The Cat and Mouse Games That Genes, Viruses, and Cells Play

The serial cultivation of human diploid cell strains

1961 • 7,886 citations

p53, the Cellular Gatekeeper for Growth and Division

1997 • 7,621 citations

The retinoblastoma protein and cell cycle control

1995 • 4,873 citations

Oncogenic ras Provokes Premature Cell Senescence Associated with Accumulation of p53 and p16INK4a

1997 • 4,870 citations

Induction of apoptosis in fibroblasts by c-myc protein

1992 • 2,977 citations

Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes

1983 • 2,871 citations

The multistep nature of cancer

1993 • 1,872 citations

Adenovirus early region 1A enables viral and cellular transforming genes to transform primary cells in culture

1983 • 1,358 citations

Wild-type p53 mediates apoptosis by E1A, which is inhibited by E1B.

1993 • 875 citations

Database of p53 gene somatic mutations in human tumors and cell lines.

1994 • 866 citations

Cdc25 cell-cycle phosphatase as a target of c-myc

1996 • 691 citations

Stabilization of the p53 tumor suppressor is induced by adenovirus 5 E1A and accompanies apoptosis.

1993 • 677 citations

Fibroblast immortality is a prerequisite for transformation by EJ c-Ha-ras oncogene

1983 • 446 citations

Role of the cyclin-dependent kinase inhibitors in the development of cancer

1995 • 404 citations

Role of the cyclin-dependent kinase inhibitors in the development of cancer

1995 • 321 citations

Human cytomegalovirus down-regulates HLA class I expression by reducing the stability of class I H chains.

1993 • 215 citations

Activated H-ras Rescues E1A-Induced Apoptosis and Cooperates with E1A To Overcome p53-Dependent Growth Arrest

1995 • 94 citations

Involvement of RB-1, p53, p16INK4 and telomerase in immortalisation of human cells.

1995 • 75 citations

Regulation of radiation-induced apoptosis in oncogene-transfected fibroblasts: influence of H-ras on the G2 delay.

1996 • 65 citations

Molecular markers of senescence in fibroblast-like cultures

1996 • 60 citations