Antitumor promotion and antiinflammation: Down-modulation of AP-1 (Fos/Jun) activity by glucocorticoid hormone

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Molecular Cloning: A Laboratory Manual

2001 • 133,517 citations

A new technique for the assay of infectivity of human adenovirus 5 DNA

1973 • 9,740 citations

Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells.

1982 • 8,069 citations

The Steroid and Thyroid Hormone Receptor Superfamily

1988 • 7,590 citations

Gene regulation by steroid hormones

1989 • 3,466 citations

Transcriptional Regulation in Mammalian Cells by Sequence-Specific DNA Binding Proteins

1989 • 3,219 citations

Stimulation of 3T3 cells induces transcription of the c-fos proto-oncogene

1984 • 3,150 citations

Phorbol ester-inducible genes contain a common cis element recognized by a TPA-modulated trans-acting factor

1987 • 3,057 citations

Sizing and mapping of early adenovirus mRNAs by gel electrophoresis of S1 endonuclease-digested hybrids

1977 • 3,019 citations

Electroblotting of multiple gels: a simple apparatus without buffer tank for rapid transfer of proteins from polycrylamide to nitrocellulose

1984 • 2,553 citations

Analysis of single- and double-stranded nucleic acids on polyacrylamide and agarose gels by using glyoxal and acridine orange.

1977 • 2,408 citations

How eukaryotic transcriptional activators work

1988 • 1,924 citations

CAT constructions with multiple unique restriction sites for the functional analysis of eukaryotic promoters and regulatory elements

1987 • 1,792 citations

Fos and jun: The AP-1 connection

1988 • 1,597 citations

Proteases and biological control

1976 • 1,380 citations

The Rous sarcoma virus long terminal repeat is a strong promoter when introduced into a variety of eukaryotic cells by DNA-mediated transfection.

1982 • 1,371 citations

The c-fos protein interacts with c-JunAP-1 to stimulate transcription of AP-1 responsive genes

1988 • 1,352 citations

Control of Cachectin (Tumor Necrosis Factor) Synthesis: Mechanisms of Endotoxin Resistance

1986 • 1,305 citations

c-Jun dimerizes with itself and with c-Fos, forming complexes of different DNA binding affinities

1988 • 1,084 citations

Characterization of DNA sequences through which cadmium and glucocorticoid hormones induce human metallothionein-IIA gene

1984 • 955 citations

Platelet-derived growth factor induces rapid but transient expression of the c-fos gene and protein

1984 • 949 citations

Oncogene jun encodes a sequence-specific trans- activator similar to AP-1

1988 • 940 citations

Functional domains of the human glucocorticoid receptor

1986 • 933 citations

Anti-inflammatory steroids induce biosynthesis of a phospholipase A2 inhibitor which prevents prostaglandin generation

1979 • 928 citations

Multiple hormone interactions in the developmental biology of the mammary gland.

1980 • 866 citations

The role of the leucine zipper in the fos–jun interaction

1988 • 836 citations

Prolonged activation of jun and collagenase genes by tumour necrosis factor-α

1989 • 726 citations

Multiple and cooperative trans-activation domains of the human glucocorticoid receptor

1988 • 705 citations

12-O-tetradecanoyl-phorbol-13-acetate induction of the human collagenase gene is mediated by an inducible enhancer element located in the 5'-flanking region.

1987 • 699 citations

DNA sequences bound specifically by glucocorticoid receptor in vitro render a heterologous promoter hormone responsive in vivo

1983 • 692 citations

Transcription activation by the adenovirus E1a protein

1989 • 667 citations

Direct visualization of binding, aggregation, and internalization of insulin and epidermal growth factor on living fibroblastic cells

1978 • 647 citations

Disappearance of Ca2+-sensitive, phospholipid-dependent protein kinase activity in phorbol ester-treated 3T3 cells

1984 • 643 citations

The glucocorticoid receptor binds to defined nucleotide sequences near the promoter of mouse mammary tumour virus

1983 • 619 citations

Requirement for fos gene expression in the transcriptional activation of collagenase by other oncogenes and phorbol esters

1988 • 597 citations

Steroid hormone receptors compete for factors that mediate their enhancer function

1989 • 580 citations

UV-induced DNA damage is an intermediate step in UV-induced expression of human immunodeficiency virus type 1, collagenase, c-fos, and metallothionein.

1989 • 549 citations

Inhibition of phospholipase A2 by "lipocortins" and calpactins. An effect of binding to substrate phospholipids.

1987 • 534 citations

Colocalization of DNA-binding and transcriptional activation functions in the human glucocorticoid receptor

1987 • 512 citations

Glucocorticoids selectively inhibit the transcription of the interleukin 1 beta gene and decrease the stability of interleukin 1 beta mRNA.

1988 • 510 citations

fos-associated cellular p39 is related to nuclear transcription factor AP-1

1988 • 508 citations

Three amino acids of the oestrogen receptor are essential to its ability to distinguish an oestrogen from a glucocorticoid-responsive element

1989 • 507 citations

Tissue effects of glucocorticoids

1972 • 503 citations

Negative Regulation by Glucocorticoids Through Interference with a cAMP Responsive Enhancer

1988 • 502 citations

Hormone-mediated repression: a negative glucocorticoid response element from the bovine prolactin gene.

1988 • 485 citations

New procedure for DNA transfection with polycation and dimethyl sulfoxide.

1984 • 481 citations

Comparison of human stromelysin and collagenase by cloning and sequence analysis

1986 • 443 citations

Identification and characterization of HAP4: a third component of the CCAAT-bound HAP2/HAP3 heteromer.

1989 • 432 citations

Mutually exclusive interaction of the CCAAT-binding factor and of a displacement protein with overlapping sequences of a histone gene promoter

1987 • 407 citations

The hormone regulatory element of mouse mammary tumour virus mediates progesterone induction.

1986 • 406 citations

Macrophage plasminogen activator: Modulation of enzyme production by anti-inflammatory steroids, mitotic inhibitors, and cyclic nucleotides

1976 • 405 citations

Textbook of endocrinology

1982 • 388 citations

Cocarcinogenic principles from the seed oil of Croton tiglium and from other Euphorbiaceae.

1968 • 376 citations

Diversity in the lipocortin/calpactin family

1988 • 376 citations

A DNA sequence of 15 base pairs is sufficient to mediate both glucocorticoid and progesterone induction of gene expression.

1987 • 360 citations

Functional dissection of the hormone and DNA binding activities of the glucocorticoid receptor.

1987 • 299 citations

Definition of multiple, functionally distinct TATA elements, one of which is a target in the hsp70 promoter for E1A regulation

1988 • 292 citations

INHIBITION OF PHOSPHOLIPASE

1983 • 284 citations

Dexamethasone-mediated induction of mouse mammary tumor virus RNA: a system for studying glucocorticoid action

1975 • 284 citations

Inflammation: Basic Principles and Clinical Correlates

1988 • 275 citations

Activation of the c-fos gene by UV and phorbol ester: different signal transduction pathways converge to the same enhancer element.

1988 • 271 citations

Prolactin and glucocorticoid hormones synergistically induce expression of transfected rat beta-casein gene promoter constructs in a mammary epithelial cell line.

1989 • 257 citations

Steroid receptor-mediated inhibition of rat prolactin gene expression does not require the receptor DNA-binding domain

1988 • 238 citations

Subfragments of the large terminal repeat cause glucocorticoid-responsive expression of mouse mammary tumor virus and of an adjacent gene.

1983 • 238 citations

Down-regulation and Phosphorylation of Glucocorticoid Receptors in Cultured Cells

1989 • 223 citations

Transcription from the stromelysin promoter is induced by interleukin-1 and repressed by dexamethasone.

1987 • 217 citations

Binding of the virion protein mediating alpha gene induction in herpes simplex virus 1-infected cells to its cis site requires cellular proteins.

1987 • 217 citations

Posttranscriptional regulation of c-fos mRNA expression

1987 • 215 citations

Induction of metallothionein and other mRNA species by carcinogens and tumor promoters in primary human skin fibroblasts.

1986 • 215 citations

A small region of the mouse mammary tumor virus long terminal repeat confers glucocorticoid hormone regulation on a linked heterologous gene.

1983 • 213 citations

Autoregulation of fos: the dyad symmetry element as the major target of repression.

1989 • 211 citations

Differential gene activation by glucocorticoids and progestins through the hormone regulatory element of mouse mammary tumor virus

1988 • 205 citations

E1A 13S and 12S mRNA Products Made in Escherichia coli Both Function as Nucleus-Localized Transcription Activators but Do Not Directly Bind DNA

1985 • 190 citations

UASs and enhancers: Common mechanism of transcriptional activation in yeast and mammals

1988 • 187 citations

Steroid-free glucocorticoid receptor binds specifically to mouse mammary tumour virus DNA

1986 • 185 citations

DNA sequences outside the receptor-binding sites differently modulate the responsiveness of the mouse mammary tumour virus promoter to various steroid hormones.

1988 • 184 citations

Specific binding of the glucocorticoid-receptor complex to the mouse mammary tumor proviral promoter region

1982 • 181 citations

Isolation of lymphoma cell variants resistant to killing by glucocorticoids

1974 • 176 citations

Glucocorticoids and Transaminase Activity

1963 • 160 citations

The Purified Activated Glucocorticoid Receptor is a Homodimer

1989 • 156 citations

Co-localization of elements required for phorbol ester stimulation and glucocorticoid repression of proliferin gene expression.

1989 • 154 citations

Glucocorticoid receptors recognize DNA sequences in and around murine mammary tumour virus DNA.

1982 • 153 citations

The inhibition of croton oil-promoted mouse skin tumorigenesis by steroid hormones.

1972 • 145 citations

A novel function of the transforming domain of E1a: Repression of AP-1 activity

1990 • 142 citations

The Fos and Jun/AP-1 proteins are involved in the downregulation of Fos transcription.

1989 • 135 citations

Transcriptional inhibition by a glucocorticoid receptor-β-galactosidase fusion protein

1988 • 129 citations

Effects of antiinflammatory agents on mouse skin tumor promotion, epidermal DNA synthesis, phorbol ester-induced cellular proliferation, and production of plasminogen activator.

1977 • 117 citations

Enhancer and promoter elements directing activation and glucocorticoid repression of the alpha 1-fetoprotein gene in hepatocytes.

1988 • 110 citations

A specific 15-bp TATA box promoter element is required for expression of a herpes simplex virus type 1 late gene.

1988 • 98 citations

Ha-ras and c-myc oncogene expression interferes with morphological and functional differentiation of mammary epithelial cells in single and double transgenic mice.

1988 • 87 citations

Suppression of urokinase-type plasminogen activator mRNA levels in human fibrosarcoma cells and synovial fibroblasts by anti-inflammatory glucocorticoids.

1986 • 85 citations

‘Nuclear’ oncogenes convert extracellular stimuli into changes in the genetic program

1989 • 83 citations

Glucocorticoid-receptor interaction and induction of murine mammary tumor virus.

1975 • 76 citations

Genes and Signal Transduction in Multistage Carcinogenesis

1990 • 73 citations

A growth factor-repressible gene associated with protein kinase C-mediated inhibition of adipocyte differentiation.

1988 • 73 citations

Glucocorticoid Receptors and Glucocorticoid-Sensitive Secretion of Neutral Proteinases in a Macrophage Line

1978 • 72 citations

Kinetics of steroid induction and deinduction of tyrosine aminotransferase synthesis in cultured hepatoma cells.

1975 • 65 citations

E1A 13S and 12S mRNA products made in Escherichia coli both function as nucleus-localized transcription activators but do not directly bind DNA.

1985 • 62 citations

Similar effects of adenovirus E1A and glucocorticoid hormones on the expression of the metalloprotease stromelysin

1988 • 60 citations

Liver cell specific gene transcriptionin vitro: the promoter elements HP1 and TATA box are necessary and sufficient to generate a liver-specific promoter

1989 • 57 citations

Regulation of glutamine synthetase by dexamethasone in hepatoma tissue culture cells.

1978 • 54 citations

Glucocorticoid resistance in humans and nonhuman primates.

1989 • 54 citations

Multiple effects of dexamethasone on protein synthesis and hyperplasia caused by a tumor promoter.

1973 • 49 citations

Mechanisms of the ultraviolet light response in mammalian cells*

1989 • 45 citations

Glucocorticoid antagonists

1987 • 38 citations

12-O-tetradecanoylphorbol 13-acetate-inducible proteins are synthesized at an increased rate in Bloom syndrome fibroblasts.

1982 • 34 citations

An Update of the Mammalian UV Response: Gene Regulation and Induction of a Protective Function

1989 • 29 citations

Glucocorticoid inhibition of the fibrinolytic activity of tumor cells

1975 • 28 citations

Induction of metallothionein mRNA by tumor promoters in mouse skin and its constitutive expression in papillomas

1989 • 25 citations

Nuclear Oncoproteins Determine the Genetic Program in Response to External Stimuli

1988 • 24 citations

Differential modulation of gene induction by glucocorticoids and antiglucocorticoids in rat hepatoma tissue culture cells.

1989 • 21 citations

jun: Oncogene and Transcriptional Regulator

1988 • 20 citations

Physiological action and receptor binding of a newly synthesized and novel antiglucocorticoid

1986 • 20 citations

Mechanisms and consequences of DNA damage processing

1989 • 16 citations

Immunopathogenetic Mechanisms of Arthritis

1988 • 15 citations

Vectors as Tools for the Study of Normal and Abnormal Growth and Differentiation

1989 • 12 citations

Immunopathogenetic mechanisms of arthritis and modes of action of antirheumatic therapies

1988 • 10 citations

A Major Decision: Proliferation or Differentiation. Interactions Between Pathwayspecific Transcription Factors Exemplify a Molecular Mechanism for the Decision

1990 • 4 citations

Two Nuclear Oncogene Products Cooperate in the Formation of the Transcription Factor Ap-1

1989 • 2 citations