p21WAF1/Cip1: more than a break to the cell cycle?
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References (121)
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1994 • 941 citations
Human DNA-(Cytosine-5) Methyltransferase-PCNA Complex as a Target for p21 WAF1
1997 • 895 citations
Structure of the C-Terminal Region of p21WAF1/CIP1 Complexed with Human PCNA
1996 • 790 citations
Uncoupling of S phase and mitosis induced by anticancer agents in cells lacking p21
1996 • 746 citations
A Family of Stress-Inducible GADD45-like Proteins Mediate Activation of the Stress-Responsive MTK1/MEKK4 MAPKKK
1998 • 740 citations
Regulation of NF-κB by Cyclin-Dependent Kinases Associated with the p300 Coactivator
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Transcriptional Regulation of the p21(WAF1/CIP1)Gene
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1994 • 657 citations
p21-containing cyclin kinases exist in both active and inactive states.
1994 • 646 citations
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Topological control of p21WAF1/CIP1 expression in normal and neoplastic tissues.
1995 • 593 citations
Apoptosis inhibitory activity of cytoplasmic p21Cip1/WAF1 in monocytic differentiation
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Separate domains of p21 involved in the inhibition of Cdk kinase and PCNA
1995 • 561 citations
Cell-cycle inhibition by independent CDK and PCNA binding domains in p21Cip1
1995 • 552 citations
Inhibition of CDK activity and PCNA-dependent DNA replication by p21 is blocked by interaction with the HPV-16 E7 oncoprotein
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1996 • 463 citations
The human papillomavirus E7 oncoprotein can uncouple cellular differentiation and proliferation in human keratinocytes by abrogating p21Cip1-mediated inhibition of cdk2
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Cleavage of p21Cip1/Waf1 and p27Kip1 Mediates Apoptosis in Endothelial Cells through Activation of Cdk2: Role of a Caspase Cascade
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p21CIP1 and p57KIP2 control muscle differentiation at the myogenin step
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CCAAT/enhancer-binding protein alpha (C/EBP alpha) inhibits cell proliferation through the p21 (WAF-1/CIP-1/SDI-1) protein.
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1998 • 355 citations
Cyclin-Binding Motifs Are Essential for the Function of p21CIP1
1996 • 313 citations
p21Waf1/Cip1 protects against p53-mediated apoptosis of human melanoma cells
1997 • 305 citations
Inhibitory Function of p21 Cip1/WAF1 in Differentiation of Primary Mouse Keratinocytes Independent of Cell Cycle Control
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The p53 tumour suppressor protein is phosphorylated at serine 389 by casein kinase II.
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A small peptide inhibitor of DNA replication defines the site of interaction between the cyclin-dependent kinase inhibitor p21WAF1 and proliferating cell nuclear antigen
1995 • 276 citations
Lagging Strand DNA Synthesis at the Eukaryotic Replication Fork Involves Binding and Stimulation of FEN-1 by Proliferating Cell Nuclear Antigen
1995 • 276 citations
Inhibition of cyclin-dependent kinase 2 by p21 is necessary for retinoblastoma protein-mediated G 1 arrest after γ-irradiation
1999 • 259 citations
A non-enzymatic p21 protein inhibitor of stress-activated protein kinases
1996 • 248 citations
Caspase-mediated cleavage of p21Waf1/Cip1 converts cancer cells from growth arrest to undergoing apoptosis
1999 • 238 citations
CCAAT/Enhancer Binding Protein α Regulates p21 Protein and Hepatocyte Proliferation in Newborn Mice
1997 • 236 citations
The Role of Far1p in Linking the Heterotrimeric G Protein to Polarity Establishment Proteins During Yeast Mating
1998 • 232 citations
Gadd45 is a nuclear cell cycle regulated protein which interacts with p21Cip1.
1995 • 229 citations
Complexity and Climate
1999 • 228 citations
Purification of PCNA as a nucleotide excision repair protein
1992 • 228 citations
The Cyclin-Dependent Kinase Inhibitor p21WAF1 Is Required for Survival of Differentiating Neuroblastoma Cells
1996 • 226 citations
Cleavage of CDK Inhibitor p21Cip1/Waf1 by Caspases Is an Early Event during DNA Damage-induced Apoptosis
1998 • 215 citations
Stress signals for apoptosis: ceramide and c-Jun kinase
1998 • 211 citations
A Cdc24p-Far1p-Gβγ Protein Complex Required for Yeast Orientation during Mating
1999 • 202 citations
p21 WAF1/Cip1 functions as a suppressor of malignant skin tumor formation and a determinant of keratinocyte stem-cell potential
1999 • 201 citations
Processing of branched DNA intermediates by a complex of human FEN-1 and PCNA
1996 • 200 citations
The cell cycle inhibitor p21 controls T-cell proliferation and sex-linked lupus development
2000 • 197 citations
Caspase activation in the terminal differentiation of human epidermal keratinocytes
1999 • 196 citations
Activation of the cryptic DNA binding function of mutant forms of p53
1993 • 190 citations
The differentiation primary response gene MyD118, related to GADD45, encodes for a nuclear protein which interacts with PCNA and p21WAF1/CIP1.
1996 • 176 citations
Replication factor encoded by a putative oncogene, set, associated with myeloid leukemogenesis.
1995 • 173 citations
Members of the NAP/SET family of proteins interact specifically with B-type cyclins.
1995 • 167 citations
Protective Role of p21Waf1/Cip1 against Prostaglandin A2-Mediated Apoptosis of Human Colorectal Carcinoma Cells
1996 • 160 citations
Caspase 3 inactivation to suppress Fas-mediated apoptosis: identification of binding domain with p21 and ILP and inactivation machinery by p21
1999 • 157 citations
Protein–PCNA interactions: a DNA-scanning mechanism?
1998 • 155 citations
Homologous regions of Fen1 and p21Cip1 compete for binding to the same site on PCNA: a potential mechanism to co-ordinate DNA replication and repair
1997 • 155 citations
Caspase-dependent activation of cyclin-dependent kinases during Fas-induced apoptosis in Jurkat cells
1998 • 154 citations
Ultraviolet Light Induces Expression of p53 and p21 in Human Skin: Effect of Sunscreen and Constitutive p21 Expression in Skin Appendages
1995 • 154 citations
Cip1 inhibits DNA replication but not PCNA-dependent nucleotide excision—repair
1994 • 152 citations
Suppression of cell transformation by the cyclin-dependent kinase inhibitor p57 KIP2 requires binding to proliferating cell nuclear antigen
1998 • 152 citations
Inhibition of Nucleotide Excision Repair by the Cyclin-dependent Kinase Inhibitor p21
1995 • 151 citations
Control of E2F activity by p21Waf1/Cip1
1999 • 148 citations
Mitochondrial Regulation of Cell Death: Mitochondria Are Essential for Procaspase 3-p21 Complex Formation To Resist Fas-Mediated Cell Death
1999 • 133 citations
Reciprocal Regulation via Protein-Protein Interaction between c-Myc and p21 in DNA Replication and Transcription
2000 • 133 citations
Mechanism of Inhibition of Proliferating Cell Nuclear Antigen-Dependent DNA Synthesis by the Cyclin-Dependent Kinase Inhibitor p21
1995 • 126 citations
A Novel Transcriptional Repression Domain Mediates p21WAF1/CIP1 Induction of p300 Transactivation
2000 • 126 citations
p21 (WAF1/CIP1) Expression Is Induced in Newly Nondividing Cells in Diverse Epithelia and during Differentiation of the Caco-2 Intestinal Cell Line
1996 • 119 citations
p21CIP1 and Cdc25A: Competition between an Inhibitor and an Activator of Cyclin-Dependent Kinases
1997 • 109 citations
Signal Transduction Pathways Controlling the Switch Between Keratinocyte Growth and Differentiation
1999 • 106 citations
Reversible Phosphorylation at the C-terminal Regulatory Domain of p21Waf1/Cip1 Modulates Proliferating Cell Nuclear Antigen Binding
2000 • 104 citations
Characterisation of the interaction between PCNA and Gadd45.
1995 • 103 citations
The Cyclin-dependent Kinase Cdk2 Regulates Thymocyte Apoptosis
1999 • 102 citations
Tumor suppression by p27Kip1 and p21Cip1 during chemically induced skin carcinogenesis
1999 • 99 citations
A function of p21 during promyelocytic leukemia cell differentiation independent of CDK inhibition and cell cycle arrest
1999 • 98 citations
p21WAF1/CIP1 Inhibits Initiator Caspase Cleavage by TRAIL Death Receptor DR4
2000 • 97 citations
Biosynthesis of casein kinase II in lymphoid cell lines
1994 • 93 citations
Caspase-Dependent Cdk Activity Is a Requisite Effector of Apoptotic Death Events
2000 • 90 citations
The Protein SET Regulates the Inhibitory Effect of p21Cip1 on Cyclin E-Cyclin-dependent Kinase 2 Activity
1999 • 88 citations
Calmodulin and calmodulin-binding proteins in the nucleus
1994 • 87 citations
CK2A Protein Kinase in Need of Control
1999 • 86 citations
p21 Disrupts the Interaction between cdk2 and the E2F-p130 Complex
1996 • 86 citations
Evidence that cutaneous carcinogen-initiated epithelial cells from mice are quiescent rather than actively cycling.
1997 • 84 citations
Calmodulin Is Essential for Cyclin-dependent Kinase 4 (Cdk4) Activity and Nuclear Accumulation of Cyclin D1-Cdk4 during G1
1998 • 83 citations
CaMK-II Inhibition Reduces Cyclin D1 Levels and Enhances the Association of p27kip1with Cdk2 to Cause G1 Arrest in NIH 3T3 Cells
1998 • 71 citations
Mapping of the interaction sites of the growth suppressor protein p53 with the regulatory beta-subunit of protein kinase CK2.
1995 • 70 citations
p21WAF1/CIP1 interacts with protein kinase CK2.
1996 • 68 citations
A 5' to 3' exonuclease functionally interacts with calf DNA polymerase epsilon.
1992 • 68 citations
Caspase 3 specifically cleaves p21WAF1/CIP1 in the earlier stage of apoptosis in SK‐HEP‐1 human hepatoma cells
1998 • 67 citations
Genetic deletion of p21WAF1 enhances papilloma formation but not malignant conversion in experimental mouse skin carcinogenesis.
1999 • 66 citations
Commitment and Effector Phases of the Physiological Cell Death Pathway Elucidated with Respect to Bcl-2, Caspase, and Cyclin-Dependent Kinase Activities
1998 • 62 citations
Role of p21 in prostaglandin A2-mediated cellular arrest and death.
1996 • 61 citations
Functional Analysis of a p21 Mutant (Arg94→ Trp) Identified in a Human Breast Carcinoma
1996 • 59 citations
Building Working Cells 'in Silico'
1999 • 57 citations
Calmodulin Binds to p21Cip1 and Is Involved in the Regulation of Its Nuclear Localization
1999 • 56 citations
Cancer dormancy and cell signaling: Induction of p21waf1initiated by membrane IgM engagement increases survival of B lymphoma cells
1999 • 41 citations
Calmodulin regulates DNA polymerase α activity during proliferative activation of NRK cells
1992 • 41 citations
Exploring the Systems of Life
1999 • 33 citations
Calcineurin is essential for DNA synthesis in Swiss 3T3 fibroblasts
1996 • 32 citations