Overexpression of Copper and Zinc Superoxide Dismutase in Transgenic Mice Prevents the Induction and Activation of Matrix Metalloproteinases after Cold Injury-Induced Brain Trauma

Reactive oxygen species produced by macrophage-derived foam cells regulate the activity of vascular matrix metalloproteinases in vitro. Implications for atherosclerotic plaque stability.

1996 • 1,132 citations

Quantitative Zymography: Detection of Picogram Quantities of Gelatinases

1994 • 866 citations

Matrix Metalloproteinases and TIMPs Are Associated With Blood-Brain Barrier Opening After Reperfusion in Rat Brain

1998 • 847 citations

Matrix Metalloproteinase Expression Increases After Cerebral Focal Ischemia in Rats

1998 • 731 citations

Matrix metalloproteinases and diseases of the CNS

1998 • 646 citations

Identification of the Second Membrane-type Matrix Metalloproteinase (MT-MMP-2) Gene from a Human Placenta cDNA Library

1995 • 474 citations

Transgenic mice with increased Cu/Zn-superoxide dismutase activity: animal model of dosage effects in Down syndrome.

1987 • 461 citations

Role of Oxidants and Antioxidants in the Induction of AP-1, NF-κB, and Glutathione S-Transferase Gene Expression

1996 • 457 citations

Proteolytic Cascade Enzymes Increase in Focal Cerebral Ischemia in Rat

1996 • 408 citations

Early Appearance of Activated Matrix Metalloproteinase-9 after Focal Cerebral Ischemia in Mice: A Possible Role in Blood—Brain Barrier Dysfunction

1999 • 403 citations

Brain injury, edema, and vascular permeability changes induced by oxygen‐derived free radicals

1984 • 387 citations

Matrix metalloproteinase-9 (MMP-9) is synthesized in neurons of the human hippocampus and is capable of degrading the amyloid-beta peptide (1-40).

1996 • 341 citations

Increased gelatinase A (MMP-2) and gelatinase B (MMP-9) activities in human brain after focal ischemia

1997 • 319 citations

Metalloproteinase inhibition blocks edema in intracerebral hemorrhage in the rat

1997 • 307 citations

Matrix Metalloproteinase-9 (MMP-9) Is Synthesized in Neurons of the Human Hippocampus and Is Capable of Degrading the Amyloid-β Peptide (1–40)

1996 • 293 citations

Protective effects of liposome‐entrapped superoxide dismutase on posttraumatic brain edema

1987 • 283 citations

Differential matrix metalloproteinase expression in cases of multiple sclerosis and stroke

1997 • 265 citations

Expression of c‐fos and c‐jun family genes after focal cerebral ischemia

1993 • 222 citations

Cold‐induced brain edema and infarction are reduced in transgenic mice overexpressing CuZn‐Superoxide dismutase

1991 • 207 citations

Matrix metalloproteinases contribute to the blood—brain barrier disruption during bacterial meningitis

1998 • 198 citations

Vascular extracellular matrix remodeling in cerebral aneurysms

1998 • 194 citations

Cytokines Regulate Gelatinase A and B (Matrix Metalloproteinase 2 and 9) Activity in Cultured Rat Astrocytes

1995 • 193 citations

Matrix metalloproteinases and their inhibitors

1995 • 165 citations

Increased production of gelatinase B (matrix metalloproteinase‐9) and interleukin‐6 by activated rat microglia in culture

1995 • 154 citations

Alteration of Transcription Factor Binding Activities in the Ischemic Rat-Brain

1995 • 153 citations

Oligodendrocytes utilize a matrix metalloproteinase, MMP-9, to extend processes along an astrocyte extracellular matrix

1998 • 143 citations

Cold-induced brain edema in mice. Involvement of extracellular superoxide dismutase and nitric oxide

1993 • 119 citations

Zymographic measurement of gelatinase activity in brain tissue after detergent extraction and affinity-support purification

1997 • 117 citations

Cold injury in mice: a model to study mechanisms of brain edema and neuronal apoptosis

1999 • 113 citations

Regional and differential expression of gelatinases in rat brain after systemic kainic acid or bicuculline administration

1998 • 112 citations

Active and Tissue Inhibitor of Matrix Metalloproteinase-free Gelatinase B Accumulates within Human Microvascular Endothelial Vesicles

1998 • 87 citations

Increased expression of c-fos mRNA and AP-1 transcription factors after cortical impact injury in rats

1994 • 84 citations

Subtractive Cloning Identifies Tissue Inhibitor of Matrix Metalloproteinase-1 (TIMP-1) Increased Gene Expression Following Focal Stroke

1998 • 59 citations

Cold-Injury of the Cerebral Cortex: Immunolocalization of Cellular Proteins and Blood-Brain Barrier Permeability Studies

1996 • 58 citations

Inhibition of Interleukin-1β Converting Enzyme Family Proteases (Caspases) Reduces Cold Injury-Induced Brain Trauma and DNA Fragmentation in Mice

1999 • 41 citations