Transcription and cancer

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

1983 • 11,902 citations

The Steroid and Thyroid Hormone Receptor Superfamily

1988 • 7,590 citations

Organization and Expression of Eucaryotic Split Genes Coding for Proteins

1981 • 4,730 citations

Mutations affecting segment number and polarity in Drosophila

1980 • 4,280 citations

The Leucine Zipper: A Hypothetical Structure Common to a New Class of DNA Binding Proteins

1988 • 3,479 citations

Gene regulation by steroid hormones

1989 • 3,466 citations

Transcriptional Regulation in Mammalian Cells by Sequence-Specific DNA Binding Proteins

1989 • 3,219 citations

Phorbol ester-inducible genes contain a common cis element recognized by a TPA-modulated trans-acting factor

1987 • 3,057 citations

The Human Papilloma Virus-16 E7 Oncoprotein Is Able to Bind to the Retinoblastoma Gene Product

1989 • 3,036 citations

A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma

1986 • 2,968 citations

Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes

1983 • 2,871 citations

A new DNA binding and dimerization motif in immunoglobulin enhancer binding, daughterless, MyoD, and myc proteins

1989 • 2,706 citations

Association of Human Papillomavirus Types 16 and 18 E6 Proteins with p53

1990 • 2,587 citations

Repetitive zinc-binding domains in the protein transcription factor IIIA from Xenopus oocytes.

1985 • 2,450 citations

T antigen is bound to a host protein in SY40-transformed cells

1979 • 2,378 citations

Cell-specific regulation of the c-myc gene by lymphocyte mitogens and platelet-derived growth factor

1983 • 2,350 citations

The protein Id: A negative regulator of helix-loop-helix DNA binding proteins

1990 • 2,273 citations

IκB: a Specific Inhibitor of the NF-κB Transcription Factor

1988 • 2,203 citations

Purified transcription factor AP-1 interacts with TPA-inducible enhancer elements

1987 • 2,107 citations

Isolation and characterization of a zinc finger polypeptide gene at the human chromosome 11 Wilms' tumor locus

1990 • 1,882 citations

Interactions between heterologous helix-loop-helix proteins generate complexes that bind specifically to a common DNA sequence

1989 • 1,876 citations

Characterization of a 54K Dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cells

1979 • 1,830 citations

Suppression of Human Colorectal Carcinoma Cell Growth by Wild-Type p53

1990 • 1,796 citations

PROTEIN-DNA RECOGNITION

1984 • 1,649 citations

Regulation of Inducible and Tissue-Specific Gene Expression

1987 • 1,640 citations

Isolation of cDNA encoding transcription factor Sp1 and functional analysis of the DNA binding domain

1987 • 1,640 citations

Antitumor promotion and antiinflammation: Down-modulation of AP-1 (Fos/Jun) activity by glucocorticoid hormone

1990 • 1,605 citations

Transcriptional interference between c-Jun and the glucocorticoid receptor: Mutual inhibition of DNA binding due to direct protein-protein interaction

1990 • 1,583 citations

The c-erb-A gene encodes a thyroid hormone receptor

1986 • 1,505 citations

Phosphorylation of c-jun mediated by MAP kinases

1991 • 1,495 citations

SV40 large tumor antigen forms a specific complex with the product of the retinoblastoma susceptibility gene

1988 • 1,490 citations

Chromosomal translocation t(15;17) in human acute promyelocytic leukemia fuses RARα with a novel putative transcription factor, PML

1991 • 1,463 citations

The E2F transcription factor is a cellular target for the RB protein

1991 • 1,461 citations

Association between an oncogene and an anti-oncogene: the adenovirus E1A proteins bind to the retinoblastoma gene product

1988 • 1,440 citations

Amplified DNA with limited homology to myc cellular oncogene is shared by human neuroblastoma cell lines and a neuroblastoma tumour

1983 • 1,407 citations

The c-fos protein interacts with c-JunAP-1 to stimulate transcription of AP-1 responsive genes

1988 • 1,352 citations

The c-erb-A protein is a high-affinity receptor for thyroid hormone

1986 • 1,340 citations

Transcription Factor Interactions: Selectors of Positive or Negative Regulation from a Single DNA Element

1990 • 1,326 citations

The regulation of transcription by phosphorylation

1992 • 1,316 citations

Homozygous deletion in Wilms tumours of a zinc-finger gene identified by chromosome jumping

1990 • 1,300 citations

EUKARYOTIC TRANSCRIPTIONAL REGULATORY PROTEINS

1989 • 1,299 citations

Myogenin, a factor regulating myogenesis, has a domain homologous to MyoD

1989 • 1,286 citations

Functional antagonism between oncoprotein c-Jun and the glucocorticoid receptor

1990 • 1,272 citations

Control of eukaryotic messenger RNA synthesis by sequence-specific DNA-binding proteins

1985 • 1,248 citations

The estrogen receptor binds tightly to its responsive element as a ligand-induced homodimer

1988 • 1,233 citations

Dwarf locus mutants lacking three pituitary cell types result from mutations in the POU-domain gene pit-1

1990 • 1,211 citations

Identification of p53 as a Sequence-Specific DNA-Binding Protein

1991 • 1,109 citations

Activation of protein kinase C decreases phosphorylation of c-Jun at sites that negatively regulate its DNA-binding activity

1991 • 1,071 citations

A conserved DNA sequence in homoeotic genes of the Drosophila Antennapedia and bithorax complexes

1984 • 1,066 citations

Nuclear receptors enhance our understanding of transcription regulation

1988 • 1,062 citations

Transcription factor ATF cDNA clones: an extensive family of leucine zipper proteins able to selectively form DNA-binding heterodimers.

1989 • 1,046 citations

Five intermediate complexes in transcription initiation by RNA polymerase II

1989 • 1,033 citations

The retinoblastoma protein is phosphorylated during specific phases of the cell cycle

1989 • 1,031 citations

Mechanism of transcriptional activation by Sp1: Evidence for coactivators

1990 • 1,029 citations

The molecular basis for metameric pattern in the Drosophila embryo

1987 • 1,028 citations

The murine and Drosophila homeobox gene complexes have common features of organization and expression

1989 • 1,021 citations

Isolation of a recombinant copy of the gene encoding C/EBP.

1988 • 1,003 citations

A tissue-specific transcription factor containing a homeodomain specifies a pituitary phenotype

1988 • 998 citations

Scissors-Grip Model for DNA Recognition by a Family of Leucine Zipper Proteins

1989 • 996 citations

Crystal structure of an engrailed homeodomain-DNA complex at 2.8 Å resolution: A framework for understanding homeodomain-DNA interactions

1990 • 996 citations

Phosphorylation of the retinoblastoma gene product is modulated during the cell cycle and cellular differentiation

1989 • 990 citations

Regulated expression of a gene encoding a nuclear factor, IRF-1, that specifically binds to IFN-β gene regulatory elements

1988 • 984 citations

Structurally similar but functionally distinct factors, IRF-1 and IRF-2, bind to the same regulatory elements of IFN and IFN-inducible genes

1989 • 970 citations

Determinants of target gene specificity for steroid/thyroid hormone receptors

1989 • 954 citations

Oncogene jun encodes a sequence-specific trans- activator similar to AP-1

1988 • 940 citations

Oncogenic forms of p53 inhibit p53-regulated gene expression

1992 • 933 citations

A novel human muscle factor related to but distinct from MyoD1 induces myogenic conversion in 10T1/2 fibroblasts.

1989 • 919 citations

A cluster of phosphorylation sites on the cyclic AMP-regulated nuclear factor CREB predicted by its sequence

1989 • 914 citations

Homeo Boxes in the Study of Development

1987 • 905 citations

Abnormalities in Structure and Expression of the Human Retinoblastoma Gene in SCLC

1988 • 905 citations

The DNA binding subunit of NF-κB is identical to factor KBF1 and homologous to the rel oncogene product

1990 • 900 citations

Sequence-Specific DNA Binding by the c-Myc Protein

1990 • 893 citations

Gene regulation by proteins acting nearby and at a distance

1986 • 886 citations

The candidate Wilms' tumour gene is involved in genitourinary development

1990 • 884 citations

Adenovirus E1b-58kd tumor antigen and SV40 large tumor antigen are physically associated with the same 54 kd cellular protein in transformed cells

1982 • 883 citations

Cloning of the p50 DNA binding subunit of NF-κB: Homology to rel and dorsal

1990 • 870 citations

The sex-determining region of the human Y chromosome encodes a finger protein

1987 • 847 citations

Increased expression of the epidermal growth factor receptor gene in malignant gliomas is invariably associated with gene amplification.

1987 • 843 citations

Presence of a Potent Transcription Activating Sequence in the p53 Protein

1990 • 811 citations

Structural Evidence for the Authenticity of the Human Retinoblastoma Gene

1987 • 809 citations

Oncogenic and transcriptional cooperation with Ha-Ras requires phosphorylation of c-Jun on serines 63 and 73

1991 • 800 citations

The MyoD DNA binding domain contains a recognition code for muscle-specific gene activation

1990 • 794 citations

The proline-rich transcriptional activator of CTF/NF-I is distinct from the replication and DNA binding domain

1989 • 781 citations

Identification of MRF4: a new member of the muscle regulatory factor gene family.

1989 • 779 citations

Structural relationships among genes that control development: sequence homology between the Antennapedia, Ultrabithorax, and fushi tarazu loci of Drosophila.

1984 • 776 citations

p53 functions as a cell cycle control protein in osteosarcomas.

1990 • 774 citations

A gene activated by growth factors is related to the oncogene v-jun.

1988 • 771 citations

Identification of cooperating oncogenes in Eμ-myc transgenic mice by provirus tagging

1991 • 765 citations

The POU domain: a large conserved region in the mammalian pit-1, oct-1, oct-2, and Caenorhabditis elegans unc-86 gene products.

1988 • 750 citations

A multiplicity of CCAAT box-binding proteins

1987 • 745 citations

The human c-myc oncogene: Structural consequences of translocation into the igh locus in Burkitt lymphoma

1983 • 732 citations

RNA POLYMERASE II

1991 • 729 citations

A new homeobox gene contributes the DNA binding domain of the t(1;19) translocation protein in pre-B all

1990 • 726 citations

Transcriptional selectivity of viral genes in mammalian cells

1986 • 722 citations

THE myc ONCOGENE: ITS ROLE IN TRANSFORMATION AND DIFFERENTIATION

1986 • 714 citations

Human CCAAT-binding proteins have heterologous subunits

1988 • 712 citations

Isolation of coactivators associated with the TATA-binding protein that mediate transcriptional activation

1991 • 711 citations

Differential transcriptional activation by Oct-1 and Oct-2: Interdependent activation domains induce Oct-2 phosphorylation

1990 • 696 citations

Chromosomal translocation t(1;19) results in synthesis of a homeobox fusion mRNA that codes for a potential chimeric transcription factor

1990 • 692 citations

Characterization of SAP-1, a protein recruited by serum response factor to the c-fos serum response element

1992 • 688 citations

Sequence of a Drosophila segmentation gene: protein structure homology with DNA-binding proteins

1984 • 686 citations

Identification of an Amplified, Highly Expressed Gene in a Human Glioma

1987 • 671 citations

The ubiquitous octamer-binding protein Oct-1 contains a POU domain with a homeo box subdomain.

1988 • 670 citations

Extensive homology among the largest subunits of eukaryotic and prokaryotic RNA polymerases

1985 • 670 citations

L-myc, a new myc-related gene amplified and expressed in human small cell lung cancer

1985 • 652 citations

Molecular Analysis of Acute Promyelocytic Leukemia Breakpoint Cluster Region on Chromosome 17

1990 • 650 citations

The retinoblastoma susceptibility gene encodes a nuclear phosphoprotein associated with DNA binding activity

1987 • 649 citations

Transcriptional Activation by Wild-Type but Not Transforming Mutants of the p53 Anti-Oncogene

1990 • 644 citations

Fos-Associated Protein p39 Is the Product of the jun Proto-Oncogene

1988 • 643 citations

Direct and selective binding of an acidic transcriptional activation domain to the TATA-box factor TFIID

1990 • 620 citations

Protein-Binding Sites in Ig Gene Enhancers Determine Transcriptional Activity and Inducibility

1987 • 619 citations

Transcription from a TATA-less promoter requires a multisubunit TFIID complex.

1991 • 618 citations

Adenovirus E1A, simian virus 40 tumor antigen, and human papillomavirus E7 protein share the capacity to disrupt the interaction between transcription factor E2F and the retinoblastoma gene product.

1992 • 617 citations

Common DNA binding site for Fos protein complexesand transcription factor AP-1

1988 • 613 citations

Solution Structure of the Glucocorticoid Receptor DNA-Binding Domain

1990 • 609 citations

Inactivation of the Retinoblastoma Susceptibility Gene in Human Breast Cancers

1988 • 608 citations

The unc-86 gene product couples cell lineage and cell identity in C. elegans

1990 • 606 citations

c-fos protein can induce cellular transformation: A novel mechanism of activation of a cellular oncogene

1984 • 601 citations

Protein encoded by v-erbA functions as a thyroid-hormone receptor antagonist

1989 • 599 citations

Binding of the Wilms' Tumor Locus Zinc Finger Protein to the EGR-1 Consensus Sequence

1990 • 588 citations

The adenovirus major late transcription factor USF is a member of the helix-loop-helix group of regulatory proteins and binds to DNA as a dimer.

1990 • 584 citations

Activators and targets

1990 • 582 citations

The product of a novel growth factor activated gene, fos B, interacts with JUN proteins enhancing their DNA binding activity.

1989 • 572 citations

Mechanism of action of an acidic transcriptional activator in vitro

1991 • 557 citations

GLI3 zinc-finger gene interrupted by translocations in Greig syndrome families

1991 • 549 citations

Multiple factors required for accurate initiation of transcription by purified RNA polymerase II.

1980 • 541 citations

Identification of cellular proteins that can interact specifically with the T/ElA-binding region of the retinoblastoma gene product

1991 • 541 citations

Repression of the Insulin-Like Growth Factor II Gene by the Wilms Tumor Suppressor WT1

1992 • 535 citations

Analysis of FBJ-MuSV provirus and c-fos (mouse) gene reveals that viral and cellular fos gene products have different carboxy termini

1983 • 532 citations

Activation of Cell-Specific Expression of Rat Growth Hormone and Prolactin Genes by a Common Transcription Factor

1988 • 525 citations

Viral and cellular fos proteins: A comparative analysis

1984 • 523 citations

Nucleoprotein complexes that regulate gene expression in adipocyte differentiation: direct participation of c-fos

1987 • 523 citations

Jun-Fos and receptors for vitamins A and D recognize a common response element in the human osteocalcin gene

1990 • 522 citations

fra-1: a serum-inducible, cellular immediate-early gene that encodes a fos-related antigen.

1988 • 518 citations

Novel zinc finger gene implicated as myc collaborator by retrovirally accelerated lymphomagenesis in Eμ-myc transgenic mice

1991 • 516 citations

fos-associated cellular p39 is related to nuclear transcription factor AP-1

1988 • 508 citations

Myf-6, a new member of the human gene family of myogenic determination factors: evidence for a gene cluster on chromosome 12.

1990 • 508 citations

The c-ets proto-oncogenes encode transcription factors that cooperate with c-Fos and c-Jun for transcriptional activation

1990 • 507 citations

Three amino acids of the oestrogen receptor are essential to its ability to distinguish an oestrogen from a glucocorticoid-responsive element

1989 • 507 citations

Negative growth regulation in a glioblastoma tumor cell line that conditionally expresses human wild-type p53.

1990 • 502 citations

The role of phosphorylation and the CDC28 protein kinase in cell cycle-regulated nuclear import of the S. cerevisiae transcription factor SW15

1991 • 501 citations

The achaete-scute gene complex of D. melanogaster: Conserved Domains in a subset of genes required for neurogenesis and their homology to myc

1987 • 501 citations

The sequence specificity of homeodomain-DNA interaction

1988 • 501 citations

Eukaryotic RNA Polymerase

1985 • 500 citations

A cloned octamer transcription factor stimulates transcription from lymphoid–specific promoters in non–B cells

1988 • 494 citations

Characterization of junD: a new member of the jun proto-oncogene family.

1989 • 492 citations

Transcriptional Repression Mediated by the WT1 Wilms Tumor Gene Product

1991 • 492 citations

Divergent homeo box proteins recognize similar DNA sequences in Drosophila

1988 • 491 citations

DNA specificity of the bicoid activator protein is determined by homeodomain recognition helix residue 9

1989 • 487 citations

Herculin, a fourth member of the MyoD family of myogenic regulatory genes.

1990 • 482 citations

Myc and Max proteins possess distinct transcriptional activities

1992 • 478 citations

Formation of stable preinitiation complexes between eukaryotic class B transcription factors and promoter sequences

1983 • 477 citations

Functional Domains and Upstream Activation Properties of Cloned Human TATA Binding Protein

1990 • 471 citations

jun-D: a third member of the jun gene family.

1989 • 469 citations

A putative second cell-derived oncogene of the avian leukaemia retrovirus E26

1983 • 462 citations

Wild-type p53 can down-modulate the activity of various promoters.

1991 • 461 citations

The v-myb oncogene product binds to and activates the promyelocyte-specific mim-1 gene

1989 • 460 citations

Definition of regions in human c-myc that are involved in transformation and nuclear localization.

1987 • 457 citations

Serum-, TPA-, and Ras-induced expression from Ap-1/Ets-driven promoters requires Raf-1 kinase.

1992 • 453 citations

Expression of the Wilms' tumor gene WT1 in the murine urogenital system.

1991 • 447 citations

Ets-related protein Elk-1 is homologous to the c-fos regulatory factor p62TCF

1991 • 447 citations

Avian sarcoma virus 17 carries the jun oncogene.

1987 • 445 citations

Rous Sarcoma Virus: a Function required for the Maintenance of the Transformed State

1970 • 444 citations

HOMEOTIC GENES AND THE HOMEOBOX

1986 • 442 citations

Acid blobs and negative noodles

1988 • 438 citations

Oestradiol induction of a glucocorticoid-responsive gene by a chimaeric receptor

1987 • 434 citations

Tripartite structure of the avian erythroblastosis virus E26 transforming gene

1983 • 430 citations

The B-cell-specific Oct-2 protein contains POU box- and homeo box-type domains.

1988 • 429 citations

Myc and Max associate in vivo.

1992 • 428 citations

The TATA-binding protein and associated factors are integral components of the RNA polymerase I transcription factor, SL1

1992 • 427 citations

The T/E1A-binding domain of the retinoblastoma product can interact selectively with a sequence-specific DNA-binding protein

1991 • 420 citations

Retroviral activation of a novel gene encoding a zinc finger protein in IL-3-dependent myeloid leukemia cell lines

1988 • 417 citations

An amino-terminal c-myc domain required for neoplastic transformation activates transcription.

1990 • 413 citations

The primary structure of transcription factor TFIIIA has 12 consecutive repeats

1985 • 413 citations

Deregulation of a Homeobox Gene, HOX11, by the t(10;14) in T Cell Leukemia

1991 • 411 citations

A conserved family of nuclear proteins containing structural elements of the finger protein encoded by Krüppel, a Drosophila segmentation gene

1986 • 409 citations

Mutant p53 DNA clones from human colon carcinomas cooperate with ras in transforming primary rat cells: a comparison of the "hot spot" mutant phenotypes.

1990 • 409 citations

Introduction of a Normal Human Chromosome 11 into a Wilms' Tumor Cell Line Controls Its Tumorigenic Expression

1987 • 407 citations

extramacrochaetae, a negative regulator of sensory organ development in Drosophila, defines a new class of helix-loop-helix proteins

1990 • 407 citations

Erythroleukemia induction by Friend murine leukemia virus: insertional activation of a new member of the ets gene family, Fli-1, closely linked to c-ets-1.

1991 • 404 citations

The POU-specific domain of Pit-1 is essential for sequence-specific, high affinity DNA binding and DNA-dependent Pit-1—Pit-1 interactions

1990 • 403 citations

B cell lymphoma-associated chromosomal translocation involves candidate oncogene lyt-10, homologous to NF-κB p50

1991 • 403 citations

A human lymphoid- specific transcription factor that activates immunoglobulin genes is a homoeobox protein

1988 • 399 citations

The GLI gene is a member of the Kruppel family of zinc finger proteins

1988 • 396 citations

Repression of the interleukin 6 gene promoter by p53 and the retinoblastoma susceptibility gene product.

1991 • 391 citations

The Drosophila extramacrochaetae locus, an antagonist of proneural genes that, like these genes, encodes a helix-loop-helix protein

1990 • 387 citations

Wild-type but not mutant p53 immunopurified proteins bind to sequences adjacent to the SV40 origin of replication

1991 • 382 citations

Herpes simplex virus regulatory elements and the immunoglobulin octamer domain bind a common factor and are both targets for virion transactivation

1988 • 377 citations

Cell cycle regulation of the E2F transcription factor involves an interaction with cyclin A

1991 • 374 citations

New chromosomal translocations correlate with specific immunophenotypes of childhood acute lymphoblastic leukemia

1984 • 365 citations

The gene SCL is expressed during early hematopoiesis and encodes a differentiation-related DNA-binding motif.

1989 • 363 citations

PU.1 recruits a second nuclear factor to a site important for immunoglobulin kappa 3' enhancer activity.

1992 • 362 citations

The rhombotin family of cysteine-rich LIM-domain oncogenes: distinct members are involved in T-cell translocations to human chromosomes 11p15 and 11p13.

1991 • 360 citations

Two amino acids within the knuckle of the first zinc finger specify DNA response element activation by the glucocorticoid receptor

1989 • 358 citations

lyl-1, a novel gene altered by chromosomal translocation in T cell leukemia, codes for a protein with a helix-loop-helix DNA binding motif

1989 • 358 citations

RNA Polymerase B (II) And General Transcription Factors

1990 • 355 citations

Factors involved in specific transcription in mammalian RNA polymerase II. Functional analysis of initiation factors IIA and IID and identification of a new factor operating at sequences downstream of the initiation site.

1987 • 355 citations

Prokaryotic and eukaryotic RNA polymerases have homologous core subunits.

1987 • 355 citations

Myb DNA binding inhibited by phosphorylation at a site deleted during oncogenic activation

1990 • 355 citations

Saturation Mutagenesis of the Yeast his3 Regulatory Site: Requirements for Transcriptional Induction and for Binding by GCN4 Activator Protein

1986 • 352 citations

A pituitary POU domain protein, Pit-1, activates both growth hormone and prolactin promoters transcriptionally.

1989 • 352 citations

Site-specific recombination of the tal-1 gene is a common occurrence in human T cell leukemia.

1990 • 350 citations

Heterodimer formation between CREB and JUN proteins.

1990 • 347 citations

The tal gene undergoes chromosome translocation in T cell leukemia and potentially encodes a helix-loop-helix protein.

1990 • 347 citations

Delineation of three functional domains of the transcriptional activator encoded by the c-myb protooncogene.

1989 • 342 citations

Fly and frog homoeo domains show homologies with yeast mating type regulatory proteins

1984 • 341 citations

Transcriptional activation of the translocated c- myc oncogene in Burkitt lymphoma

1983 • 340 citations

The C. elegans cell lineage and differentiation gene unc-86 encodes a protein with a homeodomain and extended similarity to transcription factors

1988 • 334 citations

Cloning of a Transcriptionally Active Human TATA Binding Factor

1990 • 332 citations

Expression of homeo box genes during mouse development: a review.

1988 • 331 citations

Transcription factor AP-4 contains multiple dimerization domains that regulate dimer specificity.

1990 • 330 citations

Wild-type p53 mediates positive regulation of gene expression through a specific DNA sequence element.

1992 • 328 citations

Amino-terminal domains of c-myc and N-myc proteins mediate binding to the retinoblastoma gene product

1991 • 326 citations

The v-rel oncogene encodes a κB enhancer binding protein that inhibits NF-κB function

1990 • 325 citations

The mec-3 gene of Caenorhabditis elegans requires its own product for maintained expression and is expressed in three neuronal cell types.

1989 • 321 citations

Physical Analysis of Transcription Preinitiation Complex Assembly on a Class II Gene Promoter

1988 • 320 citations

Family of proteins that interact with TFIID and regulate promoter activity

1991 • 319 citations

Separation and partial characterization of three functional steps in transcription initiation by human RNA polymerase II.

1985 • 311 citations

Factors Involved in Specific Transcription by Mammalian RNA Polymerase II

1989 • 304 citations

The POU domain is a bipartite DNA-binding structure

1988 • 304 citations

Cloning and structure of a yeast gene encoding a general transcription initiation factor TFIID that binds to the TATA box

1989 • 303 citations

Transcriptional activation by the v-myb oncogene and its cellular progenitor, c-myb

1989 • 302 citations

A pituitary-specific trans-acting factor can stimulate transcription from the growth hormone promoter in extracts of nonexpressing cells

1987 • 301 citations

Nuclear localization and DNA binding of the transforming gene product of avian myelocytomatosis virus

1982 • 298 citations

Negative regulation of human c-fos expression by thes retinoblastoma gene product

1990 • 298 citations

Definition of multiple, functionally distinct TATA elements, one of which is a target in the hsp70 promoter for E1A regulation

1988 • 292 citations

Fusion of the Leucine Zipper Gene HLF to the E2A Gene in Human Acute B-Lineage Leukemia

1992 • 290 citations

The segmentation and homeotic gene network in early Drosophila development

1987 • 286 citations

The leucine repeat motif in Fos protein mediates complex formation with Jun/AP-1 and is required for transformation

1989 • 286 citations

Leucine zippers of fos, jun and GCN4 dictate dimerization specificity and thereby control DNA binding

1989 • 281 citations

Max: functional domains and interaction with c-Myc.

1992 • 280 citations

Homology between the DNA-binding domain of the GCN4 regulatory protein of yeast and the carboxyl-terminal region of a protein coded for by the oncogene jun.

1987 • 279 citations

Cloning of a human gene encoding the general transcription initiation factor IIB

1991 • 274 citations

Different requirements for formation of Jun: Jun and Jun: Fos complexes.

1989 • 272 citations

Phosphorylation of RNA polymerase by the murine homologue of the cell-cycle control protein cdc2

1989 • 270 citations

Zinc fingers, zinc clusters, and zinc twists in DNA-binding protein domains.

1991 • 268 citations

v-maf, a viral oncogene that encodes a "leucine zipper" motif.

1989 • 266 citations

elk , Tissue-Specific ets -Related Genes on Chromosomes X and 14 Near Translocation Breakpoints

1989 • 261 citations

Isolation of the gene encoding the yeast TATA binding protein TFIID: A gene identical to the SPT15 suppressor of Ty element insertions

1989 • 256 citations

The serum-inducible mouse gene Krox-24 encodes a sequence-specific transcriptional activator.

1990 • 256 citations

Gene Regulation by Steroid Hormones

1990 • 255 citations

Retinoblastoma gene product activates expression of the human TGF-β2 gene through transcription factor ATF-2

1992 • 255 citations

Isolation and characterization of the Drosophila gene encoding the TATA box binding protein, TFIID

1990 • 254 citations

A role for the adenovirus inducible E2F transcription factor in a proliferation dependent signal transduction pathway.

1990 • 253 citations

HOX11, a homeobox-containing T-cell oncogene on human chromosome 10q24.

1991 • 252 citations

Growth suppression induced by wild-type p53 protein is accompanied by selective down-regulation of proliferating-cell nuclear antigen expression.

1991 • 251 citations

Mammalian ets-1 and ets-2 genes encode highly conserved proteins.

1988 • 248 citations

Regulation of transcription by cyclic AMP-dependent protein kinase.

1989 • 247 citations

Cyclic AMP-dependent protein kinase phosphorylates and inactivates the yeast transcriptional activator ADR1

1989 • 247 citations

EXAFS study of the zinc-binding sites in the protein transcription factor IIIA

1986 • 247 citations

Nuclear location of the putative transforming protein of avian myelocytomatosis virus

1982 • 245 citations

Sequence similarity between the mammalian bmi-1 proto-oncogene and the Drosophila regulatory genes Psc and Su(z)2

1991 • 242 citations

c-ets1 proto-oncogene is a transcription factor expressed in endothelial cells during tumor vascularization and other forms of angiogenesis in humans.

1992 • 242 citations

Solution structure of a DNA-binding unit of Myb: a helix-turn-helix-related motif with conserved tryptophans forming a hydrophobic core.

1992 • 241 citations

The mechanism of chromosomal translocation t(11;14) involving the T-cell receptor C delta locus on human chromosome 14q11 and a transcribed region of chromosome 11p15.

1988 • 236 citations

The ankyrin repeat domains of the NF-kappa B precursor p105 and the protooncogene bcl-3 act as specific inhibitors of NF-kappa B DNA binding.

1992 • 234 citations

The t(11;14)(p15;q11) in a T-Cell Acute Lymphoblastic Leukemia Cell Line Activates Multiple Transcripts, Including Ttg-1, a Gene Encoding a Potential Zinc Finger Protein

1989 • 234 citations

Casein kinase II inhibits the DNA-binding activity of Max homodimers but not Myc/Max heterodimers.

1992 • 230 citations

Several distinct "CCAAT" box binding proteins coexist in eukaryotic cells.

1988 • 230 citations

Sequence-Specific Binding of Human Ets-1 to the T Cell Receptor α Gene Enhancer

1990 • 229 citations

Involvement of the TCL5 gene on human chromosome 1 in T-cell leukemia and melanoma.

1989 • 227 citations

Subcellular localization of proteins encoded by oncogenes of avian myeloblastosis virus and avian leukemia virus E26 and by the chicken c-myb gene

1984 • 225 citations

EGR3, a novel member of the Egr family of genes encoding immediate-early transcription factors.

1991 • 218 citations

I-POU: a POU-domain protein that inhibits neuron-specific gene activation

1991 • 217 citations

Steroid Receptors in Breast Cancer

1979 • 213 citations

Control of c-Jun activity by interaction of a cell-specific inhibitor with regulatory domain δ: Differences between v- and c-Jun

1990 • 212 citations

IP-1: A dominant inhibitor of Fos/Jun whose activity is modulated by phosphorylation

1991 • 212 citations

Mechanism of RNA polymerase II-specific initiation of transcription in vitro: ATP requirement and uncapped runoff transcripts

1982 • 206 citations

Analysis of the gene encoding the largest subunit of RNA polymerase II in Drosophila

1989 • 205 citations

Identification of a common ecotropic viral integration site, Evi-1, in the DNA of AKXD murine myeloid tumors.

1988 • 203 citations

The retinoblastoma gene is frequently altered leading to loss of expression in primary breast tumours.

1989 • 202 citations

TATA-binding protein is a classless factor

1992 • 202 citations

Involvement of the 'leucine zipper' region in the oligomerization and transforming activity of human c-myc protein

1989 • 198 citations

The product of the retroviral transforming gene v-myb is a truncated version of the protein encoded by the cellular oncogene c-myb

1983 • 197 citations

A multigene family encoding several “finger” structures is present and differentially active in mammalian genomes

1987 • 197 citations

PEA3 is a nuclear target for transcription activation by non-nuclear oncogenes.

1989 • 197 citations

v-jun encodes a nuclear protein with enhancer binding properties of AP-1

1988 • 196 citations

DNA Binding by Proteins

1988 • 195 citations

Functional heterogeneity of mammalian TATA-box sequences revealed by interaction with a cell-specific enhancer

1990 • 193 citations

Structure and associated DNA-helicase activity of a general transcription initiation factor that binds to RNA polymerase II

1989 • 193 citations

Sequence-specific DNA binding of the proto-oncoprotein ets-1 defines a transcriptional activator sequence within the long terminal repeat of the Moloney murine sarcoma virus.

1990 • 192 citations

Yeast TATA-box transcription factor gene.

1989 • 191 citations

Drosophila genes Posterior Sex Combs and Suppressor two of zeste encode proteins with homology to the murine bmi-1 oncogene

1991 • 190 citations

Phosphorylation of the C terminus of Fos protein is required for transcriptional transrepression of the c-fos promoter

1990 • 189 citations

The ski oncogene induces muscle differentiation in quail embryo cells

1989 • 188 citations

A novel human homeobox gene lies at the chromosome 10 breakpoint in lymphoid neoplasias with chromosomal translocation t(10;14)

1991 • 186 citations

Determination of the c-MYC DNA-binding site.

1991 • 181 citations

The JUN oncoprotein, a vertebrate transcription factor, activates transcription in yeast

1988 • 180 citations

Cross-coupling of signal transduction pathways: zinc finger meets leucine zipper

1991 • 177 citations

Efficient transformation of chicken embryo fibroblasts by c-Jun requires structural modification in coding and noncoding sequences.

1990 • 175 citations

Discrimination between related DNA sites by a single amino acid residue of Myc-related basic-helix-loop-helix proteins.

1992 • 171 citations

Binding of a Drosophila POU-domain protein to a sequence element regulating gene expression in specific dopaminergic neurons

1990 • 170 citations

Energy requirement for specific transcription initiation by the human RNA polymerase II system.

1984 • 166 citations

Casein kinase II phosphorylation increases the rate of serum response factor-binding site exchange.

1992 • 165 citations

The erg gene: a human gene related to the ets oncogene.

1987 • 164 citations

Cloning and sequence analysis of the mouse genomic locus encoding the largest subunit of RNA polymerase II.

1987 • 161 citations

Characterization of the sequence-specific interaction of mouse c-myb protein with DNA.

1990 • 159 citations

Different pathways mediate virus inducibility of the human IFN-α1 and IFN-β genes

1990 • 158 citations

Direct combinatorial interaction between a herpes simplex virus regulatory protein and a cellular octamer-binding factor mediates specific induction of virus immediate-early gene expression.

1988 • 157 citations

Developmental regulation of c-myb in normal myeloid progenitor cells.

1985 • 155 citations

Cloning of the gene encoding the yeast protein BTF1Y, which can substitute for the human TATA box-binding factor.

1989 • 154 citations

Trans-activation by thyroid hormone receptors: functional parallels with steroid hormone receptors.

1989 • 154 citations

v-erbA specifically suppresses transcription of the avian erythrocyte anion transporter (Band 3) gene

1988 • 153 citations

Nucleotide sequence of v-rel: the oncogene of reticuloendotheliosis virus.

1983 • 150 citations

DNA rearrangement of a homeobox gene in myeloid leukaemic cells.

1988 • 148 citations

Reciprocal expression of human ETS1 and ETS2 genes during T-cell activation: regulatory role for the protooncogene ETS1.

1990 • 146 citations

Specific DNA Binding by c-Myb: Evidence for a Double Helix-Turn-Helix-Related Motif

1991 • 143 citations

A homeodomain substitution changes the regulatory specificity of the Deformed protein in drosophila embryos

1989 • 142 citations

Estrogen receptor assay in primary breast cancer and early recurrence of the disease.

1978 • 135 citations

The proto-oncogene c-fos is over-expressed in the majority of human osteosarcomas.

1990 • 135 citations

Transcription initiation by RNA polymerase II in vitro. Properties of preinitiation, initiation, and elongation complexes.

1987 • 132 citations

Identification of multiple SRF N-terminal phosphorylation sites affecting DNA binding properties.

1992 • 132 citations

Gene encoding the alpha chain of the T-cell receptor is moved immediately downstream of c-myc in a chromosomal 8;14 translocation in a cell line from a human T-cell leukemia.

1986 • 131 citations

A role for the TATA-box-binding protein component of the transcription factor IID complex as a general RNA polymerase III transcription factor.

1992 • 129 citations

v-rel oncoproteins in the nucleus and in the cytoplasm transform chicken spleen cells

1988 • 126 citations

RNA contacts subunits IIo and IIc in HeLa RNA polymerase II transcription complexes.

1986 • 126 citations

RPA190, the gene coding for the largest subunit of yeast RNA polymerase A.

1988 • 124 citations

A protein kinase that phosphorylates the C-terminal repeat domain of the largest subunit of RNA polymerase II.

1989 • 123 citations

The protein Id: a negative regulator of helix-loop-helix DNA binding proteins

1990 • 123 citations

Cloning of the 62-Kilodalton Component of Basic Transcription Factor BTF2

1992 • 120 citations

Expression of novel DNA-binding protein with zinc finger structure in various tumor cells.

1990 • 120 citations

RNA polymerase II of Drosophila

1987 • 115 citations

fra-1: a Serum-Inducible, Cellular Immediate-Early Gene That Encodes a Fos-Related Antigen

1988 • 115 citations

Evi-1, a murine zinc finger proto-oncogene, encodes a sequence-specific DNA-binding protein.

1991 • 113 citations

Segmental and developmental regulation of a presumptive T-cell oncogene in the central nervous system

1990 • 109 citations

Coordination of gene expression in the formation of mammalian mitochondria

1991 • 107 citations

Functional Domains of a Positive Regulatory Protein, PH04, for Transcriptional Control of the Phosphatase Regulon in Saccharomyces cerevisiae

1990 • 106 citations

Analysis of p53 mutants for transcriptional activity.

1991 • 106 citations

Erythroid expression of the 'helix-loop-helix' gene, SCL.

1991 • 106 citations

Identification of a Naturally Occurring Transforming Variant of the p65 Subunit of NF-κB

1992 • 105 citations

The amino acid sequence of murine p53 determined from a c-DNA clone

1984 • 104 citations

Response of hemopoietic cells to avian acute leukemia viruses: Effects on the differentiation of the target cells

1979 • 102 citations

Transactivation of gene expression by nuclear and cytoplasmic rel proteins.

1989 • 100 citations

Systematic Binding Analysis of the Insulin Gene Transcription Control Region: Insulin and Immunoglobulin Enhancers Utilize Similar Transactivators

1988 • 98 citations

The TATA-binding protein: a central role in transcription by RNA polymerases I, II and III

1992 • 97 citations

Transcription-dependent Structural Changes in the C-terminal Domain of Mammalian RNA Polymerase Subunit IIa/o

1989 • 97 citations

Patterns of Evi-1 expression in embryonic and adult tissues suggest that Evi-1 plays an important regulatory role in mouse development*

1991 • 97 citations

Malignant transformation by mutant Rel proteins

1991 • 96 citations

Eukaryotic Transcriptional Regulatory Proteins

1989 • 93 citations

Isolation, Sequence, and Expression of a Human Keratin K5 Gene: Transcriptional Regulation of Keratins and Insights into Pairwise Control

1989 • 93 citations

Retinoblastoma gene deletions in human glioblastomas.

1991 • 89 citations

Amanitin-resistant RNA polymerase II mutations are in the enzyme's largest subunit.

1983 • 89 citations

A mutation in the largest subunit of RNA polymerase II alters RNA chain elongation in vitro.

1985 • 87 citations

Cloning genes for the biosynthesis of a macrolide antibiotic.

1987 • 87 citations

The oncogenic potential of an activated Hox-2.4 homeobox gene in mouse fibroblasts.

1991 • 80 citations

p53 expression is common in malignant mesothelioma

1992 • 78 citations

Activation Domains of L-Myc and c-Myc Determine Their Transforming Potencies in Rat Embryo Cells

1992 • 77 citations

Structure and transcription of the cellular homolog (c-myb) of the avian myeloblastosis virus transforming gene (v-myb)

1983 • 77 citations

Sequence-specific interaction of the Ets1 protein with the long terminal repeat of the human T-lymphotropic virus type I

1991 • 75 citations

Protein-DNA Recognition

1984 • 73 citations

The c-ets-1 protein is chromatin associated and binds to DNA in vitro.

1989 • 70 citations

Identification and characterization of the protein encoded by the human c-myb proto-oncogene.

1986 • 69 citations

Retinoblastoma and p53 gene expression related to relapse and survival in human breast cancer: An immunohistochemical study

1992 • 67 citations

Functional domains of a positive regulatory protein, PHO4, for transcriptional control of the phosphatase regulon in Saccharomyces cerevisiae.

1990 • 67 citations

Myc meets its max

1991 • 66 citations

A Short-Lived Nuclear Phosphoprotein Encoded by the Human ets-2 Proto-Oncogene Is Stabilized by Activation of Protein Kinase C

1988 • 66 citations

The protooncogene c-myb increases the expression of insulin-like growth factor 1 and insulin-like growth factor 1 receptor messenger RNAs by a transcriptional mechanism.

1991 • 64 citations

The myc Oncogene: Its Role in Transformation and Differentiation

1986 • 64 citations

The Drosophila ets-2 gene: Molecular structure, chromosomal localization, and developmental expression

1988 • 61 citations

C-myc and the yeast transcription factor PHO4 share a common CACGTG-binding motif.

1991 • 59 citations

The v-ski Oncogene Encodes a Truncated Set of c-ski Coding Exons with Limited Sequence and Structural Relatedness to v-myc

1989 • 59 citations

Retroviral insertions in the CB-1/Fim-3 common site of integration activate expression of the Evi-1 gene.

1989 • 57 citations

Characterization and localization of the products of the human homologs of the v-ets oncogene.

1988 • 55 citations

The ets sequence is required for induction of erythroblastosis in chickens by avian retrovirus E26

1989 • 55 citations

Induction of Human Growth Hormone Promoter Activity by the Adenosine 3′,5′-Monophosphate Pathway Involves a Novel Responsive Element

1989 • 53 citations

Identification of an Adenosine 3′,5′-Monophosphate (cAMP)-Responsive Region in the Rat Growth Hormone Gene: Evidence for Independent and Synergistic Effects of cAMP and Thyroid Hormone on Gene Expression

1989 • 50 citations

Isolation, sequence, and expression of a human keratin K5 gene: transcriptional regulation of keratins and insights into pairwise control.

1989 • 48 citations

Expression, regulation, and chromosomal localization of the Max gene.

1992 • 47 citations

Determining the effect of inducible protein phosphorylation on the DNA-binding activity of transcription factors

1992 • 47 citations

Evidence that stimulatory factor(s) of RNA polymerase II participates in accurate transcription in a HeLa cell lysate.

1982 • 43 citations

The induction of Friend erythroleukaemia differentiation is markedly affected by expression of a transfected c-myb cDNA.

1988 • 43 citations

Epithelial-specific keratin gene expression: identification of a 300 base-pair controlling segment

1990 • 41 citations

A real receptor-operated calcium channel?

1988 • 40 citations

5,6-Dichloro-1-β-D-ribofuranosylbenzimidazole inhibits a HeLa protein kinase that phosphorylates an RNA polymerase II-derived peptide

1989 • 39 citations

A short-lived nuclear phosphoprotein encoded by the human ets-2 proto-oncogene is stabilized by activation of protein kinase C.

1988 • 38 citations

The v-ski oncogene encodes a truncated set of c-ski coding exons with limited sequence and structural relatedness to v-myc.

1989 • 37 citations

The homeo box and mammalian development

1985 • 37 citations

Suppression of MHC gene expression in cancer cells

1987 • 33 citations

Tissue specific trans-acting factor interaction with proximal rat prolactin gene promoter sequences.

1988 • 31 citations

A distinct octamer-binding protein present in malignant melanoma cells

1988 • 31 citations

Interaction of nucleic acids with the DNA‐dependent RNA polymerases of Drosophila

1983 • 30 citations

Formation of transcription preinitiation complexes with an amanitin-resistant RNA polymerase II.

1988 • 29 citations

Association of genetic alterations of c-myc, c-fos, and c-Ha-ras proto-oncogenes in colorectal tumors

1992 • 24 citations

Cellular proteins involved in SV40 transformation☆

1983 • 24 citations

Biochemical mechanisms of oncogene activity: proteins encoded by oncogenes. Introduction.

1986 • 24 citations

Positive and negative factors regulate the transcription of the ETS2 gene via an oncogene-responsive-like unit within the ETS2 promoter region.

1991 • 23 citations

The ski oncogene.

1991 • 23 citations

Mapping of MAX to human chromosome 14 and mouse chromosome 12 by in situ hybridization.

1992 • 16 citations

Identification of the DNA Binding Subunit of RNA Polymerase II from Ehrlich Ascites Tumor Cells1

1983 • 15 citations

The nuclear oncogenes v-erbA and v-ets cooperate in the induction of avian erythroleukemia.

1992 • 13 citations

Incidence of the 15q+;17q- chromosome translocation in acute promyelocytic leukaemia (APL)

1985 • 12 citations

Transcription factors as oncogenes

1987 • 9 citations

Glucocorticoid inhibition of gene expression and proliferation of murine lymphoid cells in vitro.

1989 • 9 citations

The 180 KDa polypeptide contains the DNA-binding domain of RNA polymerase II

1987 • 8 citations

A monoclonal antibody directed against a small subunit of RNA polymerase B blocks the initiation step

1987 • 8 citations

Biochemical mechanisms of oncogene activity: proteins encoded by oncogenes.

1986 • 3 citations