DNA Topoisomerase Inhibitors Induce Reversible Senescence in Normal Human Fibroblasts

A biomarker that identifies senescent human cells in culture and in aging skin in vivo.

1995 • 6,950 citations

The limited in vitro lifetime of human diploid cell strains

1965 • 5,595 citations

Oncogenic ras Provokes Premature Cell Senescence Associated with Accumulation of p53 and p16INK4a

1997 • 4,870 citations

DNA TOPOISOMERASE POISONS AS ANTITUMOR DRUGS

1989 • 1,799 citations

DNA TOPOISOMERASES

1996 • 1,771 citations

Positional Cloning of the Werner's Syndrome Gene

1996 • 1,696 citations

Cloning of Senescent Cell-Derived Inhibitors of DNA Synthesis Using an Expression Screen

1994 • 1,368 citations

Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts

1996 • 944 citations

Mild Hyperoxia Shortens Telomeres and Inhibits Proliferation of Fibroblasts: A Model for Senescence?

1995 • 849 citations

Identification of mammalian DNA topoisomerase I as an intracellular target of the anticancer drug camptothecin.

1988 • 843 citations

Nonintercalative antitumor drugs interfere with the breakage-reunion reaction of mammalian DNA topoisomerase II.

1984 • 491 citations

p53 in growth control and neoplasia

1996 • 488 citations

Evidence for a Critical Telomere Length in Senescent Human Fibroblasts

1995 • 391 citations

Human xeroderma pigmentosum group D gene encodes a DMA helicase

1993 • 310 citations

Human Fibroblast Commitment to a Senescence-Like State in Response to Histone Deacetylase Inhibitors Is Cell Cycle Dependent

1996 • 265 citations

DNA Topoisomerases as Anticancer Drug Targets

1990 • 195 citations

Inhibition of intracellular topoisomerase II by antitumor bis(2,6-dioxopiperazine) derivatives: mode of cell growth inhibition distinct from that of cleavable complex-forming type inhibitors.

1991 • 192 citations

Increased p53 Protein Associated with Aging in Human Diploid Fibroblasts

1995 • 151 citations

Increase in expression level of p21sdi1/cip1/waf1 with increasing division age in both normal and SV40-transformed human fibroblasts.

1995 • 111 citations

Chromosome 7 suppresses indefinite division of nontumorigenic immortalized human fibroblast cell lines KMST-6 and SUSM-1.

1993 • 109 citations

Decrease in Amplified Telomeric Sequences and Induction of Senescence Markers by Introduction of Human Chromosome 7 or Its Segments in SUSM-1

1997 • 59 citations

DNA Topoisomerases as Targets of Therapeutics: An Overview

1994 • 51 citations

Expression of the human cGMP‐dependent protein kinase II gene is lost upon introduction of SV40 T antigen or immortalization in human cells

1995 • 28 citations

Clinical Development of Topoisomerase-Interactive Drugs

1994 • 23 citations

Inhibitors of cGMP-dependent protein kinase block senescence induced by inactivation of T antigen in SV40-transformed immortal human fibroblasts.

1995 • 22 citations