Matrix metalloproteinase expression during experimental autoimmune encephalomyelitis and effects of a combined matrix metalloproteinase and tumour necrosis factor-α inhibitor

Matrix Metalloproteinases: A Review

1993 • 2,998 citations

Processing of tumour necrosis factor-α precursor by metalloproteinases

1994 • 1,200 citations

Identification of lymphotoxin and tumor necrosis factor in multiple sclerosis lesions.

1991 • 735 citations

A novel coumarin‐labelled peptide for sensitive continuous assays of the matrix metalloproteinases

1992 • 692 citations

Protection against a lethal dose of endotoxin by an inhibitor of tumour necrosis factor processing

1994 • 607 citations

T cell gelatinases mediate basement membrane transmigration in vitro.

1995 • 507 citations

Cloning and characterization of a unique elastolytic metalloproteinase produced by human alveolar macrophages.

1993 • 479 citations

Neutral metalloproteinases produced by human mononuclear phagocytes. Enzyme profile, regulation, and expression during cellular development.

1990 • 459 citations

Matrix metalloproteinase degradation of elastin, type IV collagen and proteoglycan. A quantitative comparison of the activities of 95 kDa and 72 kDa gelatinases, stromelysins-1 and -2 and punctuated metalloproteinase (PUMP)

1991 • 454 citations

Purification of rabbit bone inhibitor of collagenase

1981 • 352 citations

A rapid and reproducible assay for collagenase using [1-14C]acetylated collagen

1979 • 350 citations

The antidepressant rolipram suppresses cytokine production and prevents autoimmune encephalomyelitis

1995 • 345 citations

Experimental Allergic Encephalomyelitis. A Useful Model for Multiple Sclerosis

1984 • 340 citations

Reversal of experimental autoimmune encephalomyelitis with a hydroxamate inhibitor of matrix metalloproteases.

1994 • 338 citations

Matrix metalloproteinases degrade myelin basic protein

1995 • 291 citations

Gelatinase in the cerebrospinal fluid of patients with multiple sclerosis and other inflammatory neurological disorders

1992 • 286 citations

TIMP-2 reduces proteolytic opening of blood-brain barrier by type IV collagenase

1992 • 282 citations

The C-terminal Region of Membrane Type Matrix Metalloproteinase Is a Functional Transmembrane Domain Required for Pro-gelatinase A Activation

1995 • 269 citations

Tumor necrosis factor-α-induced gelatinase B causes delayed opening of the blood-brain barrier: an expanded therapeutic window

1995 • 260 citations

A metalloprotease inhibitor blocks shedding of the 80-kD TNF receptor and TNF processing in T lymphocytes.

1995 • 234 citations

Control of established experimental allergic encephalomyelitis by inhibition of tumor necrosis factor (TNF) activity within the central nervous system using monoclonal antibodies and TNF receptor‐immunoglobulin fusion proteins

1994 • 232 citations

Extracellular Matrix‐Degrading Proteinases in the Nervous System

1994 • 208 citations

In vivo relationship of tumor necrosis factor-α to blood-brain barrier damage in patients with active multiple sclerosis

1992 • 207 citations

Gelatinase B is present in the cerebrospinal fluid during experimental autoimmune encephalomyelitis and cleaves myelin basic protein

1993 • 192 citations

Recombinant human tumor necrosis factor α constricts pial arterioles and increases blood-brain barrier permeability in newborn piglets

1992 • 192 citations

Experimental allergic encephalomyelitis in the absence of a classical delayed-type hypersensitivity reaction. Severe paralytic disease correlates with the presence of interleukin 2 receptor-positive cells infiltrating the central nervous system.

1987 • 182 citations

Leukocyte Gelatinase B Cleavage Releases Encephalitogens from Human Myelin Basic Protein

1993 • 181 citations

Suppression of experimental allergic encephalomyelitis in the Lewis rat by the matrix metalloproteinase inhibitor Ro31-9790

1995 • 146 citations

Human tumor necrosis factor-α augments experimental allergic encephalomyelitis in rats

1991 • 130 citations

The matrix metalloprotease matrilysin (PUMP) is expressed in developing human mononuclear phagocytes.

1992 • 121 citations

Matrilysin expression by human mononuclear phagocytes and its regulation by cytokines and hormones.

1995 • 115 citations

Proteolysis and myelin breakdown: a review of recent histochemical and biochemical studies

1969 • 101 citations

Proteolytic enzyme activity of blood leukocytes and cerebrospinal fluid in multiple sclerosis

1978 • 89 citations

White matter microglia produce membrane-type matrix metalloprotease, an activator of gelatinase A, in human brain tissues

1995 • 78 citations

Contribution of the C-terminal domain of metalloproteinases to binding by tissue inhibitor of metalloproteinases. C-terminal truncated stromelysin and matrilysin exhibit equally compromised binding affinities as compared to full-length stromelysin.

1994 • 75 citations

Quantitation of matrix metalloproteinases in cultured rat astrocytes using the polymerase chain reaction with a multi-competitor cDNA standard

1996 • 70 citations

Relaxed Specificity of Matrix Metalloproteinases (MMPS) and TIMP Insensitivity of Tumor Necrosis Factor-α (TNF-α) Production Suggest the Major TNF-α Converting Enzyme Is Not an MMP

1996 • 69 citations

Tumour necrosis factor-alpha synthesis by cerebrospinal-fluid-derived T cell clones from patients with multiple sclerosis

1991 • 55 citations

Involvement of a metalloprotease in low-affinity nerve growth factor receptor truncation: inhibition of truncation in vitro and in vivo

1993 • 53 citations

Selective localization of gelatinase A, an enzyme degrading ?-amyloid protein, in white matter microglia and in Schwann cells

1995 • 46 citations

Human t lymphocytes express a member of the matrix metalloproteinase gene family

1994 • 27 citations

Neutral protease in cerebrospinal fluid from patients with multiple sclerosis and other neurological diseases

1987 • 23 citations

What Experimental Allergic Encephalomyelitis Teaches Us About Multiple Sclerosis

1984 • 11 citations