The expression profile of matrix metalloproteinases (MMPs) and their inhibitors (TIMPs) in lesions and normal appearing white matter of multiple sclerosis

New diagnostic criteria for multiple sclerosis: Guidelines for research protocols

1983 • 7,404 citations

Heterogeneity of multiple sclerosis lesions: Implications for the pathogenesis of demyelination

2000 • 3,258 citations

A novel method for real time quantitative RT-PCR.

1996 • 2,093 citations

An Immunohistochemical Study

1989 • 1,928 citations

Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-α

1997 • 1,608 citations

Processing of tumour necrosis factor-α precursor by metalloproteinases

1994 • 1,200 citations

Tumor necrosis factor identified in multiple sclerosis brain.

1989 • 793 citations

The adhesion molecule and cytokine profile of multiple sclerosis lesions

1995 • 761 citations

Identification of lymphotoxin and tumor necrosis factor in multiple sclerosis lesions.

1991 • 735 citations

Axonal loss in multiple sclerosis lesions: Magnetic resonance imaging insights into substrates of disability

1999 • 713 citations

Matrix metalloproteinases and diseases of the CNS

1998 • 646 citations

BREAKDOWN OF THE BLOOD-BRAIN BARRIER PRECEDES SYMPTOMS AND OTHER MRI SIGNS OF NEW LESIONS IN MULTIPLE SCLEROSIS

1990 • 571 citations

T cell gelatinases mediate basement membrane transmigration in vitro.

1995 • 507 citations

Matrix Metalloproteinase-8 Is Expressed in Rheumatoid Synovial Fibroblasts and Endothelial Cells

1997 • 493 citations

Interferon β‐1b decreases the migration of T lymphocytes in vitro: Effects on matrix metalloproteinase‐9

1996 • 363 citations

Reversal of experimental autoimmune encephalomyelitis with a hydroxamate inhibitor of matrix metalloproteases.

1994 • 338 citations

The pathogenesis of lesions and normal-appearing white matter changes in multiple sclerosis: A serial diffusion MRI study

2000 • 314 citations

Interferon beta‐1b inhibits gelatinase secretion and in vitro migration of human T cells: A possible mechanism for treatment efficacy in multiple sclerosis

1996 • 302 citations

Staging of multiple sclerosis (MS) lesions: pathology of the time frame of MS

2000 • 293 citations

Matrix metalloproteinases degrade myelin basic protein

1995 • 291 citations

Matrix Metalloproteinases in the Normal Human Central Nervous System, Microglial Nodules, and Multiple Sclerosis Lesions

1996 • 290 citations

Gelatinase in the cerebrospinal fluid of patients with multiple sclerosis and other inflammatory neurological disorders

1992 • 286 citations

Differential matrix metalloproteinase expression in cases of multiple sclerosis and stroke

1997 • 265 citations

Differential expression of matrix metalloproteinase and tissue inhibitor of matrix metalloproteinase genes in the mouse central nervous system in normal and inflammatory states.

1998 • 262 citations

Tumor necrosis factor-α-induced gelatinase B causes delayed opening of the blood-brain barrier: an expanded therapeutic window

1995 • 260 citations

Matrix Metalloproteinase (MMP)-8 and MMP-9 in Cerebrospinal Fluid during Bacterial Meningitis: Association with Blood-Brain Barrier Damage and Neurological Sequelae

2000 • 252 citations

Matrix metalloproteinase-9 (gelatinase B) is selectively elevated in CSF during relapses and stable phases of multiple sclerosis

1998 • 248 citations

The Expression of Tissue-type Plasminogen Activator, Matrix Metalloproteases and Endogenous Inhibitors in the Central Nervous System in Multiple Sclerosis

1996 • 247 citations

Serum MMP-9 and TIMP-1 levels are related to MRI activity in relapsing multiple sclerosis

1999 • 232 citations

Pathogenesis of multiple sclerosis

1994 • 230 citations

The Matrix Metalloproteinase Family

1998 • 225 citations

Matrix metalloproteinase expression during experimental autoimmune encephalomyelitis and effects of a combined matrix metalloproteinase and tumour necrosis factor-α inhibitor

1997 • 205 citations

Cytokine and chemokine regulation of proMMP-9 and TIMP-1 production by human peripheral blood lymphocytes.

1997 • 205 citations

Serum gelatinase B, TIMP-1 and TIMP-2 levels in multiple sclerosis

1999 • 199 citations

Leukocyte Gelatinase B Cleavage Releases Encephalitogens from Human Myelin Basic Protein

1993 • 181 citations

Matrix metalloproteinase expression in an experimentally-induced DTH model of multiple sclerosis in the rat CNS

1998 • 179 citations

Stimulus specificity of matrix metalloproteinase dependence of human T cell migration through a model basement membrane.

1996 • 173 citations

Enhanced expression of MMP-7 and MMP-9 in demyelinating multiple sclerosis lesions

1997 • 169 citations

Matrix metalloproteinases in inflammatory demyelination

1999 • 168 citations

Matrix metalloproteinase-9 and -7 are regulated in experimental autoimmune encephalomyelitis

1998 • 166 citations

T cell receptor V alpha-V beta repertoire and cytokine gene expression in active multiple sclerosis lesions.

1992 • 163 citations

Blood-Brain Barrier Abnormalities in Longstanding Multiple Sclerosis Lesions. An Immunohistochemical Study

1994 • 162 citations

Transcriptional Analysis of Multiple Sclerosis Brain Lesions Reveals a Complex Pattern of Cytokine Expression

2000 • 157 citations

Suppression of experimental allergic encephalomyelitis in the Lewis rat by the matrix metalloproteinase inhibitor Ro31-9790

1995 • 146 citations

In vivo collagenase-2 (MMP-8) expression by human bronchial epithelial cells and monocytes/macrophages in bronchiectasis

2001 • 131 citations

Tumour necrosis factor alpha mRNA expression in early multiple sclerosis lesions: Correlation with demyelinating activity and oligodendrocyte pathology

2000 • 131 citations

Changes of serum sICAM-1 and MMP-9 induced by rIFNβ-1b treatment in relapsing-remitting MS

1999 • 127 citations

Macrophage inflammatory protein-1α(MIP-1α), MIP-1β, and RANTES mRNA semiquantification and protein expression in active demyelinating multiple sclerosis (MS) lesions

2000 • 101 citations

Expression of matrix metalloproteinase-9 and its inhibitors in mononuclear blood cells of patients with multiple sclerosis

1999 • 95 citations

Multiple sclerosis:

2000 • 84 citations

Multiple sclerosis: expression of molecules of the tumor necrosis factor ligand and receptor families in relationship to the demyelinated plaque.

1998 • 80 citations

Rattlesnake Hunting Behavior: Correlations between Plasticity of Predatory Performance and Neuroanatomy

1998 • 65 citations

Frontiers in Multiple Sclerosis

1998 • 63 citations

Multiple Sclerosis: Magnetization Transfer Histogram Analysis of Segmented Normal-appearing White Matter

2000 • 60 citations

Matrix metalloproteinases in multiple sclerosis

1999 • 22 citations

Tumor necrosis factor alpha and lymphotoxin stimulate human myeloblastic leukemia cell (ML-1) invasion through a reconstituted basement membrane (Matrigel) with concomitant induction of 92 kDa gelatinase secretion

1996 • 12 citations