Absence of cancer–associated changes in human fibroblasts immortalized with telomerase

A biomarker that identifies senescent human cells in culture and in aging skin in vivo.

1995 • 6,950 citations

Oncogenic ras Provokes Premature Cell Senescence Associated with Accumulation of p53 and p16INK4a

1997 • 4,870 citations

Extension of Life-Span by Introduction of Telomerase into Normal Human Cells

1998 • 4,845 citations

The p53 tumour suppressor gene

1991 • 3,871 citations

Participation of p53 protein in the cellular response to DNA damage.

1991 • 3,818 citations

Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes

1983 • 2,871 citations

Telomerase Catalytic Subunit Homologs from Fission Yeast and Human

1997 • 2,256 citations

hEST2, the Putative Human Telomerase Catalytic Subunit Gene, Is Up-Regulated in Tumor Cells and during Immortalization

1997 • 1,786 citations

DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts.

1994 • 1,165 citations

The retinoblastoma protein is phosphorylated during specific phases of the cell cycle

1989 • 1,031 citations

Reconstitution of telomerase activity in normal human cells leads to elongation of telomeres and extended replicative life span

1998 • 1,001 citations

The product of the retinoblastoma susceptibility gene has properties of a cell cycle regulatory element

1989 • 931 citations

Bypass of Senescence After Disruption of p21 ^CIP1/WAF1 Gene in Normal Diploid Human Fibroblasts

1997 • 797 citations

The AGT Cytogenetics Laboratory Manual

2017 • 527 citations

Fibroblast immortality is a prerequisite for transformation by EJ c-Ha-ras oncogene

1983 • 446 citations

Defining the molecular mechanisms of human cell immortalization

1991 • 384 citations

Differential disruption of genomic integrity and cell cycle regulation in normal human fibroblasts by the HPV oncoproteins.

1994 • 371 citations

Contact inhibition in tissue culture

1970 • 369 citations

The E6 and E7 genes of human papillomavirus type 6 have weak immortalizing activity in human epithelial cells

1992 • 280 citations

Senescence as a mode of tumor suppression.

1991 • 195 citations

ANEUPLOIDY IN THE DEGENERATIVE PHASE OF SERIAL CULTIVATION OF HUMAN CELL STRAINS

1963 • 193 citations

Specific chromosome aberrations in senescent fibroblast cell lines derived from human embryos.

1976 • 166 citations

Lack of cell cycle regulation of telomerase activity in human cells

1997 • 162 citations

Spontaneous In Vitro Immortalization of Breast Epithelial Cells from a Patient with Li-Fraumeni Syndrome

1995 • 152 citations

Selective growth of human neoplastic cells in medium lacking serum growth factor

1971 • 24 citations

Development and Recognition of the Transformed Cell

1987 • 23 citations

p53 levels in human mammary epithelial cells expressing wild-type and mutant human papillomavirus type 16 (HPV-16) E6 proteins

1996 • 10 citations

Spontaneous immortalization of cultured skin fibroblasts obtained from a high-dose atomic bomb survivor

1996 • 8 citations

Cytogenetics of Neoplasia

1987 • 5 citations