Accumulation of single-strand breaks is the major cause of telomere shortening in human fibroblasts

Telomeres shorten during ageing of human fibroblasts

1990 • 5,530 citations

Extension of Life-Span by Introduction of Telomerase into Normal Human Cells

1998 • 4,845 citations

Mammalian Telomeres End in a Large Duplex Loop

1999 • 2,372 citations

A theory of marginotomy

1973 • 1,770 citations

Control of telomere length by the human telomeric protein TRF1

1997 • 1,197 citations

Long G Tails at Both Ends of Human Chromosomes Suggest a C Strand Degradation Mechanism for Telomere Shortening

1997 • 897 citations

Mild Hyperoxia Shortens Telomeres and Inhibits Proliferation of Fibroblasts: A Model for Senescence?

1995 • 849 citations

Detection of picomole levels of hydroperoxides using a fluorescent dichlorofluorescein assay

1983 • 844 citations

Normal human chromosomes have long G-rich telomeric overhangs at one end

1997 • 707 citations

Dissociation among in vitro telomerase activity, telomere maintenance, and cellular immortalization

1998 • 629 citations

Senescence-like growth arrest induced by hydrogen peroxide in human diploid fibroblast F65 cells.

1994 • 617 citations

Preferential Accumulation of Single-Stranded Regions in Telomeres of Human Fibroblasts

1998 • 414 citations

Evidence for a Critical Telomere Length in Senescent Human Fibroblasts

1995 • 391 citations

Low oxygen concentration extends the lifespan of cultured human diploid cells

1977 • 387 citations

Telomerase extends the lifespan of virus-transformed human cells without net telomere lengthening

1999 • 384 citations

Short telomeres on human chromosome 17p

1998 • 367 citations

The terminal DNA structure of mammalian chromosomes

1997 • 360 citations

From telomere loss to p53 induction and activation of a DNA-damage pathway at senescence: The telomere loss/DNA damage model of cell aging

1996 • 205 citations

Cell cycle-regulated generation of single-stranded G-rich DNA in the absence of telomerase

1996 • 202 citations

Telomere shortening triggers a p53-dependent cell cycle arrest via accumulation of G-rich single stranded DNA fragments

1999 • 178 citations

Accelerated Telomere Shortening in Fibroblasts After Extended Periods of Confluency

1998 • 165 citations

Short telomeres on human chromosome 17p

1998 • 159 citations

Control of telomere growth by interactions of RAP1 with the most distal telomeric repeats

1996 • 152 citations

Flow cytometric detection of hydrogen peroxide production induced by doxorubicin in cancer cells

1994 • 151 citations

The Effect of Low Oxygen Tension on the in Vitro-Replicative Life Span of Human Diploid Fibroblast Cells and Their Transformed Derivatives

1995 • 97 citations

The effect of oxygen and vitamin E on the lifespan of human diploid cells in vitro.

1977 • 86 citations

Similar Gene Expression Pattern in Senescent and Hyperoxic-Treated Fibroblasts

1998 • 74 citations

Mitochondrial water loss and aging of cells

1995 • 11 citations