1 and Regulates Its Kinase Activity

2004 • 83 citations

The Death Effector Domain Protein PEA-15 Prevents Nuclear Entry of ERK2 by Inhibiting Required Interactions

2004 • 81 citations

Activation of JNK3α1 Requires both MKK4 and MKK7: Kinetic Characterization of in Vitro Phosphorylated JNK3α1

2000 • 78 citations

Synergistic Interaction of MEK Kinase 2, c-Jun N-Terminal Kinase (JNK) Kinase 2, and JNK1 Results in Efficient and Specific JNK1 Activation

2000 • 74 citations

A direct interaction between JNK1 and CrkII is critical for Rac1-induced JNK activation

2001 • 64 citations

MAPKKK6, a Novel Mitogen-Activated Protein Kinase Kinase Kinase, That Associates with MAPKKK5

1998 • 64 citations

cDNA Cloning and Mapping of a Novel Islet-Brain/JNK-Interacting Protein

2000 • 63 citations

Binding of JNK/SAPK to MEKK1 Is Regulated by Phosphorylation

2002 • 56 citations

Differential interaction of nuclear factors with the PRE-I enhancer element of the human IL-4 promoter in different T cell subsets.

1997 • 53 citations

Embryonic morphogenesis signaling pathway mediated by JNK targets the transcription factor JUN and the TGF-β homologuedecapentaplegic

1997 • 52 citations

p115 Rho GTPase activating protein interacts with MEKK1

2002 • 41 citations

Molecular Basis of T-cell Differentiation

1999 • 31 citations

Structure of MAPKs

2004 • 24 citations

Gene Therapy Approaches to Sensitization of Human Prostate Carcinoma to Cisplatin by Adenoviral Expression of p53 and by Antisense Jun Kinase Oligonucleotide Methods

2003 • 8 citations