Gelatinase B is present in the cerebrospinal fluid during experimental autoimmune encephalomyelitis and cleaves myelin basic protein

Interferon beta 2/B-cell stimulatory factor type 2 shares identity with monocyte-derived hepatocyte-stimulating factor and regulates the major acute phase protein response in liver cells.

1987 • 1,667 citations

Spreading of T-cell autoimmunity to cryptic determinants of an autoantigen

1992 • 1,200 citations

Immunological Aspects of Demyelinating Diseases

1992 • 1,021 citations

Large Scale Preparation of Myelin Basic Protein from Central Nervous Tissue of Several Mammalian Species

1972 • 949 citations

Biology of disease. Analysis of autoimmune demyelination: its impact upon multiple sclerosis.

1984 • 424 citations

Induction of rat acute‐phase proteins by interleukin 6 in vivo

1988 • 412 citations

Experimental Allergic Encephalomyelitis. A Useful Model for Multiple Sclerosis

1984 • 340 citations

Cytokine levels in the cerebrospinal fluid and serum of patients with multiple sclerosis

1991 • 330 citations

Gelatinase in the cerebrospinal fluid of patients with multiple sclerosis and other inflammatory neurological disorders

1992 • 286 citations

TIMP-2 reduces proteolytic opening of blood-brain barrier by type IV collagenase

1992 • 282 citations

Interleukin-6 induces the synthesis of tissue inhibitor of metalloproteinases-1/erythroid potentiating activity (TIMP-1/EPA)

1991 • 278 citations

Degradation of basic protein in myelin by neutral proteases secreted by stimulated macrophages: A possible mechanism of inflammatory demyelination

1978 • 276 citations

Cytokine accumulations in CSF of multiple sclerosis patients

1990 • 270 citations

Purification and identification of 91‐kDa neutrophil gelatinase

1991 • 259 citations

Production of B cell stimulatory factor-2 and interferon gamma in the central nervous system during viral meningitis and encephalitis. Evaluation in a murine model infection and in patients.

1988 • 246 citations

Elevated levels of the 26K human hybridoma growth factor (interleukin 6) in cerebrospinal fluid of patients with acute infection of the central nervous system.

1988 • 229 citations

Release of plasminogen activator and a calcium-dependent metalloprotease from cultured sympathetic and sensory neurons

1985 • 221 citations

Cytokines and proteases in invasive processes: Molecular similarities between inflammation and cancer

1992 • 160 citations

Characterization of a major encephalitogenic T cell epitope in SJL/J mice with synthetic oligopeptides of myelin basic protein

1988 • 154 citations

Interleukin 6 production in the central nervous system during experimental autoimmune encephalomyelitis

1990 • 149 citations

Inhibition of murine relapsing experimental autoimmune encephalomyelitis by immune tolerance to proteolipid protein and its encephalitogenic peptides.

1990 • 140 citations

Lymphocytes from SJL/J mice immunized with spinal cord respond selectively to a peptide of proteolipid protein and transfer relapsing demyelinating experimental autoimmune encephalomyelitis.

1991 • 130 citations

Studies on the ability of 65-kDa and 92-kDa tumor cell gelatinases to degrade type IV collagen.

1990 • 118 citations

Proteinase inhibitors suppress the development of experimental allergic encephalomyelitis

1980 • 114 citations

Interleukin 6 enhances the production of tissue inhibitor of metalloproteinases (TIMP) but not that of matrix metalloproteinases by human fibroblats

1990 • 109 citations

Cytokine-mediated regulation of human leukocyte gelatinases and role in arthritis.

1991 • 107 citations

Encephalitogenic Epitopes of Myelin Basic Protein

1989 • 89 citations

Proteolytic enzyme activity of blood leukocytes and cerebrospinal fluid in multiple sclerosis

1978 • 89 citations

Hyperacute, neutrophilic, and localized forms of experimental allergic encephalomyelitis: A review

1974 • 77 citations

Human hepatoma cells produce an 85 kDa gelatinase regulated by phorbol 12-myristate 13-acetate

1990 • 75 citations

Recognition of peptides that are immunopathogenic but cryptic. Mechanisms that allow lymphocytes sensitized against cryptic peptides to initiate pathogenic autoimmune processes.

1991 • 65 citations

Allergic encephalomyelitis: Isolation and characterization of encephalitogenic peptides from the basic protein of bovine spinal cord

1969 • 63 citations

Natural human monocyte gelatinase and its inhibitor

1991 • 48 citations

Model Systems for Study of Perturbations of Myelin Metabolism

1984 • 43 citations

Degradation of myelin basic protein by cerebrospinal fluid: Preservation of antigenic determinants under physiological conditions

1979 • 39 citations

Neutral protease in cerebrospinal fluid from patients with multiple sclerosis and other neurological diseases

1987 • 23 citations

Role of Enzyme Receptors and Inhibitors in Regulating Proteolytic Activities of Macrophages^a

1991 • 22 citations

The Precursor of Bone Collagenase and its Activation

1975 • 17 citations

Suppressive effect of camostat mesilate (FOY 305) on acute experimental allergic encephalomyelitis (EAE)

1988 • 8 citations

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