Neutral proteases and disruption of the blood–brain barrier in rat

Intravenous thrombolysis with recombinant tissue plasminogen activator for acute hemispheric stroke. The European Cooperative Acute Stroke Study (ECASS)

1995 • 3,456 citations

Intravenous Thrombolysis With Recombinant Tissue Plasminogen Activator for Acute Hemispheric Stroke

1995 • 2,209 citations

Effect of plasminogen activator (urokinase), plasmin, and thrombin on glycoprotein and collagenous components of basement membrane.

1981 • 587 citations

Collagenase-induced intracerebral hemorrhage in rats.

1990 • 584 citations

Elastase in Tissue Injury

1985 • 512 citations

Oxidative Autoactivation of Latent Collagenase by Human Neutrophils

1985 • 466 citations

Proteolytic Cascade Enzymes Increase in Focal Cerebral Ischemia in Rat

1996 • 408 citations

Plasminogen Activator Release at the Neuronal Growth Cone

1981 • 388 citations

Hemorrhagic cerebral infarction--a prospective study.

1986 • 333 citations

Urokinase-type plasminogen activator is induced in migrating capillary endothelial cells.

1987 • 286 citations

Gelatinase in the cerebrospinal fluid of patients with multiple sclerosis and other inflammatory neurological disorders

1992 • 286 citations

TIMP-2 reduces proteolytic opening of blood-brain barrier by type IV collagenase

1992 • 282 citations

Effect of steroids on CSF matrix metalloproteinases in multiple sclerosis

1996 • 278 citations

Degradation of basic protein in myelin by neutral proteases secreted by stimulated macrophages: A possible mechanism of inflammatory demyelination

1978 • 276 citations

Tumor necrosis factor-α-induced gelatinase B causes delayed opening of the blood-brain barrier: an expanded therapeutic window

1995 • 260 citations

Effect of plasminogen activator (urokinase), plasmin, and thrombin on glycoprotein and collagenous components of basement membrane

1982 • 226 citations

Vascular Injury and Lysis of Basement Membrane in vitro by Neutral Protease of Human Leukocytes

1968 • 211 citations

Factors related to intracranial hematoma formation in patients receiving tissue-type plasminogen activator for acute ischemic stroke.

1994 • 211 citations

Neutrophil inhibitory factor is neuroprotective after focal Ischemia in rats

1995 • 150 citations

Identification of Elastase as a Secretory Protease from Cultured Rat Microglia

1992 • 137 citations

Microglia isolated from rat brain secrete a urokinase-type plasminogen activator

1992 • 127 citations

Injury-induced 92-kilodalton gelatinase and urokinase expression in rat brain.

1994 • 115 citations

Plasminogen activator in the rodent brain

1981 • 105 citations

Glutamate-Induced Disruption of the Blood-Brain Barrier in Rats

1996 • 99 citations

Hemorrhagic transformation following tissue plasminogen activator in experimental cerebral infarction.

1990 • 78 citations

A specific neutrophil elastase inhibitor (ONO-5046.Na) attenuates LPS-induced acute lung inflammation in the hamster

1995 • 46 citations

Neutrophil elastase inhibitor (ONO-5046) prevents lung hemorrhage induced by lipopolysaccharide in rat model of cerulein pancreatitis

1995 • 42 citations

Detection of extracellular neutrophil elastase in hamster lungs after intratracheal instillation of E. coli lipopolysaccharide using a fluorogenic, elastase-specific, synthetic substrate.

1992 • 19 citations

Perturbation of the blood-retinal barrier after enzyme perfusion. A cytochemical study.

1987 • 17 citations

Activation of astrocytic lysosomal proteinases by factors released by mononuclear leukocytes

1989 • 16 citations

Modulation of Serine Proteinases and Metalloproteinases During Morphogenic Glial-Endothelial Interactions

1996 • 14 citations

Changes Induced in Astrocyte Cathepsin D by Cytokines and Leupeptin

1991 • 11 citations

Elastase Given Intracisternally Opens Blood-Brain Barrier in Newborn Piglets

1995 • 10 citations

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