Hydroxyurea induces a senescence-like change of K562 human erythroleukemia cell

WAF1, a potential mediator of p53 tumor suppression

1993 • 8,360 citations

A biomarker that identifies senescent human cells in culture and in aging skin in vivo.

1995 • 6,950 citations

The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

1993 • 5,680 citations

Handbook of the Biology of Aging

1990 • 1,219 citations

Replicative Senescence: the Human Fibroblast Comes of Age

1990 • 649 citations

Senescence-like growth arrest induced by hydrogen peroxide in human diploid fibroblast F65 cells.

1994 • 617 citations

Repression of c- fos Transcription and an Altered Genetic Program in Senescent Human Fibroblasts

1990 • 478 citations

Role of Ceramide in Cellular Senescence

1995 • 453 citations

Inhibition of ribonucleoside diphosphate reductase by hydroxyurea.

1968 • 423 citations

Failure to Phosphorylate the Retinoblastoma Gene Product in Senescent Human Fibroblasts

1990 • 367 citations

Evidence for the Recessive Nature of Cellular Immortality

1983 • 286 citations

Growth-regulated expression of D-type cyclin genes in human diploid fibroblasts.

1992 • 277 citations

Expression of cell cycle-dependent genes in young and senescent WI-38 fibroblasts.

1986 • 247 citations

Existence of High Abundance Antiproliferative mRNA's in Senescent Human Diploid Fibroblasts

1986 • 194 citations

Senescent cells fail to express cdc2, cycA, and cycB in response to mitogen stimulation.

1991 • 183 citations

Cellular Senescence revisited: a review

1987 • 171 citations

Distinction of apoptotic and necrotic cell death by in situ labelling of fragmented DNA

1994 • 158 citations

Sodium Butyrate Induces NIH3T3 Cells to Senescence-like State and Enhances Promoter Activity of p21WAF/CIP1in p53-Independent Manner

1997 • 92 citations

Diminished heat-shock protein synthesis following mitogen stimulation of lymphocytes from aged donors

1989 • 63 citations

Inhibition of DNA synthesis in senescent-proliferating human cybrids is mediated by endogenous proteins

1984 • 50 citations

Nitric Oxide Generation from Hydroxyurea via Copper‐catalyzed Peroxidation and Implications for Pharmacological Actions of Hydroxyurea

1997 • 46 citations

Cloning and expression of SAG: A novel marker of cellular senescence

1992 • 34 citations

Granular presence of terminin is the marker to distinguish between the senescent and quiescent states

1991 • 32 citations

Regulation of c-jun mRNA expression by hydroxyurea in human K562 cells during erythroid differentiation

1995 • 24 citations