Radiation-Induced Senescence-like Growth Arrest Requires TP53 Function but not Telomere Shortening

The serial cultivation of human diploid cell strains

1961 • 7,886 citations

A biomarker that identifies senescent human cells in culture and in aging skin in vivo.

1995 • 6,950 citations

The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

1993 • 5,680 citations

Participation of p53 protein in the cellular response to DNA damage.

1991 • 3,818 citations

p53: puzzle and paradigm.

1996 • 2,363 citations

A highly conserved repetitive DNA sequence, (TTAGGG)n, present at the telomeres of human chromosomes.

1988 • 2,281 citations

Telomere length predicts replicative capacity of human fibroblasts.

1992 • 2,209 citations

Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity.

1992 • 2,096 citations

DNA Damage-Induced Phosphorylation of p53 Alleviates Inhibition by MDM2

1997 • 2,089 citations

Cloning of Senescent Cell-Derived Inhibitors of DNA Synthesis Using an Expression Screen

1994 • 1,368 citations

DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts.

1994 • 1,165 citations

Telomere loss: mitotic clock or genetic time bomb?

1991 • 1,144 citations

p53- and ATM-Dependent Apoptosis Induced by Telomeres Lacking TRF2

1999 • 1,076 citations

The retinoblastoma protein is phosphorylated during specific phases of the cell cycle

1989 • 1,031 citations

Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts

1996 • 944 citations

p53 controls both the G2/M and the G1 cell cycle checkpoints and mediates reversible growth arrest in human fibroblasts.

1995 • 865 citations

DNA strand breaks: the DNA template alterations that trigger p53-dependent DNA damage response pathways.

1994 • 850 citations

Structure and variability of human chromosome ends.

1990 • 833 citations

DNA damage induces phosphorylation of the amino terminus of p53

1997 • 829 citations

Regulation of p16^CDKN2 Expression and Its Implications for Cell Immortalization and Senescence

1996 • 713 citations

Agents that cause DNA double strand breaks lead to p16INK4a enrichment and the premature senescence of normal fibroblasts

1998 • 481 citations

Roles for p53 in growth arrest and apoptosis: putting on the brakes after genotoxic stress

1998 • 421 citations

ATM-dependent telomere loss in aging human diploid fibroblasts and DNA damage lead to the post-translational activation of p53 protein involving poly(ADP-ribose) polymerase

1997 • 376 citations

Human telomeres contain at least three types of G–rich repeat distributed non-randomly

1989 • 374 citations

Increased activity of p53 in senescing fibroblasts.

1995 • 303 citations

Wild-type p53 triggers a rapid senescence program in human tumor cells lacking functional p53

1997 • 295 citations

COMMENTARY: p⁵³ Tumor suppressor gene: from the basic research laboratory to the clinic—an abridged historical perspective

1996 • 284 citations

p21Waf1/Cip1/Sdi1 induces permanent growth arrest with markers of replicative senescence in human tumor cells lacking functional p53

1999 • 200 citations

Evidence that transcriptional activation by p53 plays a direct role in the induction of cellular senescence.

1996 • 151 citations

p53 mediates permanent arrest over multiple cell cycles in response to gamma-irradiation.

1997 • 143 citations

Effect of Confluent Holding on Potentially Lethal Damage Repair, Cell Cycle Progression, and Chromosomal Aberrations in Human Normal and Ataxia-Telangiectasia Fibroblasts

1985 • 104 citations

Induced p53 expression in lung cancer cell line promotes cell senescence and differentially modifies the cytotoxicity of anti-cancer drugs

1998 • 104 citations

Comparison of kinetics of X-ray-induced cell killing in normal, ataxia telangiectasia and hereditary retinoblastoma fibroblasts

1983 • 96 citations

Telomerase, checkpoints and cancer.

1997 • 72 citations

The Nuclear Localization Signal of the Human Ku70 Is a Variant Bipartite Type Recognized by the Two Components of Nuclear Pore-Targeting Complex

1999 • 55 citations

Effect of Multiple Irradiation with Low Doses of Gamma-rays on Morphological Transformation and Growth Ability of Human Embryo Cellsin Vitro

1992 • 53 citations

Proliferative lifespan checkpoints: Cell-type specificity and influence on tumour biology

1997 • 49 citations

Signalling to p53: where does it all start?

1996 • 32 citations

Telomeres, senescence and cellular radiation response

1997 • 32 citations

Telomerase Activity, Telomere Length, and Chromosome Aberrations in the Extension of Life Span of Human Embryo Cells Induced by Low-dose X-rays.

1998 • 23 citations

Mutation induction in γ-irradiated primary human bronchial epithelial cells and molecular analysis of the HPRT− mutants

1996 • 14 citations