Plasminogen activators and matrix metalloproteases, mediators of extracellular proteolysis in inflammatory demyelination of the central nervous system

Matrix metalloproteinases and their inhibitors in connective tissue remodeling

1991 • 3,309 citations

A metalloproteinase disintegrin that releases tumour-necrosis factor-α from cells

1997 • 3,094 citations

A matrix metalloproteinase expressed on the surface of invasive tumour cells

1994 • 2,561 citations

Caspases: Intracellular Signaling by Proteolysis

1997 • 2,114 citations

Mechanism Of Cell Surface Activation Of 72-kDa Type IV Collagenase

1995 • 1,576 citations

Molecular mimicry in T cell-mediated autoimmunity: Viral peptides activate human T cell clones specific for myelin basic protein

1995 • 1,528 citations

The cysteine switch: a principle of regulation of metalloproteinase activity with potential applicability to the entire matrix metalloproteinase gene family.

1990 • 1,423 citations

The matrix‐degrading metalloproteinases

1992 • 1,383 citations

ECM and Cell Surface Proteolysis: Regulating Cellular Ecology

1997 • 1,311 citations

COLLAGENOLYTIC ACTIVITY IN AMPHIBIAN TISSUES: A TISSUE CULTURE ASSAY

1962 • 1,275 citations

SV40-transformed Human Lung Fibroblasts Secrete a 92-kDa Type IV Collagenase Which Is Identical to That Secreted by Normal Human Macrophages

1989 • 1,122 citations

Proteolytic remodeling of extracellular matrix

1995 • 1,086 citations

Immunological Aspects of Demyelinating Diseases

1992 • 1,021 citations

The T Lymphocyte in Experimental Allergic Encephalomyelitis

1990 • 1,005 citations

Tissue-plasminogen activator is induced as an immediate–early gene during seizure, kindling and long-term potentiation

1993 • 841 citations

The adhesion molecule and cytokine profile of multiple sclerosis lesions

1995 • 761 citations

Regulation of Integrin Function by the Urokinase Receptor

1996 • 734 citations

Concepts and Principles of O-Linked Glycosylation

1998 • 730 citations

Endogenous Activation of Latent Collagenase by Rheumatoid Synovial Cells

1977 • 686 citations

Matrix metalloproteinases and diseases of the CNS

1998 • 646 citations

Neuronal Death in the Hippocampus Is Promoted by Plasmin-Catalyzed Degradation of Laminin

1997 • 629 citations

Matrix metalloproteinase 3 (stromelysin) activates the precursor for the human matrix metalloproteinase 9.

1992 • 620 citations

The Matrix Metalloproteinases and Their Inhibitors

1992 • 604 citations

Interaction of 92-kDa type IV collagenase with the tissue inhibitor of metalloproteinases prevents dimerization, complex formation with interstitial collagenase, and activation of the proenzyme with stromelysin.

1992 • 519 citations

T cell gelatinases mediate basement membrane transmigration in vitro.

1995 • 507 citations

Stromelysin is an activator of procollagenase. A study with natural and recombinant enzymes

1987 • 474 citations

Plasminogen activators, integrins, and the coordinated regulation of cell adhesion and migration

1997 • 472 citations

Determinant spreading and the dynamics of the autoimmune T-cell repertoire

1993 • 467 citations

Is plasminogen activator inhibitor-1 the molecular switch that governs urokinase receptor-mediated cell adhesion and release?

1996 • 460 citations

Glycosylation: Heterogeneity and the 3D Structure of Proteins

1997 • 422 citations

Further studies on the activation of procollagenase, the latent precursor of bone collagenase. Effects of lysosomal cathepsin B, plasmin and kallikrein, and spontaneous activation

1977 • 389 citations

Nervous tissue as an immune compartment: the dialect of the immune response in the CNS

1994 • 366 citations

Interferon β‐1b decreases the migration of T lymphocytes in vitro: Effects on matrix metalloproteinase‐9

1996 • 363 citations

The X-ray crystal structure of the catalytic domain of human neutrophil collagenase inhibited by a substrate analogue reveals the essentials for catalysis and specificity.

1994 • 342 citations

Reversal of experimental autoimmune encephalomyelitis with a hydroxamate inhibitor of matrix metalloproteases.

1994 • 338 citations

The application of multifactorial cluster analysis in the staging of plaques in early multiple sclerosis. Identification and characterization of the primary demyelinating lesion

1997 • 326 citations

Activation of progelatinase B (MMP-9) by gelatinase A (MMP-2).

1995 • 324 citations

Proteolytic cleavage of the urokinase receptor substitutes for the agonist-induced chemotactic effect.

1996 • 306 citations

Interferon beta‐1b inhibits gelatinase secretion and in vitro migration of human T cells: A possible mechanism for treatment efficacy in multiple sclerosis

1996 • 302 citations

Matrix metalloproteinases degrade myelin basic protein

1995 • 291 citations

Matrix Metalloproteinases in the Normal Human Central Nervous System, Microglial Nodules, and Multiple Sclerosis Lesions

1996 • 290 citations

Gelatinase in the cerebrospinal fluid of patients with multiple sclerosis and other inflammatory neurological disorders

1992 • 286 citations

Degradation of basic protein in myelin by neutral proteases secreted by stimulated macrophages: A possible mechanism of inflammatory demyelination

1978 • 276 citations

Animal models

1994 • 276 citations

Fibrinolysis in the Animal Organism

1947 • 265 citations

Differential matrix metalloproteinase expression in cases of multiple sclerosis and stroke

1997 • 265 citations

Differential expression of matrix metalloproteinase and tissue inhibitor of matrix metalloproteinase genes in the mouse central nervous system in normal and inflammatory states.

1998 • 262 citations

Purification and identification of 91‐kDa neutrophil gelatinase

1991 • 259 citations

Plasminogen activator–plasmin system and neuronal migration

1982 • 256 citations

The Expression of Tissue-type Plasminogen Activator, Matrix Metalloproteases and Endogenous Inhibitors in the Central Nervous System in Multiple Sclerosis

1996 • 247 citations

uPA, uPAR, PAI-I: Key intersection of proteolytic, adhesive and chemotacfic highways?

1997 • 246 citations

Cytokine mRNA expression in inflammatory multiple sclerosis lesions: Detection by non-radioactive in situ hybridization

1993 • 239 citations

Chemotaxis by a CNS macrophage, the microglia

1990 • 215 citations

Cytokine-regulated proteases in autoimmune diseases

1994 • 214 citations

Extracellular Matrix‐Degrading Proteinases in the Nervous System

1994 • 208 citations

Concepts and principles of glycobiology

1993 • 206 citations

T cell recognition of carbohydrates on type II collagen.

1994 • 206 citations

Matrix metalloproteinase expression during experimental autoimmune encephalomyelitis and effects of a combined matrix metalloproteinase and tumour necrosis factor-α inhibitor

1997 • 205 citations

Identification of a novel granulocyte chemotactic protein (GCP-2) from human tumor cells. In vitro and in vivo comparison with natural forms of GRO, IP-10, and IL-8.

1993 • 196 citations

Gelatinase B is present in the cerebrospinal fluid during experimental autoimmune encephalomyelitis and cleaves myelin basic protein

1993 • 192 citations

Recognition of carbohydrate by major histocompatibility complex class I-restricted, glycopeptide-specific cytotoxic T lymphocytes.

1994 • 184 citations

Leukocyte Gelatinase B Cleavage Releases Encephalitogens from Human Myelin Basic Protein

1993 • 181 citations

Direct contact between T lymphocytes and monocytes is a major pathway for induction of metalloproteinase expression.

1994 • 180 citations

Matrix metalloproteinase expression in an experimentally-induced DTH model of multiple sclerosis in the rat CNS

1998 • 179 citations

Expression of immunologically relevant endothelial cell activation antigens on isolated central neurvous system microvessels from patients with multiple sclerosis

1994 • 170 citations

Matrix metalloproteinase-9 and -7 are regulated in experimental autoimmune encephalomyelitis

1998 • 166 citations

The molecular basis of leukocytosis

1998 • 161 citations

Cytokines and proteases in invasive processes: Molecular similarities between inflammation and cancer

1992 • 160 citations

Immunologic Mechanisms and Therapy in Multiple Sclerosis

1995 • 147 citations

Suppression of experimental allergic encephalomyelitis in the Lewis rat by the matrix metalloproteinase inhibitor Ro31-9790

1995 • 146 citations

Oligodendrocytes utilize a matrix metalloproteinase, MMP-9, to extend processes along an astrocyte extracellular matrix

1998 • 143 citations

The precursor of a metalloendopeptidase from human rheumatoid synovial fibroblasts. Purification and mechanisms of activation by endopeptidases and 4-aminophenylmercuric acetate

1988 • 142 citations

Microglia isolated from rat brain secrete a urokinase-type plasminogen activator

1992 • 127 citations

Effective treatment of models of multiple sclerosis by matrix metalloproteinase inhibitors

1998 • 124 citations

Bacterial collagenase disrupts extracellular matrix and opens blood-brain barrier in rat

1993 • 114 citations

Proteinase inhibitors suppress the development of experimental allergic encephalomyelitis

1980 • 114 citations

Identification of mouse granulocyte chemotactic protein-2 from fibroblasts and epithelial cells. Functional comparison with natural KC and macrophage inflammatory protein-2.

1996 • 110 citations

Subcellular localization and release of human neutrophil gelatinase, confirming the existence of separate gelatinase-containing granules

1992 • 107 citations

Cytokine-mediated regulation of human leukocyte gelatinases and role in arthritis.

1991 • 107 citations

Inflammation in the nervous system. Basic mechanisms and immunological concepts.

1991 • 100 citations

Monoclonal Antibodies Specific for Natural Human Neutrophil Gelatinase B Used for Affinity Purification, Quantitation by Two‐Site ELISA and Inhibition of Enzymatic Activity

1995 • 100 citations

Matrix metalloproteinases MMP‐9 and MMP‐7 are expressed in experimental autoimmune neuritis and the guillain‐barré syndrome

1998 • 95 citations

Integrin-dependent induction of functional urokinase receptors in primary T lymphocytes.

1996 • 95 citations

Mouse gelatinase B

1993 • 93 citations

The Extracellular Matrix in Multiple Sclerosis Lesions

1998 • 83 citations

Matrix metalloproteinase expression during experimental autoimmune neuritis

1998 • 83 citations

Production and regulation of gelatinase B by human T-cells

1993 • 80 citations

Cells regulate the activities of cytokines by glycosylation

1995 • 78 citations

Vitronectin and Integrin Vitronectin Receptor Localization in Multiple Sclerosis Lesions

1995 • 75 citations

Evaluation of gelatinases and IL‐6 in the cerebrospinal fluid of patients with optic neuritis, multiple sclerosis and other inflammatory neurological diseases

1994 • 74 citations

Delayed-type hypersensitivity lesions in the central nervous system are prevented by inhibitors of matrix metalloproteinases

1996 • 69 citations

Interleukin 1 preferentially stimulates the production of tissue-type plasminogen activator by human articular chondrocytes

1987 • 63 citations

Plasminogen activators and their inhibitors in synovial fluids from normal, osteoarthritis, and rheumatoid arthritis knees.

1996 • 63 citations

A Brief History of the Use of Interferons as Treatment of Multiple Sclerosis

1994 • 60 citations

mRNAs encoding urokinase-type plasminogen activator and plasminogen activator inhibitor-1 are elevated in the mouse brain following kainate-mediated excitation

1997 • 56 citations

Localization of urokinase-type plasminogen activator mRNA in the adult mouse brain

1996 • 55 citations

The Development of Rational Strategies for Selective Immunotherapy against Autoimmune Demyelinating Disease

1991 • 54 citations

Biochemistry of Demyelination

1996 • 42 citations

Production and Characterization of Recombinant Active Mouse Gelatinase B from Eukaryotic Cells and in vivo Effects after Intravenous Administration

1997 • 41 citations

Prevention of acute autoimmune encephalomyelitis and abrogation of relapses in murine models of multiple sclerosis by the protease inhibitor D-penicillamine

1995 • 40 citations

Expression of the activation marker urokinase plasminogen-activator receptor in cultured human central nervous system microglia

1996 • 38 citations

The Activation of Type 1 and Type 2 Plasminogen by Type I and Type II Tissue Plasminogen Activator

1995 • 37 citations

Cytokine and Protease Glycosylation as a Regulatory Mechanism in Inflammation and Autoimmunity

1998 • 34 citations

Components of the Plasminogen Activator System in Astrocytes Are Modulated by Tumor Necrosis Factor‐α and Interleukin‐1β Through Similar Signal Transduction Pathways

1995 • 32 citations

Administration of systemic matrix metalloproteinase inhibitors maintains bone mechanical integrity in adjuvant arthritis.

1997 • 23 citations

Toxicity in a double-blind, placebo-controlled pilot trial with D-penicillamine and metacycline in secondary progressive multiple sclerosis

1998 • 21 citations

Increased axon growth through astrocyte cell lines transfected with urokinase.

1998 • 19 citations

Increased axon growth through astrocyte cell lines transfected with urokinase

1998 • 15 citations

Cloning and expression in Escherichia coli of a human gelatinase B‐inhibitory single‐chain immunoglobulin variable fragment (scFv)

1997 • 14 citations

Formation of a covalent Hg‐Cys‐bond during mercurial activation of PMNL procollagenase gives evidence of a cysteine‐switch mechanism

1992 • 13 citations

[The T-lymphocyte].

1997 • 10 citations

On the Regulation of EAE

1993 • 10 citations