Effective treatment of models of multiple sclerosis by matrix metalloproteinase inhibitors

Interferon beta‐1b is effective in relapsing‐remitting multiple sclerosis

1993 • 2,032 citations

Copolymer 1 reduces relapse rate and improves disability in relapsing‐remitting multiple sclerosis

1995 • 1,903 citations

Tumor necrosis factor mediates myelin and oligodendrocyte damage in vitro

1988 • 1,371 citations

Processing of tumour necrosis factor-α precursor by metalloproteinases

1994 • 1,200 citations

Immunological Aspects of Demyelinating Diseases

1992 • 1,021 citations

Multiple Sclerosis: A Coordinated Immunological Attack against Myelin in the Central Nervous System

1996 • 903 citations

Association between Tumor Necrosis Factor-α and Disease Progression in Patients with Multiple Sclerosis

1991 • 794 citations

Tumor necrosis factor identified in multiple sclerosis brain.

1989 • 793 citations

Identification of lymphotoxin and tumor necrosis factor in multiple sclerosis lesions.

1991 • 735 citations

An antibody to lymphotoxin and tumor necrosis factor prevents transfer of experimental allergic encephalomyelitis.

1990 • 692 citations

Protection against a lethal dose of endotoxin by an inhibitor of tumour necrosis factor processing

1994 • 607 citations

Cytokine-induced immune deviation as a therapy for inflammatory autoimmune disease.

1994 • 599 citations

Adoptive transfer of experimental allergic encephalomyelitis in SJL/J mice after in vitro activation of lymph node cells by myelin basic protein: requirement for Lyt 1+ 2- T lymphocytes.

1981 • 592 citations

Regulation of tumour necrosis factor-α processing by a metalloproteinase inhibitor

1994 • 571 citations

GFAP Is Necessary for the Integrity of CNS White Matter Architecture and Long-Term Maintenance of Myelination

1996 • 521 citations

T cell gelatinases mediate basement membrane transmigration in vitro.

1995 • 507 citations

Anti—tumor necrosis factor therapy abrogates autoimmune demyelination

1991 • 434 citations

Production of cytotoxic factor for oligodendrocytes by stimulated astrocytes.

1987 • 426 citations

Biology of disease. Analysis of autoimmune demyelination: its impact upon multiple sclerosis.

1984 • 424 citations

Spontaneous inflammatory demyelinating disease in transgenic mice showing central nervous system-specific expression of tumor necrosis factor alpha.

1995 • 407 citations

Interferon β‐1b decreases the migration of T lymphocytes in vitro: Effects on matrix metalloproteinase‐9

1996 • 363 citations

Multiple Sclerosis: Fas Signaling in Oligodendrocyte Cell Death

1996 • 362 citations

The antidepressant rolipram suppresses cytokine production and prevents autoimmune encephalomyelitis

1995 • 345 citations

Reversal of experimental autoimmune encephalomyelitis with a hydroxamate inhibitor of matrix metalloproteases.

1994 • 338 citations

Structural requirements for binding of an immunodominant myelin basic protein peptide to DR2 isotypes and for its recognition by human T cell clones.

1994 • 323 citations

Adoptive transfer of myelin basic protein-sensitized T cells produces chronic relapsing demyelinating disease in mice

1984 • 311 citations

Apoptosis of T lymphocytes in experimental autoimmune encephalomyelitis. Evidence for programmed cell death as a mechanism to control inflammation in the brain.

1993 • 305 citations

Interferon beta‐1b inhibits gelatinase secretion and in vitro migration of human T cells: A possible mechanism for treatment efficacy in multiple sclerosis

1996 • 302 citations

Matrix Metalloproteinases in the Normal Human Central Nervous System, Microglial Nodules, and Multiple Sclerosis Lesions

1996 • 290 citations

Gelatinase in the cerebrospinal fluid of patients with multiple sclerosis and other inflammatory neurological disorders

1992 • 286 citations

Degradation of basic protein in myelin by neutral proteases secreted by stimulated macrophages: A possible mechanism of inflammatory demyelination

1978 • 276 citations

Local Delivery of Interleukin 4 by Retrovirus-Transduced T Lymphocytes Ameliorates Experimental Autoimmune Encephalomyelitis

1997 • 264 citations

The Expression of Tissue-type Plasminogen Activator, Matrix Metalloproteases and Endogenous Inhibitors in the Central Nervous System in Multiple Sclerosis

1996 • 247 citations

Clonal expansion and persistence of human T cells specific for an immunodominant myelin basic protein peptide.

1994 • 237 citations

Apoptosis in the nervous system in experimental allergic encephalomyelitis

1991 • 229 citations

Regulation of cell surface APO‐1/Fas (CD95) ligand expression by metalloproteases

1995 • 216 citations

The effects of macrophage depletion on the clinical and pathologic expression of experimental allergic encephalomyelitis.

1981 • 215 citations

Matrix metalloproteinase expression during experimental autoimmune encephalomyelitis and effects of a combined matrix metalloproteinase and tumour necrosis factor-α inhibitor

1997 • 205 citations

Multiple sclerosis: Oligodendrocytes display cell death–related molecules in situ but do not undergo apoptosis

1997 • 204 citations

Gelatinase B is present in the cerebrospinal fluid during experimental autoimmune encephalomyelitis and cleaves myelin basic protein

1993 • 192 citations

Prevention of autoimmune demyelination in non-human primates by a cAMP-specific phosphodiesterase inhibitor.

1995 • 178 citations

Nerve Growth Factor and Neurotrophin-3 Differentially Regulate the Proliferation and Survival of Developing Rat Brain Oligodendrocytes

1996 • 175 citations

TNF-alpha- and IFN-gamma-mediated signal transduction pathways: effects on glial cell gene expression and function.

1995 • 172 citations

IL-10 fails to abrogate experimental autoimmune encephalomyelitis

1996 • 169 citations

Differential tumor necrosis factor alpha expression by astrocytes from experimental allergic encephalomyelitis-susceptible and -resistant rat strains.

1991 • 157 citations

Suppression of experimental allergic encephalomyelitis in the Lewis rat by the matrix metalloproteinase inhibitor Ro31-9790

1995 • 146 citations

The Norton Lecture: a review of the oligodendrocyte in the multiple sclerosis lesion1Presented at the Albert Einstein College of Medicine, Bronx, NY, on February 3, 1997 in honor of the retirement of Dr. William T. Norton, a pioneer neurochemist in the myelin/oligodendrocyte arena.1

1997 • 140 citations

Tumor necrosis factor (TNF-α) and lymphotoxin (TNF-β)

1992 • 136 citations

Proteinase inhibitors suppress the development of experimental allergic encephalomyelitis

1980 • 114 citations

Two models of multiple sclerosis: Experimental allergic encephalomyelitis (EAE) and theiler's murine encephalomyelitis virus (TMEV) infection. A pathological and immunological comparison

1995 • 104 citations

Tumor necrosis factor (TNF-α) and lymphotoxin (TNF-β)

1992 • 97 citations

Proteolytic enzyme activity of blood leukocytes and cerebrospinal fluid in multiple sclerosis

1978 • 89 citations

Multiple sclerosis: TNF revisited, with promise

1995 • 88 citations

Delayed-type hypersensitivity lesions in the central nervous system are prevented by inhibitors of matrix metalloproteinases

1996 • 69 citations

Human autoreactive and foreign antigen-specific T cells resist apoptosis induced by soluble recombinant CD95 ligand.

1997 • 61 citations

RT-PCR and mRNA Quantitation

1994 • 44 citations

Prevention of acute autoimmune encephalomyelitis and abrogation of relapses in murine models of multiple sclerosis by the protease inhibitor D-penicillamine

1995 • 40 citations

A Review of T‐Cell Receptors in Multiple Sclerosis: Clonal Expansion and Persistence of Human T‐Cells Specific for an Immunodominant Myelin Basic Protein Peptide^a

1995 • 35 citations

A comparison of methods for RNA extraction from lymphocytes for RT-PCR.

1994 • 23 citations

Synthesis of RNA probes by the direct in vitro transcription of PCR-generated DNA templates

1993 • 22 citations

Advanced methods in PCR product detection.

1994 • 19 citations

Multiple sclerosis. Clinical and pathogenetic basis

1997 • 17 citations