Extracellular Matrix Degradation

Angiogenic Factors

1987 • 3,702 citations

Plasminogen Activators, Tissue Degradation, and Cancer

1985 • 2,584 citations

Metastatic potential correlates with enzymatic degradation of basement membrane collagen

1980 • 1,778 citations

The role of the macrophage in wound repair. A study with hydrocortisone and antimacrophage serum.

1975 • 1,445 citations

The cysteine switch: a principle of regulation of metalloproteinase activity with potential applicability to the entire matrix metalloproteinase gene family.

1990 • 1,423 citations

SV40-transformed Human Lung Fibroblasts Secrete a 92-kDa Type IV Collagenase Which Is Identical to That Secreted by Normal Human Macrophages

1989 • 1,122 citations

Signal transduction through the fibronectin receptor induces collagenase and stromelysin gene expression.

1989 • 1,073 citations

Tissue Inhibitor of Metalloproteinase (TIMP-2)

1989 • 899 citations

Mechanochemical switching between growth and differentiation during fibroblast growth factor-stimulated angiogenesis in vitro: role of extracellular matrix.

1989 • 877 citations

Cell-Associated Plasminogen Activation: Regulation and Physiological Functions

1988 • 826 citations

An activated form of transforming growth factor beta is produced by cocultures of endothelial cells and pericytes.

1989 • 767 citations

Tumor invasion through the human amniotic membrane: Requirement for a proteinase cascade

1986 • 764 citations

Role of transforming growth factor-beta in the development of the mouse embryo.

1987 • 760 citations

92-kD type IV collagenase mediates invasion of human cytotrophoblasts.

1991 • 722 citations

Multiple modes of activation of latent human fibroblast collagenase: evidence for the role of a Cys73 active-site zinc complex in latency and a "cysteine switch" mechanism for activation.

1990 • 699 citations

Jun-B differs in its biological properties from, and is a negative regulator of, c-Jun

1989 • 698 citations

Transforming Growth Factor‐β

1990 • 696 citations

Endogenous Activation of Latent Collagenase by Rheumatoid Synovial Cells

1977 • 686 citations

Antibodies to plasminogen activator inhibit human tumor metastasis

1983 • 651 citations

Urokinase-type plasminogen activator: proenzyme, receptor, and inhibitors

1987 • 625 citations

Textbook of Rheumatology.

1988 • 593 citations

Plasminogen activator in early embryogenesis: Enzyme production by trophoblast and parietal endoderm

1976 • 590 citations

UV-induced DNA damage is an intermediate step in UV-induced expression of human immunodeficiency virus type 1, collagenase, c-fos, and metallothionein.

1989 • 549 citations

Release of basic fibroblast growth factor-heparan sulfate complexes from endothelial cells by plasminogen activator-mediated proteolytic activity.

1990 • 545 citations

Distribution of basic fibroblast growth factor in the 18-day rat fetus: localization in the basement membranes of diverse tissues.

1990 • 533 citations

Secretion of metalloproteinases by stimulated capillary endothelial cells. II. Expression of collagenase and stromelysin activities is regulated by endogenous inhibitors.

1986 • 531 citations

Evolution of the proteases of blood coagulation and fibrinolysis by assembly from modules

1985 • 492 citations

The receptor for urokinase type plasminogen activator polarizes expression of the protease to the leading edge of migrating monocytes and promotes degradation of enzyme inhibitor complexes.

1990 • 480 citations

Adhesive and degradative properties of human placental cytotrophoblast cells in vitro.

1989 • 477 citations

Tumor-promoting phorbol esters induce angiogenesis in vitro

1985 • 470 citations

Transforming growth factor beta 1-induced changes in cell migration, proliferation, and angiogenesis in the chicken chorioallantoic membrane.

1990 • 470 citations

Transforming growth factor-beta 1 modulates basic fibroblast growth factor-induced proteolytic and angiogenic properties of endothelial cells in vitro.

1990 • 466 citations

In vitro angiogenesis on the human amniotic membrane: requirement for basic fibroblast growth factor-induced proteinases.

1989 • 462 citations

Antisense RNA-Induced Reduction in Murine TIMP Levels Confers Oncogenicity on Swiss 3T3 Cells

1989 • 459 citations

Increased proteolytic activity is responsible for the aberrant morphogenetic behavior of endothelial cells expressing the middle T oncogene

1990 • 452 citations

The collagenase gene promoter contains a TPA and oncogene-responsive unit encompassing the PEA3 and AP-1 binding sites.

1990 • 450 citations

Characterization of the activation of latent TGF-beta by co-cultures of endothelial cells and pericytes or smooth muscle cells: a self-regulating system.

1990 • 449 citations

Mammary plasminogen activator: correlation with involution, hormonal modulation and comparison between normal and neoplastic tissue

1979 • 437 citations

Tissue inhibitor of metalloproteinases-2 (TIMP-2) mRNA expression in tumor cell lines and human tumor tissues.

1990 • 428 citations

Discoordinate expression of stromelysin, collagenase, and tissue inhibitor of metalloproteinases-1 in rheumatoid human synovial fibroblasts. Synergistic effects of interleukin-1 and tumor necrosis factor-alpha on stromelysin expression.

1990 • 408 citations

Plasminogen Activator Release at the Neuronal Growth Cone

1981 • 388 citations

Cellular Biology and Biochemical Mechanism of Bone Resorption

1988 • 383 citations

Stepwise activation mechanisms of the precursor of matrix metalloproteinase 3 (stromelysin) by proteinases and (4-aminophenyl)mercuric acetate

1990 • 381 citations

The opposing effects of basic fibroblast growth factor and transforming growth factor beta on the regulation of plasminogen activator activity in capillary endothelial cells.

1987 • 378 citations

Receptor-mediated internalization and degradation of urokinase is caused by its specific inhibitor PAI-1.

1990 • 374 citations

Membrane and matrix localization of proteinases: a common theme in tumor cell invasion and angiogenesis

1988 • 354 citations

Effects of inhibitors of plasminogen activator, serine proteinases, and collagenase IV on the invasion of basement membranes by metastatic cells

1988 • 352 citations

Growth factors in the regulation of pericellular proteolysis: a review.

1989 • 342 citations

Cellular biology and biochemical mechanism of bone resorption. A review of recent developments on the formation, activation, and mode of action of osteoclasts.

1988 • 332 citations

Immunohistochemical distribution of type IV collagenase in normal, benign, and malignant breast tissue.

1990 • 323 citations

Inhibition by human recombinant tissue inhibitor of metalloproteinases of human amnion invasion and lung colonization by murine B16-F10 melanoma cells.

1988 • 312 citations

Ultrastructural localization of plasma membrane-associated urokinase-type plasminogen activator at focal contacts.

1988 • 312 citations

Immunohistochemical detection and immunochemical analysis of type II collagen degradation in human normal, rheumatoid, and osteoarthritic articular cartilages and in explants of bovine articular cartilage cultured with interleukin 1.

1989 • 298 citations

A glia-derived neurite promoting factor with protease inhibitory activity belongs to the protease nexins

1986 • 297 citations

Plasminogen activators in tissue remodeling and invasion: mRNA localization in mouse ovaries and implanting embryos.

1989 • 287 citations

Urokinase-type plasminogen activator is induced in migrating capillary endothelial cells.

1987 • 286 citations

Genes for extracellular-matrix-degrading metalloproteinases and their inhibitor, TIMP, are expressed during early mammalian development.

1989 • 284 citations

In vivo invasion of modified chorioallantoic membrane by tumor cells: the role of cell surface-bound urokinase.

1988 • 273 citations

Activation of the endogenous metalloproteinase, gelatinase, by triggered human neutrophils.

1986 • 267 citations

Collagenolytic activity during mammalian wound repair

1967 • 261 citations

Follicular plasminogen and plasminogen activator and the effect of plasmin on ovarian follicle wall

1975 • 248 citations

Transforming growth factor-beta. Major role in regulation of extracellular matrix.

1990 • 230 citations

Colocalization of TGF-beta 1 and collagen I and III, fibronectin and glycosaminoglycans during lung branching morphogenesis*

1990 • 226 citations

Proteinases and extracellular remodeling

1989 • 224 citations

Metalloproteinases mediate extracellular matrix degradation by cells from mouse blastocyst outgrowths

1992 • 221 citations

Purification and properties of a small latent matrix metalloproteinase of the rat uterus.

1988 • 220 citations

8 Growth Factor-Regulated Proteases and Extracellular Matrix Remodeling during Mammalian Development

1990 • 219 citations

Fragments of human fibroblast collagenase. Purification and characterization

1989 • 210 citations

Mr 92,000 gelatinase release correlates with the metastatic phenotype in transformed rat embryo cells.

1990 • 202 citations

cDNA cloning and expression of a metalloproteinase inhibitor related to tissue inhibitor of metalloproteinases.

1990 • 202 citations

Inactivation of tissue inhibitor of metalloproteinases by neutrophil elastase and other serine proteinases

1988 • 199 citations

Purification and Characterization of Two Related but Distinct Metalloproteinase Inhibitors Secreted by Bovine Aortic Endothelial Cells

1989 • 193 citations

Characterization of a proteinase that cleaves zona pellucida glycoprotein ZP2 following activation of mouse eggs

1989 • 189 citations

Transforming growth factor beta₁ modulates extracellular matrix organization and cell‐cell junctional complex formation during in vitro angiogenesis

1990 • 184 citations

Disruption of the subendothelial basement membrane during neutrophil diapedesis in an in vitro construct of a blood vessel wall.

1989 • 183 citations

Distribution of urokinase-type plasminogen activator immunoreactivity in the mouse.

1984 • 181 citations

Proteinases of the mammary gland: developmental regulation in vivo and vectorial secretion in culture

1991 • 181 citations

Expression of metalloproteinases and metalloproteinase inhibitors by fetal astrocytes and glioma cells.

1990 • 180 citations

Plasminogen activator inhibitor 1 (PAI) is bound to vitronectin in plasma

1988 • 178 citations

Alpha 1-proteinase inhibitor is a neutrophil chemoattractant after proteolytic inactivation by macrophage elastase.

1988 • 170 citations

Structure-function relationships in the collagenase family member transin.

1988 • 169 citations

Mouse blastocysts hatch in vitro by using a trypsin-like proteinase associated with cells of mural trophectoderm

1986 • 163 citations

Early expression of a collagenase-like hatching enzyme gene in the sea urchin embryo.

1990 • 158 citations

Linkage of extracellular plasminogen activator to the fibroblast cytoskeleton: colocalization of cell surface urokinase with vinculin.

1988 • 158 citations

Monoclonal antibody preparation and purification of a tumor cell collagenase-stimulatory factor.

1989 • 155 citations

A growth-responsive gene (16C8) in normal mouse fibroblasts homologous to a human collagenase inhibitor with erythroid-potentiating activity: evidence for inducible and constitutive transcripts

1986 • 155 citations

Half-life of synovial cell collagenase mRNA is modulated by phorbol myristate acetate but not by all-trans-retinoic acid or dexamethasone

1986 • 140 citations

Mechanisms of Matrix Degradation in Rheumatoid Arthritis^a

1990 • 132 citations

Pericellular proteolysis by neutrophils in the presence of proteinase inhibitors: effects of substrate opsonization.

1988 • 128 citations

Sequences coding for part of oncogene-induced transin are highly conserved in a related rat gene

1987 • 127 citations

Cellular Localisation in Placenta of Placental Type Plasminogen Activator Inhibitor

1986 • 126 citations

Plasminogen activator and mouse spermatozoa: urokinase synthesis in the male genital tract and binding of the enzyme to the sperm cell surface.

1987 • 125 citations

Immunolocalization of metalloproteinases and their inhibitor in the rabbit growth plate.

1989 • 125 citations

Generation of collagenase-resistant collagen by site-directed mutagenesis of murine pro alpha 1(I) collagen gene.

1990 • 121 citations

Transin/stromelysin expression in rheumatoid synovium. A transformation-associated metalloproteinase secreted by phenotypically invasive synoviocytes.

1989 • 120 citations

An anticatalytic monoclonal antibody to avian plasminogen activator: Its effect on behavior of RSV-transformed chick fibroblasts

1986 • 114 citations

Developmental expression of tissue inhibitor of metalloproteinase (TIMP) RNA

1989 • 114 citations

Purification and characterization of a novel low molecular weight form of single-chain urokinase-type plasminogen activator.

1986 • 114 citations

Inhibitors of Mammalian Tissue Collagenase and Metalloproteinases Suppress Ovulation in the Perfused Rat Ovary*

1988 • 113 citations

Junctional communication is induced in migrating capillary endothelial cells.

1989 • 113 citations

Expression pattern of a gene for a secreted metalloproteinase during late stages of tumor progression

1988 • 112 citations

Vectorial secretion of extracellular matrix proteins, matrix-degrading proteinases, and tissue inhibitor of metalloproteinases by endothelial cells.

1990 • 107 citations

Schistosome proteases

1988 • 103 citations

Platelet-derived growth factor and IL-1 interactions in rheumatoid arthritis. Regulation of synoviocyte proliferation, prostaglandin production, and collagenase transcription.

1989 • 101 citations

Glioblastoma infiltration into central nervous system tissue in vitro: involvement of a metalloprotease.

1988 • 100 citations

Mutational analysis of the transin (rat stromelysin) autoinhibitor region demonstrates a role for residues surrounding the “cysteine switch”

1991 • 99 citations

Proteolytic inactivation of alpha-1-proteinase inhibitor by a neutrophil metalloproteinase.

1988 • 99 citations

Type IV collagen-mediated melanoma cell adhesion and migration: involvement of multiple, distinct domains of the collagen molecule.

1989 • 96 citations

Human osteoblasts in vitro secrete tissue inhibitor of metalloproteinases and gelatinase but not interstitial collagenase as major cellular products.

1989 • 94 citations

Purification of the neutral proteoglycan-degrading metalloproteinase from human articular cartilage tissue and its identification as stromelysin matrix metalloproteinase-3

1989 • 93 citations

Monoclonal antibodies to human fibroblast procollagenase. Inhibition of enzymatic activity, affinity purification of the enzyme, and evidence for clustering of epitopes in the amino-terminal end of the activated enzyme

1988 • 91 citations

Developmental expression of the endogenous TIMP gene and a TIMP-lacZ fusion gene in transgenic mice.

1990 • 86 citations

Characterization and expression of a murine gene homologous to human EPA/TIMP: a virus-induced gene in the mouse.

1987 • 79 citations

Induction of angiogenesis in vitro by vanadate, an inhibitor of phosphotyrosine phosphatases

1988 • 76 citations

An Essay on Biological Degradation of Collagen

1981 • 76 citations

Localization of collagenase mRNA in rheumatoid arthritis synovium byin situ hybridization histochemistry

1990 • 73 citations

Morphology and biochemistry of bone remodeling: possible control by vitamin D, parathyroid hormone, and other substances.

1988 • 71 citations

Role of Specific Membrane Receptors in Urokinase-Dependent Migration of Human Keratinocytes

1990 • 70 citations

Localization of protease nexin‐1 on the fibroblast extracellular matrix

1988 • 69 citations

Transforming growth factor-beta causes partial inhibition of interleukin 1 — Stimulated cartilage degradation in vitro

1989 • 68 citations

The prenatal development of the skeleton and joints of the human hand

1957 • 68 citations

Molecular cloning of preproacrosin and analysis of its expression pattern in spermatogenesis

1989 • 67 citations

Regulation of collagenase and collagenase mRNA production in early‐ and late‐passage human diploid fibroblasts

1989 • 66 citations

Modulation of granule cell migration by a glia-derived protein.

1986 • 65 citations

Degradation of basement membranes by human matrix metalloproteinase 3 (stromelysin)

1988 • 63 citations

Regulation of extracellular matrix degradation by cell—extracellular matrix interactions

1990 • 63 citations

Type I collagen degradation by mouse calvarial osteoblasts stimulated with 1,25-dihydroxyvitamin D-3: evidence for a plasminogen-plasmin-metalloproteinase activation cascade

1989 • 59 citations

Hyperoxic exposure alters gene expression in the lung

1989 • 56 citations

Binding of Protease Nexin-1 to the Fibroblast Surface Alters Its Target Proteinase Specificity

1989 • 53 citations

Extraction of type‐IV collagenase/gelatinase from plasma membranes of human cancer cells

1990 • 51 citations

Heat shock of rabbit synovial fibroblasts increases expression of mRNAs for two metalloproteinases, collagenase and stromelysin.

1989 • 51 citations

A Critical Appraisal of the Role of Proteolytic Enzymes in Cancer Invasion: Emphasis on Tumor Surface Proteinases

1988 • 44 citations

Normal and malignant cells, including neurons, deposit plasminogen activator on the growth substrata

1986 • 43 citations

The alpha 1-antitrypsin gene and emphysema

1989 • 43 citations

Cellular interactions determining the production of collagenase by a rat mammary carcinoma cell line

1989 • 41 citations

The effects of protease inhibitors on axon growth through astrocytes

1990 • 39 citations

Plasminogen activators in the mouse mammary gland

1989 • 39 citations

Directed migration of murine and human tumor cells to collagenases and other proteases.

1989 • 37 citations

Localization of the gene encoding human erythroid-potentiating activity to chromosome region Xp11.1----Xp11.4.

1986 • 35 citations

Identification of a new metalloproteinase inhibitor that forms tight-binding complexes with collagenase

1990 • 34 citations

Down-regulation of Plasmin Receptors on Human Sarcoma Cells by Glucocorticoids

1989 • 30 citations

In vitro synthesis of the active tissue inhibitor of metalloproteinases encoded by a complementary DNA from virus-infected murine fibroblasts.

1988 • 26 citations

Sixth Annual Herman Beerman Lecture

1966 • 22 citations

Metalloproteinases in endochondral bone formation: Appearance of tissue inhibitor-resistant metalloproteinases

1987 • 17 citations

Caprine acrosin. Purification, characterization and proteolysis of the porcine zona pellucida

1989 • 14 citations

A Monoclonal Antibody that Does Not Recognize Tissue-Type Plasminogen Activator Bound to Its Naturally Occurring Inhibitor

1986 • 13 citations

Comparison of basement membrane matrix degradation by purified proteases and by metastatic tumor cells

1987 • 11 citations

Effects of fibroblasts and endothelial cells on inactivation of target proteases by protease nexin‐1, heparin cofactor II, and C1‐inhibitor

1988 • 7 citations