Reduction in glial immunity and neuropathology by a PAF antagonist and an MMP and TNFα inhibitor in SCID mice with HIV-1 encephalitis

Matrix Metalloproteinases: A Review

1993 • 2,998 citations

Detection of AIDS Virus in Macrophages in Brain Tissue from AIDS Patients with Encephalopathy

1986 • 1,694 citations

The AIDS dementia complex: I. Clinical features

1986 • 1,679 citations

Molecular profile of reactive astrocytes—Implications for their role in neurologic disease

1993 • 1,436 citations

The AIDS Dementia Complex

1988 • 1,387 citations

Matrix Metalloproteinases and TIMPs Are Associated With Blood-Brain Barrier Opening After Reperfusion in Rat Brain

1998 • 847 citations

Efficient isolation and propagation of human immunodeficiency virus on recombinant colony-stimulating factor 1-treated monocytes.

1988 • 785 citations

Immunocytochemical quantitation of human immunodeficiency virus in the brain: Correlations with dementia

1995 • 663 citations

Neuronal cell killing by the envelope protein of HIV and its prevention by vasoactive intestinal peptide

1988 • 616 citations

Cytokine expression in the brain during the acquired immunodeficiency syndrome

1992 • 572 citations

Quinolinic acid in cerebrospinal fluid and serum in HIV‐1 Infection: Relationship to clinical and neurological status

1991 • 563 citations

Potentiation of NMDA receptor currents by arachidonic acid

1992 • 428 citations

Immunologic NO Synthase: Elevation in Severe AIDS Dementia and Induction by HIV-1 gp41

1996 • 422 citations

Neuropathology of Human Immunodeficiency Virus Infection

1991 • 411 citations

Interleukin-1 and Tumor Necrosis Factor-α Synergistically Mediate Neurotoxicity: Involvement of Nitric Oxide and of N-Methyl-D-aspartate Receptors

1995 • 409 citations

Localization of HIV‐1 in human brain using polymerase chain reaction/in situ hybridization and immunocytochemistry

1996 • 405 citations

Induction of nitric oxide synthase activity in human astrocytes by interleukin-1β and interferon-γ

1993 • 355 citations

Regulation of nitric oxide synthase activity in human immunodeficiency virus type 1 (HIV-1)-infected monocytes: implications for HIV-associated neurological disease.

1995 • 337 citations

Mechanisms for the transendothelial migration of HIV-1-infected monocytes into brain.

1996 • 321 citations

Platelet-activating factor: a candidate human immunodeficiency virus type 1-induced neurotoxin

1994 • 317 citations

Tumor Necrosis Factor α Inhibits Glutamate Uptake by Primary Human Astrocytes

1996 • 317 citations

Microglial and Astrocyte Chemokines Regulate Monocyte Migration through the Blood-Brain Barrier in Human Immunodeficiency Virus-1 Encephalitis

1999 • 278 citations

Gelatinase B modulates selective opening of the blood-brain barrier during inflammation

1998 • 233 citations

Apoptosis induced by HIV-1 infection of the central nervous system.

1996 • 230 citations

Human immunodeficiency virus encephalitis is the pathological correlate of dementia in acquired immunodeficiency syndrome

1994 • 230 citations

Regulation of cell surface APO‐1/Fas (CD95) ligand expression by metalloproteases

1995 • 216 citations

Multinucleated giant cells and HTLV-III in AIDS encephalopathy

1985 • 211 citations

Neuronal apoptosis induced by HIV-1 Tat protein and TNF-α: potentiation of neurotoxicity mediated by oxidative stress and implications for HIV-1 dementia

1998 • 189 citations

Platelet-activating factor (PAF) receptor in rat brain: PAF mobilizes intracellular Ca2+ in hippocampal neurons

1992 • 175 citations

Neurotoxic Effects of Tumor Necrosis Factor Alpha in Primary Human Neuronal Cultures are Mediated by Activation of the Glutamate AMPA Receptor Subtype: Implications for AIDS Neuropathogenesis

1993 • 175 citations

Study of Receptor-Mediated Neurotoxins Released by HIV-1-Infected Mononuclear Phagocytes Found in Human Brain

1996 • 165 citations

Suppression of Inflammatory Neurotoxins by Highly Active Antiretroviral Therapy in Human Immunodeficiency Virus‐Associated Dementia

1998 • 162 citations

Human immunodeficiency virus encephalitis in SCID mice.

1996 • 161 citations

Human immunodeficiency virus type 1 Tat protein induces death by apoptosis in primary human neuron cultures

1997 • 149 citations

Enhanced HIV replication in macrophage colony-stimulating factor-treated monocytes.

1991 • 143 citations

In vitro evidence for a dual role of tumor necrosis factor‐α in human immunodeficiency virus type 1 encephalopathy

1995 • 138 citations

A regulatory role for astrocytes in HIV-1 encephalitis. An overexpression of eicosanoids, platelet-activating factor, and tumor necrosis factor-alpha by activated HIV-1-infected monocytes is attenuated by primary human astrocytes.

1995 • 137 citations

Intracerebral cytokine mRNA expression during fatal and nonfatal alphavirus encephalitis suggests a predominant type 2 T cell response.

1994 • 132 citations

Chronic exposure of human neurons to quinolinic acid results in neuronal changes consistent with AIDS dementia complex

1998 • 132 citations

The neuropathogenesis of the AIDS dementia complex.

1997 • 129 citations

An analysis of HIV-1-associated inflammatory products in brain tissue of humans and SCID mice with HIV-1 encephalitis

1997 • 124 citations

Effective treatment of models of multiple sclerosis by matrix metalloproteinase inhibitors

1998 • 124 citations

Quantitation of human immunodeficiency virus in brains of demented and nondemented patients with acquired immunodeficiency syndrome

1996 • 120 citations

Activation of monocytes by HIV-Tat treatment is mediated by cytokine expression.

1997 • 105 citations

Tumor necrosis factor modulates Ca2+ currents in cultured sympathetic neurons

1992 • 91 citations

New α-Substituted Succinate-Based Hydroxamic Acids as TNFα Convertase Inhibitors

1999 • 90 citations

AIDS DEMENTIA COMPLEX

1999 • 85 citations

A combined inhibitor of matrix metalloproteinase activity and tumour necrosis factor-alpha processing attenuates experimental autoimmune neuritis

1997 • 82 citations

Randomized trial of the platelet-activating factor antagonist lexipafant in HIV–associated cognitive impairment

1999 • 80 citations

Delayed-type hypersensitivity lesions in the central nervous system are prevented by inhibitors of matrix metalloproteinases

1996 • 69 citations

SCID Mice With HIV Encephalitis Develop Behavioral Abnormalities

1998 • 55 citations

Evaluation of antiretroviral drug efficacy for HIV-1 encephalitis in SCID mice

2000 • 44 citations

Effect of a Platelet-Activating Factor Antagonist on Pancreatitis-Associated Gut Barrier Dysfunction in Rats

1998 • 43 citations

Early HIV-1 infection of the central nervous system.

1997 • 38 citations

Platelet-activating factor production by human fetal microglia

1995 • 37 citations

Induction of matrix metalloproteinase-2 in human immunodeficiency virus-1 glycoprotein 120 transgenic mouse brains

1998 • 36 citations

Lexipafant (BB-882), a platelet activating factor receptor antagonist, ameliorates mucosal inflammation in an animal model of colitis

1996 • 27 citations

The intracellular domain of p55 tumor necrosis factor receptor induces apoptosis which requires different caspases in naive and neuronal PC12 cells

1998 • 27 citations

Role of Platelet-Activating Factor Antagonism in Haemorrhagic Shock in Pigs

1995 • 11 citations

Platelet activating factor antagonism improves cardiovascular function in non-hypotensive sepsis in pigs.

1996 • 9 citations